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Showing 1-30 of 228 results for "M6020" within Papers
Mark S Lowenthal et al.
Analytical and bioanalytical chemistry, 407(18), 5453-5462 (2015-05-01)
Chromatographic separation of monosaccharides hydrolyzed from glycoconjugates or complex, aggregate biomaterials, can be achieved by classic analytical methods without a need for derivatizing the monosaccharide subunits. A simple and sensitive method is presented for characterizing underivatized monosaccharides following hydrolysis from
Javier Sánchez-Martín et al.
Plant, cell & environment, 38(7), 1434-1452 (2014-12-24)
Although a wealth of information is available on the induction of one or several drought-related responses in different species, little is known of how their timing, modulation and crucially integration influence drought tolerance. Based upon metabolomic changes in oat (Avena
Rafał Biedroń et al.
PloS one, 10(4), e0123293-e0123293 (2015-04-08)
The initiation of adaptive immune responses to protein antigens has to be preceded by their uptake by antigen presenting cells and intracellular proteolytic processing. Paradoxically, endocytic receptors involved in antigen uptake do not bind the majority of proteins, which may
Jason R Potas et al.
Journal of immunological methods, 420, 38-49 (2015-04-04)
Macrophages play a key role in tissue regeneration following peripheral nerve injury by preparing the surrounding parenchyma for regeneration, however, they can be damaging if the response is excessive. Interleukin 10 (IL-10) is a cytokine that promotes macrophages toward an
Charles DeRossi et al.
The Journal of biological chemistry, 281(9), 5916-5927 (2005-12-13)
MPI encodes phosphomannose isomerase, which interconverts fructose 6-phosphate and mannose 6-phosphate (Man-6-P), used for glycoconjugate biosynthesis. MPI mutations in humans impair protein glycosylation causing congenital disorder of glycosylation Ib (CDG-Ib), but oral mannose supplements normalize glycosylation. To establish a mannose-responsive
Monika Poláková et al.
European journal of medicinal chemistry, 46(3), 944-952 (2011-02-08)
Human Golgi α-mannosidase II (hGM) is a pharmaceutical target for the design of inhibitors with anti-tumor activity. Nanomolar inhibitors of hGM exhibit unwanted co-inhibition of the human lysosomal α-mannosidase (hLM). Hence, improving specificity of the inhibitors directed toward hGM is
Hongxiang Sun et al.
Carbohydrate polymers, 121, 388-402 (2015-02-11)
The polysaccharide from the roots of Actinidia eriantha (AEPS), a potent antitumor agent and immunological adjuvant, was investigated for the immunomodulatory effects on RAW264.7 macrophages and its molecular mechanisms. AEPS could significantly enhance the pinocytic and phagocytic activity, induce the
Jin-Oh You et al.
Biomaterials, 57, 22-32 (2015-05-10)
A principal challenge in wound healing is a lack of cell recruitment, cell infiltration, and vascularization, which occurs in the absence of temporal and spatial cues. We hypothesized that a scaffold that expands due to local changes in pH may
M Otter et al.
Hepatology (Baltimore, Md.), 16(1), 54-59 (1992-07-01)
Various studies have shown that mannose receptors rapidly eliminate glycoproteins and microorganisms bearing high mannose-type carbohydrate chains from the blood circulation. The purpose of this study was to characterize the mannose receptor in the liver, which in vivo is involved
Charles D Murin et al.
Journal of virology, 88(17), 10177-10188 (2014-06-27)
The neutralizing anti-HIV-1 antibody 2G12 is of particular interest due to the sterilizing protection it provides from viral challenge in animal models. 2G12 is a unique, domain-exchanged antibody that binds exclusively to conserved N-linked glycans that form the high-mannose patch
Jianglin Tan et al.
Burns : journal of the International Society for Burn Injuries, 41(7), 1517-1523 (2015-04-30)
Hypertrophic scar is one of the unique fibrotic diseases in human. Intraepidermal blister is a common clinical symptom following the hypertrophic scar formation. However, little is known about the reason of blister creation. In this study, we selected three patients
Yukishige Ito et al.
Current opinion in structural biology, 15(5), 481-489 (2005-09-13)
High-mannose-type oligosaccharides have been shown to play important roles in protein quality control. Several intracellular proteins, such as lectins, chaperones and glycan-processing enzymes, are involved in this process. These include calnexin/calreticulin, UDP-glucose:glycoprotein glucosyltransferase (UGGT), cargo receptors (such as VIP36 and
Sasha E Parets et al.
Epigenetics, 10(9), 784-792 (2015-06-20)
African Americans are at increased risk for spontaneous preterm birth (PTB). Though PTB is heritable, genetic studies have not identified variants that account for its intergenerational risk, prompting the hypothesis that epigenetic factors may also contribute. The objective of this
Najma Bhat et al.
The Journal of biological chemistry, 282(48), 34877-34887 (2007-10-02)
Cryptosporidium sp. cause human and animal diarrheal disease worldwide. The molecular mechanisms underlying Cryptosporidium attachment to, and invasion of, host cells are poorly understood. Previously, we described a surface-associated Gal/GalNAc-specific lectin activity in sporozoites of Cryptosporidium parvum. Here we describe
Laetitia Pigeyre et al.
Viruses, 11(9) (2019-09-20)
The success of oral infection by viruses depends on their capacity to overcome the gut epithelial barrier of their host to crossing over apical, mucous extracellular matrices. As orally transmitted viruses, densoviruses, are also challenged by the complexity of the
Andreas Sichert et al.
Nature microbiology, 5(8), 1026-1039 (2020-05-27)
Brown algae are important players in the global carbon cycle by fixing carbon dioxide into 1 Gt of biomass annually, yet the fate of fucoidan-their major cell wall polysaccharide-remains poorly understood. Microbial degradation of fucoidans is slower than that of other
Pinkesh G Sutariya et al.
Talanta, 147, 590-597 (2015-11-26)
A new, simple, ultra-sensitive and selective approach has been reported for the "on spot" colorimetric detection of creatinine based on calix[4]arene functionalized gold nanoparticles (AuNPs) with excellent discrimination in the presence of other biomolecules. The lower detection limit of the
Lingyan Ma et al.
Gut microbes, 12(1), 1-19 (2020-11-06)
Obesity is associated with impaired intestinal barrier function and dysbiosis of the gut microbiota. Spermidine, a polyamine that acts as an autophagy inducer, has important benefits in patients with aging-associated diseases and metabolic dysfunction. However, the mechanism of spermidine on
Yanmei Zou et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(7), 5179-5186 (2015-02-06)
In the present study, we investigated the effects and action mechanisms of a purified polysaccharide (APWP) from Andrographis paniculata, on human hepatocellular carcinoma (HCC) HepG2 cells. The results showed that APWP was able to suppress the proliferation of HepG2 cells
Jeffrey S Hakim et al.
Tissue engineering. Part A, 21(13-14), 2099-2114 (2015-04-22)
Positively charged oligo[poly(ethylene glycol) fumarate] (OPF+) scaffolds loaded with Schwann cells bridge spinal cord injury (SCI) lesions and support axonal regeneration in rat. The regeneration achieved is not sufficient for inducing functional recovery. Attempts to increase regeneration would benefit from
Chloe L Thio et al.
Journal of virology, 79(14), 9192-9196 (2005-07-05)
Mannose binding lectin (MBL) is a central component of the innate immune response and thus may be important for determining hepatitis B virus (HBV) persistence. Since single-nucleotide polymorphisms (SNPs) in the gene encoding MBL (mbl2) alter the level of functional
Shuangquan Yao et al.
Bioresource technology, 185, 21-27 (2015-03-10)
To reduce the degradation of cellulose and obtain high molecular weight of hemicellulose from the extracts, pH pre-corrected hot water pretreatment was developed by employing sodium hydroxide (3.9mol/L). The response surface model was established to optimize the extraction process. The
P Hu et al.
Biochemical and biophysical research communications, 167(2), 520-527 (1990-03-16)
The catalytic and immunological properties of acid phosphatases (EC in different tissues were studied. It was demonstrated that high uptake forms of lysosomal enzymes like beta-galactosidase isolated from human platelets and bovine testis are mature enzymes, which have not
Brett Shannon et al.
Journal of immunology (Baltimore, Md. : 1950), 192(11), 5074-5082 (2014-04-25)
HSV-2 infection is common and generally asymptomatic, but it is associated with increased HIV susceptibility and disease progression. This may relate to herpes-mediated changes in genital and systemic immunology. Cervical cytobrushes and blood were collected from HIV-uninfected African/Caribbean women in
Cecilia W Huo et al.
Breast cancer research : BCR, 17, 79-79 (2015-06-05)
Mammographic density (MD), after adjustment for a women's age and body mass index, is a strong and independent risk factor for breast cancer (BC). Although the BC risk attributable to increased MD is significant in healthy women, the biological basis
Patricia Bonin et al.
Environmental science and pollution research international, 22(20), 15347-15359 (2015-01-07)
The impact of petroleum contamination and of burrowing macrofauna on abundances of Marinobacter and denitrifiers was tested in marine sediment mesocoms after 3 months incubation. Quantification of this genus by qPCR with a new primer set showed that the main
Ikuko Takahashi et al.
The Tohoku journal of experimental medicine, 206(4), 333-340 (2005-07-06)
Acid sphingomyelinase (ASM) is the lysosomal enzyme responsible for the hydrolysis of sphingomyelin to ceramide and phosphocholine. An inherited deficiency of this enzymatic activity results in the Type A and B forms of Niemann-Pick disease (NPD). ASM is also readily
Siniša Sić et al.
Journal of chromatography. A, 1408, 93-100 (2015-07-18)
Investigation of oligosaccharides attached to proteins as post-translational modification remains an important research field in the area of glycoproteomics as well as in biotechnology. The development of new tools for qualitative and quantitative analysis of glycans has gained high importance
Zhen-Bin Wang et al.
Carbohydrate polymers, 109, 49-55 (2014-05-13)
Three partially purified polysaccharides were extracted from Phellinus linteus mycelia using hot water, 1% (NH4)2C2O4, and 1.25M NaOH/0.05% NaBH4, and the extracts were named PL-W, PL-A, and, PL-N respectively. PL-N mainly comprised xylose and arabinose with a high molecular weight
Konstantinos Karakostis et al.
Scientific reports, 5, 17665-17665 (2015-12-08)
Galectin family members specifically bind beta-galactoside derivatives and are involved in different cellular events, including cell communication, signalling, apoptosis, and immune responses. Here, we report a tandem-repeat type galectin from the Paracentrotus lividus sea urchin embryo, referred to as Pl-GAL-8.
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