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myelin protein zero-like 2

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Showing 1-30 of 388 results for "myelin protein zero-like 2" within Papers
N Schindler et al.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 33, 1-8 (2016-12-06)
Brain growth and function are regulated by insulin-like growth factors I and II (IGF-I and IGF-II) but also by IGF-binding proteins (IGFBPs), including IGFBP-2. In addition to modulating IGF activities, IGFBP-2 interacts with a number of components of the extracellular
Fuzheng Guo et al.
Glia, 71(2), 143-154 (2022-07-17)
Clinical and basic neuroscience research is greatly benefited from the identification and characterization of lineage specific and developmental stage-specific markers. In the glial research community, histological markers that specifically label newly differentiated premyelinating oligodendrocytes are still scarce. Premyelinating oligodendrocyte markers
D L Yao et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(13), 6190-6194 (1995-06-20)
To compare effects of insulin-like growth factor I (IGF-I) and placebo treatment on lesions that resemble those seen during active demyelination in multiple sclerosis, we induced experimental autoimmune encephalomyelitis in Lewis rats with an emulsion containing guinea pig spinal cord
Isabel Herrmann et al.
Infection and immunity, 74(8), 4841-4848 (2006-07-25)
The course of autoimmune inflammatory diseases of the central nervous system (CNS) can be influenced by infections. Here we assessed the disease-modulating effects of the most frequent respiratory pathogen Streptococcus pneumonia on the course of experimental autoimmune encephalomyelitis (EAE). Mice
Isabel Herrmann et al.
Infection and immunity, 74(8), 4841-4848 (2006-07-25)
The course of autoimmune inflammatory diseases of the central nervous system (CNS) can be influenced by infections. Here we assessed the disease-modulating effects of the most frequent respiratory pathogen Streptococcus pneumonia on the course of experimental autoimmune encephalomyelitis (EAE). Mice
Aisling Dunne et al.
The Journal of biological chemistry, 285(24), 18276-18282 (2010-04-20)
Signal transduction by Toll-like receptor 2 (TLR2) and TLR4 requires the adaptors MyD88 and Mal (MyD88 adaptor-like) and serine/threonine kinases, interleukin-1 receptor-associated kinases IRAK1 and IRAK4. We have found that both IRAK1 and IRAK4 can directly phosphorylate Mal. In addition
Shaherin Basith et al.
PloS one, 6(8), e23989-e23989 (2011-09-08)
Toll-like receptors (TLRs) activate a potent immunostimulatory response. There is clear evidence that overactivation of TLRs leads to infectious and inflammatory diseases. Recent biochemical studies have shown that the membrane-bound form of ST2 (ST2L), a member of the Toll-like/IL-1 receptor
Ki H Ma et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(22), 8640-8652 (2015-06-05)
Myelination of peripheral nerves by Schwann cells requires coordinate regulation of gene repression as well as gene activation. Several chromatin remodeling pathways critical for peripheral nerve myelination have been identified, but the functions of histone methylation in the peripheral nerve
Ashley Mansell et al.
Nature immunology, 7(2), 148-155 (2006-01-18)
Toll-like receptor (TLR) signals that initiate innate immune responses to pathogens must be tightly regulated to prevent excessive inflammatory damage to the host. The adaptor protein Mal is specifically involved in signaling via TLR2 and TLR4. We demonstrate here that
Shenghua Zhou et al.
Journal of neuroimmunology, 194(1-2), 70-82 (2008-02-26)
In response to invading pathogens, Toll-like receptors (TLR) play a critical role in the initiation of the innate immune response, which can be either beneficial or detrimental to the host. In the present study, we demonstrated that central nervous system
Amy G Hise et al.
Journal of immunology (Baltimore, Md. : 1950), 178(2), 1068-1076 (2007-01-05)
The discovery that endosymbiotic Wolbachia bacteria play an important role in the pathophysiology of diseases caused by filarial nematodes, including lymphatic filariasis and onchocerciasis (river blindness) has transformed our approach to these disabling diseases. Because these parasites infect hundreds of
Chiea C Khor et al.
Nature genetics, 39(4), 523-528 (2007-02-27)
Toll-like receptors (TLRs) and members of their signaling pathway are important in the initiation of the innate immune response to a wide variety of pathogens. The adaptor protein Mal (also known as TIRAP), encoded by TIRAP (MIM 606252), mediates downstream
Jakub Siednienko et al.
European journal of immunology, 40(11), 3150-3160 (2010-10-20)
There is limited insight into the mechanisms involved in the counterregulation of TLR. Given the important role of TLR3/TIR domain-containing adaptor-inducing IFN-β (TRIF)-dependent signalling in innate immunity, novel insights into its modulation is of significance in the context of many
Samer Halabi et al.
The Journal of biological chemistry, 292(2), 652-660 (2016-12-03)
Ligand binding to Toll-like receptors (TLRs) results in dimerization of their cytosolic Toll/interleukin-1 receptor (TIR) domains and recruitment of post-receptor signal transducers into a complex signalosome. TLR activation leads to the production of transcription factors and pro-inflammatory molecules and the
Jorge Montesinos et al.
Brain, behavior, and immunity, 45, 233-244 (2014-12-09)
The adolescent brain undergoes important dynamic and plastic cell changes, including overproduction of axons and synapses, followed by rapid pruning along with ongoing axon myelination. These developmental changes make the adolescent brain particularly vulnerable to neurotoxic and behavioral effects of
Stefanie Mesch et al.
ChemMedChem, 7(1), 134-143 (2011-10-13)
Siglec-2, also known as CD22, is involved in the regulation and survival of B-cells and has been successfully targeted in cell depletion therapies with antibody-based approaches. Sialic acid derivatives, already known to bind with high affinity to myelin-associated glycoprotein (MAG
Luke A J O'Neill
Trends in immunology, 23(6), 296-300 (2002-06-20)
Recent evidence suggests that there may be specificities in the signal transduction pathways activated by different Toll-like receptors (TLRs), with different sets of genes being induced by TLR-4 when compared with TLR-2. These differences may be because of different signalling
Leah E Cole et al.
Journal of leukocyte biology, 87(2), 275-281 (2009-11-06)
TLR2 plays a central role in the activation of innate immunity in response to Ft, the causative agent of tularemia. We reported previously that Ft LVS elicited strong, dose-dependent NF-kappaB reporter activity in TLR2-expressing human embryo kidney 293 T cells
Chao Weng et al.
Molecular medicine reports, 16(2), 1864-1870 (2017-06-29)
Transcription factor 7 like 2 (TCF7L2, also termed TCF4), is a Wnt effector induced transiently in the oligodendroglial lineage. The current well accepted hypothesis is that TCF7L2 inhibits oligodendrocyte differentiation and remyelination through canonical Wnt/β‑catenin signaling. However, recent studies indicated
Silvia Alfonso-Loeches et al.
Glia, 60(6), 948-964 (2012-03-21)
Alcohol abuse and alcoholism can cause brain damage, loss of white matter, myelin fiber disruption, and even neuronal injury. The underlying mechanisms of these alterations remain elusive. We have shown that chronic ethanol intake, by activating glial toll-like receptor 4
Elizabeth Hammond et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(12), 5007-5022 (2015-03-27)
Genetic or pharmacological activation of canonical Wnt/β-catenin signaling inhibits oligodendrocyte differentiation. Transcription factor 7-like 2 (TCF7l2), also known as TCF4, is a Wnt effector induced transiently in the oligodendroglial lineage. A well accepted dogma is that TCF7l2 inhibits oligodendrocyte differentiation
S Kelm et al.
Current biology : CB, 4(11), 965-972 (1994-11-01)
Protein-carbohydrate interactions are believed to be important in many biological processes that involve cell-cell communication. Apart from the selectins, the only well-characterized vertebrate sialic acid-dependent adhesion molecules are CD22 and sialoadhesin; CD22 is a member of the immunoglobulin superfamily that
Hui Fu et al.
Cellular and molecular neurobiology, 32(3), 345-352 (2011-12-14)
Recent, studies have shown that Tcf7l2, an important transcription factor in Wnt pathway, plays critical roles in oligodendrocyte development. In this article we report a study showing that Tcf7l2 is under tight regulation during myelin formation. We have found that
Socorro Miranda-Hernandez et al.
Journal of immunology (Baltimore, Md. : 1950), 187(2), 791-804 (2011-06-21)
The potential roles of TLRs in the cause and pathogenesis of autoimmune CNS inflammation remain contentious. In this study, we examined the effects of targeted deletions of TLR1, TLR2, TLR4, TLR6, TLR9, and MyD88 on the induction of myelin oligodendrocyte
Allison L van Lint et al.
Journal of virology, 84(20), 10802-10811 (2010-08-06)
The discovery of the Toll-like receptors (TLRs) and their importance in the regulation of host responses to infection raised attention to the complex interplay between viral gene products and the host innate immune responses in determining the outcome of virus
Z-Y Zhang et al.
Neuroscience, 159(1), 136-142 (2009-01-24)
Experimental autoimmune neuritis (EAN) is a well-known animal model of Guillain-Barré syndrome (GBS) characterized by inflammation and demyelination in the peripheral nervous system. Toll-like receptors (TLRs) together with their co-receptors form the first line of the self-defense, and play important
Elizabeth J Fry et al.
Glia, 58(4), 423-433 (2009-09-26)
Receptor protein tyrosine phosphatase sigma (RPTPsigma) plays a role in inhibiting axon growth during development. It has also been shown to slow axon regeneration after peripheral nerve injury and inhibit axon regeneration in the optic nerve. Here, we assessed the
Xiaoyang Wang et al.
Journal of child neurology, 24(9), 1171-1178 (2009-09-12)
Preterm infants exposed to inflammation are at increased risk of white matter injury and/or cerebral palsy. To investigate the effect of chronic inflammation on the developing white matter, we administered low-dose lipopolysaccharide once a day from postnatal days 3 to
Yanbin Liu et al.
Oncogene, 40(12), 2230-2242 (2021-03-03)
Despite the well-established role of CMTM6 in the stabilization of cell surface PD-L1 in cancer cells, the mechanisms underlying CMTM6 expression and regulation are still largely unknown. Here we unexpectedly find a strikingly positive correlation between CMTM6 and Hu-Antigen R
Hakima Zekki et al.
Brain pathology (Zurich, Switzerland), 12(3), 308-319 (2002-07-31)
Experimental autoimmune encephalomyelitis (EAE) is an autoimmune demyelinating disease commonly used to model the pathogenetic mechanisms involved in multiple sclerosis (MS). In this study, we examined the effects of immunization with the myelin oligodendrocyte glycoprotein MOG(35-55) on the expression of
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