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Showing 1-30 of 72 results for "M5409" within Papers
Nupura Hirve et al.
PloS one, 7(9), e45158-e45158 (2012-10-03)
Binding of the membrane phospholipid phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) to the Pleckstrin Homology (PH) domain of the Tec family protein tyrosine kinase, Inducible T cell Kinase (ITK), is critical for the recruitment of the kinase to the plasma membrane and its
M Ulanova et al.
Scandinavian journal of immunology, 50(4), 387-393 (1999-10-16)
Human CD1 molecules, expressed on the surface of professional antigen-presenting cells (including dendritic cells, Langerhans' cells, B cells and activated monocytes) are structurally homologous to major histocompatibility complex (MHC) class I and class II molecules. CD1b and CD1c have been
Antibody structure, instability, and formulation.
Wang W
Journal of Pharmaceutical Sciences, 96(1), 1-26 (2007)
M Kaul et al.
FEBS letters, 500(1-2), 91-98 (2001-07-04)
The present study investigated when during "in vitro" maturation macrophages (MPhi) express membrane C1q (mC1q), and whether cell activation affects expression and function of mC1q. Although C1q mRNA was repeatedly detected in freshly isolated monocytes using reverse transcriptase-polymerase chain reaction
Emil Kofod-Olsen et al.
Journal of virology, 86(21), 11483-11492 (2012-08-17)
The immune system targets virus-infected cells by different means. One of the essential antiviral mechanisms is apoptosis induced by ligation of tumor necrosis factor receptor 1 (TNFR1). This receptor can be activated by tumor necrosis factor alpha (TNF-α), which upon
Synthetic hydrogels engineered to promote collecting lymphatic vessel sprouting.
Hooks, et al.
Biomaterials, 284, 121483-121483 (2023)
M L Schito et al.
Infection and immunity, 65(8), 3165-3170 (1997-08-01)
Severe combined immunodeficient (SCID)-beige mice inoculated with the intracellular parasite Eimeria papillata produced significantly more oocysts during primary infections than inoculated immunodeficient SCID mice. Therefore, the addition of the beige mutation, which detrimentally affects neutrophil and natural killer (NK) cell
Jennifer L McCann et al.
Nature genetics, 55(10), 1721-1734 (2023-09-22)
The single-stranded DNA cytosine-to-uracil deaminase APOBEC3B is an antiviral protein implicated in cancer. However, its substrates in cells are not fully delineated. Here APOBEC3B proteomics reveal interactions with a surprising number of R-loop factors. Biochemical experiments show APOBEC3B binding to
M Romano et al.
Gastroenterology, 110(5), 1448-1455 (1996-05-01)
The mechanism by which gastric mucosa becomes more resistant to damage by repeated aspirin administration is not known. Transforming growth factor alpha (TGF-alpha) and epidermal growth factor (EGF) prevent drug-induced gastric injury. The aim of this study was to determine
Anthony D Saleh et al.
PloS one, 6(10), e24429-e24429 (2011-10-25)
Genotoxic stressors, such as radiation, induce cellular damage that activates pre-programmed repair pathways, some of which involve microRNAs (miRNA) that alter gene expression. The let-7 family of miRNA regulates multiple cellular processes including cell division and DNA repair pathways. However
Louise A Jopling et al.
The Journal of biological chemistry, 277(9), 6864-6873 (2001-11-29)
Th2 lymphocytes play a central role in the control and maintenance of allergic inflammation. The chemokine receptor CCR4 is preferentially expressed on the surface of Th2 lymphocytes polarised in vitro. However, CCR4 is found on the surface of a significant
Alicja Karabasz et al.
Scientific reports, 11(1), 10295-10295 (2021-05-15)
The binding of mouse IgG3 to Fcγ receptors (FcγR) and the existence of a mouse IgG3-specific receptor have been discussed for 40 years. Recently, integrin beta-1 (ITGB1) was proposed to be a part of an IgG3 receptor involved in the
Alexander Henke et al.
PloS one, 7(8), e42516-e42516 (2012-08-11)
During prostate development, mesenchymal-epithelial interactions regulate organ growth and differentiation. In adult prostate, stromal-epithelial interactions are important for tissue homeostasis and also play a significant role in prostate cancer. In this study we have identified molecules that show a mesenchymal
A Chadburn et al.
The American journal of pathology, 136(1), 29-37 (1990-01-01)
LeuM5 antigen (CD11c, p150.95) expression, widely used as an immunodiagnostic marker for B-cell hairy cell leukemia, was examined on benign, normal peripheral blood T cells before and after stimulation in vitro with phytohemagglutinin and on a large, diverse panel of
Nishita Shastri et al.
Molecular cell, 72(2), 222-238 (2018-10-09)
DNA polymerase stalling activates the ATR checkpoint kinase, which in turn suppresses fork collapse and breakage. Herein, we describe use of ATR inhibition (ATRi) as a means to identify genomic sites of problematic DNA replication in murine and human cells.
Joseph N Pucella et al.
Journal of immunology (Baltimore, Md. : 1950), 194(6), 2635-2642 (2015-02-13)
MicroRNA (miR)-mediated regulation of protein abundance is a pervasive mechanism of directing cellular processes. The well-studied and abundant miR-182 has previously been implicated in many aspects of T cell function, DNA repair, and cancer. In this study, we show that
Christian Wertheimer et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 255(11), 2147-2155 (2017-08-07)
To introduce a human cell culture technique for investigating in-vitro behavior of primary epiretinal cells and membrane contraction of fibrocellular tissue surgically removed from eyes with idiopathic macular pucker. Human epiretinal membranes were harvested from ten eyes with idiopathic macular
Steven Fiering et al.
eLife, 4, e04796-e04796 (2015-07-17)
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replicating selected results from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and
Hongxia Duan et al.
The Journal of clinical investigation, 131(21) (2021-09-08)
Initiation of T cell receptor (TCR) signaling involves the activation of the tyrosine kinase LCK; however, it is currently unclear how LCK is recruited and activated. Here, we have identified the membrane protein CD146 as an essential member of the
Wei Hu et al.
Nature immunology, 22(9), 1163-1174 (2021-08-25)
The immunosuppressive function of regulatory T (Treg) cells is dependent on continuous expression of the transcription factor Foxp3. Foxp3 loss of function or induced ablation of Treg cells results in a fatal autoimmune disease featuring all known types of inflammatory
Y Fikri et al.
Scandinavian journal of immunology, 55(4), 373-381 (2002-04-23)
We have previously shown that the proliferation of freshly isolated bovine WC1+gammadelta T cells to superantigens (SAgs) including staphylococcal enterotoxin A (SEA), and staphylococcal enterotoxin B (SEB) or toxic shock syndrome type-1 (TSST-1) required the presence of antigen-presenting cells (APC)
Alexander R Langley et al.
PloS one, 5(10), e13673-e13673 (2010-11-10)
Ro ribonucleoprotein particles (Ro RNPs) consist of a non-coding Y RNA bound by Ro60, La and possibly other proteins. The physiological function of Ro RNPs is controversial as divergent functions have been reported for its different constituents. We have recently
Jing Shi et al.
Science immunology, 3(21) (2018-04-01)
Discrepancies on the role of citrullination in the induction of experimental arthritis by neutrophils extracellular traps.
Esther M Millares-Ramirez et al.
Journal of veterinary internal medicine, 35(4), 2026-2034 (2021-05-29)
Severe asthma in horses is characterized by structural changes that thicken the lower airway wall, a change that is only partially reversible by current treatments. Increased vascularization contributes to the thickening of the bronchial wall in humans with asthma and
Aikaterini Tsaousi et al.
PloS one, 11(2), e0148873-e0148873 (2016-02-18)
Thelper1 (Th1) lymphocytes have been previously implicated in atherosclerotic plaque growth but their role in plaque vulnerability to rupture is less clear. We investigated whether T-bet knockout that prevents Th1 lymphocyte differentiation modulates classical (M1) macrophage activation or production of
Gabriela Sandoval et al.
Journal of molecular recognition : JMR, 25(11), 571-579 (2012-10-31)
Different mathematical models with different degrees of complexity have been proposed to model affinity chromatography. In this work, in particular, a general rate model has been studied that considers axial dispersion, external film mass transfer, intraparticle diffusion, and kinetic effects
Jan Christian Wohlsein et al.
PloS one, 19(1), e0295268-e0295268 (2024-01-19)
In steroid-responsive meningitis-arteritis (SRMA), inflammatory dysregulation is driven by neutrophilic granulocytes resulting in purulent leptomeningitis. Neutrophils can generate neutrophil extracellular traps (NET). Uncontrolled NET-formation or impaired NET-clearance evidently cause tissue and organ damage resulting in immune-mediated diseases. The aim of
Henning Gruell et al.
Journal of virology, 87(15), 8535-8544 (2013-05-31)
The development of an effective vaccine preventing HIV-1 infection remains elusive. Thus, the development of novel approaches capable of preventing HIV-1 transmission is of paramount importance. However, this is partly hindered by the lack of an easily accessible small-animal model
Haridha Shivram et al.
RNA (New York, N.Y.), 24(9), 1266-1274 (2018-06-29)
The quality of RNA sequencing data relies on specific priming by the primer used for reverse transcription (RT-primer). Nonspecific annealing of the RT-primer to the RNA template can generate reads with incorrect cDNA ends and can cause misinterpretation of data
Rafael A Cubas et al.
Nature medicine, 19(4), 494-499 (2013-03-12)
The majority of HIV-infected individuals fail to produce protective antibodies and have diminished responses to new immunizations. We report here that even though there is an expansion of follicular helper T (TFH) cells in HIV-infected individuals, the cells are unable
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