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Showing 1-30 of 147 results for "P1754" within Papers
Mikel Anza et al.
Data in brief, 20, 1371-1377 (2018-09-27)
The bioremediation of contaminated soil often involves the addition of organic/inorganic amendments and mobilizing agents (e.g. surfactants, detergents), in order to stimulate the growth and degrading activity of soil microbial populations and increase contaminant bioavailability. For this data article we
Rokeya Tasneen et al.
Antimicrobial agents and chemotherapy, 52(10), 3664-3668 (2008-08-13)
PA-824 is in phase II clinical testing to treat tuberculosis. At a dose of 100 mg/kg of body weight, it has demonstrated bactericidal activity during the initial and continuation phases of treatment in a murine model of tuberculosis. In a
Diéssica Padilha Dalenogare et al.
Pharmaceuticals (Basel, Switzerland), 14(8) (2021-08-29)
Headaches are frequently described in progressive multiple sclerosis (PMS) patients, but their mechanism remains unknown. Transient receptor potential ankyrin 1 (TRPA1) was involved in neuropathic nociception in a model of PMS induced by experimental autoimmune encephalomyelitis (PMS-EAE), and TRPA1 activation
Sharon J Miller et al.
Translational oncology, 5(5), 313-320 (2012-10-16)
We demonstrate that rapamycin can induce regression of adenomatous polyposis coli (Apc) mutation-dependent colonic adenomas in genetically engineered mice (CPC;Apc). An endoscope was used to visualize adenomas in CPC;Apc mice weekly for 10 weeks. The lesion surface areas were measured
Léanie Kleynhans et al.
PloS one, 6(9), e24639-e24639 (2011-09-21)
Most individuals latently infected with Mycobacterium tuberculosis (M.tb) contain the infection by a balance of effector and regulatory immune responses. This balance can be influenced by steroid hormones such as glucocorticoids. The widely used contraceptive medroxyprogesterone acetate (MPA) possesses glucocorticoid
Ghaseb Naser Makhadmeh et al.
Artificial cells, nanomedicine, and biotechnology, 44(5), 1285-1289 (2015-03-27)
The synthesis of methylene blue (MB) encapsulated in silica nanoparticles (SiNPs) as an application for photodynamic therapy is reported in this study. Semi-rigid tissues with optical properties similar to that of human tissues were used as sample materials to determine
V Ryu et al.
Neuroscience, 167(4), 1227-1238 (2010-03-04)
Previous reports show that vagal afferent innervation of the stomach eventually regenerates from surviving nodose ganglion (NG) neurons after subdiaphragmatic vagotomy. Systemic capsaicin treatment destroys gastric vagal afferent neurons expressing vanilloid receptor 1 (VR1). However, it is not known whether
Chul-Su Yang et al.
Autophagy, 10(5), 785-802 (2014-03-07)
AMP-activated protein kinase (AMPK) is a crucial energy sensor and plays a key role in integration of cellular functions to maintain homeostasis. Despite this, it is largely unknown whether targeting the AMPK pathway can be used as a therapeutic strategy
F Rizzo et al.
Translational psychiatry, 7(8), e1189-e1189 (2017-08-02)
Attention deficit hyperactivity disorder (ADHD), Tourette syndrome (TS) as well as obsessive compulsive disorder (OCD) are co-occurring neurodevelopmental diseases that share alterations of frontocortical neurometabolites. In this longitudinal study we investigated the behavioral and neurochemical effects of aripiprazole and riluzole
Mingyu Pan et al.
Autophagy, 17(8), 1873-1888 (2020-08-04)
UXT (ubiquitously expressed prefoldin like chaperone), a small chaperone-like protein, is widely expressed in diverse human and mouse tissues and is more abundant in retina and kidney. However, the functional characterization of UXT at tissue level was largely unknown. Here
Taki Nishimura et al.
Molecular cell, 75(5), 1043-1057 (2019-08-14)
The plasma membrane (PM) is composed of a complex lipid mixture that forms heterogeneous membrane environments. Yet, how small-scale lipid organization controls physiological events at the PM remains largely unknown. Here, we show that ORP-related Osh lipid exchange proteins are
Karina M Lugo-Cintrón et al.
Lab on a chip, 20(9), 1586-1600 (2020-04-17)
Lymphatic vessels (LVs) have been suggested as a preferential conduit for metastatic progression in breast cancer, where a correlation between the occurrence of lymph node metastasis and an increased extracellular matrix (ECM) density has been reported. However, the effect of
R J Katz et al.
Pharmacology, biochemistry, and behavior, 5(4), 391-394 (1976-10-01)
Previous investigations of the effects of parachlorophenylalanine (PCPA) on affective attack have produced equivocal results. The present report examined the effects of PCPA upon attack elicited by electrical stimulation of the ventromedial hypothalamic nucleus in the cat. Using a within-animals
Sylvie L Lesuis et al.
Biological psychiatry, 90(7), 494-504 (2021-09-11)
Traumatic experiences, such as conditioned threat, are coded as enduring memories that are frequently subject to generalization, which is characterized by (re-) expression of fear in safe environments. However, the neurobiological mechanisms underlying threat generalization after a traumatic experience and
Maurizio Bettiga et al.
Biotechnology for biofuels, 1(1), 16-16 (2008-10-25)
Ethanolic fermentation of lignocellulosic biomass is a sustainable option for the production of bioethanol. This process would greatly benefit from recombinant Saccharomyces cerevisiae strains also able to ferment, besides the hexose sugar fraction, the pentose sugars, arabinose and xylose. Different
Audrey Bernut et al.
Cell reports, 26(7), 1828-1840 (2019-02-14)
Infection by rapidly growing Mycobacterium abscessus is increasingly prevalent in cystic fibrosis (CF), a genetic disease caused by a defective CF transmembrane conductance regulator (CFTR). However, the potential link between a dysfunctional CFTR and vulnerability to M. abscessus infection remains unknown.
Giulia Ronchi et al.
Neural regeneration research, 7(14), 1055-1063 (2012-05-15)
Stimulation of the vagus nerve has been previously reported to promote neural plasticity and neurogenesis in the brain. Several studies also revealed plastic changes in the spinal cord after injuries to somatosensory nerves originating from both the brachial and lumbo-sacral
Ran Tao et al.
BioMed research international, 2016, 4191938-4191938 (2016-09-20)
Polyprenol (GBP) from Ginkgo biloba Leaves (GBL) is an important lipid with many bioactive effects. The effect of GBP on antibacterial properties of five antibiotics belonging to different classes was through analysis of inhibition halos, MIC, and FIC index. And
Rafaela C Sartore et al.
PloS one, 6(6), e20667-e20667 (2011-06-16)
The existence of loss and gain of chromosomes, known as aneuploidy, has been previously described within the central nervous system. During development, at least one-third of neural progenitor cells (NPCs) are aneuploid. Notably, aneuploid NPCs may survive and functionally integrate
Severa Bunda et al.
Nature communications, 10(1), 661-661 (2019-02-10)
Capicua (CIC) is a transcriptional repressor that counteracts activation of genes downstream of receptor tyrosine kinase (RTK)/Ras/ERK signaling. It is well-established that tumorigenesis, especially in glioblastoma (GBM), is attributed to hyperactive RTK/Ras/ERK signaling. While CIC is mutated in other tumors
Jung-Feng Lin et al.
International journal of molecular sciences, 20(21) (2019-10-28)
Chronic renal failure involving hemodialysis results in blood loss during filtration. Iron deficiency and iron deficiency anemia can result. A compensatory increase in iron dosage has many side effects including discomfort. Elemental iron is a highly-pure iron source, which reduces
Emilie Viennois et al.
Cell reports, 33(1), 108229-108229 (2020-10-08)
Dietary emulsifiers carboxymethylcellulose (CMC) and polysorbate-80 (P80) disturb gut microbiota, promoting chronic inflammation. Mice with minimal microbiota are protected against emulsifiers' effects, leading us to hypothesize that these compounds might provoke select pathobionts to promote inflammation. Gnotobiotic wild-type (WT) and
Keisuke Yanagida et al.
Developmental cell, 52(6), 779-793 (2020-02-16)
Transcriptional mechanisms that drive angiogenesis and organotypic vascular endothelial cell specialization are poorly understood. Here, we show that retinal endothelial sphingosine 1-phosphate receptors (S1PRs), which restrain vascular endothelial growth factor (VEGF)-induced angiogenesis, spatially restrict expression of JunB, a member of
Christopher J Hansen et al.
Reproductive sciences (Thousand Oaks, Calif.) (2021-04-15)
A great need exists to develop tocolytic and uterotonic drugs that combat poor, labor-related maternal and fetal outcomes. A widely utilized method to assess novel compounds for their tocolytic and uterotonic efficacy is the isometric organ bath contractility assay. Unfortunately
Zandra Gerdes et al.
PloS one, 14(2), e0205378-e0205378 (2019-02-20)
The role of microplastic (MP) as a carrier of persistent organic pollutants (POPs) to aquatic organisms has been a topic of debate. However, the reverse POP transport can occur if relative contaminant concentrations are higher in the organism than in
Nayef Mazloum et al.
Biochemistry, 50(8), 1329-1335 (2011-01-18)
Bacterial DNA can be damaged by reactive nitrogen and oxygen intermediates (RNI and ROI) generated by host immunity, as well as by antibiotics that trigger bacterial production of ROI. Thus a pathogen's ability to repair its DNA may be important
Esther Visser et al.
Science advances, 6(19), eaax7060-eaax7060 (2020-06-05)
Alcohol use disorder is characterized by a high risk of relapse during periods of abstinence. Relapse is often triggered by retrieval of persistent alcohol memories upon exposure to alcohol-associated environmental cues, but little is known about the neuronal circuitry that
Chenran Wang et al.
The Journal of cell biology, 216(8), 2581-2596 (2017-06-22)
Recent studies have shown important roles for autophagy genes in the regulation of different tissue stem cells, including neural stem/progenitor cells (NSCs). However, little is known about whether autophagy can regulate NSCs through cell-extrinsic mechanisms. Here, we show that deletion
Hyun Yong Koh et al.
Nature medicine, 24(11), 1662-1668 (2018-09-19)
Pediatric brain tumors are highly associated with epileptic seizures1. However, their epileptogenic mechanisms remain unclear. Here, we show that the oncogenic BRAF somatic mutation p.Val600Glu (V600E) in developing neurons underlies intrinsic epileptogenicity in ganglioglioma, one of the leading causes of
Yunmee Lho et al.
International journal of molecular sciences, 22(9) (2021-05-06)
We investigated the effectiveness of the transforming growth factor beta-1 (TGF-β) receptor inhibitor GW788388 on the epithelial to mesenchymal transition (EMT) using human peritoneal mesothelial cells (HPMCs) and examined the effectiveness of GW788388 on the peritoneal membrane using a peritoneal
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