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Showing 1-30 of 340 results for "MAB397" within Papers
Taesun Yoo et al.
Frontiers in molecular neuroscience, 15, 938590-938590 (2022-08-16)
Genetic variations resulting in the loss of function of the discs large homologs (DLG2)/postsynaptic density protein-93 (PSD-93) gene have been implicated in the increased risk for schizophrenia, intellectual disability, and autism spectrum disorders (ASDs). Previously, we have reported that mice
Sumana Ghosh et al.
Frontiers in cellular neuroscience, 12, 271-271 (2018-09-07)
Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these
Giuseppe Bruschetta et al.
Molecular metabolism, 10, 28-38 (2018-02-21)
Prolyl carboxypeptidase (PRCP) plays a role in the regulation of energy metabolism by inactivating hypothalamic α-melanocyte stimulating hormone (α-MSH) levels. Although detected in the arcuate nucleus, limited PRCP expression has been observed in the arcuate POMC neurons, and its site
Susana R Louros et al.
Cell reports, 7(5), 1614-1625 (2014-06-03)
During development, neurons are constantly refining their connections in response to changes in activity. Experience-dependent plasticity is a key form of synaptic plasticity, involving changes in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) accumulation at synapses. Here, we report a critical role for
Matylda Roszkowska et al.
Cellular and molecular life sciences : CMLS, 79(5), 278-278 (2022-05-04)
Alterations in social behavior are core symptoms of major developmental neuropsychiatric diseases such as autism spectrum disorders or schizophrenia. Hence, understanding their molecular and cellular underpinnings constitutes the major research task. Dysregulation of the global gene expression program in the developing
Jian Zhang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(45), 14919-14933 (2014-11-08)
Abnormal accumulation of β-amyloid (Aβ) is the major neuropathological hallmark of Alzheimer's disease (AD). However, the mechanisms underlying aberrant Aβ formation in AD remain unclear. We showed previously that inhibition of monoacylglycerol lipase (MAGL), the primary enzyme that metabolizes the
Chaorong Yu et al.
Frontiers in cellular neuroscience, 15, 736120-736120 (2021-11-09)
Ribbon synapses of cochlear hair cells undergo pruning and maturation before the hearing onset. In the central nervous system (CNS), synaptic pruning was mediated by microglia, the brain-resident macrophages, via activation of the complement system. Whether a similar mechanism regulates
Jose M Bermúdez-Muñoz et al.
Aging cell, 19(12), e13275-e13275 (2020-11-23)
Aging of the auditory system is associated with the incremental production of reactive oxygen species (ROS) and the accumulation of oxidative damage in macromolecules, which contributes to cellular malfunction, compromises cell viability, and, ultimately, leads to functional decline. Cellular detoxification
M Kondo et al.
The European journal of neuroscience, 12(8), 2812-2822 (2000-09-06)
alpha-Amino-3-hydroxy-5-methyl-4-isoxazle propionic acid (AMPA) receptors are ubiquitously expressed; however, their subtypes and abundance vary from region to region. We classified the neurons in various forebrain regions (hippocampus, striatum, amygdala, piriform cortex and somatosensory cortex) into six types: [R1+/R2+], [R1-/R2+], [R1+/R2-]
Jason Aoto et al.
Nature neuroscience, 18(7), 997-1007 (2015-06-02)
α- and β-neurexins are presynaptic cell-adhesion molecules whose general importance for synaptic transmission is well documented. The specific functions of neurexins, however, remain largely unknown because no conditional neurexin knockouts are available and targeting all α- and β-neurexins produced by
Wolfgang Wagner et al.
Cell reports, 28(1), 11-20 (2019-07-04)
Myosin VI is an actin-based cytoskeletal motor implicated in various steps of membrane trafficking. Here, we investigated whether this myosin is crucial for synaptic function and plasticity in neurons. We find that myosin VI localizes at cerebellar parallel fiber to
Rui Cai et al.
Neurobiology of aging, 62, 53-63 (2017-11-07)
Age-related hearing loss is experienced by one-third of individuals aged 65 years and older and can be socially debilitating. Historically, there has been poor correlation between age-related threshold changes, loss of speech understanding, and loss of cochlear hair cells. We examined
Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites.
Hayashi, T; Rumbaugh, G; Huganir, RL
Neuron null
Charlene P Poore et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(25), 8457-8467 (2010-06-25)
Cyclin-dependent kinase 5 (Cdk5)-mediated phosphorylation plays an important role in proper synaptic function and transmission. Loss of Cdk5 activity results in abnormal development of the nervous system accompanied by massive disruptions in cortical migration and lamination, therefore impacting synaptic activity.
Jun Suzuki et al.
Scientific reports, 6, 24907-24907 (2016-04-26)
In acquired sensorineural hearing loss, such as that produced by noise or aging, there can be massive loss of the synaptic connections between cochlear sensory cells and primary sensory neurons, without loss of the sensory cells themselves. Because the cell
Maya Yamazaki et al.
The European journal of neuroscience, 31(12), 2204-2220 (2010-06-10)
The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors require auxiliary subunits termed transmembrane AMPA receptor regulatory proteins (TARPs), which promote receptor trafficking to the cell surface and synapses and modulate channel pharmacology and gating. Of six TARPs, gamma-2 and gamma-7 are the
Jerome Nevoux et al.
Scientific reports, 11(1), 2937-2937 (2021-02-05)
Auditory neuropathy is caused by the loss of afferent input to the brainstem via the components of the neural pathway comprising inner hair cells and the first order neurons of the spiral ganglion. Recent work has identified the synapse between
Bryan R Kuo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(30), 10786-10798 (2015-08-01)
The mammalian cochlea exhibit minimal spontaneous regeneration, and loss of sensory hair cells (HCs) results in permanent hearing loss. In nonmammalian vertebrates, spontaneous HC regeneration occurs through both proliferation and differentiation of surrounding supporting cells (SCs). HC regeneration in postnatal
Chihiro Nakamoto et al.
PloS one, 15(2), e0229288-e0229288 (2020-02-23)
The GluD1 gene is associated with susceptibility for schizophrenia, autism, depression, and bipolar disorder. However, the function of GluD1 and how it is involved in these conditions remain elusive. In this study, we generated a Grid1 gene-knockout (GluD1-KO) mouse line
Katharine A Fernandez et al.
JCI insight, 6(3) (2020-12-30)
TrkB agonist drugs are shown here to have a significant effect on the regeneration of afferent cochlear synapses after noise-induced synaptopathy. The effects were consistent with regeneration of cochlear synapses that we observed in vitro after synaptic loss due to
Linda C Jansson et al.
The European journal of neuroscience, 37(9), 1369-1382 (2013-02-07)
Neurotransmitters such as glutamate are potential regulators of neurogenesis. Interference with defined glutamate receptor subtypes affects proliferation, migration and differentiation of neural progenitor cells. The cellular targets for the actions of different glutamate receptor ligands are less well known. In
Yunping Song et al.
EBioMedicine, 39, 409-421 (2018-12-14)
It is widely accepted that cognitive and memory deficits in Alzheimer's disease (AD) primarily result from synaptic failure. However, the mechanisms that underlie synaptic and cognitive dysfunction remain unclear. We utilized molecular biology techniques, electrophysiological recordings, fluorescence in situ hybridization
Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression.
Erkens, M; Tanaka-Yamamoto, K; Cheron, G; Marquez-Ruiz, J; Prigogine, C; Schepens et al.
Molecular Brain null
Frank F Heisler et al.
Neuron, 99(6), 1155-1169 (2018-09-04)
Cellular prion protein (PrPC) modulates cell adhesion and signaling in the brain. Conversion to its infectious isoform causes neurodegeneration, including Creutzfeldt-Jakob disease in humans. PrPC undergoes rapid plasma membrane turnover and extracellular release via exosomes. However, the intracellular transport of PrPC and its
Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey.
Medalla, M; Luebke, JI
The Journal of Neuroscience null
Supriya Swarnkar et al.
Cell reports, 36(2), 109369-109369 (2021-07-15)
Synaptic structural plasticity, key to long-term memory storage, requires translation of localized RNAs delivered by long-distance transport from the neuronal cell body. Mechanisms and regulation of this system remain elusive. Here, we explore the roles of KIF5C and KIF3A, two
Liana Sargsyan et al.
International journal of molecular sciences, 23(13) (2022-07-10)
Combining aminoglycosides and loop diuretics often serves as an effective ototoxic approach to deafen experimental animals. The treatment results in rapid hair cell loss with extended macrophage presence in the cochlea, creating a sterile inflammatory environment. Although the early recruitment
Evangelia Tserga et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(10), 13978-13992 (2020-08-26)
The chemotherapeutic agent cisplatin is renowned for its ototoxic effects. While hair cells in the cochlea are established targets of cisplatin, less is known regarding the afferent synapse, which is an essential component in the faithful temporal transmission of sound.
Juhyun Lee et al.
Glia, 67(9), 1667-1679 (2019-05-03)
During postnatal neurodevelopment, excessive synapses must be eliminated by microglia to complete the establishment of neural circuits in the brain. The lack of synaptic regulation by microglia has been implicated in neurodevelopmental disorders such as autism, schizophrenia, and intellectual disability.
Keishi Ishida et al.
Biological & pharmaceutical bulletin, 46(2), 292-300 (2023-02-02)
Methylmercury (MeHg) is a well-known environmental pollutant that has harmful effects on the central nervous systems of humans and animals. The molecular mechanisms of MeHg-induced neurotoxicity at low concentrations are not fully understood. Here, we investigated the effects of low-concentration
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