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Showing 1-29 of 29 results for "M8278" within Papers
Hai Huang et al.
Nature neuroscience, 14(7), 840-847 (2011-06-15)
Little is known about which ion channels determine the resting electrical properties of presynaptic membranes. In recordings made from the rat calyx of Held, a giant mammalian terminal, we found resting potential to be controlled by KCNQ (Kv7) K(+) channels
Paulo D Koeberle et al.
Channels (Austin, Tex.), 4(5), 337-346 (2010-08-12)
Retinal ganglion cell (RGC) degeneration is an important cause of visual impairment, and results in part from microglia-mediated inflammation. Numerous experimental studies have focused on identifying drug targets to rescue these neurons. We recently showed that K(V)1.1 and K(V)1.3 channels
Stephen V Straub et al.
American journal of physiology. Endocrinology and metabolism, 301(2), E380-E390 (2011-05-19)
Genetic ablation of the voltage-gated potassium channel Kv1.3 improves insulin sensitivity and increases metabolic rate in mice. Inhibition of Kv1.3 in mouse adipose and skeletal muscle is reported to increase glucose uptake through increased GLUT4 translocation. Since Kv1.3 represents a
D Palani et al.
Neuroscience, 167(4), 1004-1013 (2010-03-23)
Strict control over the initiation of action potentials is the primary task of a neuron. One way to lose proper spike control is to create several spikes, a burst, when only one should be initiated. We describe a new site
Erich Gulbins et al.
Biochimica et biophysica acta, 1797(6-7), 1251-1259 (2010-02-02)
Mitochondria have been shown to play a pivotal role in apoptotic signalling in various cell types. We have recently reported that in lymphocytes the voltage-gated potassium channel Kv1.3, known to reside in the plasma membrane, is active also in the
I Kazama et al.
The journal of physiological sciences : JPS, 62(3), 267-274 (2012-02-14)
Lymphocytes are of rich in delayed rectifier K(+)-channels (Kv1.3) in their plasma membranes, and the channels play crucial roles in the lymphocyte activation and proliferation. Since chloroquine, a widely used anti-malarial drug, exerts immunosuppressive effects, it will affect the channel
Soo Hwa Jang et al.
European journal of pharmacology, 651(1-3), 26-32 (2010-11-23)
Voltage-gated potassium (Kv) channels are widely expressed in the plasma membranes of numerous cells and contribute to a variety of cellular functions in both excitable neuronal cells and non-excitable epithelial cells. Recently, it has been demonstrated that Kv channels are
Angelina Ramirez-Navarro et al.
Journal of neurophysiology, 105(6), 2772-2780 (2011-03-25)
The voltage-gated K(+) channel Kv1.3 has been reported to regulate transmitter release in select central and peripheral neurons. In this study, we evaluated its role at the synapse between visceral sensory afferents and secondary neurons in the nucleus of the
Gergely Toldi et al.
Immunology letters, 133(1), 35-41 (2010-07-07)
Kv1.3 and IKCa1 potassium channels participate in the maintenance of calcium-influx during lymphocyte activation. Kv1.3 channels have a prominent role in specific T cell subsets, presenting a possible target for selective immunomodulation. We investigated the impact of Kv1.3 and IKCa1
Rolando Carrisoza-Gaytán et al.
American journal of physiology. Renal physiology, 299(1), F255-F264 (2010-04-30)
The fine regulation of Na(+) and K(+) transport takes place in the cortical distal nephron. It is well established that K(+) secretion occurs through apical K(+) channels: the ROMK and the Ca(2+)- and voltage-dependent maxi-K. Previously, we identified the voltage-gated
Raveendra Anangi et al.
PloS one, 7(12), e52965-e52965 (2013-01-10)
The K(v)1.3 voltage-gated potassium channel regulates membrane potential and calcium signaling in human effector memory T cells that are key mediators of autoimmune diseases such as multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. Thus, subtype-specific K(v)1.3 blockers have potential
M F Kiernan et al.
Placenta, 31(6), 553-555 (2010-05-11)
Hypoxic fetoplacental vasoconstriction (HFPV), involving voltage-gated potassium (K(V)) channels, has been suggested in human placenta; the identity of these channels remains unclear. Using wire myography, chorionic plate blood vessels were exposed to isoform-specific K(V) channel blockers. Dose-response curves (thromboxane mimetic
Conor McCloskey et al.
The Journal of physiology, 588(Pt 9), 1399-1406 (2010-03-24)
A delayed rectifier voltage-gated K(+) channel (Kv) represents the largest ionic conductance of platelets and megakaryocytes, but is undefined at the molecular level. Quantitative RT-PCR of all known Kv alpha and ancillary subunits showed that only Kv1.3 (KCNA3) is substantially
Aleksandra Novakovic et al.
Basic & clinical pharmacology & toxicology, 111(1), 24-30 (2012-01-10)
The ATP-sensitive K(+) channels opener (K(ATP)CO), P1075 [N-cyano-N'-(1,1-dimethylpropyl)-N″-3-pyridylguanidine], has been shown to cause relaxation of various isolated animal and human blood vessels by opening of vascular smooth muscle ATP-sensitive K(+) (K(ATP)) channels. In addition to the well-known effect on the
Answer to the "comment on functional consequences of Kv1.3 ion channel rearrangement into the immunological synapse" by Stefan Bittner et al. [Immunol. Lett. 125 (Aug 15 (2)) (2009) 156-157].
Péter Hajdú et al.
Immunology letters, 129(1), 47-49 (2010-01-19)
Natalia Marek et al.
Human immunology, 71(7), 666-675 (2010-05-12)
CD4(+) T cells can be divided into three subsets: naive (Tn), central memory (Tcm), and effector memory (Tem) lymphocytes. These subpopulations differ in phenotype, migratory capacity, pattern of secreted cytokines, and activation threshold. T-cell activation is associated with changes in
J Liu et al.
Cell death & disease, 3, e254-e254 (2012-01-20)
Inflammatory responses mediated by activated microglia play a pivotal role in the pathogenesis of human immunodeficiency virus type 1 (HIV-1)-associated neurocognitive disorders. Studies on identification of specific targets to control microglia activation and resultant neurotoxic activity are imperative. Increasing evidence
Sheng-Nan Wu et al.
Toxicology, 289(1), 11-18 (2011-07-26)
Aconitine (ACO) is a highly toxic diterpenoid alkaloid and known to exert the immunomodulatory action. However, whether it has any effects on ion currents in immune cells remains unknown. The effects of ACO and other related compounds on ion currents
Núria Villalonga et al.
The Journal of general physiology, 135(2), 135-147 (2010-01-27)
Voltage-dependent potassium (K(v)) channels play a pivotal role in the modulation of macrophage physiology. Macrophages are professional antigen-presenting cells and produce inflammatory and immunoactive substances that modulate the immune response. Blockage of K(v) channels by specific antagonists decreases macrophage cytokine
Gergely Toldi et al.
Immunobiology, 218(3), 311-316 (2012-06-19)
The transient increase of the cytoplasmic free calcium level plays a key role in the process of lymphocyte activation. Kv1.3 and IKCa1 potassium channels are important regulators of the maintenance of calcium influx during lymphocyte activation and present a possible
B Kyle et al.
American journal of physiology. Cell physiology, 301(5), C1186-C1200 (2011-08-05)
We have characterized the native voltage-dependent K(+) (K(v)) current in rabbit urethral smooth muscle cells (RUSMC) and compared its pharmacological and biophysical properties with K(v)2.1 and K(v)2.2 channels cloned from the rabbit urethra and stably expressed in human embryonic kidney
Gergely Toldi et al.
International immunology, 22(9), 769-774 (2010-07-06)
Cytokine production in activated T lymphocytes of the term neonate is reduced compared with adults. We aimed to characterize the calcium influx kinetics of activated T lymphocytes in the neonate and to test the functionality and expression of Kv1.3 and
Alex Cheong et al.
Cardiovascular research, 89(2), 282-289 (2010-10-05)
The aim of the study was to determine the potential for K(V)1 potassium channel blockers as inhibitors of human neoinitimal hyperplasia. Blood vessels were obtained from patients or mice and studied in culture. Reverse transcriptase-polymerase chain reaction and immunocytochemistry were
Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels.
Bartok A
Toxicon, 87, 6-16 (2014)
M Garcia-Calvo et al.
The Journal of biological chemistry, 268(25), 18866-18874 (1993-09-05)
A novel peptidyl inhibitor of K+ channels has been purified to homogeneity from venom of the new world scorpion Centruroides margaritatus. The primary structure of this 39-amino-acid peptide, which we term margatoxin (MgTX), was determined by amino acid compositional analysis
Thomas Gerald Mast et al.
PloS one, 7(2), e31978-e31978 (2012-03-01)
Sensory deprivation induces dramatic morphological and neurochemical changes in the olfactory bulb (OB) that are largely restricted to glomerular and granule layer interneurons. Mitral cells, pyramidal-like neurons, are resistant to sensory-deprivation-induced changes and are associated with the precursor to brain-derived
Anna-Lena Unterweger et al.
Journal of Crohn's & colitis, 15(11), 1943-1958 (2021-04-24)
The potassium channel Kv1.3 is a potentially attractive therapeutic target in T cell-mediated inflammatory diseases, as the activity of antigen-activated T cells is selectively impeded by Kv1.3 inhibition. In this study, we examined Kv1.3 as a potential therapeutic intervention point
H Ouadid-Ahidouch et al.
FEBS letters, 459(1), 15-21 (1999-10-06)
Voltage-dependent K(+) channels were identified and characterized in primary culture of rat prostate epithelial cells. A voltage-dependent, inactivating K(+) channel was the most commonly observed ion channel in both lateral and dorsal cells. The K(+) current exhibited a voltage threshold
Azadeh Nikouee et al.
The journal of physical chemistry. B, 116(17), 5132-5140 (2012-04-12)
The effect of the pore-blocking peptides charybdotoxin and margatoxin, both scorpion toxins, on currents through human voltage-gated hK(v)1.3 wild-type and hK(v)1.3_H399N mutant potassium channels was characterized by the whole-cell patch clamp technique. In the mutant channels, both toxins hardly blocked
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