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Showing 1-30 of 56 results for "P6282" within Papers
D Thumkeo et al.
Science advances, 6(1), eaay2432-eaay2432 (2020-01-09)
The mechanism by which the cytosolic protein Zap70 physically interacts with and phosphorylates its substrate, the transmembrane protein LAT, upon T cell receptor (TCR) stimulation remains largely obscure. In this study, we found that the pharmacological inhibition of formins, a
Anna Moskovskich et al.
Scientific reports, 9(1), 10471-10471 (2019-07-20)
Host factor requirements for different classes of viruses have not been fully unraveled. Replication of the viral genome and synthesis of viral proteins within the human host cell are associated with an increased demand for nutrients and specific metabolites. With
Oriane Mercati et al.
Biology open, 2(3), 324-334 (2013-03-23)
The neural cell-adhesion molecules contactin 4, contactin 5 and contactin 6 are involved in brain development, and disruptions in contactin genes may confer increased risk for autism spectrum disorders (ASD). We describe a co-culture of rat cortical neurons and HEK293
Valeria Perugini et al.
Journal of materials science. Materials in medicine, 31(4), 37-37 (2020-03-25)
The in vitro study of the properties of the human mesenchymal stem cells as well as their manipulation in culture for clinical purposes depends on the elimination of artefacts caused by the lack of their natural environment. It is now
Jérôme Finke et al.
Medical microbiology and immunology, 209(4), 447-459 (2020-06-15)
Tetraspanins are master organizers of the cell membrane. Recent evidence suggests that tetraspanins themselves may become crowded by virus particles and that these crowds/aggregates co-internalize with the viral particles. Using microscopy, we studied human papillomavirus (HPV) type 16-dependent aggregates on
Shah Alam et al.
Cells, 9(10) (2020-10-02)
We have shown that sphingosine 1-phosphate (S1P) generated by sphingosine kinase 2 (SK2) is toxic in neurons lacking S1P-lyase (SGPL1), the enzyme that catalyzes its irreversible cleavage. Interestingly, patients harboring mutations in the gene encoding this enzyme (SGPL1) often present
Does NAD (P) H oxidase-derived H 2 O 2 participate in hypotonicity-induced insulin release by activating VRAC in beta-cells?
Crutzen R, et al.
Pfluegers Archiv, 463(2), 377-390 (2012)
Eberhard Grambow et al.
Platelets, 28(5), 509-517 (2016-11-08)
The volatile transmitter hydrogen sulfide (H
Catherine M Czeisler et al.
The Journal of physiology, 597(8), 2225-2251 (2019-02-02)
The embryonic PHOX2B-progenitor domain generates neuronal and glial cells which together are involved in chemosensory control of breathing and sleep homeostasis. Ablating PHOX2B-derived astrocytes significantly contributes to secondary hypoxic respiratory depression as well as abnormalities in sleep homeostasis. PHOX2B-derived astrocyte
Liuke Sun et al.
Scientific reports, 8(1), 383-383 (2018-01-13)
Neuroinflammation is involved in the pathogenesis of Parkinson's disease (PD) and other neurodegenerative disorders. We show that lack of PINK1- a mitochondrial kinase linked to recessive familial PD - leads to glia type-specific abnormalities of innate immunity. PINK1 loss enhances
Ana Cicvaric et al.
Frontiers in cellular neuroscience, 13, 561-561 (2020-02-06)
Podoplanin (Pdpn), a brain-tumor-related glycoprotein identified in humans and animals, is endogenously expressed in several organs critical for life support such as kidney, lung, heart and brain. In the brain, Pdpn has been identified in proliferative nestin-positive adult neural progenitor
Chiara Cianciaruso et al.
Cell reports, 27(10), 3062-3080 (2019-06-06)
Extracellular vesicles (EVs), including exosomes, modulate multiple aspects of cancer biology. Tumor-associated macrophages (TAMs) secrete EVs, but their molecular features and functions are poorly characterized. Here, we report methodology for the enrichment, quantification, and proteomic and lipidomic analysis of EVs
Enrico Girardi et al.
Nature communications, 11(1), 6145-6145 (2020-12-03)
About a thousand genes in the human genome encode for membrane transporters. Among these, several solute carrier proteins (SLCs), representing the largest group of transporters, are still orphan and lack functional characterization. We reasoned that assessing genetic interactions among SLCs
Katarzyna Majstrowicz et al.
Journal of cell science, 134(10) (2021-05-21)
Myosin XIX (Myo19) is an actin-based motor that competes with adaptors of microtubule-based motors for binding to the outer mitochondrial transmembrane proteins Miro1 and Miro2 (collectively Miro, also known as RhoT1 and RhoT2, respectively). Here, we investigate which mitochondrial and
Rahul Munshi et al.
Frontiers in neuroscience, 12, 560-560 (2018-08-30)
Determining the role and necessity of specific neurons in a network calls for precisely timed, reversible removal of these neurons from the circuit via remotely triggered transient silencing. Previously, we have shown that alternating magnetic field mediated heating of magnetic
Changsong Yang et al.
Nature cell biology, 21(5), 603-613 (2019-04-17)
Mitochondrial fission involves the preconstriction of an organelle followed by scission by dynamin-related protein Drp1. Preconstriction is facilitated by actin and non-muscle myosin II through a mechanism that remains unclear, largely due to the unknown cytoskeletal ultrastructure at mitochondrial constrictions.
Direct addition of poly-lysine or poly-ethylenimine to the medium: A simple alternative to plate pre-coating
Alexander Faussner, et al.
PLoS ONE, 17(7) (2022)
Angel Stanoev et al.
Cell systems, 7(3), 295-309 (2018-08-27)
The proto-oncogenic epidermal growth factor receptor (EGFR) is a tyrosine kinase whose sensitivity to growth factors and signal duration determines cellular behavior. We resolve how EGFR's response to epidermal growth factor (EGF) originates from dynamically established recursive interactions with spatially
Tamara V Milosevic et al.
International journal of antimicrobial agents, 54(5), 661-667 (2019-08-03)
Thrombocytopenia is commonly seen in patients receiving linezolid for >14 days. Linezolid is a reversible inhibitor of mitochondrial function in various cell types. This study investigated the inhibitory effects of linezolid and tedizolid, and their potential recovery on (i) CYTox
Gavin D M Jeffries et al.
Scientific reports, 10(1), 19529-19529 (2020-11-12)
Significant strides have been made in the development of in vitro systems for disease modelling. However, the requirement of microenvironment control has placed limitations on the generation of relevant models. Herein, we present a biological tissue printing approach that employs
Arkadiy K Golov et al.
Epigenetics & chromatin, 14(1), 36-36 (2021-07-30)
Cohesin is a key organizer of chromatin folding in eukaryotic cells. The two main activities of this ring-shaped protein complex are the maintenance of sister chromatid cohesion and the establishment of long-range DNA-DNA interactions through the process of loop extrusion.
Lan-Xue Zhao et al.
PloS one, 8(11), e79671-e79671 (2013-11-22)
Candida albicans is the most common human fungal pathogen and has a high propensity to develop biofilms that are resistant to traditional antifungal agents. In this study, we investigated the effect of tetrandrine (TET) on growth, biofilm formation and yeast-to-hypha
Min-Guk Cho et al.
Free radical biology & medicine, 108, 129-145 (2017-03-28)
Aneuploidy, an abnormal number of chromosomes that is a hallmark of cancer cells, can arise from tetraploid/binucleated cells through a failure of cytokinesis. Reactive oxygen species (ROS) have been implicated in various diseases, including cancer. However, the nature and role
Karine Z Oben et al.
Oncotarget, 8(44), 77436-77452 (2017-11-05)
Myelodysplastic syndromes (MDS) are a diverse group of malignant clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis, dysplastic cell morphology in one or more hematopoietic lineages, and a risk of progression to acute myeloid leukemia (AML). Approximately 50% of
Stephanie Santarriaga et al.
Molecular cell, 71(2), 216-228 (2018-07-22)
The polyglutamine (polyQ) diseases are a group of nine neurodegenerative diseases caused by the expansion of a polyQ tract that results in protein aggregation. Unlike other model organisms, Dictyostelium discoideum is a proteostatic outlier, naturally encoding long polyQ tracts yet
CXCR4 controls ventral migration of sympathetic precursor cells
Kasemeier KJC, et al.
The Journal of Neuroscience, 30(39), 13078-13088 (2010)
Kristina Riegel et al.
Cell death and differentiation, 27(4), 1300-1315 (2019-09-22)
RAF kinases (ARAF, BRAF, and CRAF) are highly conserved enzymes that trigger the RAF-MEK1/2-ERK1/2 (MAPK) pathway upon activation of RAS. Despite enormous clinical interest, relatively little is known on the role of RAFs in mediating immune responses. Here, we investigated
Polylysine for skin regeneration: A review of recent advances and future perspectives
Payam Zarrintaj, et al.
Journal of Separation Science, 7(1) (2021)
Mónica Díaz-Coránguez et al.
PloS one, 8(4), e60655-e60655 (2013-05-03)
Transit of human neural stem cells, ReNcell CX, through the blood brain barrier (BBB) was evaluated in an in vitro model of BBB and in nude mice. The BBB model was based on rat brain microvascular endothelial cells (RBMECs) cultured
Yanchao Mu et al.
Autophagy, 14(4), 654-670 (2017-11-14)
In the advanced stages of cancer, autophagy is thought to promote tumor progression through its ability to mitigate various cellular stresses. However, the details of how autophagy is homeostatically regulated in such tumors are unknown. Here, we report that NUPR1
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