Search Within
M8316
Applied Filters:
Keyword:'M8316'
Showing 1-20 of 20 results for "M8316" within Papers
Nora Freyer et al.
BioResearch open access, 5(1), 235-248 (2016-09-10)
The hepatic differentiation of human induced pluripotent stem cells (hiPSC) holds great potential for application in regenerative medicine, pharmacological drug screening, and toxicity testing. However, full maturation of hiPSC into functional hepatocytes has not yet been achieved. In this study
Biliary elimination of pemetrexed is dependent on Mrp2 in rats: Potential mechanism of variable response in nonalcoholic steatohepatitis
Dzierlenga Al, et al.
Journal of Pharmacology and Experimental Therapeutics, 358(2), 246-253 (2016)
Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance
Annereau JP, et al.
Molecular Pharmacology, 66(6), 1397-1405 (2004)
Barbara Schaarschmidt et al.
Theranostics, 8(14), 3766-3780 (2018-08-08)
Rationale: The liver is a central organ not only for metabolism but also immune function. Life-threatening infections of both bacterial and fungal origin can affect liver function but it is yet unknown whether molecular changes differ depending on the pathogen.
Peter Recknagel et al.
PLoS medicine, 9(11), e1001338-e1001338 (2012-11-16)
Hepatic dysfunction and jaundice are traditionally viewed as late features of sepsis and portend poor outcomes. We hypothesized that changes in liver function occur early in the onset of sepsis, yet pass undetected by standard laboratory tests. In a long-term
Oliver Bauhofer et al.
Gastroenterology, 143(2), 429-438 (2012-04-24)
Hepatitis C virus (HCV) is a common cause of chronic liver disease. Many patients do not clear the viral infection; little is known about the mechanisms of HCV persistence or the frequent failure of interferon (IFN) to eliminate it. Better
Pin Chen et al.
Genetic testing and molecular biomarkers, 18(2), 106-111 (2013-12-12)
The G1249A variant of the multidrug resistance-associated protein 2 (ABCC2) gene may be associated with the development of antiepileptic drug (AED) resistance. Although numerous studies have investigated the association between the G1249A variant and the risk of drug resistance in
Yabin Duan et al.
Drug metabolism and disposition: the biological fate of chemicals, 50(2), 174-186 (2021-12-01)
Hypoxia is the main characteristic of a high-altitude environment, affecting drug metabolism. However, so far, the mechanism of microRNA (miRNA) involved in the regulation of drug metabolism and transporters under high-altitude hypoxia is still unclear. This study aims to investigate
Xue Bai et al.
Frontiers in pharmacology, 13, 977370-977370 (2022-10-04)
Hypoxia, an essential feature of high-altitude environments, has a significant effect on drug metabolism. The hypoxia-gut microbiota-CYP450/drug transporter axis is emerging as a vital factor in drug metabolism. However, the mechanisms through which the gut microbiota mediates the regulation of
Anika L Dzierlenga et al.
The Journal of pharmacology and experimental therapeutics, 358(2), 246-253 (2016-05-29)
Hepatic multidrug resistance-associated protein 2 (MRP2) provides the biliary elimination pathway for many xenobiotics. Disruption of this pathway contributes to retention of these compounds and may ultimately lead to adverse drug reactions. MRP2 mislocalization from the canalicular membrane has been
A L Dzierlenga et al.
Drug metabolism and disposition: the biological fate of chemicals, 44(11), 1799-1807 (2016-09-09)
Interindividual variability in drug response in nonalcoholic steatohepatitis (NASH) can be mediated by altered regulation of drug metabolizing enzymes and transporters. Among these is the mislocalization of multidrug resistance-associated protein (MRP2)/Mrp2 away from the canalicular membrane, which results in decreased
M Richter et al.
Toxicology research, 5(1), 278-290 (2015-11-18)
The rat pancreatic progenitor cell line B-13 is of interest for research on drug metabolism and toxicity since the cells trans-differentiate into functional hepatocyte-like cells (B-13/H) when treated with glucocorticoids. In this study we investigated the trans-differentiation and liver-specific functions
Yan Liu et al.
PloS one, 9(1), e82681-e82681 (2014-01-10)
Methotrexate (MTX) is a key agent for the treatment of childhood acute lymphoblastic leukemia (ALL). Increased MTX plasma concentrations are associated with a higher risk of adverse drug effects. ATP-binding cassette subfamily C member 2 (ABCC2) is important for excretion
Anika L Dzierlenga et al.
Journal of biochemical and molecular toxicology, 32(3), e22035-e22035 (2018-01-18)
Nonalcoholic steatohepatitis (NASH) remodels the expression and function of genes and proteins that are critical for drug disposition. This study sought to determine whether disruption of membrane protein trafficking pathways in human NASH contributes to altered localization of multidrug resistance-associated
Lopes Fernanda Moreira et al.
Chemosphere, 228, 159-165 (2019-04-29)
The presence of the transmembrane proteins of the ATP-binding cassette (ABC) family, which perform the efflux of several substances, contributes to the survival of aquatic organisms in a contaminated environmental. Those proteins provide a phenotype named the multixenobiotic resistance mechanism
Nonalcoholic steatohepatitis modulates membrane protein retrieval and insertion processes
Dzierlenga AL, et al.
Drug Metabolism and Disposition, 44(11), 1799-1807 (2016)
Anne T Nies et al.
Pflugers Archiv : European journal of physiology, 453(5), 643-659 (2006-07-19)
ABCC2 is a member of the multidrug resistance protein subfamily localized exclusively to the apical membrane domain of polarized cells, such as hepatocytes, renal proximal tubule epithelia, and intestinal epithelia. This localization supports the function of ABCC2 in the terminal
Hyun-Soo Kim et al.
BioMed research international, 2013, 527534-527534 (2013-07-11)
Gallbladder carcinoma (GBCA) is one of the most aggressive malignancies. It is usually diagnosed at an advanced stage, and prognosis remains poor despite advances in imaging techniques and aggressive surgical treatment. Overexpression of multidrug resistance-associated proteins (MRPs) in tumor cells
Tsukasa Kobayashi et al.
The journal of obstetrics and gynaecology research, 48(7), 1591-1606 (2022-04-22)
Jaundice is especially common in premature infant born before 35 weeks. Because the premature infant liver is not fully developed at birth it may be incomplete the bilirubin metabolism. The purpose was to evaluate the metabolism and the excretion of bilirubin
Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma
Nies AT, et al.
International Journal of Cancer. Journal International Du Cancer, 94(4), 492-499 (2001)
Page 1 of 1