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Showing 1-30 of 314 results for "MAB386" within Papers
Quentin Delarue et al.
Journal of neuroscience research, 99(7), 1835-1849 (2021-05-08)
Spinal cord injury (SCI) is a debilitating condition, which leads to a permanent loss of functions below the injury site. The events which take place after SCI are characterized by cellular death, release of inhibitory factors, and inflammation. Many therapies
Manideep Chavali et al.
Neuron, 108(6), 1130-1145 (2020-10-22)
Recent studies have indicated oligodendroglial-vascular crosstalk during brain development, but the underlying mechanisms are incompletely understood. We report that oligodendrocyte precursor cells (OPCs) contact sprouting endothelial tip cells in mouse, ferret, and human neonatal white matter. Using transgenic mice, we
Tal Iram et al.
Nature, 605(7910), 509-515 (2022-05-12)
Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain ageing1-3. Cerebrospinal fluid (CSF) makes up the immediate environment of brain cells, providing them with nourishing compounds4,5. We discovered
Masahiro Otsu et al.
Frontiers in cell and developmental biology, 9, 688283-688283 (2021-09-11)
Embryonic stem cells (ESC) have the potential to generate homogeneous immature cells like stem/progenitor cells, which appear to be difficult to isolate and expand from primary tissue samples. In this study, we developed a simple method to generate homogeneous immature
Chang Hwa Jung et al.
Molecular biology of the cell, 20(7), 1992-2003 (2009-02-20)
Autophagy, the starvation-induced degradation of bulky cytosolic components, is up-regulated in mammalian cells when nutrient supplies are limited. Although mammalian target of rapamycin (mTOR) is known as the key regulator of autophagy induction, the mechanism by which mTOR regulates autophagy
Konstantin Feinberg et al.
Neuron, 65(4), 490-502 (2010-03-02)
Saltatory conduction requires high-density accumulation of Na(+) channels at the nodes of Ranvier. Nodal Na(+) channel clustering in the peripheral nervous system is regulated by myelinating Schwann cells through unknown mechanisms. During development, Na(+) channels are first clustered at heminodes
Vicki J Swier et al.
PloS one, 15(2), e0228222-e0228222 (2020-02-20)
Genetically modified swine disease models are becoming increasingly important for studying molecular, physiological and pathological characteristics of human disorders. Given the limited history of these model systems, there remains a great need for proven molecular reagents in swine tissue. Here
James Keaney et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 14(3), 448-461 (2019-02-14)
Bruton's tyrosine kinase (BTK), a critical component of B cell receptor signaling, has recently been implicated in regulation of the peripheral innate immune response. However, the role of BTK in microglia, the resident innate immune cells of the central nervous
Valeria de Rosa et al.
EMBO molecular medicine, 11(1) (2018-12-19)
Glutamate signaling may orchestrate oligodendrocyte precursor cell (OPC) development and myelin regeneration through the activation of glutamate receptors at OPC-neuron synapses. D-Aspartate is a D-amino acid exerting modulatory actions at glutamatergic synapses. Chronic administration of D-Aspartate has been proposed as
Yaguang Li et al.
Scientific reports, 13(1), 9394-9394 (2023-06-10)
Multiple sclerosis (MS) is an inflammatory demyelinating disease characterized by multiple lesions in the central nervous system. Although the role of B cells in MS pathogenesis has attracted much attention, but the detailed mechanisms remain unclear. To investigate the effects
Gabriela Goldberg et al.
Molecular psychiatry, 29(3), 566-579 (2023-12-22)
Three Prime Repair Exonuclease 1 (TREX1) gene mutations have been associated with Aicardi-Goutières Syndrome (AGS) - a rare, severe pediatric autoimmune disorder that primarily affects the brain and has a poorly understood etiology. Microglia are brain-resident macrophages indispensable for brain
Jureepon Roboon et al.
Frontiers in cellular neuroscience, 16, 877131-877131 (2022-10-25)
Astrocytes play key roles in supporting the central nervous system structure, regulating synaptic functions, and maintaining brain homeostasis. The number of astrocytes in the cerebrum has markedly increased through evolution. However, the manner by which astrocytes change their features during
Benjamin J Yungher et al.
Investigative ophthalmology & visual science, 58(3), 1743-1750 (2017-03-23)
Enhanced regeneration of retinal ganglion cell (RGC) axons can be achieved by modification of numerous neuronal-intrinsic factors. However, axon growth initiation and the pathfinding behavior of these axons after traumatic injury remain poorly understood outside of acute injury paradigms, despite
Zijian Zhou et al.
Biological & pharmaceutical bulletin, 46(1), 102-110 (2023-01-04)
Peripheral neuropathy is one of the major adverse effects that limit the clinical application of bortezomib (BTZ). However, the underlying mechanisms of BTZ-induced peripheral neuropathy (BIPN) remain elusive. To examine cell types potentially involved in the development of BIPN, we
Compromised Myelin and Axonal Molecular Organization Following Adult-Onset Sulfatide Depletion.
Dustin, et al.
Biomedicines, 11 (2023)
Osamu Imamura et al.
Journal of neurochemistry, 140(2), 231-244 (2016-10-19)
Oligodendrocytes are the myelin-forming cells of the central nervous system. Oligodendrocyte loss and failure of myelin development result in serious human disorders, including multiple sclerosis. Previously, using oligodendrocyte progenitor cells, we have shown that donepezil, which is an acetylcholinesterase inhibitor
Gabriella Fernandes-Pires et al.
Molecular therapy. Methods & clinical development, 32(2), 101251-101251 (2024-05-15)
Creatine deficiency syndromes (CDS), caused by mutations in GATM (AGAT), GAMT, and SLC6A8, mainly affect the central nervous system (CNS). CDS show brain creatine (Cr) deficiency, intellectual disability with severe speech delay, behavioral troubles, epilepsy, and motor dysfunction. AGAT/GAMT-deficient patients
Multiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression.
Shanshan Li et al.
Science advances, 7(30) (2021-07-23)
Transmembrane proteins play vital roles in mediating synaptic transmission, plasticity, and homeostasis in the brain. However, these proteins, especially the G protein-coupled receptors (GPCRs), are underrepresented in most large-scale proteomic surveys. Here, we present a new proteomic approach aided by
Ke Ning et al.
Journal of neuroscience research, 102(1), e25273-e25273 (2024-01-29)
Primary cilia are microtubule-based sensory organelles that project from the apical surface of most mammalian cells, including oligodendrocytes, which are myelinating cells of the central nervous system (CNS) that support critical axonal function. Dysfunction of CNS glia is associated with
Dario I Carrasco et al.
Journal of neurophysiology, 117(4), 1690-1701 (2017-01-27)
Knowledge of the molecular mechanisms underlying signaling of mechanical stimuli by muscle spindles remains incomplete. In particular, the ionic conductances that sustain tonic firing during static muscle stretch are unknown. We hypothesized that tonic firing by spindle afferents depends on
Joshua D Crapser et al.
Brain : a journal of neurology, 143(1), 266-288 (2019-12-19)
Huntington's disease is associated with a reactive microglial response and consequent inflammation. To address the role of these cells in disease pathogenesis, we depleted microglia from R6/2 mice, a rapidly progressing model of Huntington's disease marked by behavioural impairment, mutant
Lukas F Reissig et al.
Histochemistry and cell biology, 159(1), 23-45 (2022-10-07)
Immunohistochemistry is a powerful tool for studying neuronal tissue from humans at the molecular level. Obtaining fresh neuronal tissue from human organ donors is difficult and sometimes impossible. In anatomical body donations, neuronal tissue is dedicated to research purposes and
Jeroen F J Bogie et al.
The Journal of experimental medicine, 217(5) (2020-02-26)
Failure of remyelination underlies the progressive nature of demyelinating diseases such as multiple sclerosis. Macrophages and microglia are crucially involved in the formation and repair of demyelinated lesions. Here we show that myelin uptake temporarily skewed these phagocytes toward a
Sarah-Jane Bull et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(29), 9768-9778 (2014-07-18)
Paranodal axoglial junctions are critical for maintaining the segregation of axonal domains along myelinated axons; however, the proteins required to organize and maintain this structure are not fully understood. Netrin-1 and its receptor Deleted in Colorectal Cancer (DCC) are proteins
Ying-Chang Lu et al.
JCI insight, 7(20) (2022-10-25)
Recessive PJVK mutations that cause a deficiency of pejvakin, a protein expressed in both sensory hair cells and first-order neurons of the inner ear, are an important cause of hereditary hearing impairment. Patients with PJVK mutations garner limited benefits from
Joshua E Burda et al.
Nature, 606(7914), 557-564 (2022-05-26)
Astrocytes respond to injury and disease in the central nervous system with reactive changes that influence the outcome of the disorder1-4. These changes include differentially expressed genes (DEGs) whose contextual diversity and regulation are poorly understood. Here we combined biological and
Cynthia B Ripoll et al.
Stem cells (Dayton, Ohio), 29(1), 67-77 (2011-02-01)
The twitcher mouse is an animal model of Krabbe's disease (KD), which is a neurodegenerative lysosomal storage disorder resulting from the absence of functional lysosomal enzyme galactocerebrosidase (GALC). This disease affects the central and peripheral nervous systems and in its
Anuriti Aojula et al.
Fluids and barriers of the CNS, 13(1), 9-9 (2016-06-02)
In an effort to develop novel treatments for communicating hydrocephalus, we have shown previously that the transforming growth factor-β antagonist, decorin, inhibits subarachnoid fibrosis mediated ventriculomegaly; however decorin's ability to prevent cerebral cytopathology in communicating hydrocephalus has not been fully
Haritha L Desu et al.
Cells, 10(7) (2021-08-08)
Multiple sclerosis (MS) is a neuroimmune disorder characterized by inflammation, CNS demyelination, and progressive neurodegeneration. Chronic MS patients exhibit impaired remyelination capacity, partly due to the changes that oligodendrocyte precursor cells (OPCs) undergo in response to the MS lesion environment.
Victoria-Elisabeth Gruber et al.
Neuropathology and applied neurobiology, 47(6), 812-825 (2021-06-27)
We aim to evaluate if the myelin pathology observed in epilepsy-associated focal cortical dysplasia type 2B (FCD2B) and-histologically indistinguishable-cortical tubers of tuberous sclerosis complex (TSC) is primarily related to the underlying malformation or constitutes a secondary phenomenon due to the
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