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Showing 1-30 of 612 results for "N6639" within Papers
Qingqing Wang et al.
General and comparative endocrinology, 216, 9-23 (2015-05-07)
Gonadotropin-inhibitory hormone (GnIH) and its receptor (GnIHR) play an important role in reproduction regulation in birds, mammals and some teleost species. In protogynous hermaphroditic orange-spotted grouper (Epinephelus coioides), the GnIH/GnIHR signaling pathway and its reproductive function have not been addressed
Claire Chevaleyre et al.
Journal of immunology (Baltimore, Md. : 1950), 195(4), 1891-1901 (2015-07-03)
Cyclin B1 (CCNB1) is considered as a potential target for a cancer vaccine, as it is overexpressed in many malignant cells, while being transiently expressed in normal cells. To evaluate the CD4 T cell response to CCNB1, we derived T
Hye-Young Wang et al.
Experimental and molecular pathology, 98(3), 510-516 (2015-04-04)
Human papillomavirus (HPV) is a major cause of cervical cancer, which is the third most common cancer in women. Human telomerase reverse transcriptase (hTERT) and Ki67 are tumor cell markers indicating cancer cell proliferation in cancer patients, and activation of
Sanne Grundvad Boelt et al.
Analytical biochemistry, 481, 33-42 (2015-04-25)
Here we present an agarose gel shift assay that, in contrast to other electrophoresis approaches, is loaded in the center of the gel. This allows proteins to migrate in either direction according to their isoelectric points. Therefore, the presented assay
Shukai Yuan et al.
PLoS genetics, 11(5), e1005253-e1005253 (2015-05-29)
Hair follicles (HF) undergo precisely regulated recurrent cycles of growth, cessation, and rest. The transitions from anagen (growth), to catagen (regression), to telogen (rest) involve a physiological involution of the HF. This process is likely coordinated by a variety of
Chike F Oguejiofor et al.
Biology of reproduction, 93(4), 101-101 (2015-09-12)
Infection with noncytopathic bovine viral diarrhea virus (ncpBVDV) is associated with uterine disease and infertility. This study investigated the influence of ncpBVDV on immune functions of the bovine endometrium by testing the response to bacterial lipopolysaccharide (LPS). Primary cultures of
Histochemical detection of superoxide and H2O2 accumulation in Brassica juncea seedlings
Kumar D, et al.
Bio-protocol, 4(8), e1108-e1108 (2014)
John M Spear et al.
BMC biochemistry, 16, 16-16 (2015-07-15)
Potassium channels play a fundamental role in resetting the resting membrane potential of excitable cells. Determining the intracellular trafficking and localization mechanisms of potassium channels provides a platform to fully characterize their maturation and functionality. Previous investigations have discovered residues
Yuting Yang et al.
Frontiers in plant science, 11, 559070-559070 (2020-10-27)
Botrytis cinerea is an important necrotrophic fungal pathogen with a broad host range and the ability to causing great economic losses in cucumber. However, the resistance mechanism against this pathogen in cucumber was not well understood. In this study, the
Y N Lin et al.
The Journal of steroid biochemistry and molecular biology, 154, 85-93 (2015-07-03)
Ruscogenin, a natural steroidal sapogenin, presents in both food and medicinal plants. It has been found to exert significant anti-inflammatory activities. Considering that activation of neutrophil is a key feature of inflammatory diseases, this study was performed to investigate the
Oliver Dehus et al.
Analytical and bioanalytical chemistry, 407(6), 1673-1683 (2015-01-13)
Birch (Betula) pollen is a major cause of allergy in northern and central Europe. The allergenic potency of products for diagnosis and therapy of birch pollen allergy is adjusted nearly exclusively to the major birch pollen allergen Bet v 1.
J Shiu et al.
Mucosal immunology, 8(5), 1047-1059 (2015-01-22)
Lymphoid tissue inducer (LTi) cells are activated by accessory cell IL-23, and promote lymphoid tissue genesis and antibacterial peptide production by the mucosal epithelium. We investigated the role of LTi cells in the gastric mucosa in the context of microbial
Mingfu Yang et al.
FEBS letters, 588(24), 4761-4768 (2014-12-03)
MicroRNAs (miRNAs) are a class of small non-coding RNAs with important roles in various biological and pathological processes, including osteoblast differentiation. Here, we identified miR-96 as a positive regulator of osteogenic differentiation in a mouse osteoblastic cell line (MC3T3-E1) and
D P Nanda et al.
Neoplasma, 61(6), 747-757 (2014-08-26)
Carcinoma of oral cavity have a high risk of recurrence after initial treatment with surgery, radiotherapy, surgery with adjuvant radiotherapy, or radio-chemotherapy.The present study investigated the changes in expression, activity and regulation of matrix metalloproteinases (MMP) -2 and -9 in oral
Maryam Zahedifard et al.
Scientific reports, 5, 11544-11544 (2015-06-26)
The current study investigated the cytotoxic effect of 3-(5-chloro-2-hydroxybenzylideneamino)-2-(5-chloro-2-hydroxyphenyl)-2,3-dihydroquinazolin-41(H)-one (A) and 3-(5-nitro-2-hydroxybenzylideneamino)-2-(5-nitro-2-hydroxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (B) on MCF-7, MDA-MB-231, MCF-10A and WRL-68 cells. The mechanism involved in apoptosis was assessed to evaluate the possible pathways induced by compound A and B. MTT assay
Remco J Molenaar et al.
Cancer research, 75(22), 4790-4802 (2015-09-13)
Isocitrate dehydrogenase 1 (IDH1) is mutated in various types of human cancer to IDH1(R132H), a structural alteration that leads to catalysis of α-ketoglutarate to the oncometabolite D-2-hydroxyglutarate. In this study, we present evidence that small-molecule inhibitors of IDH1(R132H) that are
Lukasz Szoka et al.
Molecular and cellular biochemistry, 403(1-2), 51-60 (2015-01-30)
The oxythiamine (OXY) is antivitamin of thiamine. The finding that OXY increases the cytoplasmic concentration of pyruvate, known to enhance collagen biosynthesis, led us to investigate the mechanism of this antivitamin action on collagen biosynthesis in cultured human skin fibroblasts.
Jingyi Tu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(44), 14727-14739 (2015-11-06)
The current study examined efficacy of a small Tat (trans-activator of transcription)-conjugated peptide activator of the Nrf2 (nuclear factor-E2-related factor-2) antioxidant/cell-defense pathway as a potential injury-specific, novel neuroprotectant against global cerebral ischemia (GCI). A competitive peptide, DEETGE-CAL-Tat, was designed to
T-Y Renn et al.
Vox sanguinis, 109(2), 138-147 (2015-04-23)
Recent clinical data suggested that platelet materials used in regenerative medicine exert anti-inflammatory effects. One must understand whether functionality varies among platelet preparations and also the role of the various protein compartments. Platelet-poor-plasma (PPP), platelet lysate with cell debris (PL)
Noria Segueni et al.
PloS one, 10(5), e0126058-e0126058 (2015-05-08)
IL-36 cytokines are members of the IL-1 family of cytokines that stimulate dendritic cells and T cells leading to enhanced T helper 1 responses in vitro and in vivo; however, their role in host defense has not been fully addressed
Alexandra Kalmár et al.
Diagnostic pathology, 10, 126-126 (2015-07-26)
A recently published transcript set is suitable for gene expression-based discrimination of normal colonic and colorectal cancer (CRC) biopsy samples. Our aim was to test the discriminatory power of the CRC-specific transcript set on independent biopsies and on formalin-fixed, paraffin-embedded
Li Zhang et al.
Scientific reports, 5, 10860-10860 (2015-06-05)
Biofunctionalization with siRNA targeting the key negative modulators of bone turnover involved in the molecular mechanism of osteoporosis, such as casein kinase-2 interacting protein-1 (Ckip-1), may lead to enhanced Ti osseointegration in the osteoporotic condition. In this study, even siRNA
Raffaella Alò et al.
Brain research bulletin, 118, 65-77 (2015-09-27)
Recent evidences indicate that cerebral neurotrophic factors like vascular endothelial growth factor plus signaling pathways of the glutamatergic neuroreceptor system (L-Glu) are determinant modulators of depression-like states. In the present study, the type of interaction(s) exerted by the AMPAergic antagonist
Guan Jiang et al.
Journal of cancer research and clinical oncology, 141(1), 75-85 (2014-08-12)
The aim of this study was to investigate the effect of Ki67-ZD55-IL-24 with temozolomide (TMZ) against melanoma in mice. Seventy-eight mice with subcutaneous injection of A375 cells (2 × 10(6)) into the right flank were randomized to receive phosphate buffered
Mayada Woriedh et al.
Journal of experimental botany, 66(17), 5205-5216 (2015-06-14)
EMBRYO SAC1-4 (ES1-4) peptides belong to the defensin subgroup of cysteine-rich peptides known to mediate pollen tube burst in Zea mays (maize). ES1-4 are reported here to also be capable of inhibiting germination and growth of the maize fungal pathogens
Hui Tian et al.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 35(3), 157-167 (2014-10-28)
Melanoma differentiation-associated gene-7 (mda-7)/interleukin-24 (IL-24) induces caspase-3 cleavage and subsequent activation via the intrinsic or extrinsic pathway to result in cancer cell-selective apoptosis, but whether mda-7/IL-24 may directly regulate caspase-3 through the post-translational modification remains unknown. Here, we reported that
Darren R Bisset et al.
Human molecular genetics, 24(17), 4971-4983 (2015-06-18)
RNA interference (RNAi) offers a promising therapeutic approach for dominant genetic disorders that involve gain-of-function mechanisms. One candidate disease for RNAi therapy application is myotonic dystrophy type 1 (DM1), which results from toxicity of a mutant mRNA. DM1 is caused
Stephan Niebler et al.
BioMed research international, 2015, 380590-380590 (2015-08-15)
The transcription factor AP-2ε (activating enhancer-binding protein epsilon) is expressed in cartilage of humans and mice. However, knowledge about regulatory mechanisms influencing AP-2ε expression is limited. Using quantitative real time PCR, we detected a significant increase in AP-2ε mRNA expression
Jingliang Li et al.
Viruses, 7(7), 3891-3909 (2015-07-21)
Coxsackievirus A16 (CA16) and enterovirus 71 (EV71), both of which can cause hand, foot and mouth disease (HFMD), are responsible for large epidemics in Asian and Pacific areas. Although inactivated EV71 vaccines have completed testing in phase III clinical trials
Jie Yin et al.
Applied biochemistry and biotechnology, 177(8), 1716-1728 (2015-09-21)
Inflammatory bowel disease (IBD) correlates with oxidative stress, inflammation, and alteration in several signal pathways, including nuclear transcription factor-kappaB (NF-κB). Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-κB, has been widely demonstrated to exhibit an antioxidant and anti-inflammatory function. This study
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