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Showing 1-30 of 78 results for "M7504" within Papers
Laura Pérez-Alós et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(11), 12723-12734 (2019-08-31)
Dysregulation of the complement system is involved in the pathogenesis of several diseases, and its inhibition has been shown to be a feasible therapeutic option. Therefore, there is an interest in the development of complement modulators to treat complement activation-related
Cecilie Bo Hansen et al.
Journal of immunology (Baltimore, Md. : 1950), 195(8), 3596-3604 (2015-09-16)
C1 inhibitor (C1-INH) is known to form complexes with the lectin complement pathway serine proteases MASP-1 and MASP-2. Deficiency of C1-INH is associated with hereditary angioedema (HAE), an autosomal inherited disease characterized by swelling attacks caused by elevated levels of
Viviana Ferreira et al.
Journal of immunology (Baltimore, Md. : 1950), 172(5), 3042-3050 (2004-02-24)
The high resistance of Trypanosoma cruzi trypomastigotes, the causal agent of Chagas' disease, to complement involves several parasite strategies. In these in vitro studies, we show that T. cruzi calreticulin (TcCRT) and two subfragments thereof (TcCRT S and TcCRT R
Jiejie Sun et al.
Journal of immunology (Baltimore, Md. : 1950), 205(9), 2402-2413 (2020-09-30)
The long-term evolutionary interaction between the host and symbiotic microbes determines their cooperative relationship. It is well known that the symbiotic microbes have evolved various mechanisms to either benefit or exploit the mammalian host immune system to maintain homeostasis. However
Masahiro Hosonuma et al.
Rheumatology (Oxford, England), 60(1), 408-419 (2020-08-10)
To determine the expression of hepatocyte growth factor (HGF) in RA biological fluids, the role of HGF in monocyte migration and the therapeutic effect of the c-Met inhibitor savolitinib in an arthritis model mice. HGF/c-Met expression in serum, SF and
Andrea Osete-Alcaraz et al.
Biomolecules, 10(1) (2019-12-29)
The interactions between tannins and soluble and insoluble cell wall components are, in part, responsible for the low quantities of tannins found in wines compared with the quantities in grapes. The use of polysaccharides to compete with cell wall components
Takeshi Furuhashi et al.
Bioscience, biotechnology, and biochemistry, 73(1), 93-103 (2009-01-09)
Chitin is an insoluble component in the shells of several molluscan species. It is thought to play important roles, in biomineralization and shell structure. To date, however, reports are scarce and sometimes contradictory, and suffer from methodological problems. Only in
Y Oda et al.
Biological & pharmaceutical bulletin, 16(10), 978-981 (1993-10-01)
Four isolectins were isolated from bulbs of Croccus sativum (saffron), using affinity chromatography on mannan-Sepharose 4B, gel filtration and ion-exchange column chromatography in the presence of 8 M urea. The relative molecular masses of these lectins were determined by gel
Phagocytosis of antigens by Langerhans cells.
C Reis e Sousa et al.
Advances in experimental medicine and biology, 329, 199-204 (1993-01-01)
Vasile I Pavlov et al.
The American journal of pathology, 185(2), 347-355 (2014-12-09)
Myocardial infarction and coagulation disorders are leading causes of disability and death in the world. An important role of the lectin complement pathway in myocardial infarction and coagulation has been demonstrated in mice genetically deficient in lectin complement pathway proteins.
Wang Xialu et al.
BMB reports, 46(7), 358-363 (2013-07-26)
In this paper, we firstly reported a C-type lectin cDNA clone of 1029 bps from the larvae of A. Pernyi (Ap-CTL) using PCR and RACE techniques. The full-length cDNA contains an open reading frame encoding 308 amino acid residues which
Nicole M Gilbert et al.
Molecular microbiology, 76(2), 517-534 (2010-04-14)
The polysaccharide beta-1,6-glucan is a major component of the cell wall of Cryptococcus neoformans, but its function has not been investigated in this fungal pathogen. We have identified and characterized seven genes, belonging to the KRE family, which are putatively
T Ueki et al.
The Journal of antibiotics, 46(3), 455-464 (1993-03-01)
Based on the structure-activity relationship data of BMY-28864 and related pradimicin derivatives, the calcium salt-forming ability and the D-mannopyranoside-specific visible absorption maximum shift of BMY-28864 were analysed in the ternary complex formation of BMY-28864 with D-mannopyranoside and calcium. The free
Michael L Patnode et al.
Cell, 179(1), 59-73 (2019-09-21)
Development of microbiota-directed foods (MDFs) that selectively increase the abundance of beneficial human gut microbes, and their expressed functions, requires knowledge of both the bioactive components of MDFs and the mechanisms underlying microbe-microbe interactions. Here, gnotobiotic mice were colonized with
María Colmenares et al.
The Journal of biological chemistry, 277(39), 36766-36769 (2002-07-18)
Dendritic cells (DCs) play a critical role in the initiation of the immunological response against Leishmania parasites. However, the receptors involved in amastigote-dendritic cell interaction are unknown, especially in absence of opsonizing antibodies. We have studied the interaction of Leishmania
Hui Dai et al.
Journal of immunology (Baltimore, Md. : 1950), 192(10), 4533-4540 (2014-04-11)
Much progress has been made in recent years on the diagnostic value, Ag specificity, and pathogenic roles of autoantibodies correlated to the development of rheumatoid arthritis (RA) in humans. However, carbohydrate Ag-specific autoantibodies that may also play important roles in
Monika Jusko et al.
Journal of immunology (Baltimore, Md. : 1950), 195(5), 2231-2240 (2015-07-26)
Recent reports focusing on virulence factors of periodontal pathogens implicated proteinases as major determinants of remarkable pathogenicity of these species, with special emphasis on their capacity to modulate complement activity. In particular, bacteria-mediated cleavage of C5 and subsequent release of
Vasile I Pavlov et al.
Circulation, 126(18), 2227-2235 (2012-10-04)
Coagulation disorders and reperfusion of ischemic myocardium are major causes of morbidity and mortality. Lectin pathway initiation complexes are composed of multimolecular carbohydrate recognition subcomponents and 3 lectin pathway-specific serine proteases. We have recently shown that the lectin pathway-specific carbohydrate
Ruojing Yang et al.
JCI insight, 3(1) (2018-01-13)
Hypoglycemia is commonly associated with insulin therapy, limiting both its safety and efficacy. The concept of modifying insulin to render its glucose-responsive release from an injection depot (of an insulin complexed exogenously with a recombinant lectin) was proposed approximately 4
Mie Anemone Nordmaj et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 4945-4955 (2015-08-12)
Inhibition of the complement cascade has emerged as an option for treatment of a range of diseases. Mannose-binding lectin/ficolin/collectin-associated protein (MAP-1) is a pattern recognition molecule (PRM)-associated inhibitor of the lectin pathway. The central regulator of the alternative pathway (AP)
Cristina Miró-Julià et al.
Journal of immunology (Baltimore, Md. : 1950), 186(4), 2344-2354 (2011-01-11)
The scavenger receptor cysteine-rich superfamily (SRCR-SF) members are transmembrane and/or secreted receptors exhibiting one or several repeats of a cysteine-rich protein module of ∼100 aa, named scavenger receptor cysteine-rich (SRCR). Two types of SRCR domains (A or B) have been
Guan-Yu Lin et al.
Microorganisms, 8(2) (2020-02-27)
The emergence of drug resistance to Candida albicans is problematic in the clinical setting. Therefore, developing new antifungal drugs is in high demand. Our previous work indicated that the antimicrobial peptide P-113Tri exhibited higher antifungal activity against planktonic cells, biofilm
Yo-Min Liu et al.
Cell reports, 32(6), 108016-108016 (2020-08-07)
The influenza virus hemagglutinin (HA) and coronavirus spike (S) protein mediate virus entry. HA and S proteins are heavily glycosylated, making them potential targets for carbohydrate binding agents such as lectins. Here, we show that the lectin FRIL, isolated from
Maxwell L Van Tassell et al.
MethodsX, 1, 244-250 (2014-01-01)
We have sought a universal platform for elucidating and exploiting specificity of glycan-mediated adhesion by potentially uncharacterized microorganisms. Several techniques exist to explore microbial interactions with carbohydrate structures. Many are unsuitable for investigating specific mechanisms or uncharacterized organisms, requiring pure
Jenson Lim et al.
Journal of immunology (Baltimore, Md. : 1950), 200(10), 3539-3546 (2018-04-13)
The pathogenic fungus Cryptococcus enters the human host via inhalation into the lung and is able to reside in a niche environment that is serum- (opsonin) limiting. Little is known about the mechanism by which nonopsonic phagocytosis occurs via phagocytes
Geelsu Hwang et al.
PLoS pathogens, 13(6), e1006407-e1006407 (2017-06-16)
Candida albicans is frequently detected with heavy infection by Streptococcus mutans in plaque-biofilms from children with early-childhood caries (ECC). This cross-kingdom biofilm contains an extensive matrix of extracellular α-glucans that is produced by an exoenzyme (GtfB) secreted by S. mutans.
Yuli Talyansky et al.
PLoS pathogens, 17(2), e1009291-e1009291 (2021-02-03)
Acinetobacter baumannii is a highly antibiotic-resistant bacterial pathogen for which novel therapeutic approaches are needed. Unfortunately, the drivers of virulence in A. baumannii remain uncertain. By comparing genomes among a panel of A. baumannii strains we identified a specific gene
S H Lee et al.
The Journal of experimental medicine, 163(1), 54-74 (1986-01-01)
We have studied the effect of infection with the blood-stage of Plasmodium yoelii 17X, a nonlethal parasite, on plasma membrane antigens, receptors, and secretory properties of macrophages (M phi) in murine liver, spleen, and blood. mAb F4/80 (M phi specific)
L A Trouw et al.
Arthritis and rheumatism, 60(7), 1923-1931 (2009-07-01)
It has been suggested that anti-citrullinated protein antibodies (ACPAs) play an important role in the pathogenesis of rheumatoid arthritis (RA). To exert their pathologic effects, ACPAs must recruit immune effector mechanisms such as activation of the complement system. Mouse models
A comparison of yeast mannans and phosphomannans by acetolysis.
T S Stewart et al.
Biochemistry, 7(5), 1855-1863 (1968-05-01)
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