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Showing 1-30 of 44 results for "M9756" within Papers
Jihoe Kim et al.
The Journal of biological chemistry, 284(48), 33418-33424 (2009-10-06)
Pathways for tailoring and processing vitamins into active cofactor forms exist in mammals that are unable to synthesize these cofactors de novo. A prerequisite for intracellular tailoring of alkylcobalamins entering from the circulation is removal of the alkyl group to
Venkata R Vepachedu et al.
Journal of bacteriology, 194(16), 4161-4168 (2012-05-29)
The genome of Methanosarcina acetivorans encodes three homologs, initially annotated as hypothetical fused corrinoid/methyl transfer proteins, which are highly elevated in CO-grown cells versus cells grown with alternate substrates. Based only on phenotypic analyses of deletion mutants, it was previously
Stéphane Pierre et al.
Nature chemical biology, 8(12), 957-959 (2012-10-16)
Methylation is among the most widespread chemical modifications encountered in biomolecules and has a pivotal role in many major biological processes. In the biosynthetic pathway of the antibiotic thiostrepton A, we identified what is to our knowledge the first tryptophan
Anantharajappa Kumudha et al.
Food chemistry, 170, 316-320 (2014-10-13)
Vitamin B12 is among the most essential biomolecules required for crucial metabolic processes in humans. Vitamin B12 was extracted from Chlorella vulgaris biomass under aqueous conditions, partially purified by passing the extract through amberlite XAD-2, Sep-Pak columns, and further purified
Methylcobalamin: a potential vitamin of pain killer
Zhang M, et al.
Neural Plast. (2013)
Kiyoshi Okada et al.
Neuroscience letters, 495(3), 201-204 (2011-04-05)
Methylcobalamin (MeCbl), a vitamin B12 analog, promotes neurite outgrowth by activating Akt in neurons. However, Akt is involved in many cellular functions, and the downstream signal of Akt that promotes neurite outgrowth in neurons in the presence of MeCbl remains
C L Drennan et al.
Current opinion in structural biology, 4(6), 919-929 (1994-12-01)
Cobalamin-dependent methionine synthase is a large enzyme composed of structurally and functionally distinct regions. Recent studies have begun to define the roles of several regions of the protein. In particular, the structure of a 27 kDa cobalamin-binding fragment of the
Cortical blindness caused by hypoxemia following an asthma attack.
Tomoyuki Kunishige et al.
Japanese journal of ophthalmology, 55(5), 588-590 (2011-07-01)
Ken Ikeda et al.
Journal of the neurological sciences, 354(1-2), 70-74 (2015-05-20)
High-dose of methylcobalamin promotes nerve regeneration in rats with acrylamide neuropathy. A double-blind controlled trial suggested that high-dose methylcobalamin could increase compound muscle action potentials in patients with amyotrophic lateral sclerosis (ALS). A large-scale extended period human trial is now
Williard J Werner et al.
Biochemistry, 50(42), 8986-8988 (2011-09-29)
Radical S-adenosyl-L-methionine, cobalamin-dependent methyltransferases have been proposed to catalyze the methylations of unreactive carbon or phosphorus atoms in antibiotic biosynthetic pathways. To date, none of these enzymes has been purified or shown to be active in vitro. Here we demonstrate
Ruma Banerjee
ACS chemical biology, 1(3), 149-159 (2006-12-14)
Many coenzymes are vitamins that are assimilated in mammals into their active form from precursors obtained from the diet. They are often both rare and reactive rendering the likelihood low that the cell uses a collision-based strategy for their delivery
Antonín Bednařík et al.
Journal of chromatography. A, 1364, 271-275 (2014-09-07)
Here we present a novel coupling of thin-layer chromatography (TLC) to diode laser thermal vaporization inductively coupled plasma mass spectrometry (DLTV ICP MS). DLTV is a new technique of aerosol generation which uses a diode laser to induce pyrolysis of
Andrew McCaddon et al.
CNS spectrums, 15(1 Suppl 1), 2-5 (2010-04-20)
Neuroinflammatory oxidative stress occurs early in AD pathology. Elevated blood Hcy is a useful marker for such neuroinflammation. Hcy contributes to pathological cascades involving AP and NFTs. In AD, Hcy should be lowered by B-vitamin supplements and NAC.
John David Spence
Clinical chemistry and laboratory medicine, 51(3), 633-637 (2013-03-02)
Therapy to lower homocysteine with B vitamins does reduce the risk of stroke, if not myocardial infarction. The apparent lack of efficacy of vitamin therapy in most of the large clinical trials was probably determined by the failure to take
Su-Rong Zhou et al.
World journal of gastroenterology, 18(33), 4627-4628 (2012-09-13)
Gastrointestinal complications caused by herpes zoster are extremely rare. Here, we described a case of abdominal distention caused by herpes zoster. The patient was a 59-year-old female who suffered from unexplained paroxysmal and a burning pain on the right part
Manoj Kumar et al.
Chemical communications (Cambridge, England), 48(37), 4456-4458 (2012-03-29)
The density functional calculations suggest that the expansion of the corrin macrocycle's N(4) core by 0.06-0.10 Å leads to an appreciable lowering of 100-150 mV vs. saturated calomel electrode in the reduction potentials of two biologically important B(12) cofactors namely
Ashit Syngle et al.
International journal of rheumatic diseases, 15(1), 45-55 (2012-02-14)
Chronic inflammation in rheumatoid arthritis is associated with vascular endothelial dysfunction. The objective was to study the efficacy and safety of advanced glycation end products (AGEs) inhibitor (benfotiamine 50 mg + pyridoxamine 50 mg + methylcobalamin 500 μg, Vonder(®) (ACME
Frank Thomas et al.
Applied and environmental microbiology, 77(24), 8669-8675 (2011-10-18)
In spite of the significant impact of biomethylation on the mobility and toxicity of metals and metalloids in the environment, little is known about the biological formation of these methylated metal(loid) compounds. While element-specific methyltransferases have been isolated for arsenic
Qian Xu et al.
Diabetes research and clinical practice, 101(2), 99-105 (2013-05-15)
To compare the efficacy and safety of daily lipoic acid (300-600 mg i.v.) plus methylcobalamin (500-1000 mg i.v. or im.) (LA-MC) with that of methylcobalamin alone (MC) on diabetic peripheral neuropathy (DPN). Electronic database were searched for studies published up
Chenglin Tian
Neurology India, 59(3), 429-431 (2011-07-12)
Symmetrical hyperintense signals in lateral columns and posterior columns in T2-weighted images is a characteristic finding in subacute combined degeneration (SCD) secondary to vitamin B12 deficiency. Manifestation of SCD on diffusion-weighted imaging (DWI) has not been well characterised till date.
Y Yamamoto et al.
European journal of pharmacology, 281(3), 335-340 (1995-08-15)
The effects of methylcobalamin, a vitamin B12 analogue, on the hypoxia/hypoglycemia- or glutamate-induced reduction in hippocampal CA1 presynaptic fiber spikes elicited by Schaffer collateral stimulation in rat brain slices were evaluated. Hippocampal slices were exposed to 15 min of hypoxia/hypoglycemia
Kenneth M Prentice et al.
mAbs, 5(6), 974-981 (2013-08-09)
Process control of protein therapeutic manufacturing is central to ensuring the product is both safe and efficacious for patients. In this work, we investigate the cause of pink color variability in development lots of monoclonal antibody (mAb) and Fc-fusion proteins.
Markos Koutmos et al.
The Journal of biological chemistry, 286(34), 29780-29787 (2011-06-24)
An early step in the intracellular processing of vitamin B(12) involves CblC, which exhibits dual reactivity, catalyzing the reductive decyanation of cyanocobalamin (vitamin B(12)), and the dealkylation of alkylcobalamins (e.g. methylcobalamin; MeCbl). Insights into how the CblC scaffold supports this
Bridget Wilcken
Seminars in neurology, 32(1), 68-74 (2012-03-17)
Disorders of cobalamin and folate intracellular metabolism that result in defective remethylation of homocysteine to methionine are associated with leukodystrophy, whereas disorders of cobalamin transport generally are not. Cobalamin derivatives are needed for only two reactions in man; remethylation of
Neeraj Kumar et al.
The journal of physical chemistry. B, 115(20), 6722-6731 (2011-05-05)
Complete active space self-consistent field (CASSCF) computations followed by the second-order perturbation theory have been applied to investigate the electronic properties of a structural mimic of the reactant complex formed in the catalytic cycle of cobalamin-dependent methionine synthase (MetH). Two
Alex R Jones et al.
The journal of physical chemistry. A, 116(23), 5586-5594 (2012-05-23)
Vitamin B(12) (cyanocobalamin, CNCbl) and its derivatives are structurally complex and functionally diverse biomolecules. The excited state and radical pair reaction dynamics that follow their photoexcitation have been previously studied in detail using UV-visible techniques. Similar time-resolved infrared (TRIR) data
Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model
Okada K, et al.
Experimental Neurology, 222(2), 191-203 (2010)
Hyoung-Il Kim et al.
Annals of surgical oncology, 18(13), 3711-3717 (2011-05-11)
Vitamin B12 deficiency is a common long-term sequelae after total gastrectomy. Intramuscular injection of vitamin B12 is the only known treatment. We investigated the efficacy and safety of oral vitamin B12 replacement for gastric cancer patients with vitamin B12 deficiency
Neeraj Kumar et al.
Inorganic chemistry, 52(4), 1762-1771 (2013-01-31)
The electronic and structural properties of the one-electron-oxidized form of methylcobalamin (MeCbl) cofactor have been investigated using density functional theory (DFT) and CASSCF/MC-XQDPT2 calculations. We applied two types of functionals (hybrid and GGA) which produced quite different results in terms
Jeongdae Im et al.
Environmental science & technology, 48(22), 13181-13187 (2014-10-21)
The hydrofluoroolefin 2,3,3,3-tetrafluoropropene (HFO-1234yf) has been introduced to replace 1,1,1,2-tetrafluoroethane (HFC-134a) as refrigerant in mobile, including vehicle, air conditioning systems because of its lower global warming potential. HFO-1234yf is volatile at ambient temperatures; however, high production volumes and widespread handling
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