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Showing 1-30 of 110 results for "MAB363" within Papers
Bas M J Olthof et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(5), 876-887 (2018-12-12)
Nitric oxide (NO) is a neurotransmitter synthesized in the brain by neuronal nitric oxide synthase (nNOS). Using immunohistochemistry and confocal imaging in the inferior colliculus (IC, auditory midbrain) of the guinea pig (Cavia porcellus, male and female), we show that
Pei-Yu Shih et al.
Cell reports, 5(4), 941-951 (2013-11-26)
Synaptic NMDA receptors (NMDARs) carry inward Ca(2+) current responsible for postsynaptic signaling and plasticity in dendritic spines. Whether the concurrent K(+) efflux through the same receptors into the synaptic cleft has a physiological role is not known. Here, we report
Csaba Cserép et al.
PloS one, 7(5), e37753-e37753 (2012-06-05)
GABA (gamma-aminobutyric-acid), the main inhibitory neurotransmitter in the adult brain, exerts depolarizing (excitatory) actions during development and this GABAergic depolarization cooperates with NMDARs (N-methyl-D-aspartate receptors) to drive spontaneous synchronous activity (SSA) that is fundamentally important for developing neuronal networks. Although
Salima El Chehadeh et al.
Nature communications, 13(1), 4112-4112 (2022-07-16)
SLITRK2 is a single-pass transmembrane protein expressed at postsynaptic neurons that regulates neurite outgrowth and excitatory synapse maintenance. In the present study, we report on rare variants (one nonsense and six missense variants) in SLITRK2 on the X chromosome identified
John E Rash et al.
Journal of neurocytology, 34(3-5), 307-341 (2006-07-15)
Odorant/receptor binding and initial olfactory information processing occurs in olfactory receptor neurons (ORNs) within the olfactory epithelium. Subsequent information coding involves high-frequency spike synchronization of paired mitral/tufted cell dendrites within olfactory bulb (OB) glomeruli via positive feedback between glutamate receptors
Masafumi Shimojo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(17), 3491-3501 (2020-04-09)
Synaptic dysfunction provoking dysregulated cortical neural circuits is currently hypothesized as a key pathophysiological process underlying clinical manifestations in Alzheimer's disease and related neurodegenerative tauopathies. Here, we conducted PET along with postmortem assays to investigate time course changes of excitatory
Stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size.
Kalev-Zylinska, ML; Symes, W; Little, KC; Sun, P; Wen, D; Qiao, L; Young, D; During, MJ; Barber, PA
Stroke null
Alejandro Martín-Belmonte et al.
Frontiers in aging neuroscience, 12, 577996-577996 (2020-11-03)
Synapse loss occurs early in Alzheimer's disease (AD) patients and animal models. Alterations at synaptic level are a major morphological correlate of the memory deficits and related symptoms of AD. Given the predominant roles of synaptic AMPA receptors (AMPARs) in
Annika van Hummel et al.
PloS one, 11(10), e0163236-e0163236 (2016-10-14)
Several mouse lines with knockout of the tau-encoding MAPT gene have been reported in the past; they received recent attention due to reports that tau reduction prevented Aβ-induced deficits in mouse models of Alzheimer's disease. However, the effects of long-term
Ümit Suat Mayadali et al.
Brain structure & function, 226(7), 2125-2151 (2021-06-29)
Extraocular motoneurons initiate dynamically different eye movements, including saccades, smooth pursuit and vestibulo-ocular reflexes. These motoneurons subdivide into two main types based on the structure of the neuro-muscular interface: motoneurons of singly-innervated (SIF), and motoneurons of multiply-innervated muscle fibers (MIF).
Daniel T Christian et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(39), 8262-8277 (2021-08-21)
Cue-induced cocaine craving progressively intensifies (incubates) after withdrawal from cocaine self-administration in rats and humans. In rats, the expression of incubation ultimately depends on Ca2+-permeable AMPARs that accumulate in synapses onto medium spiny neurons (MSNs) in the NAc core. However
Madhuchhanda Mandal et al.
Molecular pharmacology, 76(6), 1349-1359 (2009-09-23)
The membrane phospholipid phosphatidylinositol (4,5)-bisphosphate (PIP(2)) has been implicated in the regulation of several ion channels and transporters. In this study, we examined the impact of PIP(2) on N-methyl-D-aspartate receptors (NMDARs) in cortical neurons. Blocking PIP(2) synthesis by inhibiting phosphoinositide-4
M Darvas et al.
Neuroscience, 284, 934-942 (2014-12-03)
Behavioral flexibility is known to be mediated by corticostriatal systems and to involve several major neurotransmitter signaling pathways. The current study investigated the effects of inactivation of glutamatergic N-methyl-D-aspartate-(NMDA) receptor signaling in the dorsal striatum on behavioral flexibility in mice.
Differential regulation of ionotropic glutamate receptor subunits following cocaine self-administration.
Hemby, SE; Horman, B; Tang, W
Brain Research null
Yingxiao Shi et al.
JCI insight, 5 (2019-07-17)
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease with diverse etiologies. Therefore, the identification of common disease mechanisms and therapeutics targeting these mechanisms could dramatically improve clinical outcomes. To this end, we developed induced motor neuron (iMN) models
Caroline Corbel et al.
Neural development, 10, 20-20 (2015-09-19)
N-methyl-D-aspartate receptors (NMDARs) are a subtype of ionotropic glutamate receptors and are expressed throughout the central nervous system (CNS). Their activity is required for excitatory synaptic transmission, the developmental refinement of neural circuits and for the expression of many forms
Eric W Buss et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(8) (2021-02-18)
Behaviors that rely on the hippocampus are particularly susceptible to chronological aging, with many aged animals (including humans) maintaining cognition at a young adult-like level, but many others the same age showing marked impairments. It is unclear whether the ability
Ashleigh L Osborne et al.
Brain, behavior, and immunity, 81, 574-587 (2019-07-22)
Cognitive impairment is a major source of disability in schizophrenia and current antipsychotic drugs (APDs) have minimal efficacy for this symptom domain. Cannabidiol (CBD), the major non-intoxicating component of Cannabis sativa L., exhibits antipsychotic and neuroprotective properties. We recently reported
Single-synapse analysis of a diverse synapse population: proteomic imaging methods and markers.
Micheva, KD; Busse, B; Weiler, NC; O'Rourke, N; Smith, SJ
Neuron null
Benjamin Serraz et al.
Neuropharmacology, 109, 196-204 (2016-06-12)
Recent human genetic studies have identified a surprisingly high number of alterations in genes encoding NMDA receptor (NMDAR) subunits in several common brain diseases. Among NMDAR subunits, the widely-expressed GluN2A subunit appears particularly affected, with tens of de novo or
Jian Zhang et al.
Molecular neurobiology, 55(6), 4802-4810 (2017-07-25)
Inhibition of monoacylglycerol lipase (MAGL), the primary enzyme that hydrolyzes the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain, produces profound anti-inflammatory and neuroprotective effects and improves synaptic and cognitive functions in animal models of Alzheimer's disease (AD). However, the molecular mechanisms
Jing Fan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(35), 10928-10938 (2009-09-04)
Evidence suggests that NMDA-type glutamate receptors contribute to degeneration of striatal medium-sized spiny neurons (MSNs) in Huntington's disease (HD). Previously, we demonstrated that NMDA receptor (NMDAR)-mediated current and/or toxicity is increased in MSNs from the yeast artificial chromosome (YAC) transgenic
Amina Benhadda et al.
ACS chemical neuroscience, 12(7), 1133-1149 (2021-03-20)
The serotonin 2B (5-HT2B) receptor coupled to Gq-protein contributes to the control of neuronal excitability and is implicated in various psychiatric disorders. The mechanisms underlying its brain function are not fully described. Using peptide affinity chromatography combined with mass spectrometry
Anna García-Serra et al.
Neurology(R) neuroimmunology & neuroinflammation, 8(6) (2021-09-29)
To determine in a mouse model whether neonatal Fc receptor (FcRn) blockade prevents the placental transfer of class G immunoglobulin (IgG) derived from patients with anti-NMDA receptor (NMDAR) encephalitis and their pathogenic effects on the fetuses and offspring. Pregnant C57BL/6J
Jeremy S Lum et al.
Journal of psychiatry & neuroscience : JPN, 43(2), 102-110 (2018-02-27)
The nucleus accumbens (NAcc) has been implicated in the pathology and treatment of schizophrenia. Recent postmortem evidence suggests a hyperglutamatergic state in the NAcc. With the present study we aimed to explore possible glutamatergic alterations in the NAcc of a
Jonathan Aow et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(47), 14711-14716 (2015-11-11)
The NMDA receptor (NMDAR) is known to transmit important information by conducting calcium ions. However, some recent studies suggest that activation of NMDARs can trigger synaptic plasticity in the absence of ion flow. Does ligand binding transmit information to signaling
Veerle Bergink et al.
The American journal of psychiatry, 172(9), 901-908 (2015-07-18)
Significant immunological alterations have been observed in women with first-onset affective psychosis during the postpartum period. Recent studies have highlighted the possibility that a subset of patients with first-onset severe psychiatric episodes might suffer from undiagnosed autoimmune encephalitis. Therefore, the
Forrest Collman et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(14), 5792-5807 (2015-04-10)
Synapses of the mammalian CNS are diverse in size, structure, molecular composition, and function. Synapses in their myriad variations are fundamental to neural circuit development, homeostasis, plasticity, and memory storage. Unfortunately, quantitative analysis and mapping of the brain's heterogeneous synapse
Janin Schütt et al.
The Journal of biological chemistry, 284(38), 25479-25487 (2009-07-31)
Functional absence of fragile X mental retardation protein (FMRP) causes the fragile X syndrome, a hereditary form of mental retardation characterized by a change in dendritic spine morphology. The RNA-binding protein FMRP has been implicated in regulating postsynaptic protein synthesis.
Mats Julius Stensrud et al.
The Journal of comparative neurology, 523(18), 2698-2713 (2015-05-27)
There is compelling evidence that glutamate can act as a cotransmitter in the mammalian brain. Interestingly, the third vesicular glutamate transporter (VGLUT3) is primarily found in neurons that were anticipated to be nonglutamatergic. Whereas the function of VGLUT3 in acetylcholinergic
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