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Showing 1-19 of 19 results for "MAK145" within Papers
Jing-Li Tao et al.
Antioxidants (Basel, Switzerland), 10(2) (2021-02-03)
In mammalian ovaries, the avascular environment within follicular cavity is supposed to cause hypoxic status in granulosa cells (GCs), leading to apoptotic cell death accompanied by cumulative reactive oxygen species (ROS) production. Melatonin (N-acetyl-5-methoxytryptamine, MT), a broad-spectrum antioxidant that exists
Reactive oxygen species (ROS) and response of antioxidants as ROS-scavengers during environmental stress in plants.
Das K and Roychoudhury A
Frontiers in Endocrinology, 2, 53-53 (2014)
Minghui Liu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(4), 5535-5547 (2019-01-17)
Tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) plays a critical role in regulating cell survival, cell growth, and proliferation by antagonizing the PI3K-AKT-mTOR pathway. The regulatory mechanism of PTEN protein is still not completely understood. Here
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.
Wallace D C.
Annual Review of Genetics, 39, 359-407 (2005)
Comparative in vitro toxicity of a graphene oxide-silver nanocomposite and the pristine counterparts toward macrophages.
Luna L A V, et al.
Journal of Nanobiotechnology, 14(1), 12-12 (2016)
Sean A Misek et al.
Frontiers in oncology, 12, 766794-766794 (2022-04-22)
Single agent and combination therapy with BRAFV600E/K and MEK inhibitors have remarkable efficacy against melanoma tumors with activating BRAF mutations, but in most cases BRAF inhibitor (BRAFi) resistance eventually develops. One resistance mechanism is reactivation of the ERK pathway. However
Yara E Elakkad et al.
Breast cancer (Dove Medical Press), 13, 675-689 (2021-12-23)
Female breast cancer is the most prevalent cancer worldwide. Emerging evidence shows that simvastatin (SIM) has promising anticancer activities. However, the underlying mechanisms are not fully elucidated. Increasing reports imply statins can modulate ferroptosis through disrupting reactive oxygen species (ROS)
Neurodegenerative diseases and oxidative stress.
Barnham K J, et al.
Nature Reviews. Drug Discovery, 3(3), 205-205 null
Jianyong Yu et al.
Experimental and therapeutic medicine, 22(3), 946-946 (2021-07-27)
Salinomycin is a polyether antiprotozoal antibiotic that is widely used as an animal food additive. Some antifungal, antiparasitic, antiviral and anti-inflammatory activities have been reported for salinomycin. Recently, the anti-cancer effect of salinomycin has been demonstrated in breast cancer; however
Sanjib Chaudhary et al.
Cancer letters, 510, 79-92 (2021-04-21)
Despite preclinical success, monotherapies targeting EGFR or cyclin D1-CDK4/6 in Head and Neck squamous cell carcinoma (HNSCC) have shown a limited clinical outcome. Here, we aimed to determine the combined effect of palbociclib (CDK4/6) and afatinib (panEGFR) inhibitors as an
Zhewen Zhang et al.
Current issues in molecular biology, 44(6), 2759-2771 (2022-06-24)
Parkin is a well-established synergistic mediator of mitophagy in dysfunctional mitochondria. Mitochondria are the main target of arsenic trioxide (ATO) cytotoxicity, and the effect of mitophagy on ATO action remains unclear. In this study, we used stable Parkin-expressing (YFP-Parkin) and
Xin Yang et al.
Cancer research, 78(2), 372-386 (2017-11-29)
The mitochondrial serine hydroxymethyltransferase SHMT2, which catalyzes the rate-limiting step in serine catabolism, drives cancer cell proliferation, but how this role is regulated is undefined. Here, we report that the sirtuin SIRT5 desuccinylates SHMT2 to increase its activity and drive
Reactive oxygen species and reactive nitrogen species in peroxisomes. Production, scavenging, and role in cell signaling.
Luis A, et al.
Plant Physiology, 141(2), 330-335 (2006)
SHMT2 desuccinylation by SIRT5 drives cancer cell proliferation.
Yang X, et al.
Cancer Research (2017)
Antje Dittmann et al.
Molecular systems biology, 15(8), e8849-e8849 (2019-08-30)
Obesity-associated type 2 diabetes and accompanying diseases have developed into a leading human health risk across industrialized and developing countries. The complex molecular underpinnings of how lipid overload and lipid metabolites lead to the deregulation of metabolic processes are incompletely
D S Matassa et al.
Cell death and differentiation, 23(9), 1542-1554 (2016-05-21)
Tumour cells have long been considered defective in mitochondrial respiration and mostly dependent on glycolytic metabolism. However, this assumption is currently challenged by several lines of evidence in a growing number of tumours. Ovarian cancer (OC) is one of the
Knockdown of ferroportin accelerates erastin-induced ferroptosis in neuroblastoma cells.
Geng N, et al.
European Review for Medical and Pharmacological Sciences, 22(12), 3826-3836 (2018)
Wandayi Emmanuel Amlabu et al.
PloS one, 16(11), e0258996-e0258996 (2021-11-23)
In the midst of numerous setbacks that beclouds the fight against leishmaniasis; a neglected tropical disease, the search for new chemotherapeutics against this disease is of utmost importance. Leishmaniasis is a disease closely associated with poverty and endemic in Africa
Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer.
Matassa D S, et al.
Cell Death and Differentiation, 23(9), 1542-1542 (2016)
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