Search Within


Applied Filters:
Showing 1-21 of 21 results for "MAK164" within Papers
Robert B Rosenblatt et al.
Theranostics, 11(2), 602-613 (2021-01-05)
Mechanical forces from non-ablative pulsed focused ultrasound (pFUS) generate pro-inflammatory tumor microenvironments (TME), marked by increased cytokines, chemokines, and trophic factors, as well as immune cell infiltration and reduced tumor growth. pFUS also causes DNA damage within tumors, which is
Maqusood Ahamed et al.
International journal of nanomedicine, 16, 89-104 (2021-01-16)
Therapeutic selectivity and drug resistance are critical issues in cancer therapy. Currently, zinc oxide nanoparticles (ZnO NPs) hold considerable promise to tackle this problem due to their tunable physicochemical properties. This work was designed to prepare SnO2-doped ZnO NPs/reduced graphene
Emily A Teslow et al.
Molecular oncology, 13(4), 894-908 (2019-01-13)
Obesity is a risk factor for triple-negative breast cancer (TNBC) incidence and poor outcomes, but the underlying molecular biology remains unknown. We previously identified in TNBC cell cultures that expression of epigenetic reader methyl-CpG-binding domain protein 2 (MBD2), specifically the
Maqusood Ahamed et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 143, 111515-111515 (2020-07-08)
Numerous applications of reduced graphene oxide (RGO) and pervasive cadmium (Cd) have led concern about their co-exposure to the environment and human. We studied the combined effects of RGO and Cd in human liver (HepG2) cells. Initially, we found that
Maqusood Ahamed et al.
International journal of environmental research and public health, 17(21) (2020-11-12)
Combined exposure of single-walled carbon nanotubes (SWCNTs) and trace metal lead (Pb) in ambient air is unavoidable. Most of the previous studies on the toxicity of SWCNTs and Pb have been conducted individually. There is a scarcity of information on
Bin Bao et al.
Scientific reports, 7, 44125-44125 (2017-03-11)
Among breast cancer patients, those diagnosed with the triple-negative breast cancer (TNBC) subtype have the worst prog-nosis. TNBC does not express estrogen receptor-alpha, progesterone receptor, or the HER2 oncogene; therefore, TNBC lacks targets for molecularly-guided therapies. The concept that EGFR
Maqusood Ahamed et al.
Environmental science and pollution research international, 27(10), 10425-10435 (2020-01-17)
Widespread application of titanium dioxide nanoparticles (nTiO2) and ubiquitous cadmium (Cd) pollution may increase their chance of co-existence in the natural environment. Toxicological information on co-exposure of nTiO2 and Cd in mammalian models is largely lacking. Hence, we studied the
Xianjun Tan et al.
Journal of molecular neuroscience : MN, 70(11), 1728-1741 (2020-06-05)
Secreted protein acidic and rich in cysteine (SPARC) has a close association with inflammatory response and oxidative stress in tissues and is widely expressed in intracranial aneurysms (IAs), especially in smooth muscle cells. Therefore, it is inferred that SPARC might
Evidence of oxidative stress and mitochondrial dysfunction in spinocerebellar ataxia type 2 (SCA2) patient fibroblasts: effect of coenzyme Q10 supplementation on these parameters.
Cornelius N, et al.
Mitochondrion, 34, 103-114 (2017)
Qing You et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 7(17), 1903341-1903341 (2020-10-01)
Multifunctional nanoplatforms for imaging-guided synergistic antitumor treatment are highly desirable in biomedical applications. However, anticancer treatment is largely affected by the pre-existing hypoxic tumor microenvironment (TME), which not only causes the resistance of the tumors to photodynamic therapy (PDT), but
Nanna Cornelius et al.
Mitochondrion, 34, 103-114 (2017-03-07)
Spinocerebellar ataxia type 2 (SCA2) is a rare neurodegenerative disorder caused by a CAG repeat expansion in the ataxin-2 gene. We show increased oxidative stress, abnormalities in the antioxidant system, changes in complexes involved in oxidative phosphorylation and changes in
Carmen Sarcinelli et al.
Archaea (Vancouver, B.C.), 2016, 7424870-7424870 (2016-10-19)
Peroxiredoxins (Prxs) are ubiquitous thiol peroxidases that are involved in the reduction of peroxides. It has been reported that prokaryotic Prxs generally show greater structural robustness than their eukaryotic counterparts, making them less prone to inactivation by overoxidation. This difference
Qing Zhang et al.
Cancer cell international, 20(1), 570-570 (2020-12-10)
To investigate the efficacy of a PLGA-based nanobody complex in photodynamic therapy (PDT) and NIR-II imaging in A549 tumor hypoxic model. IR1048-MZ was firstly synthesized by conjugating a nitro imidazole group to IR1048. IR1048-MZ and Cat were then encapsulated in
Maqusood Ahamed et al.
Journal of applied toxicology : JAT, 40(9), 1228-1238 (2020-03-29)
Broad application of reduced graphene oxide (rGO) and ubiquitous lead (Pb) pollution may increase the possibility of combined exposure of humans. Information on the combined effects of rGO and Pb in human cells is scarce. This work was designed to
Zheng Zhang et al.
Theranostics, 11(7), 3167-3182 (2021-02-05)
Rationale: Iron-saturated Lf (Holo-Lactoferrin, Holo-Lf) exhibits a superior anticancer property than low iron-saturated Lf (Apo-Lf). Ferroptosis is an iron-dependent cell death characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS). Radiotherapy also exerts its therapeutic
Maqusood Ahamed et al.
Nanomaterials (Basel, Switzerland), 10(11) (2020-12-04)
Barium titanate (BaTiO3) nanoparticles (BT NPs) have shown exceptional characteristics such as high dielectric constant and suitable ferro-, piezo-, and pyro-electric properties. Thus, BT NPs have shown potential to be applied in various fields including electro-optical devices and biomedicine. However
Ji Young Oh et al.
Free radical biology & medicine, 130, 328-342 (2018-11-10)
17β-estradiol (E2) is an important regulator of energy homeostasis and glucose metabolism, thus making it a potential target for preventing or treating metabolic disorders. However, the exact mechanism by which E2 affects high glucose-induced oxidative stress remains unclear. Therefore, the
Mohd Javed Akhtar et al.
Molecules (Basel, Switzerland), 25(5) (2020-03-07)
This study aimed to generate a comparative data on biological response of yttrium oxide nanoparticles (Y2O3 NPs) with the antioxidant CeO2 NPs and pro-oxidant ZnO NPs. Sizes of Y2O3 NPs were found to be in the range of 35±10 nm
Xia-Zhen Bao et al.
Free radical biology & medicine, 152, 597-608 (2019-12-06)
Targeting redox vulnerability of cancer cells by pro-oxidants capable of generating reactive oxygen species (ROS) has surfaced as an important anticancer strategy. Due to the intrinsic narrow therapeutic window and other dangerous side effects of ROS generation, it is highly
Dongdong Wang et al.
iScience, 9, 14-26 (2018-10-28)
Therapeutic effects of photodynamic therapy (PDT) remain largely limited because of tumor hypoxia. Herein, we report safe and versatile nanocatalysts (NCs) for endogenous oxygen generation and imaging-guided enhanced PDT. The NCs (named as PSP) are prepared by coating Prussian blue
Hyewon Park et al.
Scientific reports, 10(1), 17451-17451 (2020-10-17)
Because inflammation in osteoarthritis (OA) is related to the Toll-like receptor 4 (TLR4) signaling cascades, TLR4 is a reasonable target for developing therapeutics for OA. Thus, we investigated whether TAP2, a peptide antagonist of TLR4, reduces the monoiodoacetate (MIA)-induced arthritic
Page 1 of 1