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Showing 1-30 of 118 results for "P3143" within Papers
Laura Mayne et al.
ACS nano, 12(5), 4844-4852 (2018-05-03)
Aptamer-modified nanomaterials provide a simple, yet powerful sensing platform when combined with resistive pulse sensing technologies. Aptamers adopt a more stable tertiary structure in the presence of a target analyte, which results in a change in charge density and velocity
Kang Wang et al.
Science advances, 7(8) (2021-02-19)
An R loop is a unique triple-stranded structure that participates in multiple key biological processes and is relevant to human diseases. Accurate and comprehensive R loop profiling is a prerequisite for R loops studies. However, current R loop mapping methods
Luis Pinzon-Herrera et al.
Journal of materials chemistry. B, 8(38), 8809-8819 (2020-08-29)
In this work, we evaluate the enhancing effect of six bilayers of heparin/collagen (HEP/COL)6 layer-by-layer coatings on human Schwann cell (hSCs) adhesion and proliferation in the presence or absence of nerve growth factor (NGF). hSCs behavior and in vitro bioactivity
Šlena V Mitroshina et al.
Oxidative medicine and cellular longevity, 2019, 1036907-1036907 (2019-12-13)
Glial cell line-derived neurotrophic factor (GDNF) has a pronounced neuroprotective effect in various nervous system pathologies, including ischaemic brain damage and neurodegenerative diseases. In this work, we studied the effect of GDNF on the ultrastructure and functional activity of neuron-glial
Hayder Amin et al.
Frontiers in neuroscience, 10, 121-121 (2016-04-12)
The recent availability of human induced pluripotent stem cells (hiPSCs) holds great promise as a novel source of human-derived neurons for cell and tissue therapies as well as for in vitro drug screenings that might replace the use of animal
Maria Savyuk et al.
Antioxidants (Basel, Switzerland), 9(8) (2020-07-30)
A novel potent analog of the branched tail oxyquinoline group of hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors, neuradapt, has been studied in two treatment regimes in an in vitro hypoxia model on murine primary hippocampal cultures. Neuradapt activates the expression
Brenton C Peters et al.
Heliyon, 5(8), e02277-e02277 (2019-08-24)
Various pesticide nanocarriers have been developed. However, their pest-control applications remain limited in laboratories. Herein, we developed silica nanocapsules encapsulating fipronil (SNC) and their engineered form, poly(ethyleneimine)-coated SNC (SNC-PEI), based on recombinant catalytic modular protein D4S2 and used them against
Maria Vedunova et al.
Frontiers in cellular neuroscience, 7, 149-149 (2013-09-26)
The extracellular matrix (ECM) plays an important role in use-dependent synaptic plasticity. Hyaluronic acid (HA) is the backbone of the neural ECM, which has been shown to modulate Ī±-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate (AMPA) receptor mobility, paired-pulse depression, L-type voltage-dependent Ca(2+) channel (L-VDCC) activity
Aurore Schneider et al.
Langmuir : the ACS journal of surfaces and colloids, 23(5), 2655-2662 (2007-02-21)
Hyaluronan is a polysaccharide that is increasingly investigated for its role in cellular adhesion and for the preparation of biomimetic matrices for tissue engineering. Hyaluronan gels are prepared for application as space fillers, whereas hyaluronan films are usually obtained by
Alexey Pimashkin et al.
Frontiers in computational neuroscience, 5, 46-46 (2011-11-17)
Dense dissociated hippocampal cultures are known to generate spontaneous bursting electrical activity which can be recorded by multielectrode arrays. We have analyzed spatio-temporal profiles of the distribution of spikes in the bursts recorded after 2āweeks in vitro. We have found
Nathaniel Safren et al.
The Journal of biological chemistry, 297(3), 101003-101003 (2021-07-26)
Autophagy is an evolutionarily conserved pathway mediating the breakdown of cellular proteins and organelles. Emphasizing its pivotal nature, autophagy dysfunction contributes to many diseases; nevertheless, development of effective autophagy modulating drugs is hampered by fundamental deficiencies in available methods for
Nesha May Octavio Andoy et al.
Microorganisms, 9(10) (2021-10-24)
Interactions between a widely used polycationic polymer, polyethyleneimine (PEI), and a Gram-negative bacteria, E. coli, are investigated using atomic force microscopy (AFM) quantitative imaging. The effect of PEI, a known membrane permeabilizer, is characterized by probing both the structure and
Reinhard David et al.
The European journal of neuroscience, 31(6), 978-993 (2010-04-10)
Nicotinic acetylcholine receptors (nAChRs) mediate fast synaptic transmission in ganglia of the autonomic nervous system. Here, we determined the subunit composition of hetero-pentameric nAChRs in the mouse superior cervical ganglion (SCG), the function of distinct receptors (obtained by deletions of
Jerome Pine et al.
IEEE transactions on bio-medical engineering, 56(4), 1184-1188 (2009-03-11)
The use of an optical tweezer for moving dissociated neurons was studied. The main features of the tweezers are outlined as well as the general principles of its operation. Infrared beams at 980 and 1064 nm were used, focused so
Tali Mass et al.
Current biology : CB, 27(20), 3191-3196 (2017-10-17)
Calcium carbonate platforms produced by reef-building stony corals over geologic time are pervasive features around the world [1]; however, the mechanism by which these organisms produce the mineral is poorly understood (see review by [2]). It is generally assumed that
Carl M Sellgren et al.
Nature neuroscience, 22(3), 374-385 (2019-02-06)
Synapse density is reduced in postmortem cortical tissue from schizophrenia patients, which is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of microglia-mediated synapse engulfment, we demonstrate increased synapse elimination in patient-derived neural cultures and isolated synaptosomes.
Manuele Castelnuovo et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(10), 4033-4046 (2010-06-29)
Neuroblastoma (NB) is a pediatric cancer characterized by remarkable cell heterogeneity within the tumor nodules. Here, we demonstrate that the synthesis of a pol III-transcribed noncoding (nc) RNA (NDM29) strongly restricts NB development by promoting cell differentiation, a drop of
Dimitri E Grigoriadis et al.
The Journal of pharmacology and experimental therapeutics, 361(3), 454-461 (2017-04-14)
The vesicular monoamine transporter 2 (VMAT2) is an integral presynaptic protein that regulates the packaging and subsequent release of dopamine and other monoamines from neuronal vesicles into the synapse. Valbenazine (NBI-98854), a novel compound that selectively inhibits VMAT2, is approved
Rina Fujiwara et al.
Methods (San Diego, Calif.), 159-160, 82-89 (2019-03-25)
Transcription initiation can be reconstituted from highly purified general transcription factors (GTFs), RNA polymerase II (pol II), and promoter DNA. However, earlier biochemical reconstitution systems had a serious technical limitation, namely very poor initiation efficiency. Due to the poor efficiency
Kai O Bƶker et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 26(2), 634-647 (2017-12-10)
Efficient transduction tools are a hallmark for both research and therapy development. Here, we introduce new insights into the generation of lentiviral vectors with improved performance by utilizing producer cells with increased production rates of extracellular vesicles through CD9 overexpression.
Mauricio Dos-Santos-Pereira et al.
Glia, 68(3), 561-573 (2019-10-28)
We used mouse microglial cells in culture activated by lipopolysaccharide (LPS, 10 ng/ml) to study the anti-inflammatory potential of cannabidiol (CBD), the major nonpsychoactive component of cannabis. Under LPS stimulation, CBD (1-10 Ī¼M) potently inhibited the release of prototypical proinflammatory
Sergei Svarovsky et al.
BioTechniques, 45(5), 535-540 (2008-11-15)
Here we report preparation and properties of positively charged gold microparticles, and their use for biolistic DNA delivery. Micron-sized gold microparticles were modified by building self-assembling polyethylenimine monolayers on their surfaces, which enabled their electrostatic interaction with negatively charged molecules
Arne Herring et al.
Brain pathology (Zurich, Switzerland), 20(1), 166-175 (2009-01-13)
Oxidative stress is a key feature during progression of chronic neurodegenerative conditions such as Alzheimer's disease. In aging humans and animals, voluntary exercise lowers oxidative stress reactions. Additionally, recent work in our lab demonstrated that cognitive and physical stimulation (termed
Liangqi Xie et al.
Nature methods, 17(4), 430-436 (2020-03-24)
To image the accessible genome at nanometer scale in situ, we developed three-dimensional assay for transposase-accessible chromatin-photoactivated localization microscopy (3D ATAC-PALM) that integrates an assay for transposase-accessible chromatin with visualization, PALM super-resolution imaging and lattice light-sheet microscopy. Multiplexed with oligopaint
Martina HolubovĆ” et al.
The Journal of pharmacology and experimental therapeutics, 366(3), 422-432 (2018-06-20)
Ghrelin, the only known orexigenic gut hormone produced primarily in the stomach, has lately gained attention as a potential treatment of anorexia and cachexia. However, its biologic stability is highly limited; therefore, a number of both peptide and nonpeptide ghrelin
David Wegrzyn et al.
Frontiers in synaptic neuroscience, 13, 637549-637549 (2021-03-13)
Perineuronal nets (PNNs) are specialized, reticular structures of the extracellular matrix (ECM) that can be found covering the soma and proximal dendrites of a neuronal subpopulation. Recent studies have shown that PNNs can highly influence synaptic plasticity and are disrupted
Alec R Nickolls et al.
Cell reports, 30(3), 932-946 (2020-01-23)
Efficient and homogeneous inĀ vitro generation of peripheral sensory neurons may provide a framework for novel drug screening platforms and disease models of touch and pain. We discover that, by overexpressing NGN2 and BRN3A, human pluripotent stem cells can be transcriptionally
Xiao-Yan Zhao et al.
Molecular pain, 5, 55-55 (2009-09-24)
Pain is known to be processed by a complex neural network (neuromatrix) in the brain. It is hypothesized that under pathological state, persistent or chronic pain can affect various higher brain functions through ascending pathways, leading to co-morbidities or mental
Allyson L Mayer et al.
Scientific reports, 6, 38586-38586 (2016-12-07)
Trehalose is a disaccharide demonstrated to mitigate disease burden in multiple murine neurodegenerative models. We recently revealed that trehalose rapidly induces hepatic autophagy and abrogates hepatic steatosis by inhibiting hexose transport via the SLC2A family of facilitative transporters. Prior studies
Micro-nano structure poly (ether sulfones)/poly (ethyleneimine) nanofibrous affinity membranes for adsorption of anionic dyes and heavy metal ions in aqueous solution
Min M, et al.
Chemical Engineering Journal, 197, 88-100 (2012)
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