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Showing 1-30 of 93 results for "P0899" within Papers
Zhou Xu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(10), 3426-3435 (2011-06-24)
Misfolding of the prion protein (PrP) is the central feature of prion diseases. The conversion of the normal α-helical PrP(C) into a pathological β-enriched PrP(Sc) constitutes an early event in the infectious process. Several hypotheses, involving different regions of the
Mei-Ling Yan et al.
Cell communication and signaling : CCS, 18(1), 57-57 (2020-04-08)
Chronic brain hypoperfusion (CBH) is closely related to Alzheimer's disease (AD) and vascular dementia (VaD). Meanwhile, synaptic pathology plays a prominent role in the initial stage of AD and VaD. However, whether and how CBH impairs presynaptic plasticity is currently
Jian Zhao et al.
PloS one, 12(6), e0180038-e0180038 (2017-06-28)
Charcot-Marie-Tooth (CMT) disease or hereditary motor and sensory neuropathy is the most prevalent inherited peripheral neuropathy and is associated with over 90 causative genes. Mutations in neurofilament light polypeptide gene, NEFL cause CMT2E, an axonal form of CMT that results
Ji Won Um et al.
STAR protocols, 1(2), 100095-100095 (2020-10-29)
Clustering of synaptic vesicles along the neuronal axons is a critical mechanism underpinning proper synaptic transmission. Here, we provide a detailed protocol for analyzing the distribution of synaptic vesicles in presynaptic boutons of cultured neurons. The protocol covers preparation of
Shen Lin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(40), 14033-14049 (2012-10-05)
Microtubules are nearly uniformly oriented in the axons of vertebrate neurons but are non-uniformly oriented in their dendrites. Studies to date suggest a scenario for establishing these microtubule patterns whereby microtubules are transported into the axon and nascent dendrites with
Hemalatha Muralidharan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(20), 3792-3811 (2019-02-26)
KIFC1 (also called HSET or kinesin-14a) is best known as a multifunctional motor protein essential for mitosis. The present studies are the first to explore KIFC1 in terminally postmitotic neurons. Using RNA interference to partially deplete KIFC1 from rat neurons
Carl Herdenberg et al.
Communications biology, 4(1), 90-90 (2021-01-21)
Leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins have been implicated as regulators of growth factor signaling; however, the possible redundancy among mammalian LRIG1, LRIG2, and LRIG3 has hindered detailed elucidation of their physiological functions. Here, we show that Lrig-null mouse
Shun-Qi Hu et al.
Experimental cell research, 395(2), 112239-112239 (2020-08-24)
Our present study investigated whether exosome secretion of nucleus pulposus cells (NPCs) is regulated by autophagy. Different autophagic states of NPCs were induced by rapamycin (Rap), bafilomycin A1 (Baf) and other agents, and it was found that exosomes were secreted
S Fernández-García et al.
BMC biology, 18(1), 58-58 (2020-05-30)
Network alterations underlying neurodegenerative diseases often precede symptoms and functional deficits. Thus, their early identification is central for improved prognosis. In Huntington's disease (HD), the cortico-striatal networks, involved in motor function processing, are the most compromised neural substrate. However, whether
Laura Kerosuo et al.
Journal of cell science, 121(Pt 23), 3941-3950 (2008-11-13)
The mechanisms underlying the decision of a stem or progenitor cell to either self-renew or differentiate are incompletely understood. To address the role of Myc in this process, we expressed different forms of the proto-oncogene Myc in multipotent neural progenitor
Hyosun Choi et al.
Molecular brain, 13(1), 86-86 (2020-06-04)
Propionic acid (PPA) is a short-chain fatty acid that is an important mediator of cellular metabolism. It is also a by-product of human gut enterobacteria and a common food preservative. A recent study found that rats administered with PPA showed
Faith C Blum et al.
Infection and immunity, 80(5), 1662-1669 (2012-03-07)
Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most toxic proteins for humans. While BoNTs cause flaccid paralysis, TeNT causes spastic paralysis. Characterized BoNT serotypes enter neurons upon binding dual receptors, a ganglioside and a neuron-specific protein, either synaptic
Takeshi Shimizu et al.
Glia, 65(2), 360-374 (2016-11-04)
Oligodendrocytes (OLs) are myelinating cells of the central nervous system. Recent studies have shown that mechanical factors influence various cell properties. Mechanical stimuli can be transduced into intracellular biochemical signals through mechanosensors and intracellular mechanotransducers, such as YAP. However, the
Yamei Liu et al.
Neurochemical research, 45(12), 2949-2958 (2020-10-10)
The abnormal function of the voltage-gated potassium channel Kv10.2 can induce epilepsy. However, the physiological function of Kv10.2 in the central nervous system remains unclear. In this study, we found that Kv10.2 knockout (KO) increased the complexity of neurons in
Xue-Jun Cheng et al.
World journal of stem cells, 12(11), 1354-1365 (2020-12-15)
As the third most abundant element, aluminum is widespread in the environment. Previous studies have shown that aluminum has a neurotoxic effect and its exposure can impair neuronal development and cognitive function. To study the effects of aluminum on epigenetic
Melisa Herrero et al.
Neuromolecular medicine, 21(3), 303-313 (2019-05-28)
Vanishing white matter (VWM) disease (OMIM#306896) is an autosomal recessive neurodegenerative leukodystrophy caused by hypomorphic mutations in any of the five genes encoding the subunits of eukaryotic translation initiation factor 2B (eIF2B). The disease is manifested by loss of cerebral
Hao Jiang et al.
Scientific reports, 10(1), 3412-3412 (2020-02-27)
Accurate quantification of synaptic changes is essential for understanding the molecular mechanisms of synaptogenesis, synaptic plasticity, and synaptic toxicity. Here we demonstrate a robust high-content imaging method for the assessment of synaptic changes and apply the method to brain homogenates
Takuma Sumi et al.
Soft matter, 16(13), 3195-3202 (2020-02-26)
The spontaneous activity pattern of cortical neurons in dissociated culture is characterized by burst firing that is highly synchronized among a wide population of cells. The degree of synchrony, however, is excessively higher than that in cortical tissues. Here, we
Amy N Shore et al.
Cell reports, 33(4), 108303-108303 (2020-10-29)
Gain-of-function (GOF) variants in K+ channels cause severe childhood epilepsies, but there are no mechanisms to explain how increased K+ currents lead to network hyperexcitability. Here, we introduce a human Na+-activated K+ (KNa) channel variant (KCNT1-Y796H) into mice and, using
Nicholas W Mathy et al.
Journal of neuroinflammation, 18(1), 16-16 (2021-01-08)
Microglia are resident immunocompetent and phagocytic cells in the CNS. Pro-inflammatory microglia, stimulated by microbial signals such as bacterial lipopolysaccharide (LPS), viral RNAs, or inflammatory cytokines, are neurotoxic and associated with pathogenesis of several neurodegenerative diseases. Long non-coding RNAs (lncRNA)
M W Hayman et al.
Journal of biochemical and biophysical methods, 62(3), 231-240 (2005-03-01)
Understanding neural differentiation and the development of complex neurite networks in three-dimensional matrices is critical for neural tissue engineering in vitro. In this study we describe for the first time the growth of human stem cell-derived neurons on solid polystyrene
Juhyung Lee et al.
Scientific reports, 8(1), 13676-13676 (2018-09-14)
Cyclin-dependent kinase 5 (CDK5) plays a pivotal role in neural development and neurodegeneration. CDK5 activity can be regulated by posttranslational modifications, including phosphorylation and S-nitrosylation. In this study, we demonstrate a novel mechanism by which the acetylation of CDK5 at
Hyun-Joo Seo et al.
BMB reports, 41(7), 523-528 (2008-08-07)
BMI-1026 is a synthetic aminopyrimidine compound that targets cyclin dependent kinases (cdks) and was initially designed as a potential anticancer drug. Even though it has been well documented that BMI-1026 is a potent cdk inhibitor, little is known about the
Maya Ando et al.
Molecular neurodegeneration, 12(1), 32-32 (2017-04-26)
Mutations in PINK1 and PARKIN are the most common causes of recessive early-onset Parkinson's disease (EOPD). Together, the mitochondrial ubiquitin (Ub) kinase PINK1 and the cytosolic E3 Ub ligase PARKIN direct a complex regulated, sequential mitochondrial quality control. Thereby, damaged
Na Zhang et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(15), e2100805-e2100805 (2021-05-30)
Current treatment approaches toward spinal cord injuries (SCI) have mainly focused on overcoming the inhibitory microenvironment that surrounds lesion sites. Unfortunately, the mere modulation of the cell/tissue microenvironment is often insufficient to achieve desired functional recovery. Therefore, stimulating the intrinsic
Roberto de la Rica et al.
Analytical chemistry, 81(24), 10167-10171 (2009-11-17)
While cancer is still an implacable disease, many cancers can be cured if they are diagnosed in an early stage. Recently, it was reported that the transformation from normal cells to cancer cells can change their mechanoelastic properties to become
Pearl P Y Lie et al.
Cell reports, 35(4), 109034-109034 (2021-04-29)
Lysosomal trafficking and maturation in neurons remain poorly understood and are unstudied in vivo despite high disease relevance. We generated neuron-specific transgenic mice to track vesicular CTSD acquisition, acidification, and traffic within the autophagic-lysosomal pathway in vivo, revealing that mature lysosomes are
Giuseppe Pani et al.
PloS one, 8(9), e73857-e73857 (2013-09-26)
One of the objectives of the current international space programmes is to investigate the possible effects of the space environment on the crew health. The aim of this work was to assess the particular effects of simulated microgravity on mature
Horia Vais et al.
eLife, 9 (2020-05-19)
Modulating cytoplasmic Ca2+ concentration ([Ca2+]i) by endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptor (InsP3R) Ca2+-release channels is a universal signaling pathway that regulates numerous cell-physiological processes. Whereas much is known regarding regulation of InsP3R activity by cytoplasmic ligands and processes, its
Pavithra Aravamudhan et al.
PLoS pathogens, 16(2), e1008380-e1008380 (2020-02-29)
Several barriers protect the central nervous system (CNS) from pathogen invasion. Yet viral infections of the CNS are common and often debilitating. Understanding how neurotropic viruses co-opt host machinery to overcome challenges to neuronal entry and transmission is important to
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