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Showing 1-21 of 21 results for "P6031" within Papers
Shiori Toba et al.
Cell motility and the cytoskeleton, 58(4), 281-289 (2004-07-06)
Cytoplasmic dynein is a minus-end directed microtubule motor and plays important roles in the transport of various intracellular cargoes. Cytoplasmic dynein comprises two identical heavy chains and forms a dimer (double-headed dynein); the total molecular weight of the cytoplasmic dynein
Zhe Yang et al.
Cell research, 28(10), 1013-1025 (2018-09-14)
Adequate protein intake is crucial for the survival and well-being of animals. How animals assess prospective protein sources and ensure dietary amino acid intake plays a critical role in protein homeostasis. By using a quantitative feeding assay, we show that
F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects.
Enrica Calzoni et al.
The Journal of allergy and clinical immunology, 143(6), 2317-2321 (2019-03-02)
K Reithmayer et al.
The British journal of dermatology, 161(1), 78-89 (2009-05-07)
Hair follicle (HF) ostia represent a potential port of microbial entry into the skin. However, they rarely show clinical signs of infection. This suggests the presence of local, efficient, antimicrobial defence systems, which may include antimicrobial peptides (AMPs). We determined
Surface Passivation with a Perfluoroalkane Brush Improves the Precision of Single-Molecule Measurements.
Bueno-Alejo, et al.
ACS Applied Materials & Interfaces, 14, 49604-49616 (2022)
Julien Pothlichet et al.
Frontiers in immunology, 13, 824746-824746 (2022-04-09)
The origin of the impaired CD4 T-cell response and immunodeficiency of HIV-infected patients is still only partially understood. We recently demonstrated that PLA2G1B phospholipase synergizes with the HIV gp41 envelope protein in HIV viremic plasma to induce large abnormal membrane
Shiori Toba et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(15), 5741-5745 (2006-04-06)
Structural differences between dynein and kinesin suggest a unique molecular mechanism of dynein motility. Measuring the mechanical properties of a single molecule of dynein is crucial for revealing the mechanisms underlying its movement. We measured the step size and force
Hwa-Young Lee et al.
Redox biology, 37, 101727-101727 (2020-10-04)
Oxidative stress attributable to the activation of a Nox4-containing NADPH oxidase is involved in aging-associated vascular dysfunction. However, the Nox4-induced signaling mechanism for the vascular alteration in aging remains unclear. In an aged aorta, the expression of Nox4 mRNA and
April R Giles et al.
Frontiers in immunology, 11, 1135-1135 (2020-08-01)
With the advent of single B-cell cloning technology, we can isolate antibodies against virtually any antigen to study the interaction of a given pathogen with the immune system and develop novel therapeutic strategies. Antibodies directed against the capsid of adeno-associated
R Dubé et al.
Gut, 31(4), 431-434 (1990-04-01)
The proportion of oligosaccharide chains on the Fc fragment of IgG which terminate with N-acetylglucosamine (GlcNAc) rather than galactose is increased in rheumatoid arthritis and tuberculosis, and in sera from patients with Crohn's disease, probably because of decreased activity of
R P Kengne-Momo et al.
Biointerphases, 7(1-4), 67-67 (2012-11-07)
A simple electrochemical procedure was used for the synthesis of a polythiophene containing para-benzenesulfonyl chloride groups. The obtained polymer was shown to be very reactive and directly able to covalently bind nucleophile biomolecules. Protein A and a specific antibody were
Polly A Machin et al.
Frontiers in immunology, 14, 1180886-1180886 (2023-06-29)
Rac-GTPases and their Rac-GEF activators play important roles in neutrophil-mediated host defence. These proteins control the adhesion molecules and cytoskeletal dynamics required for neutrophil recruitment to inflamed and infected organs, and the neutrophil effector responses that kill pathogens. Here, we
Katrin Frese et al.
mAbs, 5(2), 279-287 (2013-02-16)
Antibody-based therapeutics are of great value for the treatment of human diseases. In addition to functional activity, affinity or physico-chemical properties, antibody specificity is considered to be one of the most crucial attributes for safety and efficacy. Consequently, appropriate studies
Avanish K Varshney et al.
PloS one, 13(1), e0190537-e0190537 (2018-01-25)
Staphylococcus aureus can cause devastating and life-threatening infections. With the increase in multidrug resistant strains, novel therapies are needed. Limited success with active and passive immunization strategies have been attributed to S. aureus immune evasion. Here, we report on a
Anders Esberg et al.
Microorganisms, 10(8) (2022-08-27)
Microbiota has been associated with autoimmune diseases, with nasal Staphylococcus aureus being implicated in the pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). Little is known about the role of oral microbiota in AAV. In this study, levels of IgG antibodies
J Dehli et al.
Colloids and surfaces. B, Biointerfaces, 180, 326-333 (2019-05-11)
Percutaneous devices suffer from imperfect sealing of the epidermis-implant interphase, the so-called three-phase junction, allowing invading pathogens access to colonize the implant at the tissue interface and potentially cause an infection. In skin, one of the key components of the
Masayasu Suzuki et al.
Analytical and bioanalytical chemistry, 372(2), 301-304 (2002-04-09)
Miniaturized immunosensors based on surface-plasmon resonance (SPR) have been developed by using the sensor recently developed by Texas Instruments. By using this sensor for human immunoglobulin G (IgG) rapid and repetitive measurements could be performed by alternate injection of sample
Aulanni'am Aulanni'am et al.
Heliyon, 8(1), e08695-e08695 (2022-01-15)
Diabetes mellitus (DM) is a chronic and costly disease that has become a primary concern worldwide. Type 1 diabetes mellitus is categorized as an autoimmune disease, which results in islet cell apoptosis and insulin-dependent. GAD65 is known as a potential
O Sørensen et al.
Blood, 90(7), 2796-2803 (1997-11-05)
hCAP-18 is the only human member of the antibacterial and endotoxin-binding family of proteins known as cathelicidins. The antibacterial and endotoxin binding domains reside in the C-terminal 37 amino acids of the protein (LL-37) and this is believed to be
Carlota Tosat-Bitrián et al.
Nanomaterials (Basel, Switzerland), 11(3) (2021-04-04)
CdSe quantum dots (QDs) are valuable tools for deciphering molecular mechanisms in cells. Their conjugation with antibodies offers a unique staining source with optimal characteristics, including increased photostability and narrow emission spectra, allowing for improved multiplexing capabilities using a single
Regina Stoltenburg et al.
Scientific reports, 6, 33812-33812 (2016-09-22)
Aptamers for whole cell detection are selected mostly by the Cell-SELEX procedure. Alternatively, the use of specific cell surface epitopes as target during aptamer selections allows the development of aptamers with ability to bind whole cells. In this study, we
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