Search Within
M6020
Applied Filters:
Keyword:'M6020'
Showing 1-30 of 228 results for "M6020" within Papers
Youya Nakazawa et al.
Cancer science, 106(2), 201-207 (2014-12-03)
Almost all cancers show intrinsic and/or evasive resistance to vascular endothelial growth factor (VEGF) inhibitors by multiple mechanisms. Serum angiopoietin-2 (Ang2) level has been proposed as a potential biomarker of VEGF inhibitor response in several cancers. From these clinical observations
Polina Maximchik et al.
The FEBS journal, 285(24), 4590-4601 (2018-10-31)
The dependence of tumors on glycolysis for ATP generation offers a rationale for therapeutic strategies aimed at selective inhibition of the glycolytic pathway. Analysis of tumor cell responses to anticancer drugs revealed that inhibition of glycolysis by 2-deoxy-D-glucose (2-DG) generally
Hui Shen et al.
Infection and immunity, 83(7), 2694-2704 (2015-04-22)
Fungi can shield surface pathogen-associated molecular patterns (PAMPs) for evading host immune attack. The most common and opportunistic human pathogen, Candida albicans, can shield β-(1 3)-glucan on the cell wall, one of the major PAMPs, to avoid host phagocyte Dectin-1
Stephanie C Gordts et al.
The Journal of antimicrobial chemotherapy, 70(6), 1674-1685 (2015-02-24)
This study aimed to assess the antiviral properties of a unique lectin (NICTABA) produced by the tobacco plant, Nicotiana tabacum. Cellular assays were used to investigate the antiviral activity of NICTABA and Urtica dioica agglutinin (UDA). Surface plasmon resonance (SPR)
Mark S Lowenthal et al.
Analytical and bioanalytical chemistry, 407(18), 5453-5462 (2015-05-01)
Chromatographic separation of monosaccharides hydrolyzed from glycoconjugates or complex, aggregate biomaterials, can be achieved by classic analytical methods without a need for derivatizing the monosaccharide subunits. A simple and sensitive method is presented for characterizing underivatized monosaccharides following hydrolysis from
Javier Sánchez-Martín et al.
Plant, cell & environment, 38(7), 1434-1452 (2014-12-24)
Although a wealth of information is available on the induction of one or several drought-related responses in different species, little is known of how their timing, modulation and crucially integration influence drought tolerance. Based upon metabolomic changes in oat (Avena
Varnica Khetrapal et al.
Nucleic acids research, 43(13), e83-e83 (2015-03-25)
Creation of defined genetic mutations is a powerful method for dissecting mechanisms of bacterial disease; however, many genetic tools are only developed for laboratory strains. We have designed a modular and general negative selection strategy based on inducible toxins that
Broder Rühmann et al.
Journal of chromatography. A, 1350, 44-50 (2014-05-28)
A fast carbohydrate screening platform processible in 96-well format is described. The method is suitable for the determination of various carbohydrates out of complex mixtures as obtained by acidic hydrolysis of carbohydrates polymers. The chromatographic conditions for an efficient separation
Michiko Shimokawa et al.
Bioscience, biotechnology, and biochemistry, 78(12), 2036-2044 (2014-08-27)
Two jacalin-related lectins (JRLs) were purified by mannose-agarose and melibiose-agarose from seeds of Treculia africana. One is galactose-recognizing JRL (gJRL), named T. africana agglutinin-G (TAA-G), and another one is mannose-recognizing JRL (mJRL), TAA-M. The yields of the two lectins from
Hideko Ohama et al.
The American journal of pathology, 185(2), 420-431 (2014-12-09)
Alcohol abuse was found to predispose persons to opportunistic infections. In this study, we tried to improve the host antibacterial resistance of chronic alcohol-consuming (CAC) mice to opportunistic infections. Bactericidal macrophages with functions to produce IL-12 and to express mRNAs
Ellen C Dengler et al.
Journal of neuroinflammation, 11, 92-92 (2014-06-03)
Peri-spinal subarachnoid (intrathecal; i.t.) injection of non-viral naked plasmid DNA encoding the anti-inflammatory cytokine, IL-10 (pDNA-IL-10) suppresses chronic neuropathic pain in animal models. However, two sequential i.t. pDNA injections are required within a discrete 5 to 72-hour period for prolonged
Joanna Berlowska et al.
Enzyme and microbial technology, 75-76, 44-48 (2015-06-07)
This paper presents the results of a study to determine the effect of Quillaja saponaria saponins on the lysis of industrial yeast strains. Cell lysis induced by saponin from Q. saponaria combined with the plasmolysing effect of 5% NaCl for
Jun Zhou et al.
Journal of ethnopharmacology, 164, 229-238 (2015-02-24)
Rehmannia glutinosa (Gaertn.) DC. (RG) has been widely used as traditional Chinese herbal medicine for treatment of diabetes and its complications. The polysaccharide fraction of RG has been proposed to possess hypoglycemic effect by intraperitoneal administration, however, the mechanisms responsible
Elena Enzo et al.
The EMBO journal, 34(10), 1349-1370 (2015-03-23)
Increased glucose metabolism and reprogramming toward aerobic glycolysis are a hallmark of cancer cells, meeting their metabolic needs for sustained cell proliferation. Metabolic reprogramming is usually considered as a downstream consequence of tumor development and oncogene activation; growing evidence indicates
Daniela Cavallone et al.
The Journal of biological chemistry, 279(1), 216-222 (2003-10-23)
Tamm-Horsfall glycoprotein (THP), the most abundant protein in mammalian urine, has been implicated in defending the urinary tract against infections by type 1-fimbriated Escherichia coli. Recent experimental evidence indicates that the defensive capability of THP relies on its single high
Angela L Man et al.
Clinical science (London, England : 1979), 129(7), 515-527 (2015-05-08)
The physical and immunological properties of the human intestinal epithelial barrier in aging are largely unknown. Ileal biopsies from young (7-12 years), adult (20-40 years) and aging (67-77 years) individuals not showing symptoms of gastrointestinal (GI) pathologies were used to assess levels of
Patricia Bonin et al.
Environmental science and pollution research international, 22(20), 15347-15359 (2015-01-07)
The impact of petroleum contamination and of burrowing macrofauna on abundances of Marinobacter and denitrifiers was tested in marine sediment mesocoms after 3 months incubation. Quantification of this genus by qPCR with a new primer set showed that the main
Helena Osterholz et al.
Nature communications, 6, 7422-7422 (2015-06-19)
Dissolved organic matter (DOM) in the oceans constitutes a major carbon pool involved in global biogeochemical cycles. More than 96% of the marine DOM resists microbial degradation for thousands of years. The composition of this refractory DOM (RDOM) exhibits a
Jason R Potas et al.
Journal of immunological methods, 420, 38-49 (2015-04-04)
Macrophages play a key role in tissue regeneration following peripheral nerve injury by preparing the surrounding parenchyma for regeneration, however, they can be damaging if the response is excessive. Interleukin 10 (IL-10) is a cytokine that promotes macrophages toward an
Monika Poláková et al.
European journal of medicinal chemistry, 46(3), 944-952 (2011-02-08)
Human Golgi α-mannosidase II (hGM) is a pharmaceutical target for the design of inhibitors with anti-tumor activity. Nanomolar inhibitors of hGM exhibit unwanted co-inhibition of the human lysosomal α-mannosidase (hLM). Hence, improving specificity of the inhibitors directed toward hGM is
Charles DeRossi et al.
The Journal of biological chemistry, 281(9), 5916-5927 (2005-12-13)
MPI encodes phosphomannose isomerase, which interconverts fructose 6-phosphate and mannose 6-phosphate (Man-6-P), used for glycoconjugate biosynthesis. MPI mutations in humans impair protein glycosylation causing congenital disorder of glycosylation Ib (CDG-Ib), but oral mannose supplements normalize glycosylation. To establish a mannose-responsive
Yukishige Ito et al.
Current opinion in structural biology, 15(5), 481-489 (2005-09-13)
High-mannose-type oligosaccharides have been shown to play important roles in protein quality control. Several intracellular proteins, such as lectins, chaperones and glycan-processing enzymes, are involved in this process. These include calnexin/calreticulin, UDP-glucose:glycoprotein glucosyltransferase (UGGT), cargo receptors (such as VIP36 and
DNA methylation provides insight into intergenerational risk for preterm birth in African Americans.
Sasha E Parets et al.
Epigenetics, 10(9), 784-792 (2015-06-20)
African Americans are at increased risk for spontaneous preterm birth (PTB). Though PTB is heritable, genetic studies have not identified variants that account for its intergenerational risk, prompting the hypothesis that epigenetic factors may also contribute. The objective of this
Laetitia Pigeyre et al.
Viruses, 11(9) (2019-09-20)
The success of oral infection by viruses depends on their capacity to overcome the gut epithelial barrier of their host to crossing over apical, mucous extracellular matrices. As orally transmitted viruses, densoviruses, are also challenged by the complexity of the
Rafał Biedroń et al.
PloS one, 10(4), e0123293-e0123293 (2015-04-08)
The initiation of adaptive immune responses to protein antigens has to be preceded by their uptake by antigen presenting cells and intracellular proteolytic processing. Paradoxically, endocytic receptors involved in antigen uptake do not bind the majority of proteins, which may
Cryptosporidium p30, a galactose/N-acetylgalactosamine-specific lectin, mediates infection in vitro.
Najma Bhat et al.
The Journal of biological chemistry, 282(48), 34877-34887 (2007-10-02)
Cryptosporidium sp. cause human and animal diarrheal disease worldwide. The molecular mechanisms underlying Cryptosporidium attachment to, and invasion of, host cells are poorly understood. Previously, we described a surface-associated Gal/GalNAc-specific lectin activity in sporozoites of Cryptosporidium parvum. Here we describe
Yingyu Wang et al.
Carbohydrate polymers, 127, 215-221 (2015-05-13)
In this study, one polysaccharide (GFP1), with an average molecular weight of 1.4 × 10(5)Da, was isolated from Ginseng fruits. GFP1 was composed of galactose, glucose, rhamnose, and arabinose in a molar ratio of 6.1:2.0:1.1:3.2, and had a backbone mainly
Kenji Okamoto et al.
SpringerPlus, 3, 121-121 (2014-03-14)
Second-generation bioethanol production requires the development of economically feasible and sustainable processes that use renewable lignocellulosic biomass as a starting material. However, the microbial fermentation of xylose, which is the principal pentose sugar in hemicellulose, is a limiting factor in
Xu Song et al.
Pharmaceutical research, 32(5), 1741-1751 (2014-11-20)
In this study, cationic mannosylated nanostructured lipid carriers (Man-NLCs) were developed for the targeted delivery of rifampicin to alveolar macrophages. Rifampicin loaded Man-NLCs (RFP-Man-NLCs) and rifampicin loaded unmodified nanostructured lipid carriers (REP-NLCs) were prepared using thin film homogenization method and
Differential stimulation of peripheral blood mononuclear cells in Crohn's disease by fungal glycans.
Liran Baram et al.
Journal of gastroenterology and hepatology, 29(12), 1976-1984 (2014-08-06)
Crohn's disease (CD) is characterized by loss of tolerance to intestinal microorganisms. This is reflected by serological responses to fungal glycans such as mannan and β-glucans. Fungal glycans have various effects on immune cells. However, the evidence for their effects
Page 1 of 8