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Showing 1-24 of 24 results for "MAB4419" within Papers
Pushpa Singh et al.
Stem cell research & therapy, 13(1), 60-60 (2022-02-07)
True identity and specific set of markers to enrich endometrial stem cells still remains elusive. Present study was undertaken to further substantiate that very small embryonic-like stem cells (VSELs) are the true and elusive stem cells in adult mice endometrium.
Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures.
Cossec, et al.
Cell Reports, 42, 112380-112380 (2023)
Inês Gomes et al.
Oncotarget, 11(19), 1714-1728 (2020-06-02)
The role of RANKL-RANK pathway in progesterone-driven mammary carcinogenesis and triple negative breast cancer tumorigenesis has been well characterized. However, and despite evidences of the existence of RANK-positive hormone receptor (HR)-positive breast tumors, the implication of RANK expression in HR-positive
Renjitha Gopurappilly et al.
Stem cell research, 67, 103033-103033 (2023-01-28)
Phospholipase A2 group 6 (PLA2G6, iPLA2β or PARK14) gene encodes a calcium-independent group 6 phospholipase A2 enzyme and is associated with young-onset autosomal recessive Parkinson's disease (PD). We generated human induced pluripotent stem cell (iPSC) lines from a patient with
Gisele C M Dias et al.
Molecular reproduction and development (2020-06-20)
The objective of this study was to establish a protocol for the characterization, isolation, and culture of type A spermatogonia using specific molecular markers for these cells in fish. To this end, adult Prochilodus lineatus testes were collected and digested
Meital Gabay et al.
Science signaling, 4(200), ra79-ra79 (2011-11-25)
Ric-8A (resistance to inhibitors of cholinesterase 8A) and Ric-8B are guanine nucleotide exchange factors that enhance different heterotrimeric guanine nucleotide-binding protein (G protein) signaling pathways by unknown mechanisms. Because transgenic disruption of Ric-8A or Ric-8B in mice caused early embryonic
Hannah C Leeson et al.
Stem cell research, 56, 102527-102527 (2021-09-11)
Human olfactory neurosphere-derived (ONS) cells are derived from the olfactory mucosa and display some progenitor- and neuronal cell-like properties, making them useful models of neurological disorders. However, they lack several important characteristics of true neurons, which can be overcome using
Ana Joana Duarte et al.
Stem cell research, 45, 101794-101794 (2020-05-11)
Fabry Disease (FD) is a multisystemic X-linked disorder that belongs to the group of lysosomal storage disorders (LSDs). Causal mutations on alpha-galactosidase A (α-Gal A) commonly lead to abnormal protein and consequently to FD. Since it is an X-linked disease
Shingo Miyawaki et al.
Nature communications, 7, 11471-11471 (2016-05-11)
The naked mole-rat (NMR, Heterocephalus glaber), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response to reprogramming induction. In this study, we generate NMR-induced pluripotent stem
Lyle Armstrong et al.
Stem cells (Dayton, Ohio), 28(4), 661-673 (2010-01-15)
The generation of induced pluripotent stem cells (iPSC) has enormous potential for the development of patient-specific regenerative medicine. Human embryonic stem cells (hESC) are able to defend their genomic integrity by maintaining low levels of reactive oxygen species (ROS) through
Molecular signatures to define spermatogenic cells in common marmoset (Callithrix jacchus).
Lin, ZY; Imamura, M; Sano, C; Nakajima, R; Suzuki, T; Yamadera, R; Takehara, Y; Okano et al.
Reproduction (Cambridge, England) null
Teresa Starzyńska et al.
Journal of cellular and molecular medicine, 17(6), 792-799 (2013-05-16)
Various experimental studies indicate potential involvement of bone marrow (BM)-derived stem cells (SCs) in malignancy development and progression. In this study, we comprehensively analysed systemic trafficking of various populations of BM-derived SCs (BMSCs), i.e., mesenchymal, haematopoietic, endothelial stem/progenitor cells (MSCs
Asuka Eguchi et al.
Proceedings of the National Academy of Sciences of the United States of America, 120(6), e2209967120-e2209967120 (2023-02-01)
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease caused by the lack of dystrophin. Heart failure, driven by cardiomyocyte death, fibrosis, and the development of dilated cardiomyopathy, is the leading cause of death in DMD patients. Current treatments
Shumin Xia et al.
ACS biomaterials science & engineering, 5(8), 3828-3842 (2019-08-12)
The mechanical microenvironment serves as an important factor influencing stem cell differentiation. Mechanobiological responses depend strongly on actomyosin contractility and integrin-based cell-extracellular matrix (ECM) interactions mediated by adhesive structures such as focal adhesions (FAs). While the roles of FAs in
Xiao Han et al.
Stem cell research & therapy, 4(3), 74-74 (2013-06-20)
So far, no effective therapy is available for acute kidney injury (AKI), a common and serious complication with high morbidity and mortality. Interest has recently been focused on the potential therapeutic effect of mouse adult renal progenitor cells (MRPC), erythropoietin
Carina Maranga et al.
Stem cell research, 61, 102757-102757 (2022-03-28)
Angelman Syndrome is a rare neurodevelopmental disorder caused by several (epi)genetic alterations. The patients present strong neurological impairment due to the absence of a functional maternal UBE3A gene in neurons. Here, we generated and characterized a new induced pluripotent stem
Yi Sui et al.
British journal of cancer, 125(7), 1003-1015 (2021-07-12)
Metastasis is the major cause of treatment failure and cancer-related deaths in prostate cancer (PCa) patients. Our previous study demonstrated that a CD44+ subpopulation isolated from PCa cells or tumours possesses both stem cell properties and metastatic potential, serving as
Foster Birnbaum et al.
NPJ Regenerative medicine, 7(1), 19-19 (2022-03-20)
Duchenne muscular dystrophy (DMD) is a progressive genetic myopathy that leads to heart failure from dilated cardiomyopathy by early adulthood. Recent evidence suggests that tamoxifen, a selective estrogen receptor modulator widely used to treat breast cancer, ameliorates DMD cardiomyopathy. However
Global and gene-specific histone modification profiles of mouse multipotent adult germline stem cells.
Khromov, T; Pantakani, DV; Nolte, J; Wolf, M; Dressel, R; Engel, W; Zechner, U
Molecular Human Reproduction null
Alfonso L Sabater et al.
Investigative ophthalmology & visual science, 58(2), 745-754 (2017-02-02)
The purpose of this study was to develop a culture method for expansion of corneal endothelial cells (CEC) based on the combined activation of PI3K/Akt and Smad2. Morphology, proliferation, and migration of cultured rabbit and nonhuman primate CEC were examined
Filipa Vlahova et al.
Scientific reports, 9(1), 8126-8126 (2019-06-01)
Expression of OCT4A is one of the hallmarks of pluripotency, defined as a stem cell's ability to differentiate into all the lineages of the three germ layers. Despite being defined as non-tumorigenic cells with high translational potential, human mid-trimester amniotic
Ana Joana Duarte et al.
Stem cell research, 41, 101595-101595 (2019-11-05)
Gaucher Disease (GD) type 3 is a neurological form of a multisystemic autosomal recessive disorder belonging to the group of lysosomal storage diseases. Causal mutations in the glucocerebrosidase 1 (GBA1) commonly lead to abnormal protein and GD, heterozygosity is a
Sara Pijuan-Galitó et al.
The Journal of biological chemistry, 289(48), 33492-33502 (2014-10-11)
We have previously demonstrated that the Src family kinase Yes, the Yes-associated protein (YAP) and TEA domain TEAD2 transcription factor pathway are activated by leukemia inhibitory factor (LIF) and contribute to mouse embryonic stem (mES) cell maintenance of pluripotency and
Dmitry A Ovchinnikov et al.
Stem cell research, 13(2), 251-261 (2014-08-12)
Optimization of pluripotent stem cell expansion and differentiation is facilitated by biological tools that permit non-invasive and dynamic monitoring of pluripotency, and the ability to select for an undifferentiated input cell population. Here we report on the generation and characterisation
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