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Showing 1-30 of 144 results for "P3655" within Papers
Jillian Belgrad et al.
Glia, 67(11), 2107-2124 (2019-07-25)
Low level sarin nerve gas and other anti-cholinesterase agents have been implicated in Gulf War illness (GWI), a chronic multi-symptom disorder characterized by cognitive, pain and fatigue symptoms that continues to afflict roughly 32% of veterans from the 1990-1991 Gulf
Gustav Y Cederquist et al.
Cell stem cell, 27(1), 35-49 (2020-07-04)
Autism is a clinically heterogeneous neurodevelopmental disorder characterized by impaired social interactions, restricted interests, and repetitive behaviors. Despite significant advances in the genetics of autism, understanding how genetic changes perturb brain development and affect clinical symptoms remains elusive. Here, we
Philipp Pottmeier et al.
Stem cells and development, 29(23), 1497-1509 (2020-10-13)
Human neural stem cells (hNSCs) have long been used as an in vitro model to study neurogenesis and as candidates for nervous system therapy. Many parameters have been considered when evaluating the success of transplantation, but sex of donor and
Anna L Hillberg et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 101(2), 258-268 (2012-11-21)
DIABECELL® capsules comprise an inner core of alginate (Alg) coated with a polycationic polymer, poly-L-ornithine (PLO), designed as a stabilizing agent for strengthening the capsule wall, which is masked by an outer layer of biocompatible Alg. These polymeric microcapsules have
Omaditya Khanna et al.
Journal of visualized experiments : JoVE, (66)(66), doi:10-doi:10 (2012-08-22)
Alginate-based materials have received considerable attention for biomedical applications because of their hydrophilic nature, biocompatibility, and physical architecture. Applications include cell encapsulation, drug delivery, stem cell culture, and tissue engineering scaffolds. In fact, clinical trials are currently being performed in
Henrik Ring et al.
PloS one, 7(5), e36874-e36874 (2012-05-17)
GABA is more than the main inhibitory neurotransmitter found in the adult CNS. Several studies have shown that GABA regulates the proliferation of progenitor and stem cells. This work examined the effects of the GABA(A) receptor system on the proliferation
Elaine M Harnett et al.
Colloids and surfaces. B, Biointerfaces, 55(1), 90-97 (2007-01-09)
This study calculates the surface energy of polystyrene tissue culture plastic, silicon, silicon dioxide and indium tin oxide, all of which have applications in tissue culture. The adhesion molecules: collagen, fibronectin, poly-L-ornithine and poly-D-lysine, were coated onto these various surfaces
Patricia Martín-Maestro et al.
Frontiers in molecular neuroscience, 10, 291-291 (2017-09-30)
Familial Alzheimer's disease (FAD) is clearly related with the accumulation of amyloid-beta (Aβ) and its deleterious effect on mitochondrial function is well established. Anomalies in autophagy have also been described in these patients. In the present work, functional analyses have
Nam-Kyung Yu et al.
iScience, 24(11), 103321-103321 (2021-11-25)
A single protein can be multifaceted depending on the cellular contexts and interacting molecules. LIN28A is an RNA-binding protein that governs developmental timing, cellular proliferation, differentiation, stem cell pluripotency, and metabolism. In addition to its best-known roles in microRNA biogenesis
Florian Völlner et al.
Differentiation; research in biological diversity, 77(5), 433-441 (2009-04-28)
Human dental follicle cells (DFCs) derived from wisdom teeth are precursor cells for cementoblasts. In this study, we recognized that naïve DFCs express constitutively the early neural cell marker beta-III-tubulin. Interestingly, DFCs formed beta-III-tubulin-positive neurosphere-like cell clusters (NLCCs) on low-attachment
Keisuke Oda et al.
Drug metabolism and pharmacokinetics, 27(6), 570-578 (2012-04-19)
In this study, we elucidated the effect of poly(amino acid)s such as poly-L-ornithine (PLO) on FITC-insulin uptake in cultured alveolar type II epithelial cells, RLE-6TN. FITC-insulin uptake by RLE-6TN cells as well as its cell surface binding was markedly increased
Vasiliki Mahairaki et al.
Tissue engineering. Part A, 17(5-6), 855-863 (2010-10-27)
The potential of human embryonic stem (ES) cells as experimental therapies for neuronal replacement has recently received considerable attention. In view of the organization of the mature nervous system into distinct neural circuits, key challenges of such therapies are the
Yu-Xin Cui et al.
Journal of microencapsulation, 23(6), 663-676 (2006-11-23)
The viability, proliferation and insulin production of RIN-m5F cells when loaded into alginate beads to form a 3D culture system has been investigated. The mechanism of alginate cross-linking (calcium ions vs barium ions), the addition of poly(L-lysine) (PLL) and poly(L-ornithine
Christopher S Morrow et al.
Cell stem cell, 26(4), 558-568 (2020-02-29)
Maintaining a healthy proteome throughout life is critical for proper somatic stem cell function, but the complexities of the stem cell response to increases in damaged or aggregated proteins remain unclear. Here we demonstrate that adult neural stem cells (NSCs)
Michael Peitz et al.
STAR protocols, 1(1), 100038-100038 (2020-10-29)
This protocol describes a highly standardized pipeline for transcription factor-mediated forward programming of human pluripotent stem cells into highly enriched glutamatergic or GABAergic neurons followed by a cryopreservation step that enables the generation of large quality-controlled batches. This approach is particularly
Carl M Sellgren et al.
Nature neuroscience, 22(3), 374-385 (2019-02-06)
Synapse density is reduced in postmortem cortical tissue from schizophrenia patients, which is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of microglia-mediated synapse engulfment, we demonstrate increased synapse elimination in patient-derived neural cultures and isolated synaptosomes.
Stefano Giovagnoli et al.
Pharmaceutical research, 27(2), 285-295 (2010-01-01)
To assess whether prevention of unexpected in vivo adverse inflammatory and immune responses to biohybrid organ grafts for the treatment of Type I Diabetes Mellitus (T1DM) is possible by superoxide dismutase and ketoprofen controlled release. Superoxide dismutase and ketoprofen-loaded polyester
Josine E G Vaes et al.
Glia, 69(3), 655-680 (2020-10-13)
Encephalopathy of prematurity (EoP) is a common cause of long-term neurodevelopmental morbidity in extreme preterm infants. Diffuse white matter injury (dWMI) is currently the most commonly observed form of EoP. Impaired maturation of oligodendrocytes (OLs) is the main underlying pathophysiological
Lorraine Iacovitti et al.
Brain research, 1127(1), 19-25 (2006-11-25)
Our ability to use human embryonic stem (hES) cells in cell replacement therapy for Parkinson's disease depends on the discovery of ways to simply and reliably differentiate a dopaminergic (DA) phenotype in these cells. Although several protocols exist for the
Annie Kathuria et al.
Genome medicine, 12(1), 34-34 (2020-04-21)
Reprogramming human induced pluripotent stem cells (iPSCs) from somatic cells and generating three-dimensional brain organoids from these iPSCs provide access to live human neuronal tissue with disease-specific genetic backgrounds. Cerebral organoids were generated from iPSCs of eight bipolar disorder (BPI)
Bella Koltun et al.
Nucleic acids research, 48(6), e32-e32 (2020-01-25)
In neurons, the specific spatial and temporal localization of protein synthesis is of great importance for function and survival. Here, we visualized tRNA and protein synthesis events in fixed and live mouse primary cortical culture using fluorescently-labeled tRNAs. We were
Electrophoretic deposition of chiral polymers and composites.
Wang Y, Pang X, Zhitomirsky I.
Colloids and Surfaces, B: Biointerfaces, 87, 505-509 (2011)
Preparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer
Yusuke Kamiya
Biologicals : Journal of the International Association of Biological Standardization (2017)
Examination of the biophysical interaction between plasmid DNA and the polycations, polylysine and polyornithine, as a basis for their differential gene transfection in-vitro.
Ramsay E, Hadgraft J, et al.
International Archives of Allergy and Immunology, 210, 97-107 (2000)
Praneet Opanasopit et al.
International journal of pharmaceutics, 410(1-2), 161-168 (2011-03-15)
The aim of this research was to investigate the effect of cationic polypeptides mixed with chitosan (CS) on in vitro transfection efficiency and cytotoxicity in human cervical carcinoma cells (HeLa cells). The polypeptides/DNA complexes and ternary complexes (CS, polypeptides and
Efficient DNA transfection of quiescent mammalian cells using poly-L-ornithine.
Y Dong et al.
Nucleic acids research, 21(3), 771-772 (1993-02-11)
Vasco Campos et al.
Journal of lipid research, 59(7), 1301-1310 (2018-04-07)
In vitro differentiating adipocytes are sensitive to liquid manipulations and have the tendency to float. Assessing adipocyte differentiation using current microscopy techniques involves cell staining and washing, while using flow cytometry involves cell retrieval in suspension. These methods induce biases
Eric J Allenspach et al.
The Journal of experimental medicine, 218(5) (2021-03-17)
SAMD9L is an interferon-induced tumor suppressor implicated in a spectrum of multisystem disorders, including risk for myeloid malignancies and immune deficiency. We identified a heterozygous de novo frameshift variant in SAMD9L in an infant with B cell aplasia and clinical
Lorenz Uebersax et al.
Biomaterials, 27(26), 4599-4607 (2006-05-20)
Adenosine kinase deficient (Adk-/-) embryonic stem cells (ESCs) encapsulated in synthetic polymers have previously been shown to provide therapeutic adenosine release and transient seizure suppression in epileptic rats. Here we explored the utility of biopolymer-substrates to promote long-term adenosine release
QiQi Zhou et al.
Gut, 65(5), 797-805 (2015-02-15)
Many patients with irritable bowel syndrome IBS not only have abdominal pain but also may suffer from visceral hypersensitivity and heighted visceral nociception. Moreover, IBS has few effective therapeutic agents and mechanisms of disease are unclear. Our goals were to
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