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Showing 1-30 of 619 results for "P0067" within Papers
Jeffrey Haspel et al.
Autophagy, 7(6), 629-642 (2011-04-05)
Macroautophagy is a highly conserved catabolic process that is crucial for organ homeostasis in mammals. However, methods to directly measure macroautophagic activity (or flux) in vivo are limited. In this study we developed a quantitative macroautophagic flux assay based on
Yibo Piao et al.
Molecular brain, 11(1), 11-11 (2018-03-01)
Neuropathic pain is a complex, chronic pain state characterized by hyperalgesia, allodynia, and spontaneous pain. Accumulating evidence has indicated that the microglial Toll-like receptor 4 (TLR4) and autophagy are implicated in neurodegenerative diseases, but their relationship and role in neuropathic
Mengyuan Guo et al.
CNS neuroscience & therapeutics, 29(2), 544-558 (2022-12-15)
The etiology of Parkinson's disease (PD) is complex and the mechanism is unclear. It has become a top priority to find common factors that induce and affect PD pathology. We explored the key role of hypoxia in promoting the pathological
Michela Guglielmotto et al.
Autophagy, 10(10), 1827-1843 (2014-08-20)
The role of autophagy and its relationship with apoptosis in Alzheimer disease (AD) pathogenesis is poorly understood. Disruption of autophagy leads to buildup of incompletely digested substrates, amyloid-β (Aβ) peptide accumulation in vacuoles and cell death. Aβ, in turn, has
Yufeng Wang et al.
Oncotarget, 6(37), 39692-39701 (2015-10-22)
Microtubule-associated protein 1A/1B-light chain 3 (LC3)-II is essential for autophagosome formation and is widely used to monitor autophagic activity. We show that CGK733 induces LC3 II and LC3-puncta accumulation, which are not involved in the activation of autophagy. The treatment
Letícia F Terra et al.
Free radical biology & medicine, 134, 394-405 (2019-01-31)
Maintaining islet cell viability in vitro, although challenging, appears to be a strategy for improving the outcome of pancreatic islet transplantation. We have shown that prolactin (PRL) leads to beta-cell cytoprotection against apoptosis, an effect mediated by heat shock protein
Kristine M Porter et al.
Biochimica et biophysica acta, 1843(6), 1054-1062 (2014-03-04)
The trabecular meshwork (TM) is part of a complex tissue that controls the exit of aqueous humor from the anterior chamber of the eye, and therefore helps maintaining intraocular pressure (IOP). Because of variations in IOP with changing pressure gradients
Vanessa Ginet et al.
Autophagy, 10(5), 846-860 (2014-03-29)
Neuronal autophagy is increased in numerous excitotoxic conditions including neonatal cerebral hypoxia-ischemia (HI). However, the role of this HI-induced autophagy remains unclear. To clarify this role we established an in vitro model of excitotoxicity combining kainate treatment (Ka, 30 µM)
Yan Zeng et al.
PLoS pathogens, 17(2), e1009300-e1009300 (2021-02-13)
Influenza A virus (IAV) has evolved various strategies to counteract the innate immune response using different viral proteins. However, the mechanism is not fully elucidated. In this study, we identified the PB1 protein of H7N9 virus as a new negative
Wim Martinet et al.
Autophagy, 9(3), 386-402 (2012-12-18)
Transmission electron microscopy (TEM) is an indispensable standard method to monitor macroautophagy in tissue samples. Because TEM is time consuming and not suitable for daily routine, many groups try to identify macroautophagy in tissue by conventional immunohistochemistry. The aim of
Sarassunta Ucci et al.
International journal of molecular sciences, 20(22) (2019-11-17)
Thyroid hormones regulate a wide range of cellular responses, via non-genomic and genomic actions, depending on cell-specific thyroid hormone transporters, co-repressors, or co-activators. Skeletal muscle has been identified as a direct target of thyroid hormone T3, where it regulates stem
Laura Falasca et al.
Apoptosis : an international journal on programmed cell death, 20(12), 1577-1586 (2015-10-02)
Prostate cancer is among the most commonly diagnosed male diseases and a leading cause of cancer mortality in men. There is emerging evidence that autophagy plays an important role in malignant cell survival and offers protection from the anti-cancer drugs
Sung Min Son et al.
Molecular neurodegeneration, 10, 56-56 (2015-11-02)
Insulin degrading enzyme (IDE) is a major protease of amyloid beta peptide (Aβ), a prominent toxic protein in Alzheimer's disease (AD) pathogenesis. Previous studies suggested that statins promote IDE secretion; however, the underlying mechanism is unknown, as IDE has no
Rui Ju et al.
The Journal of pharmacology and experimental therapeutics, 367(1), 20-27 (2018-07-14)
The anticancer and anti-inflammatory effects of carboxyamidotriazole (CAI) have been demonstrated in several studies, but the underlying mechanisms remain to be elucidated. This study showed that CAI caused metabolic reprogramming of pancreatic cancer cells. The inhibition of mitochondrial oxidative metabolism
Basant A Abdulrahman et al.
The Journal of biological chemistry, 288(3), 2049-2058 (2012-11-14)
Cystic fibrosis is the most common inherited lethal disease in Caucasians. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), of which the cftr ΔF508 mutation is the most common. ΔF508 macrophages are intrinsically defective in
Jing Liu et al.
BioMed research international, 2020, 9280372-9280372 (2020-07-07)
UL16-binding protein 1(ULBP1) has been reported to inhibit trophoblast invasion through the modification of secretion functions of uNK cells in the previous study, but its mechanisms remain unclear. In this study, we investigated the related mechanism by which upregulated ULBP1
Giulia Di Marco et al.
Cell death & disease, 15(1), 58-58 (2024-01-18)
MitoKATP is a channel of the inner mitochondrial membrane that controls mitochondrial K+ influx according to ATP availability. Recently, the genes encoding the pore-forming (MITOK) and the regulatory ATP-sensitive (MITOSUR) subunits of mitoKATP were identified, allowing the genetic manipulation of
Mladen Savikj et al.
Physiological reports, 6(12), e13739-e13739 (2018-06-16)
Despite the well-known role of satellite cells in skeletal muscle plasticity, the effect of spinal cord injury on their function in humans remains unknown. We determined whether spinal cord injury affects the intrinsic ability of satellite cells to differentiate and
Emad Muhammad et al.
Human molecular genetics, 24(25), 7227-7240 (2015-10-16)
Gene mutations, mostly segregating with a dominant mode of inheritance, are important causes of dilated cardiomyopathy (DCM), a disease characterized by enlarged ventricular dimensions, impaired cardiac function, heart failure and high risk of death. Another myocardial abnormality often linked to
Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway.
Fan X et al
Journal of Translational Medicine, 13 , 92-92 (2015)
Wilhelmus J Kwanten et al.
American journal of physiology. Gastrointestinal and liver physiology, 311(4), G599-G609 (2016-08-16)
Autophagy and the unfolded protein response (UPR) are key cellular homeostatic mechanisms and are both involved in liver diseases, including nonalcoholic fatty liver disease (NAFLD). Although increasing but conflicting results link these mechanisms to lipid metabolism, their role and potential
C De Palma et al.
Cell death & disease, 3, e418-e418 (2012-11-16)
A resolutive therapy for Duchene muscular dystrophy, a severe degenerative disease of the skeletal muscle, is still lacking. Because autophagy has been shown to be crucial in clearing dysfunctional organelles and in preventing tissue damage, we investigated its pathogenic role
Gehui Li et al.
Frontiers in cellular neuroscience, 14, 620020-620020 (2021-02-05)
Autophagy dysfunction has been directly linked with the onset and progression of Parkinson's disease (PD), but the underlying mechanisms are not well understood. High-mobility group A1 (HMGA1), well-known chromatin remodeling proteins, play pivotal roles in diverse biological processes and diseases.
Shashipavan Chillappagari et al.
Clinical and translational medicine, 12(7), e935-e935 (2022-07-15)
Exaggerated fibroblast proliferation is a well-known feature in idiopathic pulmonary fibrosis (IPF) which may be - in part - due to insufficient autophagy, a lysosome dependent cellular surveillance pathway. Bcl2-associated athanogene 3 (BAG3) is a pivotal co-chaperone of the autophagy
Cuicui Xie et al.
Autophagy, 12(2), 410-423 (2016-01-05)
Perinatal asphyxia induces neuronal cell death and brain injury, and is often associated with irreversible neurological deficits in children. There is an urgent need to elucidate the neuronal death mechanisms occurring after neonatal hypoxia-ischemia (HI). We here investigated the selective
Yoshihisa Watanabe et al.
Autophagy, 13(1), 133-148 (2016-11-16)
Proteostasis is important for protecting cells from harmful proteins and is mainly controlled by the HSF1 (heat shock transcription factor 1) stress response pathway. This pathway facilitates protein refolding by molecular chaperones; however, it is unclear whether it functions in
Yong-Shiou Lin et al.
Biomedicines, 10(2) (2022-02-26)
Although the effects of growth hormone (GH) therapy on spinocerebellar ataxia type 3 (SCA3) have been examined in transgenic SCA3 mice, it still poses a nonnegligible risk of cancer when used for a long term. This study investigated the efficacy
Huan Liu et al.
Metabolism: clinical and experimental, 85, 259-270 (2018-05-13)
Sidt2 is an integral lysosomal membrane protein. Previously, we generated a Sidt2 global knockout mouse and found impaired insulin secretion, along with skeletal muscle pathology. A mouse model with a muscle-specific knockout of the Sidt2 gene (Sidt2f/fCre) had been generated
Emad Muhammad et al.
Human molecular genetics, 24(25), 7227-7240 (2015-10-16)
Gene mutations, mostly segregating with a dominant mode of inheritance, are important causes of dilated cardiomyopathy (DCM), a disease characterized by enlarged ventricular dimensions, impaired cardiac function, heart failure and high risk of death. Another myocardial abnormality often linked to
Chul-Su Yang et al.
Autophagy, 10(5), 785-802 (2014-03-07)
AMP-activated protein kinase (AMPK) is a crucial energy sensor and plays a key role in integration of cellular functions to maintain homeostasis. Despite this, it is largely unknown whether targeting the AMPK pathway can be used as a therapeutic strategy
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