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Showing 1-30 of 131 results for "P4334" within Papers
Kumiko A Percival et al.
The European journal of neuroscience, 37(7), 1072-1089 (2013-01-15)
The roles of the midget and parasol pathways as the anatomical foundation for high-acuity vision at the fovea are well established. There is also evidence for the presence of other (non-midget, non-parasol) ganglion cell types in the foveal retina, but
Protein kinase C, an elusive therapeutic target?
Mochly-Rosen D, et al.
Nature Reviews Drug Discovery, 11(12), 937-937 (2012)
Xiao-Bin Liu et al.
Neural regeneration research, 16(10), 2109-2120 (2021-03-02)
Luteolin is neuroprotective for retinal ganglion cells and retinal pigment epithelial cells after oxidative injury, whereby it can inhibit microglial neurotoxicity. Therefore, luteolin holds the potential to be useful for treatment of retinal diseases. The purpose of this study was
Gema Esquiva et al.
Frontiers in neuroanatomy, 10, 61-61 (2016-07-05)
The blind mole rat, Spalax ehrenbergi, can, despite severely degenerated eyes covered by fur, entrain to the daily light/dark cycle and adapt to seasonal changes due to an intact circadian timing system. The present study demonstrates that the Spalax retina
Mei-Ling Gao et al.
Frontiers in cell and developmental biology, 8, 128-128 (2020-03-27)
Although an increasing number of disease genes have been identified, the exact cellular mechanisms of retinitis pigmentosa (RP) remain largely unclear. Retinal organoids (ROs) derived from the induced pluripotent stem cells (iPSCs) of patients provide a potential but unvalidated platform
Yumeng Shen et al.
Cell death & disease, 10(12), 905-905 (2019-12-04)
Progressive degeneration of retinal ganglion cells (RGCs) will cause a blinding disease. Most of the study is focusing on the RGCs itself. In this study, we demonstrate a decline of the presynaptic rod bipolar cells (RBCs) response precedes RGCs loss
Salvatore L Stella et al.
Brain research, 1215, 20-29 (2008-05-17)
Glutamate is the major excitatory neurotransmitter in the retina, and most glutamatergic neurons express one of the three known vesicular glutamate transporters (VGLUT1, 2, or 3). However, the expression profiles of these transporters vary greatly in the retina. VGLUT1 is
Diego F Buenaventura et al.
Investigative ophthalmology & visual science, 60(8), 2787-2799 (2019-07-02)
The early transcriptional events that occur in newly generated cone photoreceptors are not well described. Knowledge of these events is critical to provide benchmarks for in vitro-derived cone photoreceptors and to understand the process of cone and rod photoreceptor diversification.
Antonia Stefanov et al.
The Journal of comparative neurology, 528(9), 1502-1522 (2019-12-08)
Rod-cone degenerations, for example, retinitis pigmentosa are leading causes of blindness worldwide. Despite slow disease progression in humans, vision loss is inevitable; therefore, development of vision restoration strategies is crucial. Among others, promising approaches include optogenetics and prosthetic implants, which
Qinji Zhou et al.
iScience, 24(7), 102812-102812 (2021-07-27)
Atypical cadherin Celsr3 is critical for brain embryonic development, and its role in the postnatal cerebellum remains unknown. Using Celsr3-GFP mice, Celsr3 shows high expression in postnatal Purkinje cells (PCs). Mice with conditional knockout (cKO) of Celsr3 in postnatal PCs
Nicolas D Lutz et al.
PloS one, 13(8), e0202089-e0202089 (2018-08-30)
The retinal rod pathway, featuring dedicated rod bipolar cells (RBCs) and AII amacrine cells, has been intensely studied in placental mammals. Here, we analyzed the rod pathway in a nocturnal marsupial, the South American opossum Monodelphis domestica to elucidate whether
The Rod Pathway of the Microbat Retina Has Bistratified Rod Bipolar Cells and Tristratified AII Amacrine Cells
Muller B, et al.
The Journal of Neuroscience, 33(3), 1014-1023 (2013)
Marijana Samardzija et al.
Investigative ophthalmology & visual science, 55(8), 5304-5313 (2014-07-19)
Due to the low abundance of cone photoreceptors in the mouse retina and the scarcity of alternative animal models, little is known about mechanisms of cone degeneration. Nrl knockout mice develop exclusively the cone-type of photoreceptors. However, the cone photoreceptor
Mei Li et al.
Journal of inflammation research, 15, 2995-3020 (2022-06-02)
Photoreceptors are specialized retinal neurons responsible for phototransduction. Loss of photoreceptors directly leads to irreversible vision impairment. Pharmacological therapies protecting against photoreceptor degeneration are clinically lacking. Oxidative stress and inflammation are common mechanisms playing important roles in the pathogenesis of
Daniela Intartaglia et al.
Frontiers in cell and developmental biology, 8, 132-132 (2020-03-21)
Mucopolysaccharidosis type IIIA (MPS-IIIA, Sanfilippo A) is one of the most severe lysosomal storage disorder (LSD) caused by the inherited deficiency of sulfamidase, a lysosomal sulfatase enzyme involved in the stepwise degradation of heparan sulfates (HS). MPS-IIIA patients show multisystemic
Ning Shen et al.
Investigative ophthalmology & visual science, 57(6), 2788-2796 (2016-05-24)
Frizzled3 (Fzd3), a member of the core planar cell polarity (PCP) family in mammals, contributes to visual development by guiding axonal projections of some retinal ganglion cells. However, its other functions in the maturation of the visual system, especially the
Ilaria Barone et al.
PloS one, 7(11), e50726-e50726 (2012-12-05)
Slow, progressive rod degeneration followed by cone death leading to blindness is the pathological signature of all forms of human retinitis pigmentosa (RP). Therapeutic schemes based on intraocular delivery of neuroprotective agents prolong the lifetime of photoreceptors and have reached
ARHGEF3 regulates skeletal muscle regeneration and strength through autophagy.
Jae-Sung You et al.
Cell reports, 34(6), 108731-108731 (2021-02-11)
Peter G Fuerst et al.
Neuron, 64(4), 484-497 (2009-12-01)
DSCAM and DSCAM-LIKE1 (DSCAML1) serve diverse neurodevelopmental functions, including axon guidance, synaptic adhesion, and self-avoidance, depending on the species, cell type, and gene family member studied. We examined the function of DSCAM and DSCAML1 in the developing mouse retina. In
Vitor H Corredor et al.
The Journal of comparative neurology, 527(5), 903-915 (2018-11-09)
Neurons are continuously produced at different rates and locations in the teleost retina. Goldfish rods are homogeneously distributed and maintain a stable density throughout growth, whereas little is known about their postsynaptic partners. We examined the distribution and density of
Daisy Umutoni et al.
Genes to cells : devoted to molecular & cellular mechanisms, 25(6), 402-412 (2020-03-28)
Di- and trimethylation of lysine 27 on histone 3 (H3K27me2/3) is a critical gene repression mechanism. We previously showed that down-regulation of the H3K27 demethylase, Jumonji domain-containing protein 3 (JMJD3), resulted in a reduced number of protein kinase C (PKC)α-positive
Ivan A Anastassov et al.
The Journal of comparative neurology, 527(1), 52-66 (2017-05-27)
Retinal responses to photons originate in rod photoreceptors and are transmitted to the ganglion cell output of the retina through the primary rod bipolar pathway. At the first synapse of this pathway, input from multiple rods is pooled into individual
Rania A Masri et al.
Investigative ophthalmology & visual science, 62(9), 22-22 (2021-07-15)
The purpose of this study was to measure the composition of the inner nuclear layer (INL) in the central and peripheral human retina as foundation data for interpreting INL function and dysfunction. Six postmortem human donor retinas (male and female
Wenxin Ma et al.
eLife, 8 (2019-01-23)
Constitutive TGFβ signaling is important in maintaining retinal neurons and blood vessels and is a factor contributing to the risk for age-related macular degeneration (AMD), a retinal disease involving neurodegeneration and microglial activation. How TGFβ signaling to microglia influences pathological
Jongsu Choi et al.
Nature communications, 14(1), 4929-4929 (2023-08-16)
The visual signal processing in the retina requires the precise organization of diverse neuronal types working in concert. While single-cell omics studies have identified more than 120 different neuronal subtypes in the mouse retina, little is known about their spatial
Karthik Shekhar et al.
Cell, 166(5), 1308-1323 (2016-08-28)
Patterns of gene expression can be used to characterize and classify neuronal types. It is challenging, however, to generate taxonomies that fulfill the essential criteria of being comprehensive, harmonizing with conventional classification schemes, and lacking superfluous subdivisions of genuine types.
Abirami Santhanam et al.
Cells, 9(10) (2020-10-11)
More than 1.5 million people suffer from Retinitis Pigmentosa, with many experiencing partial to complete vision loss. Regenerative therapies offer some hope, but their development is challenged by the limited regenerative capacity of mammalian model systems. As a step toward
Anuradha Dhingra et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(33), 11343-11355 (2012-08-17)
Heterotrimeric G-proteins, comprising Gα and Gβγ subunits, couple metabotropic receptors to various downstream effectors and contribute to assembling and trafficking receptor-based signaling complexes. A G-protein β subunit, Gβ(3), plays a critical role in several physiological processes, as a polymorphism in
Takae Kiyama et al.
Cells, 11(14) (2022-07-28)
The retina, the accessible part of the central nervous system, has served as a model system to study the relationship between energy utilization and metabolite supply. When the metabolite supply cannot match the energy demand, retinal neurons are at risk
Masahito Yamagata et al.
eLife, 10 (2021-01-05)
Retinal structure and function have been studied in many vertebrate orders, but molecular characterization has been largely confined to mammals. We used single-cell RNA sequencing (scRNA-seq) to generate a cell atlas of the chick retina. We identified 136 cell types
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