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Showing 1-29 of 29 results for "N5288" within Papers
Kayla Lemons et al.
Neuroscience, 434, 171-190 (2020-04-01)
The mammalian main olfactory epithelium (MOE) is exposed to a wide spectrum of external chemicals during respiration and relies on adaptive plasticity to maintain its structural and functional integrity. We previously reported that the chemo-responsive and cholinergic transient receptor potential
Xuedan Nie et al.
Molecular medicine reports, 19(2), 1139-1149 (2018-12-12)
The neurological disorders and neural pathology brought about by chronic alcoholism are difficult to be reversed. Increasing evidence highlights the protective roles of erythropoietin (EPO) in neurodegenerative diseases and injuries of the central nervous system. In the present study, we
Sausan M Jaber et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(23), 4609-4619 (2020-05-01)
Idebenone is a synthetic quinone that on reduction in cells can bypass mitochondrial Complex I defects by donating electrons to Complex III. The drug is used clinically to treat the Complex I disease Leber's hereditary optic neuropathy (LHON), but has
M Belinsky et al.
Cancer metastasis reviews, 12(2), 103-117 (1993-06-01)
NAD(P)H:Quinone Oxidoreductase1 (NQO1) also known as DT-diaphorase is a flavoprotein that catalyzes the two-electron reduction of quinones, quinone imines and azo-dyes and thereby protects cells against mutagenicity and carcinogenicity resulting from free radicals and toxic oxygen metabolites generated by the
Yanxia Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(12), 5205-5210 (2007-03-16)
The antioxidant response element (ARE) is a cis-acting regulatory enhancer element found in the 5' flanking region of many phase II detoxification enzymes. Up-regulation of ARE-dependent target genes is known to have neuroprotective effects; yet, the mechanism of activation is
Rachit Bakshi et al.
Neurobiology of disease, 82, 574-579 (2015-09-06)
Urate has emerged as a promising target for neuroprotection based on epidemiological observations, preclinical models, and early clinical trial results in multiple neurologic diseases, including Parkinson's disease (PD). This study investigates the astrocytic mechanism of urate's neuroprotective effect. Targeted biochemical
Adrián Martínez-Limón et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(43), 12156-12161 (2016-10-30)
Protein biogenesis is tightly linked to protein quality control (PQC). The role of PQC machinery in recognizing faulty polypeptides is becoming increasingly understood. Molecular chaperones and cytosolic and vacuolar degradation systems collaborate to detect, repair, or hydrolyze mutant, damaged, and
Antiproliferative and antimetabolic effects behind the anticancer property of fermented wheat germ extract
Otto C, et al.
BMC Complementary and Alternative Medicine, 16(1), 160-160 (2016)
Chiung Mei Chen et al.
Cells, 9(5) (2020-05-21)
Parkinson's disease (PD) is a neurodegenerative disease characterized by selective dopaminergic (DAergic) neuronal degeneration in the substantia nigra (SN) and proteinaceous α-synuclein-positive Lewy bodies and Lewy neuritis. As a chemical chaperone to promote protein stability and an autophagy inducer to
Yannick Kopp et al.
eLife, 6 (2017-11-02)
Cells respond to protein misfolding and aggregation in the cytosol by adjusting gene transcription and a number of post-transcriptional processes. In parallel to functional reactions, cellular structure changes as well; however, the mechanisms underlying the early adaptation of cellular compartments
Qian Sun et al.
Experimental and therapeutic medicine, 21(3), 190-190 (2021-01-26)
The nuclear erythroid 2-related factor 2 (NRF2)/antioxidant response element (ARE) pathway has been shown to provide strong protection against oxidative stress injury induced by renal ischemia-reperfusion (IR). However, the endogenous regulatory mechanism of the NRF2/ARE pathway in renal IR injury
Neuroprotective effects of urate are mediated by augmenting astrocytic glutathione synthesis and release
Bakshi R, et al.
Neurobiology of Disease, 82, 574-579 (2015)
Akihiro Kimura et al.
The Journal of experimental medicine, 215(8), 2197-2209 (2018-06-24)
NAD(P)H:quinone oxidoreductase 1 (NQO1) protects cells against oxidative stress and toxic quinones. In this study, we found a novel role of NQO1 in suppressing Toll-like receptor (TLR)-mediated innate immune responses. NQO1-deficient macrophages selectively produced excessive amounts of IL-6, IL-12, and
Raimunda Sâmia Nogueira Brilhante et al.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 19(5), 459-465 (2015-06-30)
The antifungal activity of some statins against different fungal species has been reported. Thus, at the first moment, the in vitro antifungal activity of simvastatin, atorvastatin and pravastatin was tested against Candida spp. and Cryptococcus spp. Then, in a second
Volker M Arlt et al.
Archives of toxicology, 91(4), 1957-1975 (2016-08-26)
Exposure to aristolochic acid (AA) causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN). Conflicting results have been found for the role of human sulfotransferase 1A1 (SULT1A1) contributing to the metabolic activation of aristolochic acid I (AAI) in vitro.
High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma
Cui X, et al.
BMC Cancer, 15(1), 1-8 (2015)
Sara Polo et al.
Frontiers in pharmacology, 10, 283-283 (2019-04-12)
We investigated whether administration of the δ-opioid receptor (DOR) agonist H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), which also activates nuclear factor erythroid 2-related factor 2 (Nrf2), alleviated chronic inflammatory and/or neuropathic pain and inhibited the depressive-like behaviors associated with persistent neuropathic pain. The possible
Andrés Felipe Díaz et al.
Journal of clinical medicine, 8(6) (2019-06-27)
Nerve injury provokes microglial activation, contributing to the sensory and emotional disorders associated with neuropathic pain that do not completely resolve with treatment. In C57BL/6J mice with neuropathic pain induced by chronic constriction of the sciatic nerve (CCI), we evaluated
Christoph Otto et al.
BMC complementary and alternative medicine, 16, 160-160 (2016-06-02)
Fermented wheat germ extract (FWGE) sold under the trade name Avemar exhibits anticancer activity in vitro and in vivo. Its mechanisms of action are divided into antiproliferative and antimetabolic effects. Its influcence on cancer cell metabolism needs further investigation. One
Jennifer M McCracken et al.
Gene expression, 17(3), 187-205 (2017-02-25)
Biological differences exist between strains of laboratory mice, and it is becoming increasingly evident that there are differences between substrains. In the C57BL/6 mouse, the primary substrains are called 6J and 6N. Previous studies have demonstrated that 6J and 6N
Vasilis Vasiliou et al.
Human genomics, 2(5), 329-335 (2006-04-06)
The NAD(P)H:quinone acceptor oxidoreductase (NQO) gene family belongs to the flavoprotein clan and, in the human genome, consists of two genes (NQO1 and NQO2). These two genes encode cytosolic flavoenzymes that catalyse the beneficial two-electron reduction of quinones to hydroquinones.
NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger.
Siegel, D., et al.
J. Mol. Pharmacol., 65(5), 1238-1247 (2004)
Ji-Won Park et al.
Molecular medicine reports, 24(1) (2021-05-14)
3,4,5‑Trihydroxycinnamic acid (THCA) exhibits anti‑inflammatory activity in acute or chronic inflammatory disorders, such as acute lung injury and asthma. The present study investigated the anti‑inflammatory activity of THCA in a tumor necrosis factor‑α/interferon‑γ (TI) mixture‑stimulated human keratinocyte cell line. The
D Ross et al.
Chemico-biological interactions, 129(1-2), 77-97 (2001-01-13)
NAD(P)H:quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase that is involved in chemoprotection and can also bioactivate certain antitumor quinones. This review focuses on detoxification reactions catalyzed by NQO1 and its role in antioxidant defense via the generation of
David Siegel et al.
Redox biology, 39, 101840-101840 (2020-12-29)
The localization of NQO1 near acetylated microtubules has led to the hypothesis that NQO1 may work in concert with the NAD+-dependent deacetylase SIRT2 to regulate acetyl α-tubulin (K40) levels on microtubules. NQO1 catalyzes the oxidation of NADH to NAD+ and
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1
Moscovitz O, et al.
Molecular Cell, 47, 76-86 (2012)
NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms
Ross D, et al.
Chemico-Biological Interactions, 77-97 (2000)
Gerile Tu et al.
Molecular medicine reports, 13(3), 2320-2326 (2016-01-20)
Retinal pigmented epithelial cell (RPE) oxidative stress is known to have a vital role in the etiology of age‑related macular degeneration (AMD). The present study aimed to investigate whether allicin, a natural product with antioxidant activity, was able to protect
Annette M Krais et al.
Archives of toxicology, 90(4), 839-851 (2015-05-23)
The tumour suppressor p53 is one of the most important cancer genes. Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in the
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