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Showing 1-30 of 49 results for "MAB3448" within Papers
Global chromatin fibre compaction in response to DNA damage.
Hamilton, C; Hayward, RL; Gilbert, N
Biochemical and biophysical research communications null
Gohei Nishibuchi et al.
Nucleic acids research, 42(20), 12498-12511 (2014-10-22)
Heterochromatin protein 1 (HP1) is an evolutionarily conserved chromosomal protein that binds to lysine 9-methylated histone H3 (H3K9me), a hallmark of heterochromatin. Although HP1 phosphorylation has been described in several organisms, the biological implications of this modification remain largely elusive.
Petra Sehnalová et al.
Biology of the cell, 106(5), 151-165 (2014-03-13)
The optimal repair of DNA lesions is fundamental for physiological processes. We asked whether the recruitment of HP1β, 53BP1 and BMI1 proteins to ultraviolet (UVA)-induced DNA lesions requires functional A-type lamins. We found that UVA irradiation of nuclear lamina abolished
Epigenetic regulation of myogenic gene expression by heterochromatin protein 1 alpha.
Sdek, P; Oyama, K; Angelis, E; Chan, SS; Schenke-Layland, K; MacLellan, WR
Testing null
Jae Duk Choi et al.
Nucleic acids research, 40(22), 11321-11338 (2012-10-18)
Heterochromatin protein 1γ (HP1γ) is a chromatin protein involved in gene silencing. Herein, we show that HP1γ interacts with breast cancer type 1 susceptibility protein (BRCA1) and regulates BRCA1-mediated transcription via modulation of promoter occupancy and histone modification. We used
Lenka Stixová et al.
Epigenetics & chromatin, 7(1), 39-39 (2015-01-15)
The repair of spontaneous and induced DNA lesions is a multistep process. Depending on the type of injury, damaged DNA is recognized by many proteins specifically involved in distinct DNA repair pathways. We analyzed the DNA-damage response after ultraviolet A
Mammalian ChlR1 has a role in heterochromatin organization.
Inoue, A; Hyle, J; Lechner, MS; Lahti, JM
Experimental Cell Research null
Zhuo Sun et al.
Epigenetics & chromatin, 11(1), 45-45 (2018-08-15)
The product of dosage compensation in female mammals is the inactive X chromosome (Xi). Xi facultative heterochromatin is organized into two different types, one of which is defined by histone H3 trimethylated at lysine 9 (H3K9me3). The rationale for this
Le-Ben Wan et al.
Development (Cambridge, England), 135(16), 2729-2738 (2008-07-11)
CTCF is a multifunctional nuclear factor involved in epigenetic regulation. Despite recent advances that include the systematic discovery of CTCF-binding sites throughout the mammalian genome, the in vivo roles of CTCF in adult tissues and during embryonic development are largely
Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions.
Takebayashi, S; Tamura, T; Matsuoka, C; Okano, M
Molecular and cellular biology null
Qi Yi et al.
EMBO reports, 19(4) (2018-03-02)
Heterochromatin protein-1 (HP1) is a key component of heterochromatin. Reminiscent of the cohesin complex which mediates sister-chromatid cohesion, most HP1 proteins in mammalian cells are displaced from chromosome arms during mitotic entry, whereas a pool remains at the heterochromatic centromere
Yadong Wang et al.
The Journal of biological chemistry, 292(12), 4811-4817 (2017-02-06)
Production of hemoglobin during development is tightly regulated. For example, expression from the human β-globin gene locus, comprising β-, δ-, ϵ-, and γ-globin genes, switches from ϵ-globin to γ-globin during embryonic development and then from γ-globin to β-globin after birth.
Christine R Keenan et al.
JCI insight, 4(10) (2019-05-17)
Strategies that intervene with the development of immune-mediated diseases are urgently needed, as current treatments mostly focus on alleviating symptoms rather than reversing the disease. Targeting enzymes involved in epigenetic modifications to chromatin represents an alternative strategy that has the
Kyoko Hiragami-Hamada et al.
Nature communications, 7, 11310-11310 (2016-04-20)
Histone H3 trimethylation of lysine 9 (H3K9me3) and proteins of the heterochromatin protein 1 (HP1) family are hallmarks of heterochromatin, a state of compacted DNA essential for genome stability and long-term transcriptional silencing. The mechanisms by which H3K9me3 and HP1
Satoru Kobayakawa et al.
Genes to cells : devoted to molecular & cellular mechanisms, 12(4), 447-460 (2007-04-03)
Changes in nuclear organization and the epigenetic state of the genome are important driving forces for developmental gene expression. However, a strategy that allows simultaneous visualization of the dynamics of the epigenomic state and nuclear structure has been lacking to
Katharine M Irvine et al.
World journal of gastroenterology, 20(47), 17851-17862 (2014-12-31)
To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype (SASP). Hydrogen peroxide treatment was used to induce senescence in the human HepG2 hepatocyte cell line. Senescence was confirmed by cytochemical staining for a panel
Rebecca Kring Hansen et al.
Nature cell biology, 18(12), 1357-1366 (2016-11-08)
DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions, whose accurate repair by non-homologous end-joining (NHEJ) or homologous recombination (HR) is crucial for genome integrity and is strongly influenced by the local chromatin environment. Here, we identify SCAI (suppressor of cancer
Shin-Ichiro Takebayashi et al.
Cells, 10(2) (2021-02-13)
Multiple epigenetic pathways underlie the temporal order of DNA replication (replication timing) in the contexts of development and disease. DNA methylation by DNA methyltransferases (Dnmts) and downstream chromatin reorganization and transcriptional changes are thought to impact DNA replication, yet this
Erik Müllers et al.
Aging cell, 16(3), 575-584 (2017-03-28)
In response to DNA damage, a cell can be forced to permanently exit the cell cycle and become senescent. Senescence provides an early barrier against tumor development by preventing proliferation of cells with damaged DNA. By studying single cells, we
Ram Prakash Yadav et al.
Nucleic acids research, 48(13), 7135-7153 (2020-06-03)
Constitutive heterochromatin at the pericentric regions of chromosomes undergoes dynamic changes in its epigenetic and spatial organization during spermatogenesis. Accurate control of pericentric heterochromatin is required for meiotic cell divisions and production of fertile and epigenetically intact spermatozoa. In this
Shin-Ichiro Takebayashi et al.
Epigenetics & chromatin, 6(1), 42-42 (2013-12-18)
Cellular differentiation and reprogramming are accompanied by changes in replication timing and 3D organization of large-scale (400 to 800 Kb) chromosomal domains ('replication domains'), but few gene products have been identified whose disruption affects these properties. Here we show that
Eva Bártová et al.
Journal of cellular biochemistry, 119(10), 8146-8162 (2018-06-21)
We studied how deficiency in lamins A/C and lamina-associated polypeptide 2α (Lap2α) affects DNA repair after irradiation. A-type lamins and Lap2α were not recruited to local DNA lesions and did not accumulate to γ-irradiation-induced foci (IRIF), as it is generally
Julia C Cronin et al.
Cancer research, 73(18), 5709-5718 (2013-08-06)
The transcription factor SOX10 is essential for survival and proper differentiation of neural crest cell lineages, where it plays an important role in the generation and maintenance of melanocytes. SOX10 is also highly expressed in melanoma tumors, but a role
Zhen-Yu Zuo et al.
Nucleic acids research, 50(4), 2005-2018 (2022-02-10)
The second cell fate decision in the early stage of mammalian embryonic development is pivotal; however, the underlying molecular mechanism is largely unexplored. Here, we report that Prmt1 acts as an important regulator in primitive endoderm (PrE) formation. First, Prmt1
Brian P Chadwick
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 28(2), 155-169 (2019-11-30)
X chromosome structural abnormalities are relatively common in Turner syndrome patients, in particular X isochromosomes. Reports over the last five decades examining asynchronous DNA replication between the normal X and isochromosome have clearly established that the structurally abnormal chromosome is
Ashley E Culver-Cochran et al.
PloS one, 7(11), e50023-e50023 (2012-11-21)
Replicating the genome prior to each somatic cell division not only requires precise duplication of the genetic information, but also accurately reestablishing the epigenetic signatures that instruct how the genetic material is to be interpreted in the daughter cells. The
Annika Baude et al.
Nucleic acids research, 44(5), 2214-2226 (2016-01-02)
We have recently identified lens epithelium-derived growth factor (LEDGF/p75, also known as PSIP1) as a component of the homologous recombination DNA repair machinery. Through its Pro-Trp-Trp-Pro (PWWP) domain, LEDGF/p75 binds to histone marks associated with active transcription and promotes DNA
Arindam Chakraborty et al.
Nature communications, 5, 3445-3445 (2014-03-13)
Heterochromatin protein 1α (HP1α), a key player in the establishment and maintenance of higher-order chromatin regulates key cellular processes, including metaphase chromatid cohesion and centromere organization. However, how HP1α controls these processes is not well understood. Here we demonstrate that
Iyer Aditya Mahadevan et al.
Epigenetics & chromatin, 13(1), 9-9 (2020-03-07)
H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50-60% of total H1. This linker histone variant was previously reported to localize in the nucleolar rDNA element in mouse spermatocytes. Our main aim was to determine
Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter.
Wu, LP; Wang, X; Li, L; Zhao, Y; Lu, S; Yu, Y; Zhou, W; Liu, X; Yang, J; Zheng, Z; Zhang et al.
Molecular and cellular biology null
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