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Showing 1-30 of 91 results for "N3020" within Papers
Song Fan et al.
Cancer letters, 362(2), 183-191 (2015-04-07)
Mitochondria play an important role in the initiation of apoptosis. However, whether cisplatin can induce apoptosis by initiating a mitochondrial fission pathway and the mechanism underlying this effect remain poorly understood. In this study, we show that the mitochondrial fission
Yanli Gu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(5), 2001-2009 (2017-10-23)
It is well known that Plac1 is a placenta-specific gene; however, its spatiotemporal expression pattern and exact role at t h e mouse fetomaternal interface r e m a i n s unclear. In situ hybridization (ISH) was used to
Naomi D Chrispijn et al.
PloS one, 13(7), e0200316-e0200316 (2018-07-10)
Polycomb Group (PcG) genes are transcriptional repressors that are described to be important during development and differentiation. There is significant interest in PcGs proteins because of their role in stem cell biology and tumorigenesis. In this study we characterize the
Leonard Herrfurth et al.
Frontiers in molecular neuroscience, 10, 2-2 (2017-02-15)
Vascular endothelial growth factor (VEGF) is well known as the growth factor with wide-ranging functions even in the central nervous system (CNS). Presently, most attention is given to the investigation of its role in neuronal protection, growth and maturation processes
Yipeng Sui et al.
JCI insight, 3(2) (2018-01-26)
Mesenchymal stem cells (MSCs) can give rise to both adipocytes and osteoblasts, but the molecular mechanisms underlying MSC fate determination remain poorly understood. IκB kinase β (IKKβ), a central coordinator of inflammation and immune responses through activation of NF-κB, has
Jennifer Zur Bruegge et al.
Biochemical and biophysical research communications, 508(3), 832-837 (2018-12-12)
The hedgehog signaling pathway is a crucial regulator of the postnatal intestinal development. Regulation of hedgehog expression itself is poorly understood. MicroRNAs were demonstrated to control differentiation and proliferation in postnatal intestinal development. This study identifies members of the miR-15
Song Fan et al.
Oncotarget, 6(17), 14885-14904 (2015-04-29)
Cisplatin has been widely employed as a cornerstone chemotherapy treatment for a wide spectrum of solid neoplasms; increasing tumor responsiveness to cisplatin has been a topic of interest for the past 30 years. Strong evidence has indicated that mitochondrial fission
Lasse D Jensen et al.
Arteriosclerosis, thrombosis, and vascular biology, 39(7), 1432-1447 (2019-06-27)
Objective- The Wnt/β-catenin pathway orchestrates development of the blood-brain barrier, but the downstream mechanisms involved at different developmental windows and in different central nervous system (CNS) tissues have remained elusive. Approach and Results- Here, we create a new mouse model
Mitsunari Nakajima et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 27(8), 837-843 (2009-08-12)
Presenilin-1 (PS1) is a transmembrane protein that is in many cases responsible for the development of early-onset familial Alzheimer's disease. PS1 is essential for neurogenesis, somitogenesis, angiogenesis, and cardiac morphogenesis. We report here that PS1 is also required for maturation
Patrick P van Vliet et al.
Developmental biology, 429(1), 249-259 (2017-07-04)
Correct cardiac development is essential for fetal and adult life. Disruptions in a variety of signaling pathways result in congenital heart defects, including outflow and inflow tract defects. We previously found that WNT11 regulates outflow tract development. However, tissue specific
Kevin Glaesel et al.
International journal of molecular sciences, 21(11) (2020-06-03)
The wide-ranging influence of vascular endothelial growth factor (VEGF) within the central (CNS) and peripheral nervous system (PNS), for example through effects on axonal growth or neuronal cell survival, is mainly mediated by VEGF receptor 2 (VEGFR-2). However, the regulation
Hye Lim Cha et al.
Molecular brain, 12(1), 57-57 (2019-06-22)
Go is a member of the pertussis toxin-sensitive Gi/o family. Despite its abundance in the central nervous system, the precise role of Go remains largely unknown compared to other G proteins. In the present study, we explored the functions of
Luciana M Sari et al.
Molecular reproduction and development, 85(12), 934-944 (2018-10-18)
β-Nerve growth factor (β-NGF) is a seminal plasma element, responsible for inducing ovulation in camelids. The main organ of β-NGF production remains nondescript. The aims of this study were to (a) characterize gene expression and protein localization of β-NGF and
Aarthi Kannan et al.
Oncotarget, 7(6), 6576-6592 (2015-11-05)
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer. Pathologic activation of PI3K/mTOR pathway and elevated expression of c-Myc are frequently detected in MCC. Yet, there is no targeted therapy presently available for this lethal disease. Recently, MLN0128, a
Yang Liu et al.
Frontiers in neuroanatomy, 9, 120-120 (2015-09-22)
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor that was originally identified as a regulator of peroxisome proliferation and adipocyte differentiation. Emerging evidence suggests that functional PPARγ signaling also occurs within the hypothalamus. However, the exact distribution and
Marlena Rohm et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 52(6), 1412-1426 (2019-05-11)
Amyotrophic lateral sclerosis (ALS) is the most common degenerative motor neuron disease in humans. However, the pathogenesis of ALS is not yet understood. The wobbler mouse is considered as an animal model for the sporadic form of ALS due to
Chun-Te Ho et al.
Biomedicines, 9(5) (2021-06-03)
Although oncolytic viruses are currently being evaluated for cancer treatment in clinical trials, systemic administration is hindered by many factors that prevent them from reaching the tumor cells. When administered systemically, mesenchymal stem cells (MSCs) target tumors, and therefore constitute
Yu Chen et al.
Reproduction (Cambridge, England), 157(1), 1-12 (2018-11-06)
The development of the mammalian phallus involves hormone-dependent mesenchymal-epithelial signalling mechanisms that contribute to urethral closure and regulation of phallus elongation and growth. In marsupials, most differentiation and growth of the phallus occurs post-natally, making them amenable to direct hormone
Youichi Shinozaki et al.
JCI insight, 2(19) (2017-10-06)
Glaucoma is an optic neuropathy characterized by progressive degeneration of retinal ganglion cells (RGCs) and visual loss. Although one of the highest risk factors for glaucoma is elevated intraocular pressure (IOP) and reduction in IOP is the only proven treatment
Renato Zampini et al.
Animal reproduction science, 192, 223-232 (2018-03-24)
Ovulation of South American Camelids is induced by mating. After copulation, sperm are stored into the oviduct to be released near ovulation time. To study whether copulation induces matrix metalloproteinase-2 (MMP2) secretion in the oviduct, the occurrence of MMP2 in
Yu-Ting Yen et al.
Communications biology, 4(1), 658-658 (2021-06-04)
It has not been well studied which cells and related mechanisms contribute to endochondral ossification. Here, we fate mapped the leptin receptor-expressing (LepR+) mesenchymal stem cells (MSCs) in different embryonic and adult extremities using Lepr-cre; tdTomato mice and investigated the
Mahetab H Amer et al.
Stem cells translational medicine, 5(3), 366-378 (2016-01-31)
As the number of clinical trials exploring cell therapy rises, a thorough understanding of the limits of cell delivery is essential. We used an extensive toolset comprising various standard and multiplex assays for the assessment of cell delivery postejection. Primary
Morphological Plasticity of Emerging Purkinje Cells in Response to Exogenous VEGF
Herrfurth L, et al.
Frontiers in Molecular Neuroscience, 10(10), 2-2 (2017)
Fanyi Li et al.
Biomaterials science, 8(6), 1711-1725 (2020-01-30)
The encapsulation of cells into microgels is attractive for applications in tissue regeneration. While cells are protected against shear stress during injection, the assembly of microgels after injection into a tissue defect also forms a macroporous scaffold that allows effective
Jea-Hyun Baek et al.
The Journal of clinical investigation, 125(8), 3198-3214 (2015-06-30)
Macrophages (Mø) are integral in ischemia/reperfusion injury-incited (I/R-incited) acute kidney injury (AKI) that leads to fibrosis and chronic kidney disease (CKD). IL-34 and CSF-1 share a receptor (c-FMS), and both cytokines mediate Mø survival and proliferation but also have distinct
Bhavana Muralidharan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(46), 11245-11254 (2017-10-14)
Regulation of the neuron-glia cell-fate switch is a critical step in the development of the CNS. Previously, we demonstrated that Lhx2 is a necessary and sufficient regulator of this process in the mouse hippocampal primordium, such that Lhx2 overexpression promotes
Johanna Andrae et al.
Biology open, 5(4), 461-474 (2016-03-19)
Platelet-derived growth factor-C (PDGF-C) is one of three known ligands for the tyrosine kinase receptor PDGFRα. Analysis ofPdgfcnull mice has demonstrated roles for PDGF-C in palate closure and the formation of cerebral ventricles, but redundancy with other PDGFRα ligands might
Kellie Schaefer et al.
BMC research notes, 10(1), 602-602 (2017-11-22)
Our objective was to characterize CAPN5 gene expression in the mouse central nervous system. Mouse brain and eye sections were probed with two high-affinity RNA oligonucleotide analogs designed to bind CAPN5 RNA and one scramble, control oligonucleotide. Images were captured
Benoît Usunier et al.
International journal of molecular sciences, 22(4) (2021-03-07)
Fibrosis is a leading cause of death in occidental states. The increasing number of patients with fibrosis requires innovative approaches. Despite the proven beneficial effects of mesenchymal stem cell (MSC) therapy on fibrosis, there is little evidence of their anti-fibrotic
Jennifer Zieba et al.
PLoS genetics, 12(3), e1005936-e1005936 (2016-03-29)
Spondylocarpotarsal synostosis (SCT) is an autosomal recessive disorder characterized by progressive vertebral fusions and caused by loss of function mutations in Filamin B (FLNB). FLNB acts as a signaling scaffold by linking the actin cytoskleteon to signal transduction systems, yet
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