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Showing 1-30 of 274 results for "P21005" within Papers
Dmitriy I Dovzhanskiy et al.
Oncology research, 20(2-3), 103-111 (2012-12-01)
Histone deacetylase inhibitors are a new and promising drug family with a strong anticancer activity and potent modulation of connexin expression. The restoration of connexins in cancer cells has been suggested as a possible mechanism to control tumor progression. The
Mohammed Qaisiya et al.
Neuroscience letters, 661, 96-103 (2017-10-03)
Unconjugated bilirubin (UCB) neurotoxicity involves oxidative stress, calcium signaling and ER-stress. The same insults can also induce autophagy, a process of "self-eating", with both a pro-survival or a pro-apoptotic role. Our aim was to study the outcome of autophagy activation
Di Liu et al.
Biochemical and biophysical research communications, 494(1-2), 165-172 (2017-10-19)
Piperlongumine (PL), a natural alkaloid isolated from longer pepper plants, is recently found to be a potent selective anti-cancer compound. We first tested its anti-cancer effects on bladder cancer, the fifth most common and aggressive cancer worldwide, to further explore
Kévin Hardonnière et al.
Scientific reports, 6, 30776-30776 (2016-08-05)
Cancer cells display alterations in many cellular processes. One core hallmark of cancer is the Warburg effect which is a glycolytic reprogramming that allows cells to survive and proliferate. Although the contributions of environmental contaminants to cancer development are widely
Huahua Wang et al.
Clinical and experimental pharmacology & physiology, 50(10), 789-805 (2023-07-11)
Diosmetin-7-O-β-D-glucopyranoside (Diosmetin-7-O-glucoside) is a natural flavonoid glycoside known to have a therapeutic application for cardiovascular diseases. Cardiac fibrosis is the main pathological change in the end stage of cardiovascular diseases. Endothelial-mesenchymal transformation (EndMT) induced by endoplasmic reticulum stress (ER stress)
Xueyu Wang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(11), 14473-14489 (2020-09-07)
O-GlcNAcylation is a form of posttranslational modification, and serves various functions, including modulation of location, stability, and activity for the modified proteins. O-linked-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is an essential cellular enzyme that posttranslationally modifies the cellular proteins with O-GlcNAc moiety.
Yan-Ling Cui et al.
Life sciences, 222, 1-12 (2019-02-21)
Obesity is associated with increased cardiovascular morbidity and mortality. It is accompanied by augmented O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins via increasing hexosamine biosynthetic pathway (HBP) flux. However, the changes and regulation of the O-GlcNAc levels induced by obesity are
Gamze Bora-Tatar et al.
Bioorganic & medicinal chemistry, 17(14), 5219-5228 (2009-06-13)
In the light of known HDAC inhibitors, 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to develop the structure-activity relationships of carboxylic acid HDAC inhibitors. HDAC inhibition activities were
Gulab S Zode et al.
The Journal of clinical investigation, 124(5), 1956-1965 (2014-04-03)
Administration of glucocorticoids induces ocular hypertension in some patients. If untreated, these patients can develop a secondary glaucoma that resembles primary open-angle glaucoma (POAG). The underlying pathology of glucocorticoid-induced glaucoma is not fully understood, due in part to lack of
Yasir Alhamdi et al.
PLoS pathogens, 11(5), e1004836-e1004836 (2015-05-15)
Streptococcus pneumoniae accounts for more deaths worldwide than any other single pathogen through diverse disease manifestations including pneumonia, sepsis and meningitis. Life-threatening acute cardiac complications are more common in pneumococcal infection compared to other bacterial infections. Distinctively, these arise despite
Bohan Rong et al.
Journal of pineal research, 66(4), e12561-e12561 (2019-01-20)
Adipocyte-derived exosomes (Exos) serve as bioinformation-containing messengers in cell-to-cell communications, and numerous reports demonstrate that resistin, an adipokine, is strongly associated with hepatic steatosis and other fatty liver diseases, suggesting that adipose dysfunction-generated altered pattern of exosomal cytokines may contribute
Fateme Binayi et al.
Physiology & behavior, 231, 113312-113312 (2021-01-08)
This study assessed the effect of a chronic high-fat diet (HFD) on plasma and hippocampal insulin and corticosterone levels, the hippocampus insulin receptor amount, and spatial learning and memory with or without receiving 4-phenyl butyric acid (4-PBA) in male rats.
Ramya Ravi et al.
Life sciences, 246, 117397-117397 (2020-02-08)
Paraoxonase (PON), an antioxidant enzyme, comprises of three members (PON1, 2 and 3). Hyperglycemia accelerates formation of AGE in diabetes which mediates endothelial dysfunction. PON1 is studied in diabetes due to its association with HDL, lipid peroxidation and vascular complications
Supin Chompoopong et al.
Neuromolecular medicine, 18(3), 334-346 (2016-07-20)
The effects of germinated brown rice (GBR) on the motor deficits and the dopaminergic (DA) cell death were investigated in Parkinson's-like disease (PD) rats. Reactive oxidative species generated by chronic subcutaneous injection of rotenone (RT) lead to neuronal apoptosis particularly
Kineret Taler et al.
Cells, 12(21) (2023-11-10)
Cataract is the leading cause of blindness worldwide. It can be treated by surgery, whereby the damaged crystalline lens is replaced by a synthetic lens. Although cataract surgery is highly effective, a relatively common complication named posterior capsular opacification (PCO)
Luigia Cinque et al.
The Journal of clinical endocrinology and metabolism, 102(11), 3961-3969 (2017-09-25)
Familial isolated hypoparathyroidism (FIH) is a genetically heterogeneous disorder due to mutations of the calcium-sensing receptor (CASR), glial cells missing-2 (GCM2), guanine nucleotide binding protein α11 (GNA11), or parathyroid hormone (PTH) genes. Thus far, only four cases with homozygous and
Yong Wang et al.
Oncotarget, 8(44), 77685-77695 (2017-11-05)
Chronic bronchitis and emphysema are pathologic features of chronic obstructive pulmonary disease (COPD). Cigarette smoke (CS)-induced endoplasmic reticulum (ER) stress has been implicated in the COPD development, but the molecular mechanism by which it contributes to COPD etiology and the
Kyoungsub Song et al.
Hepatology (Baltimore, Md.), 58(5), 1681-1692 (2013-05-25)
MicroRNA-122 (miR-122), a pivotal liver-specific miRNA, has been implicated in several liver diseases including hepatocellular carcinoma (HCC) and hepatitis C and B viral infection. This study aimed to explore epigenetic regulation of miR-122 in human HCC cells and to examine
YuRong Fu et al.
Journal of dairy science, 102(11), 10543-10553 (2019-09-10)
Zearalenone (ZEA) is a common mycotoxin produced by fungi within the genus Fusarium. However, few studies have examined the direct effects of the toxin on the mammary glands. In the present study, the effects of ZEA treatment on bovine mammary
Qi Gao et al.
Circulation research (2012-10-11)
Apoptosis and fatty acid-binding protein-4 (FABP4) induced-endoplasmic reticulum (ER) stress in macrophage is an important pathological process in several vascular occlusive diseases, including atherosclerosis, both of which are accelerated by lipids or inflammatory cytokines. To determine whether interleukin 17A (IL-17A)
M Koyama et al.
Journal of pharmaceutical and biomedical analysis, 10(2-3), 137-140 (1992-02-01)
Anti-ubenimex antibody was produced by immunization of rabbits with ubenimex-bovine serum albumin (BSA) conjugate which was synthesized by coupling ubenimex directly to BSA using 1-ethyl-3-(3-dimethyl-aminopropyl)carbodiimide. The resulting antibody exhibited little cross-reactivity with p-hydroxyubenimex or (2S,3R)AHPA, (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid present in human
Qiong Liu et al.
Biochemical and biophysical research communications, 534, 995-1002 (2020-11-11)
Esophageal squamous cell carcinoma (ESCC) is a common type of human oral malignancy with poor survival. Presently, it is necessary to find new and effective drugs for clinical therapy. This study aimed to identify the potential anti-tumor effects of ACP-5862
Maddalena Ripamonti et al.
Frontiers in cellular neuroscience, 16, 878103-878103 (2022-07-06)
PKAN disease is caused by mutations in the PANK2 gene, encoding the mitochondrial enzyme pantothenate kinase 2, catalyzing the first and key reaction in Coenzyme A (CoA) biosynthetic process. This disorder is characterized by progressive neurodegeneration and excessive iron deposition
Weimin Yu et al.
Free radical biology & medicine, 164, 44-57 (2021-01-09)
Our previous findings have demonstrated the protective effect of endothelial Nox4-based NADPH oxidase on atherosclerosis. One of the possible mechanisms is the inhibition of soluble epoxide hydrolase (sEH), a proinflammatory and atherogenic factor. Our goal was to investigate whether in
Fangfang Wu et al.
Frontiers in pharmacology, 10, 406-406 (2019-05-21)
Traumatic brain injury (TBI) is one of the most common causes of neurological damage in young human populations. Vitamin B12 has been reported to promote axon growth of neuronal cells after peripheral nerve injury, which is currently used for the
Giovanna R Degasperi et al.
Metabolism: clinical and experimental, 58(8), 1087-1095 (2009-05-15)
Infiltrating macrophages play an important role in the production of inflammatory mediators by the adipose tissue of obese subjects. To reach the adipose tissue, peripheral monocytes are recruited by locally produced chemoattractants. However, little is known about the activation of
Hyun Jik Lee et al.
Redox biology, 13, 426-443 (2017-07-14)
Mitophagy under hypoxia is an important factor for maintaining and regulating stem cell functions. We previously demonstrated that fatty acid synthase (FASN) induced by hypoxia is a critical lipid metabolic factor determining the therapeutic efficacy of umbilical cord blood-derived human
Peng Chen et al.
FEBS open bio, 10(9), 1900-1911 (2020-08-14)
Drug-induced liver injury (DILI) can lead to acute liver failure, a lethal condition which may require liver transplantation. Hepatotoxicity associated with nonsteroidal anti-inflammatory drugs (NSAIDs) accounts for ~ 10% of all DILI. In the current study, we determined whether indomethacin, one
Mengling Li et al.
Redox biology, 36, 101632-101632 (2020-08-31)
Recent research suggests that melatonin (Mel), an endogenous hormone and natural supplement, possesses anti-proliferative effects and can sensitise cells to anti-cancer therapies. Although shikonin (SHK) also possesses potential anti-cancer properties, the poor solubility and severe systemic toxicity of this compound
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