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Showing 1-30 of 445 results for "P5669" within Papers
Daojin Li et al.
Analytical biochemistry, 561-562, 18-26 (2018-09-21)
Vitamin B12 (VB12) has an important function in human physiology. However, analysis of VB12 at natural levels in foods or biological samples is difficult because of its very low concentration level and the presence of high-abundance components which can interfere
Jyotirmaya Behera et al.
Biochemical and biophysical research communications, 510(1), 135-141 (2019-01-27)
Bone marrow (BM)-derived endothelial progenitor cells (EPCs) are the key players in angiogenesis and vascular function. Cystathionine-β-synthase (CBS), an H2S-generating enzyme in methionine metabolism, regulates the function of these EPCs. This study aims to examine whether CBS hyper-methylation contributes to
Seungho Ryu et al.
European journal of clinical nutrition, 73(10), 1343-1351 (2018-12-14)
The objective of this study was to evaluate secular trends in Dietary Inflammatory Index (DII) scores in the United States between 1999 and 2014. Data from adults over 19 years from the 1999 to 2014 National Health and Nutrition Examination
Florian Finkernagel et al.
Theranostics, 9(22), 6601-6617 (2019-10-08)
The peritoneal fluid (ascites), replete with abundant tumor-promoting factors and extracellular vesicles (EVs) reflecting the tumor secretome, plays an essential role in ovarian high-grade serous carcinoma (HGSC) metastasis and immune suppression. A comprehensive picture of mediators impacting HGSC progression is
Wei Zeng et al.
Biomedical chromatography : BMC, 34(4), e4795-e4795 (2020-01-23)
In this study, we focused on studying the changes in urine metabolites in hyperlipidemic rats using ultra-performance liquid chromatography coupled with quadrupole time-of-fight mass spectrometry (UPLC-Q-TOF/MS) and metabolomics, as well as the effect of Citri Reticulatae Chachiensis Pericarpium (CRCP) on
Young-Mi Go et al.
PloS one, 10(11), e0142916-e0142916 (2015-11-19)
High-resolution metabolomics has created opportunity to integrate nutrition and metabolism into genetic studies to improve understanding of the diverse radiation of primate species. At present, however, there is very little information to help guide experimental design for study of wild
Carolien P J Deen et al.
Nutrients, 12(7) (2020-07-16)
It is unclear whether niacin nutritional status is a target for improvement of long-term outcome after renal transplantation. The 24-h urinary excretion of N1-methylnicotinamide (N1-MN), as a biomarker of niacin status, has previously been shown to be negatively associated with
Sinan Uzman et al.
Tuberkuloz ve toraks, 61(1), 50-53 (2013-04-16)
Despite the widespread use, suicidal ingestion of isoniazid is a rare condition in Turkey. We reported a case of acute isoniazid intoxication associated with alcohol intake presenting with convulsion, coma and metabolic acidosis. The patient was treated successfully with intravenous
Michelle C Potter et al.
PloS one, 9(9), e102936-e102936 (2014-09-26)
Pyridoxine is used as a supplement for treating conditions such as vitamin deficiency as well as neurological disorders such as depression, epilepsy and autism. A significant neurologic complication of pyridoxine therapy is peripheral neuropathy thought to be a result of
Chang'an Wang et al.
Fish physiology and biochemistry, 46(3), 1011-1018 (2020-01-18)
In this study, the effects of dietary myo-inositol on the skin mucosal immunity and growth of taimen (Hucho taimen) fry were determined. Triplicate groups of 500 fish (initial weight 5.58 ± 0.15 g) were fed different diets containing graded levels of myo-inositol (28.75
Vijay P Singh et al.
The Journal of organic chemistry, 78(4), 1478-1487 (2013-01-16)
Vitamin B6 is involved in a variety of enzymatic transformations. Some recent findings also indicate an antioxidant role of the vitamin in biological systems. We set out to turn pyridoxine (1a) into a catalytic chain-breaking and hydroperoxide-decomposing antioxidant by replacing
Chenguang Wang et al.
Immunity, 48(4), 675-687 (2018-04-15)
Manganese (Mn) is essential for many physiological processes, but its functions in innate immunity remain undefined. Here, we found that Mn2+ was required for the host defense against DNA viruses by increasing the sensitivity of the DNA sensor cGAS and
Sidney M Gospe
Pediatric neurology, 26(3), 181-185 (2002-04-17)
Pyridoxine-dependent seizures, although a rare clinical entity, have been recognized as an etiology of intractable seizures in neonates and infants for more than 45 years. Recent research has focused on the molecular and neurochemical aspects of this disorder, as well
A Amoroso et al.
Journal of the American Society of Nephrology : JASN, 12(10), 2072-2079 (2001-09-20)
Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disorder that is caused by a deficiency of alanine: glyoxylate aminotransferase (AGT), which is encoded by a single copy gene (AGXT). Molecular diagnosis was used in conjunction with clinical, biochemical, and
Stroke in a young man.
Deepa Narayanan et al.
BMJ (Clinical research ed.), 347, f4484-f4484 (2013-07-17)
Yan Zhou et al.
European journal of drug metabolism and pharmacokinetics, 38(1), 5-13 (2012-10-24)
Pyridoxine is always simultaneously administered orally with isoniazid for tuberculosis patients in the clinic to prevent or treat the nervous system side effects induced by isoniazid. So the aim of this research was to investigate the effects of pyridoxine on
Troy J Plumb et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 62(6), 1155-1159 (2013-07-09)
Type 1 primary hyperoxaluria is a genetic disorder caused by deficiency of the liver-specific peroxisomal enzyme alanine-glyoxylate aminotransferase. This enzyme deficiency leads to excess oxalate production and deposition of calcium oxalate salts, resulting in kidney failure and systemic oxalosis. Aside
Barbara Plecko et al.
Neurology, 82(16), 1425-1433 (2014-03-25)
To determine whether patients with pyridoxine-responsive seizures but normal biomarkers for antiquitin deficiency and normal sequencing of the ALDH7A1 gene may have PNPO mutations. We sequenced the PNPO gene in 31 patients who fulfilled the above-mentioned criteria. We were able
Samuel Bernardo-Bermejo et al.
Journal of chromatography. A, 1596, 124-133 (2019-03-18)
Diabetes mellitus is a major health concern nowadays. It is estimated that 40% of diabetics are affected by diabetic nephropathy, one of the complications derived from high glucose blood levels which can lead to chronic loss of kidney function. It
Shenping Cao et al.
Fish & shellfish immunology, 79, 265-273 (2018-05-19)
The present study examined the effect of dietary spirulina, Arthrospira platensis on growth performance, blood physiological indices, immune-related gene expressions and resistance of juvenile gibel carp against Aeromonas hydrophila infection. Four isonitrogenous (360 g kg-1) and isolipidic (90 g kg-1) diets were formulated with
Medhat Ahmed Abu-Tahon et al.
The Journal of general and applied microbiology, 65(6), 284-292 (2019-05-28)
The aim of this work was to purify L-glutaminase from Aspergillus flavus. The enzyme was purified 12.47-fold from a cell-free extract with a final specific activity of 613.3 U/mg and the yield was 51.11%. The molecular weight of the enzyme
Kristina M Brooks et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 67(2), 193-201 (2018-02-08)
Once-weekly isoniazid and rifapentine for 3 months is a treatment option in persons with human immunodeficiency virus and latent tuberculosis infection. This study aimed to examine pharmacokinetic drug-drug interactions between this regimen and dolutegravir, a first-line antiretroviral medication. This was
Yingying Yu et al.
Marine drugs, 18(4) (2020-04-23)
The present study investigated the effect of dietary astaxanthin (AX) on the growth performance, antioxidant parameters, and repair of hepatopancreas damage in Pacific white shrimp (Litopenaeus vannamei). To evaluate the hepatopancreas protective function of AX in shrimps, we compared the
Robert T Burns et al.
PloS one, 9(11), e109535-e109535 (2014-11-13)
Marine sediments can contain B vitamins, presumably incorporated from settled, decaying phytoplankton and microorganisms associated with decomposition. Because B vitamins may be advantageous for the energetically intensive processes of metamorphosis, post-metamorphic growth, and reproduction, we tested several B vitamins to
Ziyi Yin et al.
Autophagy, 16(5), 900-916 (2019-07-18)
Cells are faced with various stresses during their growth and development, and autophagy is a degradative process in which cells can break down their own components to recycle macromolecules and provide energy under these stresses. For pathogenic fungi that utilize
Yijun Kang et al.
The British journal of nutrition, 118(6), 431-440 (2017-10-06)
Anaemia during pregnancy, characterised by Hb <110 g/l, is a specific risk factor for adverse maternal and perinatal outcomes in developing countries. The objective of this study was to determine the effectiveness of daily antenatal supplementation with multiple micronutrients (MMN)
Zhengyi Fu et al.
Fish & shellfish immunology, 95, 697-704 (2019-11-13)
This study evaluates the effects of different dietary sources of non-protein energy on growth performance, histological structure, antioxidant status and immune response of barramundi Lates calcarifer. Fish were fed with isoenergetic diets (18 kJ/g) with two types of non-protein energy in
Matthias Fellner et al.
Biochemistry, 57(38), 5513-5523 (2018-08-31)
LarE from Lactobacillus plantarum is an ATP-dependent sulfur transferase that sacrifices its Cys176 sulfur atom to form a dehydroalanine (Dha) side chain during biosynthesis of the covalently linked nickel-pincer nucleotide (NPN) cofactor (pyridinium 3-thioamide-5-thiocarboxylic acid mononucleotide) of lactate racemase. Coenzyme
Yu-Jun Wan et al.
Journal of agricultural and food chemistry, 67(3), 895-904 (2019-01-05)
It has been found that probiotic-fermented carrot pulp has a beneficial effect in reducing blood glucose, more so than unfermented pulp. This paper explores the reason for this by looking at fermentation-induced changes in nutritional components and hypoglycemic effects of
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
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