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Showing 1-12 of 12 results for "MAK160" within Papers
Daniela Marina Malcervelli et al.
Cryobiology, 95, 97-102 (2020-05-31)
Boar spermatozoa are extremely sensitive to low temperatures and the cryopreservation causes dramatic changes in sperm survivability, but it is not clear which part of the cryopreservation process affects the most. The aim of this work was to assess early
Cathrin Meissner et al.
Autophagy, 11(9), 1484-1498 (2015-06-24)
Mutations in PINK1 and PARK2/Parkin are a main risk factor for familial Parkinson disease. While the physiological mechanism of their activation is unclear, these proteins have been shown in tissue culture cells to serve as a key trigger for autophagy
Jérôme Cléach et al.
Journal of microbiology and biotechnology, 28(11), 1782-1790 (2018-12-20)
Assessment of microorganism viability is useful in many industrial fields. A large number of methods associated with the use of fluorescent probes have been developed, including fluorimetry, fluorescence microscopy, and cytometry. In this study, a microvolume spectrofluorometer was used to
Hongxin Liu et al.
Fitoterapia, 147, 104768-104768 (2020-11-10)
The chemical investigation of the secondary metabolites of Paramyrothecium roridum (homotypic synonym: Myrothecium roridum), an endophytic fungus isolated from the medicinal plant Morinda officinalis, led to the isolation of twelve cytotoxic trichothecene macrolides, including two new ones, named myrothecines H
Luping Zhang et al.
Pharmaceutical biology, 59(1), 303-310 (2021-03-16)
Physcion (Phy) exerts several pharmacological effects including anti-inflammatory, antioxidant, and antitumor properties. This study investigates the cytotoxicity and its underlying mechanisms of Phy on breast cancer. Human breast cancer cell MCF-7 was treated with 5-400 µM Phy for 24 h, MCF-7-xenografted BALB/c
Radix Ophiopogonis polysaccharide extracts alleviate MPP+-induced PC-12 cell injury through inhibition of Notch signaling pathway.
Liu R and Li X
International Journal of Clinical and Experimental Pathology, 11(1), 99-109 (2018)
Intramembrane protease PARL defines a negative regulator of PINK1-and PARK2/Parkin-dependent mitophagy.
Meissner C, et al.
Autophagy, 11(9), 1484-1498 (2015)
Chaolu Chen et al.
Free radical biology & medicine, 136, 22-34 (2019-03-31)
Endometriosis is associated with inflammatory reaction, and reactive oxidative species (ROS) are highly pro-inflammatory factors. Mitochondria are responsible for the production of ROS and energy. However, little is known about how mitochondria regulate ROS generation and energy metabolism in endometriosis.
Zhihua Zhang et al.
Journal of Alzheimer's disease : JAD, 78(3), 1161-1176 (2020-10-27)
Mesenchymal stem cells-conditioned medium (MSC-CM) provides a promising cell-free therapy for Alzheimer's disease (AD) mainly due to the paracrine of MSCs, but the precise mechanisms remain unclear. Studies suggests that mitochondrial dysfunction precedes the accumulation of amyloid-β plaques and neurofibrillary
Ruiting Liu et al.
International journal of clinical and experimental pathology, 11(1), 99-109 (2018-01-01)
Background: Parkinson's disease (PD) is a degenerative disease of central nervous system. 1-Methyl-4-phenylpyridine (MPP+) is a non-selective dopaminergic neurotoxin that induces cell injury similar to PD. This study aimed to explore the protective effects of Radix Ophiopogonis polysaccharide extracts (ROP)
Shanshan Teng et al.
Frontiers in pharmacology, 12, 639458-639458 (2021-04-13)
Background: In China, the incidence of ulcerative colitis (UC) is increasing every year, but the etiology of UC remains unclear. UC is known to increase the risk of colorectal cancer (CRC). The aim of this study was to investigate the
Jianbiao Zhou et al.
Haematologica, 105(9), 2286-2297 (2020-10-16)
Differentiation therapies achieve remarkable success in acute promyelocytic leukemia, a subtype of acute myeloid leukemia. However, excluding acute promyelocytic leukemia, clinical benefits of differentiation therapies are negligible in acute myeloid leukemia except for mutant isocitrate dehydrogenase 1/2. Dihydroorotate dehydrogenase catalyses
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