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Showing 1-30 of 539 results for "P1675" within Papers
Tharkika Nagendran et al.
Nature communications, 8(1), 625-625 (2017-09-22)
Injury of CNS nerve tracts remodels circuitry through dendritic spine loss and hyper-excitability, thus influencing recovery. Due to the complexity of the CNS, a mechanistic understanding of injury-induced synaptic remodeling remains unclear. Using microfluidic chambers to separate and injure distal
Ryan M Pace et al.
Med (New York, N.Y.), 2(9), 1027-1049 (2021-10-08)
Lactobacillus was described as a keystone bacterial taxon in the human vagina over 100 years ago. Using metagenomics, we and others have characterized lactobacilli and other vaginal taxa across health and disease states, including pregnancy. While shifts in community membership
Hoyong Park et al.
Scientific reports, 7, 40866-40866 (2017-01-21)
Rhythmicity plays an important role in a number of biological systems. The habenular complex is reported to contain an intrinsic molecular clock and to show rhythmic expression of circadian clock genes and proteins including per2/PER2. In this study, we observed
Yi Lu et al.
EBioMedicine, 102, 105045-105045 (2024-03-13)
Schizophrenia, a debilitating psychiatric disorder, displays considerable interindividual variation in clinical presentations. The ongoing debate revolves around whether this heterogeneity signifies a continuum of severity linked to a singular causative factor or a collection of distinct subtypes with unique origins.
Laura H Corbit et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(8), 1893-1901 (2014-02-18)
Exposure to drugs of abuse can result in a loss of control over both drug- and nondrug-related actions by accelerating the transition from goal-directed to habitual control, an effect argued to reflect changes in glutamate homeostasis. Here we examined whether
Sunwhi Kim et al.
Cell reports, 39(10), 110906-110906 (2022-06-09)
Dysfunctional sociability is a core symptom in autism spectrum disorder (ASD) that may arise from neural-network dysconnectivity between multiple brain regions. However, pathogenic neural-network mechanisms underlying social dysfunction are largely unknown. Here, we demonstrate that circuit-selective mutation (ctMUT) of ASD-risk
Masaki Domoto et al.
Psychopharmacology, 235(8), 2367-2376 (2018-06-03)
5F-AMB is one of the synthetic cannabinoids (SCs) designed to potentiate the ability to activate cannabinoid 1 (CB1) receptors and is abused worldwide. Although inhalation of 5F-AMB elicits serious adverse effects including impaired memory and consciousness, it is not known
Chunhua Zhou et al.
Frontiers in neuroscience, 14, 115-115 (2020-03-29)
Schizophrenia is frequently accompanied by depressive symptoms, but the pathological mechanisms remain to be elucidated. In this study, we used chronic unpredicted mild stress plus MK801 injection to generate a mouse model of schizophrenia with depression, in which in vivo
Patricia M Horvath et al.
Cell reports, 36(5), 109467-109467 (2021-08-05)
Recent studies have demonstrated that protein translation can be regulated by spontaneous excitatory neurotransmission. However, the impact of spontaneous neurotransmitter release on gene transcription remains unclear. Here, we study the effects of the balance between inhibitory and excitatory spontaneous neurotransmission
Niels R Ntamati et al.
PloS one, 13(1), e0190297-e0190297 (2018-01-06)
Neurons in the periaqueductal gray (PAG) modulate threat responses and nociception. Activity in the ventral tegmental area (VTA) on the other hand can cause reinforcement and aversion. While in many situations these behaviors are related, the anatomical substrate of a
Xuehan Zhou et al.
Nature communications, 15(1), 5353-5353 (2024-06-26)
Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide with key regulatory functions in several central behavioral processes including motivation, stress, feeding, and sleep. The functional relevance of N/OFQ action in the mammalian brain remains unclear due to a lack
C Daniel De Magalhaes Filho et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(2), 396-412 (2016-01-15)
Insulin-like growth factors control numerous processes, namely somatic growth, metabolism and stress resistance, connecting this pathway to aging and age-related diseases. Insulin-like growth factor signaling also impacts on neurogenesis, neuronal survival and structural plasticity. Recent reports demonstrated that diminished insulin-like
Dominique Chesnoy-Marchais
The European journal of neuroscience, 37(3), 366-379 (2012-11-30)
Hypoglossal motoneurons (HMs) are known to be under 'permanent' bicuculline-sensitive inhibition and to show 'transient' synaptic Ī³-aminobutyric acid (GABA)(A) and glycine inhibitory responses. The present paper describes a permanent bicuculline-sensitive current that should contribute to their tonic inhibition. This current
Gregory S Bryman et al.
Neuron, 108(2), 335-348 (2020-08-28)
The fovea is a neural specialization that endows humans and other primates with the sharpest vision among mammals. This performance originates in the foveal cones, which are extremely narrow and long to form a high-resolution pixel array. Puzzlingly, this form
Nirnath Sah et al.
Scientific reports, 7(1), 10903-10903 (2017-09-09)
Adult hippocampal neurogenesis is an important form of structural and functional plasticity in the mature mammalian brain. The existing consensus is that GABA regulates the initial integration of adult-born neurons, similar to neuronal development during embryogenesis. Surprisingly, virus-based anatomical tracing
Alfonsa Zamora-Moratalla et al.
Hippocampus, 31(3), 281-293 (2020-12-08)
Dynamic signaling between the endocrine system (ES) and the nervous system (NS) is essential for brain and body homeostasis. In particular, reciprocal interaction occurs during pregnancy and motherhood that may involve changes in some brain plasticity processes. Prolactin (PRL), a
T Saleewong et al.
Journal of integrative neuroscience, 11(3), 243-264 (2012-09-01)
Long-term potentiation (LTP) of synaptic transmission is a widely accepted model of learning and memory. In vitro brain slice techniques were used to investigate the effects of cortical-spreading depression and picrotoxin, an antagonist of the gamma-aminobutyric acid A (GABA(A)) receptor
Sukwoon Song et al.
Scientific reports, 10(1), 18227-18227 (2020-10-28)
The myristoylated zeta inhibitory peptide (ZIP), which was originally developed as a protein kinase C/MĪ¶ (PKCĪ¶/PKMĪ¶) inhibitor, is known to produce the loss of different forms of memories. However, ZIP induces memory loss even in the absence of PKMĪ¶, and
Shuanglian Wang et al.
American journal of physiology. Gastrointestinal and liver physiology, 312(3), G208-G218 (2016-12-17)
Ī³-Aminobutyric acid (GABA) is produced by various cells through the catalytic activity of glutamic acid decarboxylase (GAD). Activation of type-A GABA receptor (GABA
Estibaliz Barrio-Alonso et al.
Cell reports, 42(4), 112375-112375 (2023-04-13)
The regulation of neurons by circadian clock genes is thought to contribute to the maintenance of neuronal functions that ultimately underlie animal behavior. However, the impact of specific circadian genes on cellular and molecular mechanisms controlling synaptic plasticity and cognitive
Jiejie Wang et al.
Nature communications, 9(1), 2267-2267 (2018-06-13)
NMDA receptors (NMDARs) are crucial for excitatory synaptic transmission and synaptic plasticity. The number and subunit composition of synaptic NMDARs are tightly controlled by neuronal activity and sensory experience, but the molecular mechanism mediating NMDAR trafficking remains poorly understood. Here
Karin R Aubrey et al.
The Journal of physiology, 595(1), 165-178 (2016-07-28)
The midbrain periaqueductal grey (PAG) forms part of an endogenous analgesic system which is tightly regulated by the neurotransmitter GABA. The role of endocannabinoids in regulating GABAergic control of this system was examined in rat PAG slices. Under basal conditions
Lindsey M Biggs et al.
Scientific reports, 12(1), 11401-11401 (2022-07-07)
The neuropeptide oxytocin (OXT) modulates social behaviors across species and may play a developmental role for these behaviors and their mediating neural pathways. Despite having high, stable levels of OXT receptor (OXTR) ligand binding from birth, endopiriform nucleus (EPN) remains
A J Delaney et al.
Scientific reports, 8(1), 9908-9908 (2018-07-04)
The two main sub-divisions of the Central amygdala (CeA), the lateral-capsular (CeA-LC) and the medial (CeA-M), contain extensive networks of inhibitory interneurons. We have previously shown that activation of GABAB-receptors reduces excitatory transmission between axons of the pontine parabrachial nucleus
A F IakimovskiÄ et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 99(2), 221-229 (2013-05-09)
The influence of NMDA and metabotropic neostriatal glutamate receptors blockade to avoidance conditioning (in shuttle box) and free locomotor behavior (in open field) in chronic experiments in rats were investigated. The glutamate receptor antagonists were injected bilateral into striatum separately
Anders Enjin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(23), 5634-5647 (2017-05-10)
When activating muscles, motor neurons in the spinal cord also activate Renshaw cells, which provide recurrent inhibitory feedback to the motor neurons. The tight coupling with motor neurons suggests that Renshaw cells have an integral role in movement, a role
Phuong Thao Thi Nguyen et al.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 24(5), 433-440 (2020-08-25)
The substantia gelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) is the first relay site for the orofacial nociceptive inputs via the thin myelinated AĪ“ and unmyelinated C primary afferent fibers. Borneol, one of the valuable timehonored herbal ingredients in
Adrianne R Wilson-Poe et al.
The Journal of physiology, 595(20), 6541-6555 (2017-08-18)
Chronic treatment with opioids, such as morphine, leads to analgesic tolerance. While postsynaptic opioid tolerance is well documented, the involvement of presynaptic mechanisms remains unclear. We show that chronic morphine reduces the ability of periaqueductal grey (PAG) neurons to maintain
David Acton et al.
Cell reports, 28(3), 625-639 (2019-07-18)
Acute itch can be generated by either chemical or mechanical stimuli, which activate separate pathways in the periphery and spinal cord. While substantial progress has been made in mapping the transmission pathway for chemical itch, the central pathway for mechanical
Ahmad Salamian et al.
Cerebral cortex (New York, N.Y. : 1991), 31(8), 3804-3819 (2021-03-20)
Information coding in the hippocampus relies on the interplay between various neuronal ensembles. We discovered that the application of a cholinergic agonist, carbachol (Cch), which triggers oscillatory activity in the gamma range, induces the activity of matrix metalloproteinase 9 (MMP-9)-an
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