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Showing 1-30 of 158 results for "P3504" within Papers
Tae Hoon Kwon et al.
Molecules and cells, 38(7), 616-623 (2015-05-28)
P2 receptors are membrane-bound receptors for extracellular nucleotides such as ATP and UTP. P2 receptors have been classified as ligand-gated ion channels or P2X receptors and G protein-coupled P2Y receptors. Recently, purinergic signaling has begun to attract attention as a
David Blum et al.
eLife, 3 (2014-12-11)
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012. This Registered Report describes the proposed replication plan
R B DeMattos et al.
Journal of lipid research, 42(6), 976-987 (2001-05-23)
Susceptibility to the development of late-onset Alzheimer's disease is increased for individuals harboring one or more apolipoprotein E4 (apoE4) alleles. Although several isoform-specific effects of apoE have been identified, the relationship between biochemical function and risk factor assessment is unknown.
Quantifying protein in cerebrospinal fluid and urine: success achieved.
Michael A Pesce
Clinical chemistry, 54(4), 770-770 (2008-04-01)
Benjamin N Philip et al.
The Journal of experimental biology, 211(Pt 7), 1114-1119 (2008-03-18)
Survival of freezing not only requires organisms to tolerate ice formation within their body, but also depends on the rapid redistribution of water and cryoprotective compounds between intra- and extracellular compartments. Aquaporins are transmembrane proteins that serve as the major
Katie L Bidne et al.
Journal of animal science, 97(10), 4314-4322 (2019-08-03)
Heat stress (HS) occurs when heat dissipation mechanisms are insufficient to maintain euthermia, and it is associated with seasonal infertility (SI), which manifests as smaller litters, longer wean-to-estrus interval, increased abortions, and reduced conception rates. To understand HS-induced mechanisms underlying
Hanan Hafez Omar
Pakistan journal of biological sciences : PJBS, 11(10), 1310-1316 (2008-09-27)
This study is to inspect how the variation of molecular structures and functional groups present in our models, monoazo dye (Tartrazine) and diazo dye (Ponceau), affects decolorization capabilities of green algae, cyanobacteria and diatoms. The results revealed that the removal
Atlante S Mendes et al.
Life sciences, 244, 117153-117153 (2019-12-13)
Increased activity of calpain-1 and matrix metalloproteinase (MMP)-2 was observed in different models of arterial hypertension and contribute to thicken the left ventricle (LV) walls and to hypertrophy cardiac myocytes. MMP-2 activity may be regulated by calpain-1 via bioactive molecules
P Grundtner et al.
Genes and immunity, 10(1), 84-92 (2008-09-19)
Genetic predisposition is a risk factor for the development of inflammatory bowel diseases (IBDs). Disruption of the interleukin (IL)-10 pathway in mice causes intestinal inflammation similar to human IBD. Two common non-synonymous IL-10R1 variants, S138G and G330R, were cloned and
Youji Shimazaki et al.
Protein and peptide letters, 17(8), 1048-1052 (2010-04-17)
Mouse liver cytosolic malate dehydrogenase was separated by non-denaturing two-dimensional electrophoresis and identified. Furthermore, the activity of the enzyme was preserved even after separation, electroblotting onto a membrane and staining with Ponceau S in acidic buffer solution (pH 5.1). Using
Elena B Burova et al.
Cell cycle (Georgetown, Tex.), 10(13), 2197-2205 (2011-05-25)
Interferon gamma (IFNγ) has been demonstrated to inhibit tumor growth in vivo as well as proliferation of multiple types of cultured transformed cells. In this study, we showed that IFNγ promoted progressive death in A431 cells, overexpressing EGF receptor (EGFR).
Tomáš Dráb et al.
Electrophoresis, 32(24), 3597-3599 (2011-12-20)
A new type of native electrophoresis was developed to separate and characterize proteins. In this modification of the native blue electrophoresis, the dye Ponceau Red S is used instead of Coomassie Brilliant Blue to impose uniform negative charge on proteins
Monique Bernard et al.
Cancers, 12(9) (2020-08-23)
Genomic analyses of head and neck squamous cell carcinoma (HNSCC) have highlighted alterations in the phosphatidylinositol 3-kinase (PI3K) signaling pathway, presenting a therapeutic target for multiple ongoing clinical trials with PI3K or PI3K/MTOR inhibitors. However, these inhibitors can potentially increase
Senthil T Kumar et al.
Neurobiology of disease, 146, 105086-105086 (2020-09-25)
Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation, and may also accumulate within LBs in Parkinson's disease (PD) and other synucleinopathies. Therefore, the development of tools
Patricia Rouet-Benzineb et al.
Physiological reports, 6(21), e13912-e13912 (2018-11-16)
We investigated the potential adverse effects of hyperaldosteronism and/or hypoestrogenism on cardiac phenotype, and examined their combined effects in female mice overexpressing cardiac aldosterone synthase (AS). We focused on some signaling cascades challenging defensive responses to adapt and/or to survive
Michael A Bellio et al.
Scientific reports, 7(1), 9702-9702 (2017-08-31)
Cardiac progenitor cells (CPCs) have been shown to promote cardiac regeneration and improve heart function. However, evidence suggests that their regenerative capacity may be limited in conditions of severe hypoxia. Elucidating the mechanisms involved in CPC protection against hypoxic stress
S R Gallagher et al.
Current protocols in cell biology, Chapter 6, Unit 6-Unit 6 (2008-01-30)
This unit provides protocols for immunoblotting, which is used to identify specific protein sequences separated by electrophoresis and transferred to an appropriate membrane and recognized by a polyclonal or monoclonal antibody. After the proteins are separated on a gel, they
Julia Oyrer et al.
Frontiers in molecular neuroscience, 12, 211-211 (2019-09-27)
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels carry a non-selective cationic conductance, I h , which is important for modulating neuron excitability. Four genes (HCN1-4) encode HCN channels, with each gene having distinct expression and biophysical profiles. Here we use multiplex nucleic
Todd R Heallen et al.
Developmental cell, 15(4), 603-616 (2008-10-16)
The Aurora B kinase is the enzymatic core of the chromosomal passenger complex, which is a critical regulator of mitosis. To identify novel regulators of Aurora B, we performed a genome-wide screen for suppressors of a temperature-sensitive lethal allele of
Claudia Rehwald et al.
British journal of cancer, 122(3), 421-433 (2019-11-28)
We aimed at clarifying the role of lipocalin-2 (LCN-2) in clear-cell renal cell carcinoma (ccRCC). Since LCN-2 was recently identified as a novel iron transporter, we explored its iron load as a decisive factor in conferring its biological function. LCN-2
Jie Wang et al.
Frontiers in immunology, 10, 152-152 (2019-02-23)
The objective of this study was to evaluate the suitability of the rainbow trout intestinal epithelial cell line (RTgutGC) as an in vitro model for studies of gut immune function and effects of functional feed ingredients. Effects of lipopolysaccharide (LPS)
Garrett S Gibbons et al.
Journal of neuropathology and experimental neurology, 77(3), 216-228 (2018-02-08)
Aggregation of tau into fibrillar structures within the CNS is a pathological hallmark of a clinically heterogeneous set of neurodegenerative diseases termed tauopathies. Unique misfolded conformations of tau, referred to as strains, are hypothesized to underlie the distinct neuroanatomical and
Orsolya Polgar et al.
Molecular and cellular biochemistry, 322(1-2), 63-71 (2008-11-13)
ABCG2 is a half-transporter initially described in multidrug-resistant cancer cells and lately identified as an important factor in the pharmacokinetics of its substrates. Q141K is by far the most intensively studied single nucleotide polymorphism of ABCG2 with potential clinical relevance.
Domenico Azarnia Tehran et al.
Bio-protocol, 8(13), e2918-e2918 (2018-07-05)
Cerebellar Granule Neurons (CGN) from post-natal rodents have been widely used as a model to study neuronal development, physiology and pathology. CGN cultured in vitro maintain the same features displayed in vivo by mature cerebellar granule cells, including the development
Jack D Sanford et al.
BMC molecular and cell biology, 22(1), 46-46 (2021-09-24)
MDM2 is an E3 ubiquitin ligase that is able to ubiquitinate p53, targeting it for proteasomal degradation. Its homologue MDMX does not have innate E3 activity, but is able to dimerize with MDM2. Although mouse models have demonstrated both MDM2
Abhijeet Deshmukh et al.
Cancers, 10(2) (2018-02-01)
Tumours contain a small number of treatment-resistant cancer stem cells (CSCs), and it is through these that tumour regrowth originates at secondary sites, thus rendering CSCs an attractive target for treatment. Cancer cells adapt cellular metabolism for aggressive proliferation. Tumour
Mads Skytte Rasmussen et al.
Methods in molecular biology (Clifton, N.J.), 1880, 149-161 (2019-01-06)
The mammalian ATG8 proteins (LC3A-C/GABARAP, GABARAPL1, and GABARAPL2) are small ubiquitin-like proteins critically involved in macroautophagy. Their processed C-termini are posttranslationally conjugated to a phosphatidylethanolamine moiety, enabling their insertion into the lipid bilayers of both the inner and outer membranes
Victor A Lopez et al.
Cell, 179(1), 205-218 (2019-09-17)
The molecular chaperone HSP90 facilitates the folding of several client proteins, including innate immune receptors and protein kinases. HSP90 is an essential component of plant and animal immunity, yet pathogenic strategies that directly target the chaperone have not been described.
Tomasz A Bonda et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 74(2), 176-182 (2018-05-03)
Interleukin 6 (IL6) and p53 are linked by mutual regulatory mechanisms and are both upregulated in aging. The aim of this study was to evaluate the effects of aging and IL6 on expression of p53 in the mouse heart. Male
Gerhard Leinenga et al.
Science translational medicine, 7(278), 278ra33-278ra33 (2015-03-13)
Amyloid-β (Aβ) peptide has been implicated in the pathogenesis of Alzheimer's disease (AD). We present a nonpharmacological approach for removing Aβ and restoring memory function in a mouse model of AD in which Aβ is deposited in the brain. We
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