MAB3321

Applied Filters:

Keyword:'MAB3321'

Showing 1-13 of 13 results for "MAB3321" within Papers

Collagenase-3 (MMP-13) enhances remodeling of three-dimensional collagen and promotes survival of human skin fibroblasts.

Mervi J Toriseva et al.

The Journal of investigative dermatology, 127(1), 49-59 (2006-08-19)

Collagenase-3 (MMP-13) is a matrix metalloproteinase capable of cleaving a multitude of extracellular matrix proteins in addition to fibrillar collagens. Human MMP-13 is expressed by fibroblasts in chronic cutaneous ulcers, but not in normally healing adult skin wounds. However, MMP-13

Comparative analysis and clinical value of the expression of metalloproteases and their inhibitors by intratumor stromal fibroblasts and those at the invasive front of breast carcinomas.

J M Del Casar et al.

Breast cancer research and treatment, 116(1), 39-52 (2009-02-26)

An immunohistochemical study was performed using tissue arrays and specific antibodies against MMPs -1, -2, -7, -9, -11, -13, -14, and TIMPs -1, -2 and -3. More than 5,000 determinations on cancer specimens from 124 patients with invasive breast cancer

Matrix Metalloproteinase 13 Is Associated with Age-Related Choroidal Neovascularization.

Jorge González-Zamora et al.

Antioxidants (Basel, Switzerland), 12(4) (2023-04-28)

Age-related macular degeneration (AMD) is a leading cause of severe vision loss in older individuals in developed countries. Despite advances in our understanding of AMD, its pathophysiology remains poorly understood. Matrix metalloproteinases (MMPs) have been proposed to play a role

Interstitial collagen turnover during airway remodeling in acute and chronic experimental asthma.

Georgina González-Avila et al.

Experimental and therapeutic medicine, 12(3), 1419-1427 (2016-09-08)

Asthma airway remodeling is characterized by the thickening of the basement membrane (BM) due to an increase in extracellular matrix (ECM) deposition, which contributes to the irreversibility of airflow obstruction. Interstitial collagens are the primary ECM components to be increased

Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis.

Lin Xu et al.

Arthritis and rheumatism, 56(8), 2663-2673 (2007-08-01)

To investigate the role of the collagen receptor discoidin domain receptor 2 (DDR-2) in the pathogenesis of osteoarthritis (OA). Histologic and immunohistochemical analyses were performed to characterize femoral head cartilage from 7 patients with OA and 4 patients with fracture

ER Stress in ERp57 Knockout Knee Joint Chondrocytes Induces Osteoarthritic Cartilage Degradation and Osteophyte Formation.

Yvonne Rellmann et al.

International journal of molecular sciences, 23(1) (2022-01-12)

Ageing or obesity are risk factors for protein aggregation in the endoplasmic reticulum (ER) of chondrocytes. This condition is called ER stress and leads to induction of the unfolded protein response (UPR), which, depending on the stress level, restores normal

p38alpha and p38delta mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells.

M R Junttila et al.

Oncogene, 26(36), 5267-5279 (2007-03-06)

Recent studies indicate that the specificity of p38 mitogen-activated protein kinase (MAPK)-mediated cellular stress responses is determined by the expression pattern of the distinct p38 isoforms. Here, we have analysed the function of distinct p38 isoforms in the growth and

Effects of sesamin on chondroitin sulfate proteoglycan synthesis induced by interleukin-1beta in human chondrocytes.

Warunee Srisuthtayanont et al.

BMC complementary and alternative medicine, 17(1), 286-286 (2017-06-02)

Numerous studies have reported on the health benefits of sesamin, a major lignin found in sesame (S. indicum) seeds. Recently, sesamin was shown to have the ability to promote chondroitin sulfate proteoglycan synthesis in normal human chondrocytes. This study assesses

Complement factor I upregulates expression of matrix metalloproteinase-13 and -2 and promotes invasion of cutaneous squamous carcinoma cells.

Pegah Rahmati Nezhad et al.

Experimental dermatology, 30(11), 1631-1641 (2021-04-05)

The incidence of cutaneous squamous cell carcinoma (cSCC) is increasing globally. Here, we have studied the functional role of complement factor I (CFI) in the progression of cSCC. CFI was knocked down in cSCC cells, and RNA-seq analysis was performed.

Differential activity of matrix metalloproteinases (MMPs) during photoperiod induced uterine regression and recrudescence in Siberian hamsters (Phodopus sungorus).

Asha Shahed et al.

Molecular reproduction and development, 75(9), 1433-1440 (2008-01-24)

Siberian hamsters adapt to seasonal changes by reducing their reproductive function during short days (SD). SD exposure reduces uterine mass and reproductive capacity, but underlying cellular mechanisms remain unknown. Because matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are important

Perinatal changes in mitral and aortic valve structure and composition.

Elizabeth H Stephens et al.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 13(6), 447-458 (2010-06-12)

At birth, the mechanical environment of valves changes radically as fetal shunts close and pulmonary and systemic vascular resistances change. Given that valves are reported to be mechanosensitive, we investigated remodeling induced by perinatal changes by examining compositional and structural

Cellular and extracellular matrix changes in anterior cruciate ligaments during human knee aging and osteoarthritis.

Akihiko Hasegawa et al.

Arthritis research & therapy, 15(1), R29-R29 (2013-02-15)

Anterior cruciate ligament (ACL) degeneration is observed in most osteoarthritis (OA)-affected knee joints. However, the specific spatial and temporal relations of these changes and their association with extracellular matrix (ECM) degeneration are not well understood. The objective of this study

Development of a solid-phase assay for analysis of matrix metalloproteinase activity.

Lauer-Fields, JL; Nagase, H; Fields, GB

Journal of biomolecular techniques : JBT null

Page 1 of 1