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Showing 1-30 of 190 results for "P2443" within Papers
Graham M Burkart et al.
Molecular biology of the cell, 30(13), 1587-1597 (2019-04-25)
The microtubule-severing enzyme katanin (KTN1) regulates the organization and turnover of microtubule arrays by the localized breakdown of microtubule polymers. In land plants, KTN1 activity is essential for the formation of linearly organized cortical microtubule arrays that determine the axis
Jianan Shen et al.
Biomaterials, 34(5), 1581-1590 (2012-11-14)
The metastasis of breast cancer is the leading cause of cancer death in women, and the lung is a common location of a secondary tumor that has metastasized from the primary source tumor. In this work, an attempt to simultaneously
Ilia Zhernov et al.
Current biology : CB, 30(17), 3342-3351 (2020-07-11)
In addition to their force-generating motor domains, kinesin motor proteins feature various accessory domains enabling them to fulfill a variety of functions in the cell. Human kinesin-3, Kif14, localizes to the midbody of the mitotic spindle and is involved in
Sally Yunsun Kim et al.
Biomaterials, 267, 120480-120480 (2020-11-07)
Research into mechanisms underlying lung injury and subsequent repair responses is currently of paramount importance. There is a paucity of models that bridge the gap between in vitro and in vivo research. Such intermediate models are critical for researchers to
Janina R Lange et al.
Biophysical journal, 112(7), 1472-1480 (2017-04-14)
We describe a quantitative, high-precision, high-throughput method for measuring the mechanical properties of cells in suspension with a microfluidic device, and for relating cell mechanical responses to protein expression levels. Using a high-speed (750 fps) charge-coupled device camera, we measure
Irshad A Wani et al.
Colloids and surfaces. B, Biointerfaces, 101, 243-250 (2012-09-27)
Silver nanoparticles have been synthesized in the inverse microemulsions formed using three different surfactants viz., cetyl-trimethyl ammonium bromide (CTAB), Tergitol and Triton X-100. We have done a systematic study of the effect of the surfactants on the particle size and
Nopphadol Udomluck et al.
Biofabrication, 12(1), 015019-015019 (2019-11-30)
Differentiation of stem cells into chondrocytes has been studied for the engineering of cartilage tissue. However, stem cells cultured two-dimensionally have limited ability to differentiate into chondrocytes, which led to the development of three-dimensional culture systems. A recently developed microtechnological
Asmaa Fayed et al.
Journal of advanced veterinary and animal research, 8(1), 58-63 (2021-04-17)
This study assessed the effect of cellulose sheets fortified with Natamycin-loaded alginate nanoparticles on the growth of toxigenic Aspergillus flavus and aflatoxin production on the superficial layer of Egyptian Romy cheese after 12 weeks of maturation. Toxigenic A. flavus (GenBank
Peter Podhorec et al.
Animals : an open access journal from MDPI, 11(11) (2021-11-28)
Carp pituitary treatment versus poly (lactiac-co-glycolic acid) microparticles with slow release of Alarelin at 35 µg kg-1 or 200 µg kg-1 body weight to induce spermiation was compared in sterlet Acipenser ruthenus. All hormone treatments initially increased testosterone and 11-ketotestosterone
Flavia Mazzarda et al.
Lab on a chip, 20(16), 3011-3023 (2020-07-24)
Prior work supports the hypothesis that ATP release through connexin hemichannels drives spontaneous Ca2+ signaling in non-sensory cells of the greater epithelial ridge (GER) in the developing cochlea; however, direct proof is lacking. To address this issue, we plated cochlear
Annemarie Lüdecke et al.
Nature communications, 9(1), 2214-2214 (2018-06-09)
Form and function of the mitotic spindle depend on motor proteins that crosslink microtubules and move them relative to each other. Among these are kinesin-14s, such as Ncd, which interact with one microtubule via their non-processive motor domains and with
Francesco P Zummo et al.
Autophagy, 1-17 (2021-08-03)
Macroautophagy/autophagy is critical for the regulation of pancreatic β-cell mass and its deregulation has been implicated in the pathogenesis of type 2 diabetes (T2D). We have previously shown that treatment of pancreatic β-cells with the GLP1R (glucagon like peptide 1
Chueh-Yu Wu et al.
Advanced materials (Deerfield Beach, Fla.), 27(48), 7970-7978 (2015-10-29)
Microparticles with complex 3D shape and composition are produced using a novel fabrication method, optical transient liquid molding, in which a 2D light pattern exposes a photopolymer precursor stream shaped along the flow axis by software-aided inertial flow engineering.
Nikhlesh K Singh et al.
The Journal of biological chemistry, 292(34), 14080-14091 (2017-06-29)
Although the involvement of Rho proteins in the pathogenesis of vascular diseases is well studied, little is known about the role of their upstream regulators, the Rho guanine nucleotide exchange factors (RhoGEFs). Here, we sought to identify the RhoGEFs involved
James P K Armstrong et al.
Advanced healthcare materials, 5(14), 1724-1730 (2016-04-30)
3D tissue printing with adult stem cells is reported. A novel cell-containing multicomponent bioink is used in a two-step 3D printing process to engineer bone and cartilage architectures.
Alex Schudel et al.
Advanced healthcare materials, 4(10), 1484-1490 (2015-05-06)
A synthetic polymer nanoparticle formulation utilizing the physiological nitrosothiol chemistry for nitric oxide delivery is shown. Toxicity of S-nitroso nanoparticles against adult female Brugia malayi worms, which are responsible for lymphatic filariasis, is dependent on nitric oxide release through transnitrosation
Kideok Kim et al.
Biofabrication, 10(4), 045003-045003 (2018-08-04)
A cell spheroid culture has the benefit of simulating in vivo three-dimensional cell environments. Microwell systems have been developed to mass-produce large quantities of uniform spheroids, and are frequently used in research areas, such as cell biology, anticancer drug development
Peter Kip et al.
Journal of the American Heart Association, 9(22), e016391-e016391 (2020-11-05)
Background Failure rates after revascularization surgery remain high, both in vein grafts (VG) and arterial interventions. One promising approach to improve outcomes is endogenous upregulation of the gaseous transmitter-molecule hydrogen sulfide, via short-term dietary restriction. However, strict patient compliance stands
M Mavrakis et al.
Methods in cell biology, 136, 199-220 (2016-07-31)
Septins are guanine nucleotide-binding proteins that are conserved from fungi to humans. Septins assemble into heterooligomeric complexes and higher-order structures with key roles in various cellular functions including cell migration and division. The mechanisms by which septins assemble and interact
Matthew G Sorrells et al.
Micromachines, 11(1) (2020-01-18)
Collagen peptides are an alternative to animal derived collagens for platelet function studies under flow. The purpose of this study was to examine the use of collagen peptides in polydimethylsiloxane (PDMS) devices. Three collagen peptides with amino acid sequences and
Khaled M A Abdel-Raouf et al.
Biology, 10(6) (2021-07-03)
The development of robust skeletal muscle models has been challenging due to the partial recapitulation of human physiology and architecture. Reliable and innovative 3D skeletal muscle models recently described offer an alternative that more accurately captures the in vivo environment
Karren Dai Yang et al.
PLoS computational biology, 16(4), e1007828-e1007828 (2020-04-29)
Lineage tracing involves the identification of all ancestors and descendants of a given cell, and is an important tool for studying biological processes such as development and disease progression. However, in many settings, controlled time-course experiments are not feasible, for
Yu Cheng et al.
International journal of molecular sciences, 22(11) (2021-06-03)
The purpose of the current study was to analyze phenotypic and functional characteristics of common carp (Cyprinus carpio) spermatozoa during in vitro aging and to investigate whether global DNA methylation is affected by sperm aging. Milt was collected from five
P Guillamat et al.
Nature communications, 8(1), 564-564 (2017-09-17)
Active matter embraces systems that self-organize at different length and time scales, often exhibiting turbulent flows apparently deprived of spatiotemporal coherence. Here, we use a layer of a tubulin-based active gel to demonstrate that the geometry of active flows is
Alex Schudel et al.
Nature nanotechnology, 15(6), 491-499 (2020-06-12)
Therapeutic delivery selectively to lymph nodes has the potential to address a variety of unmet clinical needs. However, owing to the unique structure of the lymphatics and the size-restrictive nature of the lymph node reticular network, delivering cargo to specific
Carsten H Tischbirek et al.
Cell reports, 27(5), 1319-1326 (2019-05-03)
The cerebral cortex is organized in vertical columns that contain neurons with similar functions. The cellular micro-architecture of such columns is an essential determinant of brain dynamics and cortical information processing. However, a detailed understanding of columns is incomplete, even
Lucía Canclini et al.
FEBS letters, 594(14), 2311-2321 (2020-05-16)
The sorting of RNAs to specific regions of the cell for local translation represents an important mechanism directing protein distribution and cell compartmentalization. While significant progress has been made in understanding the mechanisms underlying the transport and localization of mRNAs
Elena E Grintsevich et al.
Nature communications, 12(1), 5542-5542 (2021-09-22)
Cellular events require the spatiotemporal interplay between actin assembly and actin disassembly. Yet, how different factors promote the integration of these two opposing processes is unclear. In particular, cellular monomeric (G)-actin is complexed with profilin, which inhibits spontaneous actin nucleation
Experimental composite guidance conduits for peripheral nerve repair: An evaluation of ion release
Zhang XF, et al.
Materials Science and Engineering, C, 32(6), 1654-1663 (2012)
Teagan E Bate et al.
Soft matter, 15(25), 5006-5016 (2019-06-06)
Self-organization of kinesin-driven, microtubule-based 3D active fluids relies on the collective dynamics of single microtubules. However, the connection between macroscopic fluid flows and microscopic motion of microtubules remains unclear. In this work, the motion of single microtubules was characterized by
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