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Showing 1-29 of 29 results for "M5293" within Papers
Kathy Saraiva-Pava et al.
World journal of gastroenterology, 21(21), 6526-6542 (2015-06-16)
To establish a cellular model correctly mimicking the gastric epithelium to overcome the limitation in the study of Helicobacter pylori (H. pylori) infection. Aiming to overcome this limitation, clones of the heterogenic cancer-derived NCI-N87 cell line were isolated, by stably-transducing
Optimized Protocol for Regeneration of the Conjunctival Epithelium Using the Cell Suspension Technique.
Bertolin M, et al.
Cornea, 38(4), 469-479 (2019)
Emma C Skoog et al.
PloS one, 7(5), e36378-e36378 (2012-05-09)
Helicobacter pylori colonizes the mucus niche of the gastric mucosa and is a risk factor for gastritis, ulcers and cancer. The main components of the mucus layer are heavily glycosylated mucins, to which H. pylori can adhere. Mucin glycosylation differs
Yajun Chen et al.
American journal of physiology. Lung cellular and molecular physiology, 306(8), L797-L807 (2014-02-04)
Chronic airway diseases are characterized by inflammation and mucus overproduction. The MUC5AC mucin gene is upregulated by the proinflammatory cytokine interleukin-1 β (IL-1β) via activation of cAMP response element-binding protein (CREB) in the NCI-H292 cancer cell line and nuclear factor-κB
Médea Padra et al.
Virulence, 9(1), 898-918 (2018-04-12)
Helicobacter suis colonizes the stomach of most pigs and is the most prevalent non-Helicobacter pylori Helicobacter species found in the human stomach. In the human host, H. suis contributes to the development of chronic gastritis, peptic ulcer disease and MALT
MUC5AC upstream complex repetitive region length polymorphisms are associated with susceptibility and clinical stage of gastric cancer.
Wang C
PLoS ONE, 9(6), e98327-e98327 (2014)
Dalia Fakih et al.
American journal of physiology. Lung cellular and molecular physiology, 318(6), L1270-L1279 (2020-04-30)
The organization of the normal airway mucus system differs in small experimental animals from that in humans and large mammals. To address normal murine airway mucociliary clearance, Alcian blue-stained mucus transport was measured ex vivo on tracheal tissues of naïve
Olive Jung et al.
Biofabrication, 14(2) (2022-02-16)
The COVID-19 pandemic has highlighted the need for human respiratory tract-based assay platforms for efficient discovery and development of antivirals and disease-modulating therapeutics. Physiologically relevant tissue models of the lower respiratory tract (LRT), including the respiratory bronchioles and the alveolar
Aindrias Ryan et al.
Biochemistry, 54(4), 1089-1099 (2015-01-07)
Molecular manipulation and expression of mucins, large glycoproteins that provide the structural framework of mucus, are challenging due to mucins' size and numerous domains, including variable number tandem repeat (VNTRs) regions that are sites of O-glycosylation. Only individual human mucin
Marina Bertolin et al.
Cornea, 38(4), 469-479 (2018-06-21)
To develop autologous tissue-engineered conjunctival epithelial sheets to be used as advanced therapy medicinal products for severe ocular surface disorders involving the conjunctiva. Methods used aimed at 1) mapping the conjunctiva for identification of the stem cell location, 2) establishing
Yvonne Chang et al.
Toxicology and applied pharmacology, 379, 114644-114644 (2019-07-01)
Current assumption for assessing carcinogenic risk of polycyclic aromatic hydrocarbons (PAHs) is that they function through a common mechanism of action; however, recent studies demonstrate that PAHs can act through unique mechanisms potentially contributing to cancer outcomes in a non-additive
Rachael E Rayner et al.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 19(5), 752-761 (2020-06-23)
In vitro cystic fibrosis (CF) models are crucial for understanding the mechanisms and consequences of the disease. They are also the gold standard for pre-clinical efficacy studies of current and novel CF drugs. However, few studies have investigated expansion and
C H Kim et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(12), 4188-4194 (2001-06-19)
Glutamate receptor channels are synthesized in the cell body, are inserted into intracellular vesicles, and move to dendrites where they become incorporated into synapses. Dendrites contain abundant microtubules that have been implicated in the vesicle-mediated transport of ion channels. We
Abnormal expression of M1/MUC5AC mucin in distal colon of patients with diverticulitis, ulcerative colitis and cancer.
Forgue-Lafitte ME, et al.
International Journal of Cancer. Journal International Du Cancer, 121(7), 1543-1549 (2007)
Genome reference and sequence variation in the large repetitive central exon of human MUC5AC.
Guo X
American Journal of Respiratory Cell and Molecular Biology, 50(1), 223-232 (2014)
Claudia Hempt et al.
Archives of toxicology, 95(3), 837-852 (2020-12-16)
E 551, also known as synthetic amorphous silica (SAS), is the second most produced food additive. However, according to the re-evaluation of E 551 by the European Food Safety Authority (EFSA) in 2018, the amount of available data on the oral toxicity
Josefine C Freiberg et al.
Journal of clinical medicine, 11(11) (2022-06-11)
To examine the physicochemical properties of five preservative-free (PF) 0.005% latanoprost ophthalmic products; Monoprost®, Latanest®, Gaap Ofteno®, Xalmono®, and Xaloptic® Free. Furthermore, the study investigated the mucin production and cell survival of primary cultured human conjunctival goblet cells when treated
Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical-and infection-induced intestinal inflammation.
Kim JJ, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 309(6), G455-G465 (2015)
Gastrointestinal cell lines form polarized epithelia with an adherent mucus layer when cultured in semi-wet interfaces with mechanical stimulation.
Navabi N, et al.
PLoS ONE, 8(7), e68761-e68761 (2013)
Anne Hedengran et al.
Acta ophthalmologica, 100(7), 819-827 (2022-05-10)
To investigate the effect of polyquaternium-1 (PQ)-preserved and benzalkonium chloride (BAK)-preserved travoprost eye drops on viability of primary human conjunctival goblet cell (GC) cultures and on secretion of mucin and cytokines. Furthermore, to evaluate the physicochemical properties of the branded
Newborn pig trachea cell line cultured in air-liquid interface conditions allows a partial in vitro representation of the porcine upper airway tissue.
Delgado-Ortega M, et al.
BMC Cell Biology, 15(1), 14-14 (2014)
Olivia Müllertz et al.
BMJ open ophthalmology, 6(1), e000892-e000892 (2022-01-08)
To investigate the short-term impact on human conjunctival goblet cell (GC) survival and mucin release of acute exposure to benzalkonium chloride (BAK) preserved and preservative-free (PF) 0.005% (w/v) latanoprost (LT) eye drops, and to compare the eye drops' physicochemical properties.
Minghua Li et al.
Science immunology, 6(59) (2021-05-20)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic, resulting millions of infections and deaths with few effective interventions available. Here, we demonstrate that SARS-CoV-2 evades interferon (IFN) activation in respiratory epithelial cells, resulting in a delayed
Nick J I Hamilton et al.
Tissue engineering. Part C, Methods, 25(2), 93-102 (2019-01-17)
This article describes a method for engrafting epithelial progenitor cells to a revascularized scaffold in a protective and supportive collagen-rich environment. This method has the potential to overcome two key limitations of existing grafting techniques as epithelial cells are protected
Yun Han Kwon et al.
Cellular and molecular gastroenterology and hepatology, 7(4), 709-728 (2019-02-05)
Serotonin (5-hydroxytryptamine [5-HT]) is synthesized mainly within enterochromaffin (EC) cells in the gut, and tryptophan hydroxylase 1 (Tph1) is the rate-limiting enzyme for 5-HT synthesis in EC cells. Accumulating evidence suggests the importance of gut microbiota in intestinal inflammation. Considering
Rachael E Rayner et al.
Scientific reports, 9(1), 500-500 (2019-01-27)
Robust in vitro lung models are required for risk assessment to measure key events leading to respiratory diseases. Primary normal human bronchial epithelial cells (NHBE) represent a good lung model but obtaining well-differentiated 3D cultures can be challenging. Here, we
The gastrointestinal mucus system in health and disease.
Johansson MEV, et al.
Nature Reviews. Gastroenterology & Hepatology, 10(6), 352-352 (2013)
Elizabeth F Maughan et al.
iScience, 25(11), 105409-105409 (2022-11-18)
The airway epithelium is a protective barrier that is maintained by the self-renewal and differentiation of basal stem cells. Increasing age is a principle risk factor for chronic lung diseases, but few studies have explored age-related molecular or functional changes
Janice J Kim et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(6), G455-G465 (2015-07-25)
Mucosal inflammation is accompanied by an alteration in 5-HT. Intestinal 5-HT synthesis is catalyzed by tryptophan hydroxylase 1 (Tph1) and we have shown that mice deficient in this rate-limiting enzyme have reduced severity of intestinal inflammation in models of chemical-induced
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