P6474

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Showing 1-17 of 17 results for "P6474" within Papers

Salmonella and Escherichia coli O157:H7 contamination on hides and carcasses of cull cattle presented for slaughter in the United States: an evaluation of prevalence and bacterial loads by immunomagnetic separation and direct plating methods.

Dayna M Brichta-Harhay et al.

Applied and environmental microbiology, 74(20), 6289-6297 (2008-08-30)

The hide and carcass hygiene of cull cattle at slaughter in four geographically distant regions of the United States was examined from July 2005 to April 2006 by measuring the aerobic plate counts (APC) and the prevalences and loads of

Peroral amphotericin B polymer nanoparticles lead to comparable or superior in vivo antifungal activity to that of intravenous Ambisome® or Fungizone™.

Jagdishbhai L Italia et al.

PloS one, 6(10), e25744-e25744 (2011-10-15)

Despite advances in the treatment, the morbidity and mortality rate associated with invasive aspergillosis remains unacceptably high (70-90%) in immunocompromised patients. Amphotericin B (AMB), a polyene antibiotic with broad spectrum antifungal activity appears to be a choice of treatment but

Paradoxical effect of isoniazid on the activity of rifampin-pyrazinamide combination in a mouse model of tuberculosis.

Deepak Almeida et al.

Antimicrobial agents and chemotherapy, 53(10), 4178-4184 (2009-07-22)

To investigate the antagonism between isoniazid (INH) and rifampin (rifampicin) (RIF)-pyrazinamide (PZA) combination observed in Mycobacterium tuberculosis-infected mice, extensive pharmacokinetic studies of INH were performed and followed by experiments to assess the impact of increasing doses of INH on the

High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors.

Thierry Christophe et al.

PLoS pathogens, 5(10), e1000645-e1000645 (2009-10-31)

A critical feature of Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), is its ability to survive and multiply within macrophages, making these host cells an ideal niche for persisting microbes. Killing the intracellular tubercle bacilli is a key

Removal of mercury by foam fractionation using surfactin, a biosurfactant.

Hau-Ren Chen et al.

International journal of molecular sciences, 12(11), 8245-8258 (2011-12-17)

The separation of mercury ions from artificially contaminated water by the foam fractionation process using a biosurfactant (surfactin) and chemical surfactants (SDS and Tween-80) was investigated in this study. Parameters such as surfactant and mercury concentration, pH, foam volume, and

In vitro activities of natural products against oral Candida isolates from denture wearers.

Cristina Marcos-Arias et al.

BMC complementary and alternative medicine, 11, 119-119 (2011-11-29)

Candida-associated denture stomatitis is a frequent infectious disease. Treatment of this oral condition is difficult because failures and recurrences are common. The aim of this study was to test the in vitro antifungal activity of pure constituents of essentials oils.

Neuroprotective effects of a nanocrystal formulation of sPLA(2) inhibitor PX-18 in cerebral ischemia/reperfusion in gerbils.

Qun Wang et al.

Brain research, 1285, 188-195 (2009-06-17)

The group IIA secretory phospholipase A2 (sPLA(2)-IIA) has been studied extensively because of its involvement in inflammatory processes. Up-regulation of this enzyme has been shown in a number of neurodegenerative diseases including cerebral ischemia and Alzheimer's disease. PX-18 is a

Comparing the xylose reductase/xylitol dehydrogenase and xylose isomerase pathways in arabinose and xylose fermenting Saccharomyces cerevisiae strains.

Maurizio Bettiga et al.

Biotechnology for biofuels, 1(1), 16-16 (2008-10-25)

Ethanolic fermentation of lignocellulosic biomass is a sustainable option for the production of bioethanol. This process would greatly benefit from recombinant Saccharomyces cerevisiae strains also able to ferment, besides the hexose sugar fraction, the pentose sugars, arabinose and xylose. Different

In vivo comparison of two human norovirus surrogates for testing ethanol-based handrubs: the mouse chasing the cat!

Syed A Sattar et al.

PloS one, 6(2), e17340-e17340 (2011-03-11)

Human noroviruses (HuNoV), a major cause of acute gastroenteritis worldwide, cannot be readily cultured in the lab. Therefore, a feline calicivirus (FCV) is often used as its surrogate to, among other things, test alcohol-based handrubs (ABHR). The more recent laboratory

Retinoic acid-treated pluripotent stem cells undergoing neurogenesis present increased aneuploidy and micronuclei formation.

Rafaela C Sartore et al.

PloS one, 6(6), e20667-e20667 (2011-06-16)

The existence of loss and gain of chromosomes, known as aneuploidy, has been previously described within the central nervous system. During development, at least one-third of neural progenitor cells (NPCs) are aneuploid. Notably, aneuploid NPCs may survive and functionally integrate

Chemical modification of reactive multilayered films fabricated from poly(2-alkenyl azlactone)s: design of surfaces that prevent or promote mammalian cell adhesion and bacterial biofilm growth.

Maren E Buck et al.

Biomacromolecules, 10(6), 1564-1574 (2009-05-15)

We report an approach to the design of reactive polymer films that can be functionalized post-fabrication to either prevent or promote the attachment and growth of cells. Our approach is based on the reactive layer-by-layer assembly of covalently crosslinked thin

Identification of a chemical that inhibits the mycobacterial UvrABC complex in nucleotide excision repair.

Nayef Mazloum et al.

Biochemistry, 50(8), 1329-1335 (2011-01-18)

Bacterial DNA can be damaged by reactive nitrogen and oxygen intermediates (RNI and ROI) generated by host immunity, as well as by antibiotics that trigger bacterial production of ROI. Thus a pathogen's ability to repair its DNA may be important

An oral Mycobacterium bovis BCG vaccine for wildlife produced in the absence of animal-derived reagents.

Martin L Cross et al.

Clinical and vaccine immunology : CVI, 16(9), 1378-1380 (2009-07-03)

Cultures of Mycobacterium bovis BCG, comprising predominantly single-cell bacilli, were prepared in broth without animal-derived reagents. When formulated into a vegetable-derived lipid matrix, the vaccine was stable in vitro and was immunogenic in vivo upon feeding it to mice. This

Synergy between inhibitors of androgen receptor and MEK has therapeutic implications in estrogen receptor-negative breast cancer.

Ali Naderi et al.

Breast cancer research : BCR, 13(2), R36-R36 (2011-04-05)

Estrogen receptor-negative (ER-) breast cancer is a heterogeneous disease with limited therapeutic options. The molecular apocrine subtype constitutes 50% of ER-tumors and is characterized by overexpression of steroid response genes including androgen receptor (AR). We have recently identified a positive

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice.

Stephanie J Alexopoulos et al.

Nature communications, 11(1), 2397-2397 (2020-05-16)

Obesity is a health problem affecting more than 40% of US adults and 13% of the global population. Anti-obesity treatments including diet, exercise, surgery and pharmacotherapies have so far failed to reverse obesity incidence. Herein, we target obesity with a

Medroxyprogesterone acetate alters Mycobacterium bovis BCG-induced cytokine production in peripheral blood mononuclear cells of contraceptive users.

Léanie Kleynhans et al.

PloS one, 6(9), e24639-e24639 (2011-09-21)

Most individuals latently infected with Mycobacterium tuberculosis (M.tb) contain the infection by a balance of effector and regulatory immune responses. This balance can be influenced by steroid hormones such as glucocorticoids. The widely used contraceptive medroxyprogesterone acetate (MPA) possesses glucocorticoid

Enhanced bactericidal activity of rifampin and/or pyrazinamide when combined with PA-824 in a murine model of tuberculosis.

Rokeya Tasneen et al.

Antimicrobial agents and chemotherapy, 52(10), 3664-3668 (2008-08-13)

PA-824 is in phase II clinical testing to treat tuberculosis. At a dose of 100 mg/kg of body weight, it has demonstrated bactericidal activity during the initial and continuation phases of treatment in a murine model of tuberculosis. In a

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