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Showing 1-30 of 141 results for "M9511" within Papers
Scott A Davis et al.
The Journal of dermatological treatment, 25(4), 275-277 (2013-11-01)
Millions of rosacea sufferers are not being treated, and the reasons they do not get treatment are not well characterized. The aim of this study is to determine the main reasons for visit, providers seen and treatments used for rosacea.
Oral minocycline in treatment of cutaneous sarcoidosis.
Talora Steen et al.
JAMA dermatology, 149(6), 758-760 (2013-06-21)
E P Azevedo et al.
Cell death & disease, 4, e789-e789 (2013-09-07)
Oculoleptomeningeal amyloidosis (OA) is a fatal and untreatable hereditary disease characterized by the accumulation of transthyretin (TTR) amyloid within the central nervous system. The mechanisms underlying the pathogenesis of OA, and in particular how amyloid triggers neuronal damage, are still
Jin-Shing Chen et al.
Lancet (London, England), 381(9874), 1277-1282 (2013-03-16)
Simple aspiration and drainage is a standard initial treatment for primary spontaneous pneumothorax, but the rate of pneumothorax recurrence is substantial. We investigated whether additional minocycline pleurodesis after simple aspiration and drainage reduces the rate of recurrence. In our open-label
Hongsheng Miao et al.
Journal of neurophysiology, 120(3), 1307-1317 (2018-05-24)
Intracerebral hemorrhage (ICH) is a devastating disease worldwide with increasing mortality. The present study investigated whether minocycline was neuroprotective and induced M2 microglial polarization via upregulation of the TrkB/BDNF pathway after ICH. ICH was induced via injection of autologous blood
Mariana Alves et al.
Frontiers in pharmacology, 10, 1558-1558 (2020-02-06)
Purinergic signaling via P2 receptors is now widely accepted to play a critical role during increased states of hyperexcitability and seizure-induced pathology. In the setting of seizures and epilepsy, most attention has been paid to investigating the fast-acting ATP-gated P2X
Mona Fares et al.
Biochemical and biophysical research communications, 463(3), 268-274 (2015-05-30)
We investigated mechanisms of cytotoxicity induced by doxycycline (doxy) and minocycline (mino) in the chronic myeloid leukemia K562 cell line. Doxy and mino induced cell death in exposure-dependent manner. While annexin V/propidium iodide staining was consistent with apoptosis, the morphological
Alkystis Phinikaridou et al.
Journal of the American Heart Association, 2(5), e000402-e000402 (2013-09-28)
Endothelial dysfunction promotes atherosclerosis. We investigated whether in vivo magnetic resonance imaging (MRI) using an albumin-binding contrast agent, gadofosveset, could monitor the efficacy of minocycline and ebselen in reducing endothelial permeability and atherosclerotic burden in the brachiocephalic artery of high-fat
Black bones: minocycline-induced bone pigmentation.
Vishnusai Chauhan et al.
The Medical journal of Australia, 201(2), 114-114 (2014-07-22)
Shaofeng Pu et al.
Journal of physiology and biochemistry, 69(3), 349-357 (2012-11-01)
Recent studies have indicated that minocycline, a microglia inhibitor, could potentially be used as an antinociceptive agent in pain management, although the underlying mechanisms remain elusive. In this study, we investigated the extent to which minocycline could influence pain behavior
Simon Gritsch et al.
Nature communications, 5, 5472-5472 (2014-12-02)
Mechanisms underlying central neuropathic pain are poorly understood. Although glial dysfunction has been functionally linked with neuropathic pain, very little is known about modulation of pain by oligodendrocytes. Here we report that genetic ablation of oligodendrocytes rapidly triggers a pattern
Christoph Pautke et al.
Journal of anatomy, 217(1), 76-82 (2010-05-12)
Polychrome sequential labeling with fluorochromes is a standard technique for the investigation of bone formation and regeneration processes in vivo. However, for human application, only tetracycline and its derivates are approved as fluorochromes. Therefore, the aim of this study was
Minocycline enhances the effectiveness of nociceptin/orphanin FQ during neuropathic pain
Popiolek-Barczyk K, et al.
BioMed Research International, 2014 (2014)
Zsuzsanna Winkler et al.
Scientific reports, 9(1), 6224-6224 (2019-04-19)
Glucose is a major fuel for the central nervous system and hypoglycemia is a significant homeostatic stressor, which elicits counterregulatory reactions. Hypothalamic metabolic- and stress-related neurons initiate these actions, however recruitment of glia in control such adaptive circuit remain unknown.
Giampaolo Bucaneve et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(14), 1463-1471 (2014-04-16)
Empiric antibiotic monotherapy is considered the standard of treatment for febrile neutropenic patients with cancer, but this approach may be inadequate because of the increasing prevalence of infections caused by multidrug resistant (MDR) bacteria. In this multicenter, open-label, randomized, superiority
Christopher L Cunningham et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(10), 4216-4233 (2013-03-08)
Neurogenesis must be properly regulated to ensure that cell production does not exceed the requirements of the growing cerebral cortex, yet our understanding of mechanisms that restrain neuron production remains incomplete. We investigated the function of microglial cells in the
Zhengzi Yi et al.
JCI insight, 5(15) (2020-07-08)
Acute rejection (AR) in renal transplantation is an established risk factor for reduced allograft survival. Molecules with regulatory control among immune pathways of AR that are inadequately suppressed, despite standard-of-care immunosuppression, could serve as important targets for therapeutic manipulation to
Koichi Sato et al.
Scientific reports, 10(1), 17193-17193 (2020-10-16)
Extracellular acidification in the brain has been observed in ischemia; however, the physiological and pathophysiological implications of the pH reduction remain largely unknown. Here, we analyzed the roles of proton-sensing G protein-coupled receptors, including T-cell death-associated gene 8 (TDAG8), ovarian
Thomas Schmitz et al.
Experimental neurology, 254, 153-165 (2014-02-05)
Poor neurological outcome in preterm infants is associated with periventricular white matter damage and hypomyelination, often caused by perinatal inflammation, hypoxia-ischemia, and hyperoxia. Minocycline has been demonstrated in animal models to protect the immature brain against inflammation and hypoxia-ischemia by
Mohamed Hamed Al-Agamy
Pakistan journal of pharmaceutical sciences, 26(2), 291-298 (2013-03-05)
The incidence of resistance to extended-spectrum cephalosporins (ESC) among Egyptian isolates of Klebsiella pneumoniae has already been increasing and previously reported. This work devotes to investigate the genetic basis of resistance to ESC in K. pneumoniae isolates. Disc diffusion test
Wen-tao Ni et al.
Pakistan journal of pharmaceutical sciences, 27(3), 463-467 (2014-05-09)
The shortage of effective antibiotics against multidrug-resistant Acinetobacter baumannii (MDR-Ab) has posed great threat to the public health. But the advent of tigecycline gives us new hope. The goal of our research was to assess the clinical efficacy of tigecycline
Leandro F S Bastos et al.
Neuroscience letters, 543, 157-162 (2013-03-26)
Many studies have shown that minocycline, an antibacterial tetracycline, suppresses experimental pain. While minocycline's positive effects on pain resolution suggest that clinical use of such drugs may prove beneficial, minocycline's antibiotic actions and divalent cation (Ca(2+); Mg(2+)) chelating effects detract
Maik M A Worlitzer et al.
The European journal of neuroscience, 38(5), 2684-2692 (2013-06-06)
Parkinson's disease is characterized by a selective loss of dopaminergic neurons in the substantia nigra (SN). However, whether regenerative endogenous neurogenesis is taking place in the mammalian SN of parkinsonian and non-parkinsonian brains remains of debate. Here, we tested whether
Christine L Miller
Current drug discovery technologies, 10(3), 195-208 (2013-02-01)
Over forty years ago, biochemist Lauro Galzigna conducted an in-vitro experiment showing that the antipsychotic chlorpromazine reacted with the putative psychotogen adrenochrome to form a polymer resembling melanin. The field of psychopharmacology has essentially ignored that simple but illustrative experiment
Kazuko Ishiguro et al.
Journal of microbiological methods, 115, 22-26 (2015-05-20)
Bacterial metabolic activity is associated with the onset and progression mechanisms of oral biofilm-mediated disease; however, at present no method to monitor bacterial metabolism exists, especially for periodontopathic bacteria. Therefore, we aimed to establish a novel method for monitoring the
Kenji Hashimoto et al.
Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence, 48(2), 118-125 (2013-07-03)
Accumulating evidence suggests a role of inflammation in the pathophysiology of a number of neuropsychiatric diseases. The second generation antibiotic drug minocycline has potent neuroprotective and anti-inflammatory effects. We reported that minocycline could attenuate behavioral abnormalities and dopaminergic neurotoxicity in
Anxiolytic effects of polydatin through the blockade of neuroinflammation in a chronic pain mouse model.
Shao-Yu Guan et al.
Molecular pain, 16, 1744806919900717-1744806919900717 (2020-01-23)
Practice gaps. The dermatologist's role in sarcoidosis.
Misha Rosenbach
JAMA dermatology, 149(6), 760-761 (2013-06-21)
Teresa Fernandez-Zafra et al.
Pain, 160(1), 224-236 (2018-09-25)
Recent studies have suggested a sexually dimorphic role of spinal glial cells in the maintenance of mechanical hypersensitivity in rodent models of chronic pain. We have used the collagen antibody-induced arthritis (CAIA) mouse model to examine differences between males and
Xiao-Hui Zhao et al.
Brain research bulletin, 111, 97-103 (2015-01-17)
Peripheral inflammation induces central sensitization that displays the features by the development of pain hypersensitivity to the stimuli. It has been shown that activation of glia contributes to the development of behavioral hypersensitivity after peripheral inflammation. It has been suggested
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