MABN77

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Showing 1-7 of 7 results for "MABN77" within Papers

Dendritic Inhibition by Shh Signaling-Dependent Stellate Cell Pool Is Critical for Motor Learning.

Wen Li et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 42(26), 5130-5143 (2022-05-20)

Cerebellar inhibitory interneurons are important regulators of neural circuit activity for diverse motor and nonmotor functions. The molecular layer interneurons (MLIs), consisting of basket cells (BCs) and stellate cells (SCs), provide dendritic and somatic inhibitory synapses onto Purkinje cells, respectively.

Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis.

O W Howell et al.

Brain : a journal of neurology, 129(Pt 12), 3173-3185 (2006-10-17)

Saltatory conduction in the nervous system is enabled through the intimate association between the leading edge of the myelin sheath and the axonal membrane to demarcate the node of Ranvier. The 186 kDa neuron specific isoform of the adhesion molecule

Upregulation of large myelin protein zero leads to Charcot-Marie-Tooth disease-like neuropathy in mice.

Yoshinori Otani et al.

Communications biology, 3(1), 121-121 (2020-03-15)

Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy mainly caused by gene mutation of peripheral myelin proteins including myelin protein zero (P0, MPZ). Large myelin protein zero (L-MPZ) is an isoform of P0 that contains an extended polypeptide synthesized by translational

Amyloid precursor protein at node of Ranvier modulates nodal formation.

De-En Xu et al.

Cell adhesion & migration, 8(4), 396-403 (2014-12-09)

Amyloid precursor protein (APP), commonly associated with Alzheimer disease, is upregulated and distributes evenly along the injured axons, and therefore, also known as a marker of demyelinating axonal injury and axonal degeneration. However, the physiological distribution and function of APP

Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization.

Du-Yu Nie et al.

The EMBO journal, 22(21), 5666-5678 (2003-11-01)

We report Nogo-A as an oligodendroglial component congregating and interacting with the Caspr-F3 complex at paranodes. However, its receptor Nogo-66 receptor (NgR) does not segregate to specific axonal domains. CHO cells cotransfected with Caspr and F3, but not with F3

Versican V2 assembles the extracellular matrix surrounding the nodes of ranvier in the CNS.

María T Dours-Zimmermann et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(24), 7731-7742 (2009-06-19)

The CNS-restricted versican splice-variant V2 is a large chondroitin sulfate proteoglycan incorporated in the extracellular matrix surrounding myelinated fibers and particularly accumulating at nodes of Ranvier. In vitro, it is a potent inhibitor of axonal growth and therefore considered to

Delayed nerve stimulation promotes axon-protective neurofilament phosphorylation, accelerates immune cell clearance and enhances remyelination in vivo in focally demyelinated nerves.

Nikki A McLean et al.

PloS one, 9(10), e110174-e110174 (2014-10-14)

Rapid and efficient axon remyelination aids in restoring strong electrochemical communication with end organs and in preventing axonal degeneration often observed in demyelinating neuropathies. The signals from axons that can trigger more effective remyelination in vivo are still being elucidated.

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