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Showing 1-30 of 91 results for "MAB3026" within Papers
Miles Herkenham et al.
Journal of neuroinflammation, 8, 141-141 (2011-10-18)
The characterization and cellular localization of transcription factors like NF-κB requires the use of antibodies for western blots and immunohistochemistry. However, if target protein levels are low and the antibodies not well characterized, false positive data can result. In studies
Jayeeta Ghose et al.
PloS one, 6(8), e23837-e23837 (2011-09-03)
Huntington's disease (HD) is caused by the expansion of N-terminal polymorphic poly Q stretch of the protein huntingtin (HTT). Deregulated microRNAs and loss of function of transcription factors recruited to mutant HTT aggregates could cause characteristic transcriptional deregulation associated with
Natini Jinawath et al.
PloS one, 5(6), e11198-e11198 (2010-06-30)
Ovarian cancer is one of the most lethal types of female malignancy. Although most patients are initially responsive to platinum-based chemotherapy, almost all develop recurrent chemoresistant tumors and succumb to their diseases. Elucidating the pathogenesis underlying drug resistance is fundamental
Chien-Wei Feng et al.
Parkinson's disease, 2020, 8814236-8814236 (2021-01-19)
Parkinson's disease (PD) is one of the most widespread neurodegenerative diseases. However, the currently available treatments could only relieve symptoms. Novel therapeutic targets are urgently needed. Several previous studies mentioned that protein tyrosine phosphatase 1B (PTP1B) acted as a negative
Angela L Bush et al.
Brain research, 1203, 18-25 (2008-03-04)
The avian brainstem serves as a useful model to answer the question of how afferent activity influences the viability of target neurons. Approximately 20-30% of neurons in the avian cochlear nucleus, nucleus magnocellularis (NM) die following deafferentation (i.e., deafness produced
Yuyan Cheng et al.
Brain, behavior, and immunity, 53, 207-222 (2016-01-17)
Most psychiatric and neurological diseases are exacerbated by stress. Because this may partially result from stress-induced inflammation, we examined factors involved in this stress response. After a paradigm of inescapable foot shock stress that causes learned helplessness depression-like behavior, eighteen
Weina Ke et al.
Nucleic acids research, 47(3), 1350-1361 (2018-12-06)
Nucleic acid-based assemblies that interact with each other and further communicate with the cellular machinery in a controlled manner represent a new class of reconfigurable materials that can overcome limitations of traditional biochemical approaches and improve the potential therapeutic utility
Theta-burst stimulation of hippocampal slices induces network-level calcium oscillations and activates analogous gene transcription to spatial learning.
Sheridan, GK; Moeendarbary, E; Pickering, M; O'Connor, JJ; Murphy, KJ
Testing null
Vincent Wing Sun Liu et al.
International journal of molecular sciences, 18(6) (2017-06-01)
A major current challenge in the treatment of advanced prostate cancer, which can be initially controlled by medical or surgical castration, is the development of effective, safe, and affordable therapies against progression of the disease to the stage of castration
NF-kappaB activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations.
Sheridan, GK; Pickering, M; Twomey, C; Moynagh, PN; O'Connor, JJ; Murphy, KJ
Learning & Memory null
null
Novel CARD11 Mutations in Human Cutaneous Squamous Cell Carcinoma Lead to Aberrant NF-κB Regulation.
Stephen A Watt et al.
The American journal of pathology, 185(9), 2354-2363 (2015-07-28)
NF-κB signaling plays a crucial role in regulating proliferation and differentiation in the epidermis. Alterations in the NF-κB pathway can lead to skin pathologies with a significant burden to human health such as psoriasis and cutaneous squamous cell carcinoma (cSCC).
Anita Bandrowski et al.
Brain and behavior, 6(1), e00417-e00417 (2016-04-26)
A central tenet in support of research reproducibility is the ability to uniquely identify research resources, that is, reagents, tools, and materials that are used to perform experiments. However, current reporting practices for research resources are insufficient to identify the
Maria A Tapia et al.
Cell cycle (Georgetown, Tex.), 6(18), 2284-2292 (2007-09-25)
The NF kappa B family is composed by five subunits (p65/RelA, c-Rel, RelB, p105-p50/NF kappa B(1), p100-p52/NF kappa B(2)) and controls the expression of many genes that participate in cell cycle, apoptosis, and other key cellular processes. In a canonical
Corentin Affortit et al.
BMC biology, 19(1), 18-18 (2021-02-03)
Age-related hearing loss (ARHL), also known as presbycusis, is the most common sensory impairment seen in elderly people. However, the cochlear aging process does not affect people uniformly, suggesting that both genetic and environmental (e.g., noise, ototoxic drugs) factors and
Roberto R Rosato et al.
The Journal of biological chemistry, 285(13), 10064-10077 (2010-01-13)
Mechanisms underlying histone deacetylase inhibitor (HDACI)-mediated NF-kappaB activation were investigated in human leukemia cells. Exposure of U937 and other leukemia cells to LBH-589 induced reactive oxygen species (ROS) followed by single strand (XRCC1) and double strand (gamma-H2AX) DNA breaks. Notably
Terri Phua et al.
Scientific reports, 7, 44351-44351 (2017-03-14)
Many gastrointestinal diseases exhibit a protracted and aggravated inflammatory response that can lead to hypercytokinaemia, culminating in extensive tissue damage. Recently, angiopoietin-like 4 (ANGPTL4) has been implicated in many inflammation-associated diseases. However, how ANGPTL4 regulates colonic inflammation remains unclear. Herein
Andrea Martello et al.
EMBO reports, 21(7), e48192-e48192 (2020-04-28)
Autophagy is an essential cellular quality control process that has emerged as a critical one for vascular homeostasis. Here, we show that trichoplein (TCHP) links autophagy with endothelial cell (EC) function. TCHP localizes to centriolar satellites, where it binds and
Luca Puzzi et al.
Cell cycle (Georgetown, Tex.), 14(1), 64-73 (2014-12-09)
To date, a complete understanding of the molecular events leading to DNA replication origin activation in mammalian cells still remains elusive. In this work, we report the results of a high resolution chromatin immunoprecipitation study to detect proteins interacting with
Junghyun Kim et al.
Ophthalmic research, 46(2), 92-97 (2011-01-29)
Advanced glycation end products including Nε-(carboxymethyl)lysine (CML) are believed to contribute to retinal pericyte loss in diabetic retinopathy. Nuclear factor-κB (NF-κB) activation has been considered as a potential cytotoxic modulator of retinal pericytes. Herein, we investigated whether CML accumulation can
Heparin-binding epidermal growth factor-like growth factor signaling in flow-induced arterial remodeling.
Zhang, H; Sunnarborg, SW; McNaughton, KK; Johns, TG; Lee, DC; Faber, JE
Circulation Research null
Liseth R Aldaba-Muruato et al.
Pharmacology, 92(3-4), 138-149 (2013-09-07)
Allopurinol is an inhibitor of xanthine oxidase. The aim of this work was to evaluate the efficacy of allopurinol to reverse the experimental cirrhosis induced by CCl4. Rats received CCl4 for 8 weeks, and immediately after allopurinol was administered for
Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells.
Lindeman, JH; Abdul-Hussien, H; van Bockel, JH; Wolterbeek, R; Kleemann, R
Circulation null
Sonia Paco et al.
Journal of neuropathology and experimental neurology, 71(10), 894-906 (2012-09-15)
Ullrich congenital muscular dystrophy (UCMD) is a common form of muscular dystrophy associated with defects in collagen VI. It is characterized by loss of individual muscle fibers and muscle mass and proliferation of connective and adipose tissues. We sought to
Eric A Schwartz et al.
Arteriosclerosis, thrombosis, and vascular biology, 30(4), 802-808 (2010-01-30)
Monocyte/macrophage inflammation is an important contributor to diabetes and cardiovascular disease. Studies have suggested saturated fatty acids (SFA) induce monocyte inflammation in a Toll-like receptor-4-dependent manner, but recent data suggest SFA do not directly interact with Toll-like receptor-4. The present
Zahara L Chaudhry et al.
Brain sciences, 10(11) (2020-11-05)
The current coronavirus pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a serious global health crisis. It is a major concern for individuals living with chronic disorders such as Parkinson's disease (PD). Increasing evidence
Zhixiang Sun et al.
Journal of translational medicine, 16(1), 209-209 (2018-07-23)
Dexmedetomidine (Dex) can improve neuronal viability and protect the spinal cord from ischemia-reperfusion (I/R) injury, but the underlying mechanisms are not fully understood. This study investigated the effects of dexmedetomidine on the toll-like receptor 4 (TLR4)-mediated nuclear factor κB (NF-κB)
Enrique Chávez et al.
Journal of applied toxicology : JAT, 32(1), 51-59 (2011-03-02)
Non-steroidal anti-inflammatory drugs (NSAIDs) are drugs used primarily to treat inflammation, pain and fever. Their main mechanism of action is cyclooxygenase (COX) inhibition, and this enzyme has been linked to hepatotoxicity. The association of COX and liver injury has been
Gaurav Ghag et al.
Protein engineering, design & selection : PEDS, 29(5), 177-186 (2016-03-10)
Granulins (Grns) are a family of small, cysteine-rich proteins that are generated upon proteolytic cleavage of their precursor, progranulin (Pgrn). All seven Grns (A-G) contain 12 conserved cysteines that form 6 intramolecular disulfide bonds, rendering this family of proteins unique.
Hui Lu et al.
Molecular neurobiology (2022-10-19)
We have previously shown that selective inhibition of histone deacetylase 3 (HDAC3) decreases infarct volume and improves long-term functional outcomes after stroke. In this study, we examined the effects of HDAC3 inhibition on cerebral edema and blood-brain barrier (BBB) leakage
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