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Showing 1-30 of 75 results for "P3300" within Papers
Arnaud Hecker et al.
FEBS letters, 535(1-3), 49-54 (2003-02-01)
Orchestia cavimana is a terrestrial crustacean, which cyclically stores calcium in diverticula of the midgut, in the form of calcified amorphous concretions. These concretions are associated with a proteinaceous matrix, the main constituent of the soluble matrix is Orchestin, an
Epidermal Growth Factor Receptor Down-Regulation Triggers Human Myoblast Differentiation
Leroy MC, et al.
PLoS ONE, 8(8), e71770-e71770 (2013)
P G Drake et al.
Endocrinology, 137(11), 4960-4968 (1996-11-01)
Upon insulin binding, a conformational change in the insulin receptor (IR) leads to IR beta-subunit autophosphorylation, an increase in IR beta-subunit exogenous tyrosine kinase activity, and the rapid endocytosis of the ligand-receptor complex into endosomes. Previous work has shown that
Ojas Deshpande et al.
PLoS genetics, 16(9), e1009017-e1009017 (2020-09-15)
Interpreting rare variants remains a challenge in personal genomics, especially for disorders with several causal genes and for genes that cause multiple disorders. ZNF423 encodes a transcriptional regulatory protein that intersects several developmental pathways. ZNF423 has been implicated in rare
S V Kotenko et al.
The Journal of biological chemistry, 271(29), 17174-17182 (1996-07-19)
Each cytokine which utilizes the Jak-Stat signal transduction pathway activates a distinct combination of members of the Jak and Stat families. Thus, either the Jaks, the Stats, or both could contribute to the specificity of ligand action. With the use
Robert T Davidson et al.
American journal of physiology. Endocrinology and metabolism, 282(2), E270-E276 (2002-01-15)
Skeletal muscle insulin sensitivity improves with a moderate reduction in caloric intake. We studied possible mechanisms in calorie-restricted [CR: 60% ad libitum (AL) intake] compared with AL rats, utilizing a time-matched feeding protocol (3, 5, 10, or 20 days). Visceral
E Hölttä et al.
The Journal of cell biology, 122(4), 903-914 (1993-08-01)
Ornithine decarboxylase (ODC), the key enzyme of polyamine biosynthesis, becomes upregulated during cell proliferation and transformation. Here we show that intact ODC activity is needed for the acquisition of a transformed phenotype in rat 2R cells infected with a temperature-sensitive
M Stalder et al.
The American journal of pathology, 154(6), 1673-1684 (1999-06-11)
Microglia are a key component of the inflammatory response in the brain and are associated with senile plaques in Alzheimer's disease (AD). Although there is evidence that microglial activation is important for the pathogenesis of AD, the role of microglia
Hamze Beati et al.
The Journal of cell biology, 217(3), 1079-1095 (2018-01-24)
In epithelia, cells adhere to each other in a dynamic fashion, allowing the cells to change their shape and move along each other during morphogenesis. The regulation of adhesion occurs at the belt-shaped adherens junction, the zonula adherens (ZA). Formation
H Reuveni et al.
The Journal of cell biology, 151(6), 1179-1192 (2000-12-21)
We have used the selective farnesylation inhibitor HR12 [cysteine-N(methyl)valine-N(cyclohexyl) glycine-methionine-O-methyl-ester] to study the role of oncogenic Ras in cytoskeletal reorganization in Ha-ras(V12)-transformed Rat1 cells (Rat1/ras). Application of HR12 resulted in complete restoration of the cytoskeleton and associated cell adhesions disrupted
Stefanie Margraf et al.
Immunology, 146(3), 392-400 (2015-07-30)
Signalling lymphocyte activation molecule (SLAM) family members regulate activation and inhibition in the innate and adaptive immune systems. Genome-wide association studies identified their genetic locus (1q23) as highly polymorphic and associated with susceptibility to systemic lupus erythematosus (SLE). Here we
Donald Fraser et al.
The American journal of pathology, 163(6), 2565-2574 (2003-11-25)
We have recently reported increased transforming growth factor (TGF)-beta1 gene transcription in proximal tubular cells within 12 hours of exposure to 25 mmol/L D-glucose, with a requirement for a second stimulus such as platelet-derived growth factor (PDGF) to increase its
S V Kotenko et al.
The Journal of biological chemistry, 270(36), 20915-20921 (1995-09-08)
Interferon gamma (IFN-gamma) signals through a multimeric receptor complex consisting of two different chains: the IFN-gamma receptor binding subunit (IFN-gamma R, IFN-gamma R1), and a transmembrane accessory factor (AF-1, IFN-gamma R2) necessary for signal transduction. Using cell lines expressing different
T R Cimato et al.
The Journal of cell biology, 138(5), 1089-1103 (1997-09-08)
Protein methylation is a posttranslational modification that can potentially regulate signal transduction pathways in a similar manner as protein phosphorylation. The role of protein methylation in NGF signaling was examined by metabolic labeling of PC12 cell proteins with L-[methyl-3H]methionine and
Suresh Mishra et al.
The Journal of biological chemistry, 282(25), 18108-18115 (2007-05-05)
Transglutaminase 2 (TG2, tissue transglutaminase) is a multifunctional protein involved in cross-linking a variety of proteins, including retinoblastoma protein (Rb). Here we show that Rb is also a substrate for the recently identified serine/threonine kinase activity of TG2 and that
Chiara Toniolo et al.
The Journal of biological chemistry, 290(15), 9521-9532 (2015-02-11)
The production of capsular polysaccharides (CPS) or secreted exopolysaccharides is ubiquitous in bacteria, and the Wzy pathway constitutes a prototypical mechanism to produce these structures. Despite the differences in polysaccharide composition among species, a group of proteins involved in this
Antonio Facchiano et al.
The Journal of biological chemistry, 278(10), 8751-8760 (2002-12-24)
Fibroblast growth factor 2 (FGF-2) is a potent factor modulating the activity of many cell types. Its dimerization and binding to high affinity receptors are considered to be necessary steps to induce FGF receptor phosphorylation and signaling activation. A structural
Sachin Katyal et al.
PloS one, 6(12), e28579-e28579 (2011-12-14)
The Reelin-Dab1 signaling pathway plays a critical role in the positioning of migrating neurons, dendrite formation and lamination in the developing central nervous system. We have previously identified two alternatively spliced forms of Dab1 in the developing chick retina: an
Frances Evans et al.
BioMed research international, 2021, 2641068-2641068 (2021-11-02)
Gramicidin is a thoroughly studied cation ionophore widely used to experimentally manipulate the plasma membrane potential (PMP). In addition, it has been established that the drug, due to its hydrophobic nature, is capable of affecting the organization of membrane lipids.
I Noda et al.
International journal of cancer, 80(1), 78-84 (1999-02-06)
Granulocyte-colony-stimulating factor (G-CSF), a hematopoietic cytokine, regulates the proliferation and differentiation of granulocytic progenitor cells and functionally activated mature neutrophils. G-CSF also affects nonhematopoietic tumor cells by the binding of G-CSF to its specific receptor (G-CSFR) on the cells. In
Giacomo Tampella et al.
Journal of immunology (Baltimore, Md. : 1950), 195(1), 246-256 (2015-05-31)
Previous work has shown conflicting roles for Tec family kinases in regulation of TLR-dependent signaling in myeloid cells. In the present study, we performed a detailed investigation of the role of the Tec kinases Btk and Tec kinases in regulating
K Matsui et al.
FEMS immunology and medical microbiology, 12(1), 51-53 (1995-09-01)
In a previous study, we observed that suppression of T-cell proliferation induced by Salmonella infection is associated with inhibition of tyrosine phosphorylation in T-cells, and that a cell-free Salmonella typhimurium LT2 extract (LT2 extract) also suppressed mitogen-induced T-cell proliferation. In
Masakatsu Fujinoki et al.
Reproductive medicine and biology, 5(2), 123-135 (2006-05-19)
Background and Aims:  It has been widely accepted that sperm hyperactivation is regulated by protein phosphorylations. But, the sperm hyperactivation phosphorylation pathway is not well understood yet because several different proteins have been detected in other studies. In order to
David Nakar et al.
Journal of bacteriology, 185(3), 1001-1009 (2003-01-21)
The genes associated with the biosynthesis of the polymeric bioemulsifier emulsan, produced by the oil-degrading Acinetobacter lwoffii RAG-1 are clustered within a 27-kbp region termed the wee cluster. This report demonstrates the involvement of two genes of the wee cluster
L Castellani et al.
The Journal of cell biology, 130(4), 871-885 (1995-08-01)
We have used quail skeletal myotubes expressing a temperature-sensitive allele of the v-src oncogene to address the issue of the homeostasis of sarcomeric myofibrils in differentiated muscle cells. Reactivation of the v-Src tyrosine kinase by shifting the cultures to the
T C Yeh et al.
The Journal of biological chemistry, 271(6), 2921-2928 (1996-02-09)
A monoclonal antibody has been produced which immunoprecipitates 58- and 53-kDa proteins which are rapidly tyrosine phosphorylated in insulin-treated cells. These proteins can also be tyrosine phosphorylated in vitro by the isolated human insulin receptor. Increased tyrosine phosphorylation of these
Sachin Katyal et al.
The EMBO journal, 23(8), 1878-1888 (2004-04-02)
The Reelin-Disabled 1 (Dab1)-signaling pathway plays a critical role in neuronal cell positioning in the brain. We have isolated two alternatively spliced variants of Dab1 from chick retina, an early form (chDab1-E) expressed in undifferentiated cells and a late form
Insertional oncogenesis by non-acute retroviruses: implications for gene therapy
Fan H and Johnson C
Viruses, 3(4), 398-422 (2011)
Alexander Kettner et al.
The Journal of experimental medicine, 199(3), 357-368 (2004-02-06)
Wiskott-Aldrich syndrome protein-interacting protein (WIP) stabilizes actin filaments and is important for immunoreceptor-mediated signal transduction leading to actin cytoskeleton rearrangement in T and B cells. Here we report a role for WIP in signaling pathways downstream of the high affinity
Iwona Wierzbicka-Patynowski et al.
The Journal of biological chemistry, 277(22), 19703-19708 (2002-03-26)
Fibronectin (FN) matrix assembly is a tightly regulated stepwise process that is initiated by interactions between FN and cell surface integrin receptors. These interactions activate many intracellular signaling pathways that regulate processes such as cell adhesion, migration, and survival. Here
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