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Showing 1-30 of 261 results for "P6126" within Papers
Panagiotis Laspas et al.
Experimental eye research, 127, 1-8 (2014-07-16)
Nitric oxide synthases (NOS) are involved in regulation of ocular vascular tone and blood flow. While endothelial NOS (eNOS) has recently been shown to mediate endothelium-dependent vasodilation in mouse retinal arterioles, the contribution of individual NOS isoforms to vascular responses
Jiung-Pang Huang et al.
Journal of cardiovascular pharmacology, 72(5), 231-241 (2018-11-07)
We investigated whether resveratrol (RSV) can attenuate obesity and diabetes progression and improve diabetes-induced vascular dysfunction, and we attempted to delineate its underlying mechanisms. Male C57Bl/6 mice were administered a high-fat diet (HFD) for 17 weeks. Mice developed type 2
Belthrand Habiyakare et al.
International journal of experimental pathology, 95(4), 290-295 (2014-06-24)
Novel treatments are necessary to reduce the burden of cardiovascular disease (CVD). Alamandine binds to MrgD and is reported to induce vasodilation via stimulation of endothelial nitric oxide synthase (eNOS), but its role in atherogenic blood vessels is yet to
Jacky W Y Lee et al.
Medicine, 94(8), e567-e567 (2015-02-26)
To investigate the association between macular thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in Chinese children. This cross-sectional study recruited consecutive cases of healthy pediatric subjects aged 4 to 18 from Caritas Medical Centre in Hong Kong Special
Anna Bryndis Einarsdottir et al.
Journal of Alzheimer's disease : JAD, 49(1), 79-83 (2015-10-08)
Structural and physiological abnormalities have been reported in the retina in Alzheimer's disease (AD). Retinal oximetry detects changes in retinal oxygen metabolism in many eye diseases, where structural changes are seen. To compare oxygen saturation in retinal blood vessels in
Fei Luo et al.
Journal of neurochemistry, 132(1), 38-50 (2014-09-10)
α1 -adrenoceptors (α1 -ARs) stimulation has been found to enhance excitatory processes in many brain regions. A recent study in our laboratory showed that α1 -ARs stimulation enhances glutamatergic transmission via both pre- and post-synaptic mechanisms in layer V/VI pyramidal
Xun Zhang et al.
Journal of cellular physiology, 238(4), 776-789 (2023-02-16)
Protease-activated receptor-1 & -2 (PAR1 and PAR2) are expressed widely in cardiovascular tissues including endothelial and smooth muscle cells. PAR1 and PAR2 may regulate blood pressure via changes in vascular contraction or relaxation mediated by endothelial Ca2+ signaling, but the
Antiemetics added to phenylephrine infusion during cesarean delivery: a randomized controlled trial.
Ashraf S Habib et al.
Obstetrics and gynecology, 121(3), 615-623 (2013-05-03)
To estimate whether the addition of metoclopramide or its combination with ondansetron to a prophylactic phenylephrine infusion provides improved intraoperative nausea and vomiting prophylaxis compared with phenylephrine infusion alone. Women scheduled for elective cesarean delivery were randomized to one of
Y Hattori et al.
Life sciences, 62(17-18), 1449-1453 (1998-05-19)
Both alpha1A- and alpha1B-adrenoceptor subtypes are present in mammalian myocardium. Alpha1-adrenoceptor activation can enhance myocardial contractility, and two possible inotropic mechanisms are proposed: an increase in myofilament Ca2+ sensitivity and an increase in transsarcolemmal Ca2+ influx during action potential prolongation
A myocardial slice culture model reveals alpha-1A-adrenergic receptor signaling in the human heart
Thomas RC, et al.
JACC. Basic to translational science, 1(3), 155-167 (2016)
Aaron J Polichnowski et al.
American journal of physiology. Renal physiology, 305(7), F1074-F1084 (2013-07-05)
Chronic ANG II infusion in rodents is widely used as an experimental model of hypertension, yet very limited data are available describing the resulting blood pressure-renal blood flow (BP-RBF) relationships in conscious rats. Accordingly, male Sprague-Dawley rats (n = 19)
Oluwatobiloba Osikoya et al.
Pharmacological research, 171, 105788-105788 (2021-07-27)
Uterine perivascular adipose tissue (PVAT) contributes to uterine blood flow regulation in pregnancy, at least in part, due to its effects on uterine artery reactivity. We tested the hypothesis that uterine PVAT modulates the balance between the contribution of nitric
Dale A Currigan et al.
Anesthesiology, 121(5), 930-936 (2014-09-10)
Vasopressor drugs, commonly used to treat systemic hypotension and maintain organ perfusion, may also induce regional vasoconstriction in specialized vascular beds such as the lung. An increase in pulmonary vascular tone may adversely affect patients with pulmonary hypertension or right
Yu-Hua Sun et al.
Pharmaceutical biology, 51(9), 1158-1164 (2013-06-15)
The buds of Coreopsis tinctoria Nutt (Compositae) are used in the treatment of hypertension in the Uyghur folk medicine in China. To investigate vasorelaxant properties of extracts and some flavonoids from C. tinctoria (CT) and their underlying mechanisms in isolated
Charles E Norton et al.
American journal of physiology. Heart and circulatory physiology, 320(5), H1887-H1902 (2021-03-13)
Inflammatory bowel disease (IBD) is associated with both impaired intestinal blood flow and increased risk of cardiovascular disease, but the functional role of perivascular nerves that control vasomotor function of mesenteric arteries (MAs) perfusing the intestine during IBD is unknown.
Natalia M Arzeno et al.
American journal of physiology. Heart and circulatory physiology, 304(8), H1114-H1123 (2013-02-12)
Spaceflight-induced orthostatic intolerance has been studied for decades. Although ∼22% of the astronaut corps are women, most mechanistic studies use mostly male subjects, despite known sex differences in autonomic control and postflight orthostatic intolerance. We studied adrenergic, baroreflex, and autonomic
Ruijie Liu et al.
Biochemical and biophysical research communications, 533(1), 17-22 (2020-09-13)
Extracellular signal-regulated kinase 1 and 2 (ERK1/2) have been implicated as important regulators of metabolic homeostasis. Here we generated a new mouse model with genetic deletion of two ERK1/2 phosphatases, dual specificity phosphatase (DUSP) 6 and 8, to further define
Claire Lewis et al.
Rapid communications in mass spectrometry : RCM, 29(12), 1107-1114 (2015-05-20)
A current challenge for analytical chemists is the development of the measurement systems and approaches required to understand dynamic processes such as tablet dissolution. The design and development of oral tablets could be improved by the availability of detailed information
Zhenya Wang et al.
Frontiers in cardiovascular medicine, 10, 1130635-1130635 (2023-04-01)
Pathological cardiac hypertrophy is commonly resulted from sustained pressure overload and/or metabolic disorder and eventually leads to heart failure, lacking specific drugs in clinic. Here, we aimed to identify promising anti-hypertrophic drug(s) for heart failure and related metabolic disorders by
Tiago J Costa et al.
American journal of physiology. Heart and circulatory physiology, 324(4), H417-H429 (2023-01-28)
α-Adrenergic receptors are crucial regulators of vascular hemodynamics and essential pharmacological targets for cardiovascular diseases. With aging, there is an increase in sympathetic activation, which could contribute to the progression of aging-associated cardiovascular dysfunction, including stroke. Nevertheless, there is little
Enzo R Porrello et al.
Neonatology, 97(3), 257-265 (2009-11-06)
Perinatal glucocorticoid treatment is associated with hypertrophic cardiomyopathy, but the cellular mechanism is controversial. An underlying interaction between glucocorticoids and the renin-angiotensin system may be important, but whether glucocorticoids modulate angiotensin II (AngII)-dependent cardiomyocyte growth responses in the neonate has
Molly Yao et al.
Methods and protocols, 4(4) (2021-10-27)
Homeostasis of vascular tone is intricately and delicately maintained systemically and locally, by autonomic nerves and hormones in the blood and by intimal vasoactive substances, respectively. The balance can be acutely or chronically interrupted secondary to many alterations, especially under
Hoon Dong Kim et al.
Investigative ophthalmology & visual science, 56(1), 122-131 (2014-12-17)
To evaluate the changes of retinal function with multifocal electroretinogram (mfERG), and estimate the association between functional and structural changes after selective retina therapy (SRT) with microsecond-pulsed laser in comparison to continuous wave laser photocoagulation (cwPC). Selective retina therapy and
E Delgado et al.
Ophthalmic research, 43(3), 113-121 (2009-11-06)
Although nitric oxide (NO) has been shown to be essential for maintaining the basal blood flow in the retina and optic nerve head, its exact role in vasomotion is still controversial. This study investigated L-arginine (L-Arg) and N-nitro-L-arginine methylester (L-NAME)
Su Young Han et al.
The European journal of neuroscience, 42(9), 2690-2698 (2015-09-06)
Vasopressin secretion from the posterior pituitary gland is determined by action potential discharge of hypothalamic magnocellular neurosecretory cells. Vasopressin is a potent vasoconstrictor, but vasopressin levels are paradoxically elevated in some patients with established hypertension. To determine whether vasopressin neurons
Ke Jiang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(52), E5716-E5723 (2014-12-17)
Inherited photoreceptor degenerations (IPDs), a group of incurable progressive blinding diseases, are caused by mutations in more than 200 genes, but little is known about the molecular pathogenesis of photoreceptor (PR) death. Increased retinal expression of STAT3 has been observed
Xu Zhang et al.
Methods in molecular biology (Clifton, N.J.), 2375, 77-90 (2021-10-01)
Human tissue-engineered blood vessels (TEBVs) that exhibit vasoactivity can be used to test drug toxicity, modulate pro-inflammatory cytokines, and model disease states in vitro. We developed a novel device to fabricate arteriole-scale human endothelialized TEBVs in situ with smaller volumes
K Suehiro et al.
Anaesthesia, 70(2), 150-159 (2014-10-01)
Measurement of left ventricular stroke volume and cardiac output is very important for managing haemodynamically unstable or critically ill patients. The aims of this study were to compare stroke volume measured by three-dimensional transoesophageal echocardiography with stroke volume measured using
Somruedee Yorsin et al.
Journal of ethnopharmacology, 156, 162-174 (2014-08-30)
In Thai traditional medicine, rhizomes of Kaempferia parviflora (KP) have been used for treating hypertension and for the promotion of longevity with good health and well being. Ageing is one of the most important risk factors for development of cardiovascular
Sheila A Engi et al.
PloS one, 9(8), e105172-e105172 (2014-08-15)
Concomitant use of anabolic androgenic steroids and cocaine has increased in the last years. However, the effects of chronic exposure to these substances during adolescence on cardiovascular function are unknown. Here, we investigated the effects of treatment for 10 consecutive
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