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Showing 1-20 of 20 results for "M7769" within Papers
Teizo Asano et al.
Antibodies (Basel, Switzerland), 11(4) (2022-12-23)
The epithelial cell adhesion molecule (EpCAM) is a stem cell and carcinoma antigen, which mediates cellular adhesion and proliferative signaling by the proteolytic cleavage. In contrast to low expression in normal epithelium, EpCAM is frequently overexpressed in various carcinomas, which
N Reddy et al.
Cancer immunology, immunotherapy : CII, 46(1), 25-33 (1998-03-31)
We reported previously that the blood clearance of injected mouse IgG2a was extremely rapid in many strains of nude and nu/+ mice. In an attempt to determine the cause of this phenomenon, the levels of endogenous IgG2a in the blood
Hideki Hosono et al.
Oncology letters, 20(6), 383-383 (2020-11-07)
The epithelial cell adhesion molecule (EpCAM), which is a calcium-independent homophilic intercellular adhesion factor, contributes to cell signaling, differentiation, proliferation and migration. EpCAM is essential for carcinogenesis in numerous types of human cancer. The purpose of the present study was
Hideki Hosono et al.
International journal of molecular medicine, 46(4), 1443-1452 (2020-09-19)
The epidermal growth factor receptor (EGFR), a transmembrane receptor and member of the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases, is a critical mediator of cell growth and differentiation. EGFR forms homo‑ or heterodimers with other
S Escotte et al.
The European respiratory journal, 21(4), 574-581 (2003-05-24)
Inhaled fluticasone propionate (FP) is widely used to reduce pulmonary inflammation in chronic obstructive pulmonary disease, but the potential effects of FP on airway epithelial cells from patients with cystic fibrosis (CF) are unknown. In CF disease, a nonregulated inflammatory
Non-sunscreen photoprotection: antioxidants add value to a sunscreen.
Matsui M S, et al.
The Journal of Investigative Dermatology. Symposium Proceedings / The Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research, 14(1), 56-59 (2009)
Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus.
Savitsky D A, et al.
Proceedings of the National Academy of Sciences of the USA, 201005599-201005599 (2010)
Distinct contributions of vaccine-induced immunoglobulin G1 (IgG1) and IgG2a antibodies to protective immunity against influenza.
Huber V C, et al.
Clinical and Vaccine Immunology : CVI, 13(9), 981-990 (2006)
Tobias Derfuss et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(20), 8302-8307 (2009-05-07)
Gray matter pathology is increasingly recognized as an important feature of multiple sclerosis (MS), but the nature of the immune response that targets the gray matter is poorly understood. Starting with a proteomics approach, we identified contactin-2/transiently expressed axonal glycoprotein
Juan Feng et al.
eLife, 10 (2021-12-24)
HAP2 is a transmembrane gamete fusogen found in multiple eukaryotic kingdoms and is structurally homologous to viral class II fusogens. Studies in Plasmodium have suggested that HAP2 is an attractive target for vaccines that block transmission of malaria. HAP2 has
Teizo Asano et al.
Oncology reports, 46(2) (2021-06-30)
HER3 belongs to the epidermal growth factor receptor (EGFR) family and is known to form an active heterodimer with other three family members EGFR, HER2, and HER4. HER3 is overexpressed in lung, breast, colon, prostate, and gastric cancers. In the present
Dennis Lindenblatt et al.
BMC cancer, 18(1), 922-922 (2018-09-27)
Protein kinase inhibitors (PKIs) are currently tested in clinical studies (phase I-III) as an alternative strategy against (recurrent) ovarian cancer. Besides their anti-tumour efficacy, several PKIs have also shown radiosensitizing effects when combined with external beam radiation. Based on these
O Tabary et al.
Journal of immunology (Baltimore, Md. : 1950), 164(6), 3377-3384 (2000-03-08)
Increasing evidence suggests that in airways from cystic fibrosis (CF) patients, inflammation may precede bacterial infection and be related to an endogenous dysregulation of proinflammatory cytokines in airway epithelial cells. Several investigators have reported that, in CF airway fluids, elevated
S Brézillon et al.
The Journal of biological chemistry, 272(44), 27830-27838 (1997-11-05)
To mimic the effect of ischemia on the integrity of airway epithelium and expression of cystic fibrosis transmembrane conductance regulator (CFTR), we induced an ATP depletion of the respiratory epithelium from upper airway cells (nasal tissue) and human bronchial epithelial
Astri Fjelde Maaland et al.
PloS one, 15(3), e0230526-e0230526 (2020-03-19)
Relapse of chronic lymphocytic leukaemia and non-Hodgkin's lymphoma after standard of care treatment is common and new therapies are needed. The targeted alpha therapy with 212Pb-NNV003 presented in this study combines cytotoxic α-particles from 212Pb, with the anti-CD37 antibody NNV003
Three classes and four (sub) classes of rat immunoglobulins: IgM, IgA, IgE and IgG1, IgG2a, IgG2b, IgG2c.
Bazin H, et al.
European Journal of Immunology, 4(1), 44-48 (1974)
O Tabary et al.
The American journal of pathology, 155(2), 473-481 (1999-08-06)
The inflammatory pathogenesis in airways of patients with cystic fibrosis (CF) is still unresolved. We demonstrate here that in in situ human DeltaF508 homozygous CF bronchial tissues, submucosal gland cells exhibit an absence of inhibitor factor kappaBalpha (IkappaBalpha) and high
Mika K Kaneko et al.
Oncology reports, 44(6), 2517-2526 (2020-10-31)
The epithelial cell adhesion molecule (EpCAM) is a calcium‑independent, homophilic, intercellular adhesion factor classified as a transmembrane glycoprotein. In addition to cell adhesion, EpCAM also contributes to cell signaling, differentiation, proliferation, and migration. EpCAM is an essential factor in the
TLR9 signaling in B cells determines class switch recombination to IgG2a.
Jegerlehner A, et al.
Journal of Immunology, 178(4), 2415-2420 (2007)
Urs B Hagemann et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(15), 4723-4734 (2019-05-09)
Targeted thorium-227 conjugates (TTC) represent a new class of molecules for targeted alpha therapy (TAT). Covalent attachment of a 3,2-HOPO chelator to an antibody enables specific complexation and delivery of the alpha particle emitter thorium-227 to tumor cells. Because of
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