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Showing 1-30 of 126 results for "MAB5324" within Papers
The hippocampus of the eastern rock sengi: cytoarchitecture, markers of neuronal function, principal cell numbers, and adult neurogenesis.
Slomianka, L; Drenth, T; Cavegn, N; Menges, D; Lazic, SE; Phalanndwa, M; Chimimba, CT; Amrein, I
Frontiers in Neuroanatomy null
Ourania Zygogianni et al.
Methods in molecular biology (Clifton, N.J.), 2155, 23-39 (2020-06-01)
Stem cell transplantation has attracted great interest for treatment of neurodegenerative diseases to provide neuroprotection, repair the lesioned neuronal network and restore functionality. Parkinson's disease (PD), in particular, has been a preferred target because motor disability that constitutes a core
Roberto Ripa et al.
BMC biology, 15(1), 9-9 (2017-02-15)
A widespread modulation of gene expression occurs in the aging brain, but little is known as to the upstream drivers of these changes. MicroRNAs emerged as fine regulators of gene expression in many biological contexts and they are modulated by
Maria Pina Serra et al.
Nutrients, 11(5) (2019-05-06)
The polyphenol resveratrol (RVT) may drive protective mechanisms of cerebral homeostasis during the hypoperfusion/reperfusion triggered by the transient bilateral common carotid artery occlusion followed by reperfusion (BCCAO/R). This immunochemical study investigates if a single dose of RVT modulates the plasticity-related
Marie-Claude Bélanger et al.
PloS one, 6(9), e24874-e24874 (2011-10-01)
Polysialic acid (PSA) is a unique carbohydrate composed of a linear homopolymer of α-2,8 linked sialic acid, and is mainly attached to the fifth immunoglobulin-like domain of the neural cell adhesion molecule (NCAM) in vertebrate neural system. In the brain
Venceslas Duveau et al.
The European journal of neuroscience, 32(1), 89-98 (2010-07-06)
Polysialylated neuronal cell adhesion molecule (PSA-NCAM), a polysialylated protein constitutively expressed in the hippocampus, is involved in neuronal growth, synaptic plasticity and neurotrophin signaling. In particular, PSA-NCAM mediates Ret-independent glial-derived neurotrophic factor (GDNF) signaling, leading to downstream FAK activation. GDNF
Rujia Liao et al.
Stem cell reports, 12(3), 532-544 (2019-02-13)
The neurological recovery following traumatic brain injury (TBI) is limited, largely due to a deficiency in neurogenesis. The present study explores the effects of histamine H3 receptor (H3R) antagonism on TBI and mechanisms related to neurogenesis. H3R antagonism or H3R
Tassilo Jungenitz et al.
Cerebral cortex (New York, N.Y. : 1991), 24(7), 1845-1857 (2013-02-22)
Increasing evidence shows that adult neurogenesis of hippocampal granule cells is advantageous for learning and memory. We examined at which stage of structural maturation and age new granule cells can be activated by strong synaptic stimulation. High-frequency stimulation of the
Su-Ping Peng et al.
Cellular reprogramming, 18(2), 55-66 (2016-03-19)
Intrastriatal transplantation of dopaminergic neurons has been shown to be a potentially very effective therapeutic approach for the treatment of Parkinson's disease (PD). With the detection of induced pluripotent stem cells (iPSCs), an unlimited source of autologous dopaminergic (DA) neurons
Congmin Wang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(33), 10906-10923 (2014-08-15)
In adult rodent and monkey brains, newly born neurons in the subventricular zone (SVZ) in the wall of the lateral ventricle migrate into the olfactory bulb (OB) via the rostral migratory stream (RMS). A recent study reported that interneurons are
Jie Wu et al.
Experimental neurology, 213(2), 397-404 (2008-08-05)
The cellular mechanisms underlying intrinsic epileptogenesis in human hypothalamic hamartoma (HH) are unknown. We previously reported that HH tissue is composed predominantly of GABAergic neurons, but how GABAergic-neuron-rich HH tissue is intrinsically epileptogenic is unclear. Here, we tested the hypotheses
Fabrizio Sanna et al.
Frontiers in behavioral neuroscience, 14, 58-58 (2020-05-07)
Central dopamine plays a key role in sexual behavior. Recently, a Dopamine Transporter knockout (DAT KO) rat has been developed, which displays several behavioral dysfunctions that have been related to increased extracellular dopamine levels and altered dopamine turnover secondary to
Human glial-restricted progenitors survive, proliferate, and preserve electrophysiological function in rats with focal inflammatory spinal cord demyelination.
Walczak, P; All, AH; Rumpal, N; Gorelik, M; Kim, H; Maybhate, A; Agrawal, G; Campanelli et al.
Glia null
Karin Boekhoorn et al.
Developmental neurobiology, 74(12), 1226-1242 (2014-06-10)
The hippocampus is one of the two areas in the mammalian brain where adult neurogenesis occurs. Adult neurogenesis is well known to be involved in hippocampal physiological functions as well as pathophysiological conditions. Microtubules (MTs), providing intracellular transport, stability, and
Jessica M Hogestyn et al.
Molecular and cellular neurosciences, 123, 103770-103770 (2022-09-03)
Many neurodegenerative diseases have a multifactorial etiology and variable course of progression that cannot be explained by current models. Neurotropic viruses have long been suggested to play a role in these diseases, although their exact contributions remain unclear. Human herpesvirus
Ryutaro Kajihara et al.
Bio-protocol, 11(3), e3914-e3914 (2021-03-19)
Human induced pluripotent stem cells (iPSCs) and their progeny displaying tissue-specific characteristics have paved the way for regenerative medicine and research in various fields such as the elucidation of the pathological mechanism of diseases and the discovery of drug candidates.
Marcin Czepiel et al.
Stem cells translational medicine, 3(9), 1100-1109 (2014-07-30)
Cell replacement therapy aiming at the compensation of lost oligodendrocytes and restoration of myelination in acquired or congenital demyelination disorders has gained considerable interest since the discovery of induced pluripotent stem cells (iPSCs). Patient-derived iPSCs provide an inexhaustible source for
Isabelle Westerlund et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(30), E6137-E6146 (2017-07-12)
Neuroblastoma is a pediatric cancer characterized by variable outcomes ranging from spontaneous regression to life-threatening progression. High-risk neuroblastoma patients receive myeloablative chemotherapy with hematopoietic stem-cell transplant followed by adjuvant retinoid differentiation treatment. However, the overall survival remains low; hence, there
Hui-Feng Jiao et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(5), 1177-1182 (2017-01-18)
Neurotransmission in dentate gyrus (DG) is critical for spatial coding, learning memory, and emotion processing. Although DG dysfunction is implicated in psychiatric disorders, including schizophrenia, underlying pathological mechanisms remain unclear. Here we report that transmembrane protein 108 (Tmem108), a novel
Karen Oprych et al.
Brain structure & function, 222(4), 1877-1895 (2016-10-09)
The in situ immunocytochemical properties of olfactory ensheathing cells (OECs) have been well studied in several small to medium sized animal models including rats, mice, guinea pigs, cats and canines. However, we know very little about the antigenic characteristics of OECs
Xue-Mei Zhang et al.
Frontiers in neuroanatomy, 3, 17-17 (2009-10-29)
A novel population of cells that express typical immature neuronal markers including doublecortin (DCX+) has been recently identified throughout the adult cerebral cortex of relatively large mammals (guinea pig, rabbit, cat, monkey and human). These cells are more common in
Junchao Tong et al.
Neurobiology of disease, 41(2), 458-468 (2010-10-30)
There is much controversy regarding the extent of axon regeneration/sprouting ability in adult human brain. However, intrinsic differences in axon/neurite growth capability amongst striatal (caudate, putamen, nucleus accumbens) subdivisions could conceivably underlie, in part, their differential vulnerability in degenerative human
Lucy Anne Barry et al.
PloS one, 17(4), e0261544-e0261544 (2022-04-12)
The neuronal ceroid lipofuscinoses (NCLs; Batten disease) are fatal, mainly childhood, inherited neurodegenerative lysosomal storage diseases. Sheep affected with a CLN6 form display progressive regionally defined glial activation and subsequent neurodegeneration, indicating that neuroinflammation may be causative of pathogenesis. In
Yu Ri Kim et al.
Scientific reports, 8(1), 2044-2044 (2018-02-03)
The beneficial effects of mesenchymal stem cells (MSCs) and electroacupuncture (EA) on neurogenesis and related trophic factors remain unclear. Bone marrow MSCs (mBMSC) were transplanted into the striatum of mice with middle cerebral artery occlusion (MCAO), and EA stimulation was
Vimalkumar Balasubramanian et al.
Biomaterials, 227, 119556-119556 (2019-11-02)
Generation of new neurons by utilizing the regenerative potential of adult neural stem cells (NSCs) and neuroblasts is an emerging therapeutic strategy to treat various neurodegenerative diseases, including neuronal loss after stroke. Committed to neuronal lineages, neuroblasts are differentiated from
Konstantin Khodosevich et al.
Journal of cell science, 124(Pt 8), 1268-1279 (2011-03-30)
In the postnatal brain, new neurons continue to be generated in two neurogenic areas, the subventricular zone of the lateral ventricles (SVZ) and the subgranular zone of the hippocampus. There is evidence that ephrins and their Eph receptors belong to
Yue Chen et al.
Molecular neurobiology, 52(1), 256-269 (2014-08-26)
Lactoferrin (Lf) is a sialic acid (Sia)-rich, iron-binding milk glycoprotein that has multifunctional health benefits. Its potential role in neurodevelopment and cognition remains unknown. To test the hypothesis that Lf may function to improve neurodevelopment and cognition, the diet of
Christopher T Rhodes et al.
Cell cycle (Georgetown, Tex.), 17(3), 377-389 (2018-02-13)
Histone methyltransferases (HMTs) are present in heterogeneous cell populations within the adult brain including neurogenic niches. Yet the question remains whether loss of HMTs and the resulting changes in histone methylation alter cell fate in a region-specific manner. We utilized
Hassan Azari
Methods in molecular biology (Clifton, N.J.), 2389, 111-123 (2021-09-25)
The renewable source of neural stem cells (NSCs) with multi-lineage differentiation capability toward neurons, astrocytes, and oligodendrocytes represents an ideal supply for cell therapy of central nervous system (CNS) diseases. In spite of this, the clinical use of NSCs is
Rosa López-Hidalgo et al.
Frontiers in neuroscience, 10, 75-75 (2016-03-15)
Down syndrome (DS) is caused by the presence of an extra copy of the chromosome 21 and it is the most common aneuploidy producing intellectual disability. Neural mechanisms underlying this alteration may include defects in the formation of neuronal networks
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