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Showing 1-30 of 225 results for "N5751" within Papers
Serap Gur et al.
Urology, 82(3), 745-745 (2013-07-17)
To evaluate the effect of the tyrosine kinase inhibitor imatinib mesylate (Gleevec) on human corpus cavernosum (HCC) smooth muscle tone. HCC were obtained from 18 erectile dysfunction (ED) patients undergoing penile prosthesis surgery. The effects of imatinib in HCC strips
Laurent Chatre et al.
Redox biology, 55, 102406-102406 (2022-08-15)
Preeclampsia (PE) is a high-prevalence pregnancy disease characterized by placental insufficiency, gestational hypertension, and proteinuria. Overexpression of the A isoform of the STOX1 transcription factor (STOX1A) recapitulates PE in mice, and STOX1A overexpressing trophoblasts recapitulate PE patients hallmarks in terms
Xiaogang Li et al.
iScience, 23(12), 101763-101763 (2020-12-01)
Regulation of glucose homeostasis is a fundamental process to maintain blood glucose at a physiological level, and its dysregulation is associated with the development of several metabolic diseases. Here, we report on a zebrafish mutant for Aldo-keto-reductase 1a1b (akr1a1b) as a
Esra Eyiiş et al.
Turkish journal of pharmaceutical sciences, 17(6), 586-592 (2021-01-05)
Safe and effective drugs are still lacking for many pain therapies. In recent years, growing interest has been devoted thus on herbal drugs as an option to identify new pain killers. Based on this, extensive researches are carried out on
Shusei Yamamoto et al.
Experimental and molecular pathology, 114, 104437-104437 (2020-04-05)
Nonalcoholic steatohepatitis (NASH) is linked to an increased risk of cardiovascular disease, regardless of the risk factors in metabolic syndrome. However, the intermediary factors between NASH and cardiovascular disease are still unknown. A previous study revealed that serum and hepatic
Pratish Thakore et al.
eLife, 10 (2021-02-27)
Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the dynamic metabolic demands of the brain. We hypothesized that TRPA1 channels in capillary endothelial cells are stimulated by neuronal activity and instigate a propagating retrograde signal that dilates
James T Pearson et al.
Clinical science (London, England : 1979), 135(2), 327-346 (2021-01-23)
A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress and endothelial dysfunction. Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) have been shown to abolish inflammation and redox stress but only partially
Interferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcome.
Cheng, et al.
Cell Death & Disease, 14, 319-319 (2023)
Jacqueline K Limberg et al.
American journal of physiology. Heart and circulatory physiology, 319(1), H162-H170 (2020-06-06)
Vasodilatory effects of insulin support the delivery of insulin and glucose to skeletal muscle. Concurrently, insulin exerts central effects that increase sympathetic nervous system activity (SNA), which is required for the acute maintenance of blood pressure (BP). Indeed, in a
Lindsey A Ramirez et al.
American journal of physiology. Renal physiology, 319(2), F192-F201 (2020-07-01)
We have previously shown that hypertensive female rats have more regulatory T cells (Tregs), which contribute more to blood pressure (BP) control in female versus male rats. Based on known protective properties of Tregs, the goal of the present study
Jaume Padilla et al.
Endocrinology, 160(12), 2918-2928 (2019-10-17)
Obesity and insulin resistance stiffen the vasculature, with females appearing to be more adversely affected. As augmented arterial stiffness is an independent predictor of cardiovascular disease (CVD), the increased predisposition of women with obesity and insulin resistance to arterial stiffening
María Elena Sánchez-Mendoza et al.
Molecules (Basel, Switzerland), 25(9) (2020-05-14)
Peptic ulcer disease, the most common gastrointestinal disorder, is currently treated with several types of drugs, but all have severe side effects. The aim of the present study was to evaluate the gastroprotective activity of juanislamin, isolated from Calea urticifolia
Nada M Banjac et al.
Pharmacology, 107(3-4), 150-159 (2021-12-15)
This study aimed to assess the influence of different doses of tadalafil on coronary flow and oxidative stress in isolated rat hearts. The hearts of male Wistar albino rats (n = 48) were retrogradely perfused according to the Langendorff technique
Kristine H Kurtz et al.
Microcirculation (New York, N.Y. : 1994), 21(7), 593-605 (2014-04-08)
This study investigated the roles of the H1 and H2 histamine receptors, NO synthase, and sGC cyclase in histamine-induced modulation of rat mesenteric collecting lymphatic pumping. Isolated rat mesenteric collecting lymphatics were treated with 1- to 100-μM histamine. Histamine receptors
Masahito Shimizu et al.
International journal of cancer, 135(4), 774-784 (2014-01-30)
We previously reported the cancer chemopreventive activity of 4'-geranyloxyferulic acid (GOFA, Miyamoto et al., Nutr Cancer 2008; 60:675-84) and a β-cyclodextrin inclusion compound of GOFA (Tanaka et al., Int J Cancer 2010; 126:830-40) in colitis-related colorectal carcinogenesis. In our study
D I Peregud et al.
Eksperimental'naia i klinicheskaia farmakologiia, 76(3), 3-6 (2013-06-19)
This study was aimed at evaluating the role of nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) cascade in mechanisms of morphine dependency formation. Morphine was introduced by intraperitoneal (i.p.) injections in rats twice per day over six days in doses increasing
Gry Freja Skovsted et al.
Antioxidants (Basel, Switzerland), 11(11) (2022-11-25)
Vitamin C (vitC) deficiency has been associated with an increased risk of cardiovascular disease; while several putative mechanistic links have been proposed, functional evidence supporting a causal relationship is scarce. In this study, we investigated how vitC deficiency affects coronary
E Delgado et al.
Ophthalmic research, 43(3), 113-121 (2009-11-06)
Although nitric oxide (NO) has been shown to be essential for maintaining the basal blood flow in the retina and optic nerve head, its exact role in vasomotion is still controversial. This study investigated L-arginine (L-Arg) and N-nitro-L-arginine methylester (L-NAME)
Xia Wang et al.
Molecules (Basel, Switzerland), 24(13) (2019-07-03)
Sphingosine-1-phosphate (S1P), a bioactive sphingolipid, is recognized as a critical regulator in physiological and pathophysiological processes of atherosclerosis (AS). However, the underlying mechanism remains unclear. As the precursor cells of endothelial cells (ECs), endothelial progenitor cells (EPCs) can prevent AS
Salvatore Rizza et al.
Cell reports, 42(1), 111997-111997 (2023-01-20)
Nitric oxide (NO) production in the tumor microenvironment is a common element in cancer. S-nitrosylation, the post-translational modification of cysteines by NO, is emerging as a key transduction mechanism sustaining tumorigenesis. However, most oncoproteins that are regulated by S-nitrosylation are
Junqi Wang et al.
Frontiers in pharmacology, 13, 1051694-1051694 (2022-12-20)
Chloroquine was once thought to be a promising treatment for COVID-19 but it quickly failed due to its inefficiency and association with increased mortality. Further, comorbidities such as hypertension may have contributed this failure. The safety and toxicity of chloroquine
Namgue Hong et al.
Animal cells and systems, 26(1), 1-9 (2022-03-22)
Human immunodeficiency virus type I (HIV-1) infection of the CNS produces synapse loss which correlates with cognitive decline in patients with HIV-associated neurocognitive disorders (HAND). Lithium is mood stabilizer of unknown mechanism used to treat bipolar disorder and is known
George F Lasker et al.
American journal of physiology. Heart and circulatory physiology, 304(12), H1670-H1679 (2013-04-16)
Nitric oxide (NO) is the principal mediator of penile erection, and soluble guanylate cyclase (sGC) is the receptor for NO. In pathophysiological conditions when sGC is inactivated and not responsive to NO or sGC stimulators a new class of agents
Yolanda Mendizábal et al.
Life sciences, 93(25-26), 1023-1032 (2013-11-10)
We have studied the vasoactive role of prostaglandins derived from perivascular adipose tissue (PVAT) and their effects on endothelial function in healthy rats and rats with metabolic syndrome (SHROB). Mesenteric resistance arteries (MRA) from SHROB and control rats (WKY) were
Oluwatobiloba Osikoya et al.
Pharmacological research, 171, 105788-105788 (2021-07-27)
Uterine perivascular adipose tissue (PVAT) contributes to uterine blood flow regulation in pregnancy, at least in part, due to its effects on uterine artery reactivity. We tested the hypothesis that uterine PVAT modulates the balance between the contribution of nitric
Beijian Zhang et al.
Frontiers in cardiovascular medicine, 8, 647806-647806 (2021-03-23)
Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disease, in which its pathogenesis is very complex and far from defined. Here, we explored the N6-methyladenosine (m6A) RNA methylation alteration in patients with HFpEF and mouse model of
María A Rodríguez-Hernández et al.
Biochemical pharmacology, 176, 113902-113902 (2020-03-12)
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and the fourth most frequent cause of cancer-related death worldwide. Sorafenib is the first line recommended therapy for patients with locally advanced/metastatic HCC. The low response rate is
Tiziana Ravasenga et al.
Cell reports, 38(6), 110347-110347 (2022-02-10)
The induction of synaptic plasticity at an individual dendritic glutamatergic spine can affect neighboring spines. This local modulation generates dendritic plasticity microdomains believed to expand the neuronal computational capacity. Here, we investigate whether local modulation of plasticity can also occur
Heng-Huei Lin et al.
Clinical science (London, England : 1979), 133(23), 2361-2378 (2019-11-26)
Contrast medium-induced acute kidney injury (CI-AKI) is one of the most common causes of hospital-acquired acute renal failure. However, the pathogenesis of CI-AKI remains unclear. Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase (NOS) inhibitor that is largely metabolised
Erkan Kilinc et al.
The European journal of neuroscience, 55(4), 1015-1031 (2020-07-09)
Calcitonin gene-related peptide (CGRP), substance P and dural mast cells are main contributors in neurogenic inflammation underlying migraine pathophysiology. Modulation of endocannabinoid system attenuates migraine pain, but its mechanisms of action remain unclear. We investigated receptor mechanisms mediating anti-neuroinflammatory effects
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