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Showing 1-22 of 22 results for "MAB030" within Papers
C A Cooke et al.
The Journal of cell biology, 120(5), 1083-1091 (1993-03-01)
The location of the cis-acting DNA sequences that direct the assembly of the mammalian kinetochore is not known. A variety of circumstantial evidence, however, has led to the widespread belief that they are present throughout the kinetochore including the kinetochore
Marc Lamphier et al.
Molecular pharmacology, 85(3), 429-440 (2013-12-18)
The discovery that circulating nucleic acid-containing complexes in the serum of autoimmune lupus patients can stimulate B cells and plasmacytoid dendritic cells via Toll-like receptors 7 and 9 suggested that agents that block these receptors might be useful therapeutics. We
Taeko Sasaki et al.
Scientific reports, 7(1), 11257-11257 (2017-09-14)
Mitochondrial DNA (mtDNA) is organized in nucleoprotein complexes called mitochondrial nucleoids (mt-nucleoids), which are critical units of mtDNA replication and transmission. In humans, several hundreds of mt-nucleoids exist in a cell. However, how numerous mt-nucleoids are maintained during the cell
B Zhang et al.
Nature, 390(6659), 477-484 (1997-12-11)
The nematode Caenorhabditis elegans has two sexes, males and hermaphrodites. Hermaphrodites Initially produce sperm but switch to producing oocytes. This switch appears to be controlled by the 3' untranslated region of fem-3 messenger RNA. We have now identified a binding
Linda A Hufnagel
Methods in molecular biology (Clifton, N.J.), 2364, 251-295 (2021-09-21)
The cytoskeletons of eukaryotic, cilioprotist microorganisms are complex, highly patterned, and diverse, reflecting the varied and elaborate swimming, feeding, reproductive, and sensory behaviors of the multitude of cilioprotist species that inhabit the aquatic environment. In the past 10-20 years, many new
Ailing Lu et al.
Arthritis & rheumatology (Hoboken, N.J.), 73(8), 1467-1477 (2021-02-10)
Systemic lupus erythematosus (SLE) involves kidney damage, and the inflammasome-caspase-1 axis has been demonstrated to promote renal pathogenesis. The present study was designed to explore the function of the Absent in Melanoma 2 (Aim2) protein in SLE. Female wild-type Aim2-/-
Feng Huang et al.
Molecular medicine reports, 16(4), 4817-4822 (2017-08-10)
Lupus nephritis (LN) is a common complication of systemic lupus erythematosus. The present study aimed to elucidate the protective effect of magnolol (MG) on the progression of LN, via inhibition of key signaling pathways. The results of the present study
Faith M Strickland et al.
Arthritis and rheumatism, 65(7), 1872-1881 (2013-04-12)
Lupus flares occur when genetically predisposed individuals encounter appropriate environmental agents. Current evidence indicates that the environment contributes by inhibiting T cell DNA methylation, causing overexpression of normally silenced genes. DNA methylation depends on both dietary transmethylation micronutrients and ERK-regulated
Rishi R Goel et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(10), 5409-5419 (2020-02-26)
Type III IFN lambdas (IFN-λ) have recently been described as important mediators of immune responses at barrier surfaces. However, their role in autoimmune diseases such as systemic lupus erythematosus (SLE), a condition characterized by aberrant type I IFN signaling, has
Carmelo Carmona-Rivera et al.
JCI insight, 5(13) (2020-06-03)
Rheumatoid arthritis (RA) is characterized by synovial joint inflammation, cartilage damage, and dysregulation of the adaptive immune system. While neutrophil extracellular traps (NETs) have been proposed to play a role in the generation of modified autoantigens and in the activation
Petter Langlete et al.
Frontiers in microbiology, 10, 2708-2708 (2019-12-12)
Extracellular vesicles secreted by Gram-negative bacteria have proven to be important in bacterial defense, communication and host-pathogen relationships. They resemble smaller versions of the bacterial mother cell, with similar contents of proteins, LPS, DNA, and RNA. Vesicles can elicit a
Sravani K Ramisetty et al.
International journal of biological macromolecules, 103, 845-853 (2017-05-26)
The macromolecules of the bacterial cell occupy 20-40% of the total cytosol volume, and crowded environments have long been known to compact and stabilize DNA. Nevertheless, investigations on DNA-protein binding are generally performed in the absence of crowding, which may
Aleksandrs Nasonovs et al.
PloS one, 16(3), e0249047-e0249047 (2021-03-26)
Mitochondria are commonly viewed as highly elongated organelles with regularly spaced mtDNA genomes organized as compact nucleoids that generate the local transcripts essential for production of mitochondrial ribosomes and key components of the respiratory chain. In contrast, A549 human lung
Nickie Seto et al.
JCI insight, 5(3) (2020-01-17)
Idiopathic inflammatory myopathies (IIM) are characterized by muscle inflammation and weakness, myositis-specific autoantibodies (MSAs), and extramuscular organ damage. The role of neutrophil dysregulation and neutrophil extracellular traps (NETs) in IIM is unclear. We assessed whether pathogenic neutrophil subsets (low-density granulocytes
Janet S Duerr
WormBook : the online review of C. elegans biology, 1-61 (2007-12-01)
Longyang Jin et al.
Virulence, 11(1), 1122-1130 (2020-09-01)
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) have been reported in recent years across Asian countries and pose a serious threat to public health. Neutrophils represent the first line of defense against numerous infectious pathogens, such as CR-hvKP. Neutrophil extracellular traps (NETs)
Pierre Janssen et al.
Frontiers in immunology, 13, 921077-921077 (2022-08-02)
Asthma encompasses a spectrum of heterogenous immune-mediated respiratory disorders sharing a similar clinical pattern characterized by cough, wheeze and exercise intolerance. In horses, equine asthma can be subdivided into severe or moderate asthma according to clinical symptoms and the extent
Rajeeva Singh et al.
Molecular pharmaceutics, 17(1), 50-58 (2019-11-20)
DNA-targeting indolinobenzodiazepine dimer (IGN) payloads are used in several clinical-stage antibody-drug conjugates. IGN drugs alkylate DNA through the single imine moiety present in the dimer in contrast to the pyrrolobenzodiazepine dimer drugs, such as talirine and tesirine, which contain two
Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes.
Henault, J; Martinez, J; Riggs, JM; Tian, J; Mehta, P; Clarke, L; Sasai, M; Latz et al.
Immunity null
Christin Dittmann et al.
Journal of structural biology, 191(2), 156-164 (2015-06-23)
Bacterial spores of the genera Bacillus and Clostridium are extremely resistant against desiccation, heat and radiation and involved in the spread and pathogenicity of health relevant species such as Bacillus anthracis (anthrax) or Clostridium botulinum. While the resistance of spores
Laura Patricia Whittall-Garcia et al.
Lupus science & medicine, 11(1) (2024-01-05)
To determine if the serum levels of neutrophil extracellular trap (NET) remnants (Elastase-DNA and HMGB1-DNA complexes) at the time of a lupus nephritis (LN) flare predict renal outcomes in the following 24 months. This was a retrospective study performed in
Carmelo Carmona-Rivera et al.
JCI insight, 7(16) (2022-07-20)
Dysregulation in neutrophil extracellular trap (NET) formation and degradation may play a role in the pathogenesis and severity of COVID-19; however, its role in the pediatric manifestations of this disease, including multisystem inflammatory syndrome in children (MIS-C) and chilblain-like lesions
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