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Showing 1-30 of 110 results for "P3932" within Papers
Leila Eini et al.
Journal of cellular physiology, 235(3), 2452-2463 (2019-10-04)
The development of efficient and repeatable protocols for biobanking and prolonged storage of cancer stem cells (CSCs), with minimum alterations in biological function, is valuable and desired, particularly for retrospective analysis and clinical applications. In particular, data regarding the effect
Xiaoli Liu et al.
Frontiers in oncology, 10, 600927-600927 (2021-01-26)
The principal issue derived from thyroid cancer is its high propensity to metastasize to the lymph node. Aberrant exprssion of long non-coding RNAs have been extensively reported to be significantly correlated with lymphatic metastasis of thyroid cancer. However, the clinical
Melis Savasan Sogut et al.
Journal of personalized medicine, 11(2) (2021-03-07)
Elk-1, a member of the ternary complex factors (TCFs) within the ETS (E26 transformation-specific) domain superfamily, is a transcription factor implicated in neuroprotection, neurodegeneration, and brain tumor proliferation. Except for known targets, c-fos and egr-1, few targets of Elk-1 have
Kosuke Watari et al.
Communications biology, 3(1), 107-107 (2020-03-08)
Many diseases, including cancer, have been associated with impaired regulation of angiogenesis, of which vascular endothelial growth factor (VEGF)-A is a key regulator. Here, we test the contribution of N-myc downstream regulated gene 1 (NDRG1) to VEGF-A-induced angiogenesis in vascular
Xiaomei Zhang et al.
Biochimica et biophysica acta, 1864(12), 2272-2282 (2017-09-19)
Extravasation is a rate-limiting step of tumor metastasis, for which adhesion to endothelium of circulating tumor cells (CTCs) is the prerequisite. The suspension state of CTCs undergoing detachment from primary tumor is a persistent biomechanical cue, which potentially regulates the
Rebecca Lamb et al.
Oncotarget, 6(7), 4585-4601 (2015-02-12)
We have used an unbiased proteomic profiling strategy to identify new potential therapeutic targets in tumor-initiating cells (TICs), a.k.a., cancer stem cells (CSCs). Towards this end, the proteomes of mammospheres from two breast cancer cell lines were directly compared to
Murat Yavuz et al.
Journal of food science, 78(2), E238-E243 (2013-01-22)
The objective of this study was to determine β-casein adsorption by using supermacroporous poly(2-hydroxyethyl methacrylate-N-methacryloyl-(l)-histidine methyl ester) [p(HEMA-MAH)] cryogel. β-Casein adsorption properties of p(HEMA-MAH) cryogel were studied for the application of β-casein purification. The cryogel was produced by free radical
VAP-1-Mediated M2 Macrophage Infiltration Underlies IL-1beta-but Not VEGF-A-Induced Lymph-and Angiogenesis
Nakao S, et al.
The American Journal of Pathology, 178(4), 1913-1921 (2011)
Marco Fiorillo et al.
Aging, 11(8), 2202-2216 (2019-04-20)
Here, we devised a new strategy for eradicating cancer stem cells (CSCs), via a "synthetic-metabolic" approach, involving two FDA-approved antibiotics and a dietary vitamin supplement. This approach was designed to induce a "rho-zero-like" phenotype in cancer cells. This strategy effectively
Femke Mathot et al.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 73(8), 1473-1481 (2020-05-19)
When direct nerve coaptation is impossible after peripheral nerve injury, autografts, processed allografts, or conduits are used to bridge the nerve gap. The purpose of this study was to examine if human adipose-derived Mesenchymal Stromal/Stem Cells (MSCs) could be introduced
Ayman Chmayssem et al.
Analytical and bioanalytical chemistry, 413(5), 1383-1393 (2021-01-07)
Nitric oxide (NO) and its by-products are important biological signals in human physiology and pathology particularly in the vascular and immune systems. Thus, in situ determination of the NO-related molecule (NOx) levels using embedded sensors is of high importance particularly
N Nogueira et al.
Journal of colloid and interface science, 385(1), 202-210 (2012-07-31)
The behavior of poly(2-hydroxyethyl methacrylate) (PHEMA) polymer monolayer spread on water was studied under various experimental conditions. The influence of subphase pH and temperature, compression speed, elapsed time from the deposit of the monolayer and the recording of the surface
Gloria Bonuccelli et al.
Oncotarget, 8(13), 20667-20678 (2017-02-23)
Here, we assembled a broad molecular "tool-kit" to interrogate the role of metabolic heterogeneity in the propagation of cancer stem-like cells (CSCs). First, we subjected MCF7 cells to "metabolic fractionation" by flow cytometry, using fluorescent mitochondrial probes to detect PCG1α
Yonggang Lv et al.
Biotechnology letters, 43(3), 561-578 (2021-01-03)
The mechanical forces on circulating tumor cells (CTCs) should not be ignored in blood and it is more essential that CTCs can overcome and utilize the mechanical interaction to acquire the ability of distant metastasis. At present there are few
Embryoid body formation from embryonic and induced pluripotent stem cells: Benefits of bioreactors
Rungarunlert S, et al.
World journal of stem cells, 1(1), 11-11 (2009)
Bailu Xie et al.
Bioengineering (Basel, Switzerland), 7(2) (2020-06-18)
Current therapies for treating pancreatic ductal adenocarcinoma (PDAC) are largely ineffective, with the desmoplastic environment established within these tumors being considered a central issue. We established a 3D spheroid co-culture in vitro model using a PDAC cell line (either PANC-1
Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro
Ignatova Tatyana N, et al.
Glia, 39(3), 193-206 (2002)
Beth K Neilsen et al.
PloS one, 14(1), e0209224-e0209224 (2019-01-11)
The cell cycle is under circadian regulation. Oncogenes can dysregulate circadian-regulated genes to disrupt the cell cycle, promoting tumor cell proliferation. As a regulator of G2/M arrest in response to DNA damage, the circadian gene Timeless Circadian Clock (TIMELESS) coordinates
Xiangling Meng et al.
Journal of biomedical materials research. Part A, 101(4), 1095-1102 (2012-09-26)
The objective of the present in vitro study was to investigate cardiomyocyte functions, specifically their adhesion and proliferation, on injectable scaffolds containing RNT (rosette nanotubes) and CNF (carbon nanofibers) in a pHEMA (poly(2-hydroxyethyl methacrylate)) hydrogel to determine their potential for
G Lutzweiler et al.
ACS applied materials & interfaces, 11(22), 19819-19829 (2019-05-11)
Full-scale cell penetration within porous scaffolds is required to obtain functional connective tissue components in tissue engineering applications. For this aim, we produced porous polyurethane structures with well-controlled pore and interconnection sizes. Although the influence of the pore size on
Yunfeng Li et al.
ACS applied materials & interfaces, 5(6), 2126-2132 (2013-02-23)
This paper presents a versatile way to prepare multiscale and gradient patterns of proteins. The protein patterns are fabricated by conjugating proteins covalently on patterns of polymer brush that are prepared by techniques combining colloidal lithography with photolithography, and two-step
Praachi B Jain et al.
Scientific reports, 9(1), 19843-19843 (2019-12-29)
Aberrant expression of the Spectraplakin Dystonin (DST) has been observed in various cancers, including those of the breast. However, little is known about its role in carcinogenesis. In this report, we demonstrate that Dystonin is a candidate tumour suppressor in
A Islam et al.
European cells & materials, 31, 407-424 (2016-05-28)
Many researchers world over are currently investigating the suitability of stromal cells harvested from foetal tissues for allogeneic cell transplantation therapies or for tissue engineering purposes. In this study, we have investigated the chondrogenic potential of mesenchymal stromal cells (MSCs)
Rebecca Lamb et al.
Oncotarget, 6(16), 14005-14025 (2015-06-19)
DNA-PK is an enzyme that is required for proper DNA-repair and is thought to confer radio-resistance in cancer cells. As a consequence, it is a high-profile validated target for new pharmaceutical development. However, no FDA-approved DNA-PK inhibitors have emerged, despite
Muge Andac et al.
Colloids and surfaces. B, Biointerfaces, 109, 259-265 (2013-05-15)
Macroporous cryogels imprinted with human serum albumin (HSA) have been prepared by copolymerization of 2-hydroxyethyl methacrylate with a functional co-monomer of N-methacryloyl-L-phenylalanine. The cryogels were used for the depletion of HSA from human serum. HSA-imprinted cryogels were prepared with gel
Craig N Czyz et al.
Ophthalmic plastic and reconstructive surgery, 29(1), e25-e27 (2012-07-28)
Hydrogel was a commonly used material for scleral buckling in the early 1980s to the mid-1990s. Use of hydrogel ceased due to a high complication rate, including frequent migration. Various symptoms and clinical findings have been reported with hydrogel migration.
Yu-Ichiro Ohnishi et al.
Stem cell research, 15(1), 23-29 (2015-05-13)
Olfactory stem cells are generated from olfactory mucosa. Various culture conditions generate olfactory stem cells that differ according to species and developmental stage and have different progenitor or stem cell characteristics. Olfactory spheres (OSs) are clusters of progenitor or stem
James L Chen et al.
Molecular cancer research : MCR, 15(1), 26-34 (2016-11-04)
Peritoneal carcinomatosis and peritoneal sarcomatosis is a potential complication of nearly all solid tumors and results in profoundly increased morbidity and mortality. Despite the ubiquity of peritoneal carcinomatosis/peritoneal sarcomatosis, there are no clinically relevant targeted therapies for either its treatment
Amit D Bhrany et al.
JAMA facial plastic surgery, 15(1), 29-33 (2013-01-19)
To evaluate the performance of a sphere-templated poly(2-hydroxyethyl methacrylate) (poly[HEMA]) tissue scaffold as a subcutaneous implant by comparing it with widely used high-density porous polyethylene (HDPPE) implant material. We implanted sphere-templated porous poly-(HEMA) and HDPPE disks into the dorsal subcutis
Noor A Lokman et al.
Cancers, 11(8) (2019-08-25)
We have recently shown that the extracellular matrix molecule hyaluronan (HA) plays a role in the development of ovarian cancer chemoresistance. This present study determined if HA production is increased in chemotherapy-resistant ovarian cancers and if the HA inhibitor 4-methylubelliferone
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