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Showing 1-30 of 253 results for "P6500" within Papers
Leandro F Oliveira et al.
Scientific reports, 9(1), 4051-4051 (2019-03-13)
Pre-eclampsia (PE) affects approximately 2 to 8% of pregnant women, causing blood pressure above 140 × 90 mmHg and proteinuria, normally after the 20th gestation week. If unsuccessfully treated, PE can lead to self-limited seizures (Eclampsia) that could eventually result in death of
Ekaterina Kopeikina et al.
Progress in neurobiology, 188, 101783-101783 (2020-03-07)
The drugs currently available for treating epilepsy are only partially effective in managing this condition. Therefore, it is crucial to investigate new pathways that induce and promote epilepsy development. Previously, we found that platelets interact with neuronal glycolipids and actively
Ke Mao et al.
International journal of clinical and experimental medicine, 8(6), 8820-8827 (2015-08-27)
The study was designed to investigate the effect of various concentrations of cannabidiol (CBD) in rats with chronic epilepsy. The chronic epilepsy rat model was prepared by intraperitoneally injecting pentylenetetrazole to the rats pre-treated with CBD (10, 20 and 50
Nycole Ashley Copping et al.
Epilepsy & behavior : E&B, 101(Pt A), 106547-106547 (2019-11-08)
Three highly utilized strains of mice, common for preclinical genetic studies, were evaluated for seizure susceptibility and behavioral outcomes common to the clinical phenotypes of numerous psychiatric disorders following repeated low-dose treatment with either a gamma-aminobutyric acid (GABA) receptor antagonist
Luke T Stewart et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(34), 8207-8215 (2017-08-02)
O-GlcNAcylation is a ubiquitous and dynamic post-translational modification involving the O-linkage of β-
Sadia Adil et al.
Drug development research, 79(4), 184-197 (2018-07-11)
In this study different derivatives of ferrocene-incorporated acyl ureas and homoleptic cadmium carboxylates were investigated for potential anticonvulsant, anxiolytic and sedative properties, using in-silico and in-vivo techniques. The molecular docking studies reveled that ferrocene compounds derivative 1-(4-bromobenzoyl)-3-(4-ferrocenylphenyl) urea (PB1) and
Depeng Wang et al.
Biomedical optics express, 12(7), 3887-3901 (2021-08-31)
Light-field fluorescence microscopy can record large-scale population activity of neurons expressing genetically-encoded fluorescent indicators within volumes of tissue. Conventional light-field microscopy (LFM) suffers from poor lateral resolution when using wide-field illumination. Here, we demonstrate a structured-illumination light-field microscopy (SI-LFM) modality
Leila Moezi et al.
Neuropharmacology, 72, 1-8 (2013-04-30)
Adenosine agonists or low doses of morphine exert anti-convulsant effects in different models of seizures. On the other hand, a tight interaction has been reported between morphine and adenosine in various paradigms. This study investigated the effect of the interaction
Sabina Rybka et al.
Archiv der Pharmazie, 347(10), 768-776 (2014-08-21)
A series of 22 new N-[(4-phenylpiperazin-1-yl)-methyl]-3-methyl-pyrrolidine-2,5-dione and pyrrolidine-2,5-dione derivatives were synthesized and evaluated for their anticonvulsant activities in the maximum electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) seizure tests after intraperitoneal injection into mice. The neurotoxicity was determined applying the rotarod
Reza Jahani et al.
Iranian journal of pharmaceutical research : IJPR, 19(3), 110-121 (2021-03-09)
In this study, we focused on the neuro-behavioral profile, toxicity, and possible mechanisms of action of Dorema ammoniacum gum essential oil (DAG-EO). For this purpose, passive avoidance and Y-maze tests were performed to evaluate the potential effect of DAG-EO in
Mehwish Anwer et al.
Scientific reports, 9(1), 11819-11819 (2019-08-16)
Traumatic brain injury (TBI) causes neuroendocrine dysregulation in up to 40% of humans, which is related to impaired function of the hypothalamo-hypophyseal axis and contributes to TBI-related co-morbidities. Our objective was to investigate whether hypophyseal atrophy can be recapitulated in
Christopher J Yuskaitis et al.
Annals of clinical and translational neurology, 8(7), 1388-1397 (2021-06-09)
To confirm the critical factors affecting seizure susceptibility in acute pentylenetetrazole (PTZ) mouse epilepsy models and evaluate the prior literature for these factors. Serial cohorts of wild-type mice administered intraperitoneal (IP)-PTZ were aggregated and analyzed by multivariate logistic regression for
G Asuntha et al.
Indian journal of experimental biology, 53(1), 31-35 (2015-02-14)
Argemone mexicana (L.) has a role in the treatment of epileptic disorders in Indian traditional system of medicine. We studied its effect on induced status epilepticus (SE) and oxidative stress in rats. SE was induced in male albino rats by
Toshimitsu Suzuki et al.
Annals of clinical and translational neurology, 7(7), 1117-1131 (2020-06-13)
Neurodevelopmental disorders (NDDs) often associate with epilepsy or craniofacial malformations. Recent large-scale DNA analyses identified hundreds of candidate genes for NDDs, but a large portion of the cases still remain unexplained. We aimed to identify novel candidate genes for NDDs.
Leila Moezi et al.
Pharmacology, 95(5-6), 264-270 (2015-05-30)
Almost all antipsychotics have been associated with a risk of epileptic seizure provocation. Aripiprazole is a novel atypical antipsychotic. The risk of seizures with aripiprazole is reported to be the lowest among atypical agents. In this study, we investigated the
Sophie Longueville et al.
The European journal of neuroscience, 53(5), 1450-1472 (2020-11-24)
Permanent tagging of neuronal ensembles activated in specific experimental situations is an important objective to study their properties and adaptations. In the context of learning and memory, these neurons are referred to as engram neurons. Here, we describe and characterize
Gollapalle Lakshminarayanashastry Viswanatha et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 90, 455-465 (2017-04-10)
Colebrookea oppositifolia Smith is one of the commonly used plants to treat epilepsy by various folk medicine communities like nomadic Gujjars, Tharu and Bhoxa in sub-Himalayan regions of India. The present study was undertaken to evaluate the anticonvulsant activity of
Gülsel Yurtdaş Kırımlıoğlu et al.
International journal of pharmaceutics, 495(2), 816-826 (2015-09-22)
Gamma-aminobutyric acid (GABA) is a key neurotransmitter where it usually inhibits impulse transmission. GABA release blockage or postsynaptic reaction were determined to provoke epileptic convulsions. The aim of the present study was the development of brain-targeted, nanosized, nontoxic, biocompatible, highly
Soichi Kawaharada et al.
The Journal of pharmacology and experimental therapeutics, 366(1), 58-65 (2018-04-21)
GABAA receptors containing α5 subunits (GABAAα5) are highly expressed in the hippocampus and negatively involved in memory processing, as shown by the fact that GABAAα5-deficient mice show higher hippocampus-dependent performance than wild-type mice. Accordingly, small-molecule GABAAα5 negative allosteric modulators (NAMs)
J M Witkin et al.
Pharmacology, biochemistry, and behavior, 157, 35-40 (2017-04-27)
Positive allosteric modulators of GABA
Gisele Claudine Nkamguie Nkantchoua et al.
Journal of ethnopharmacology, 212, 18-28 (2017-10-08)
Senna spectabilis (Fabaceae) is one of the medicinal plants used in Cameroon by traditional healers to treat epilepsy, constipation, insomnia, anxiety. The present study aimed to investigate the anticonvulsant effects of Senna spectabilis decoction on seizures induced by maximal electroshock
Enes Akyuz et al.
Life (Basel, Switzerland), 11(4) (2021-04-04)
Epilepsy is characterized by an imbalance in neurotransmitter activity; an increased excitatory to an inhibitory activity. Acetylcholine (ACh), serotonin, and norepinephrine (NE) may modulate neural activity via several mechanisms, mainly through its receptors/transporter activity and alterations in the extracellular potassium
Priya Mishra et al.
Epilepsy & behavior : E&B, 115, 107653-107653 (2020-12-29)
Epileptic seizures are characterized by imbalanced inhibition-excitation cycle that triggers biochemical alterations responsible for jeopardized neuronal integrity. Conventional antiepileptic drugs (AEDs) have been the mainstay option for treatment and control; however, symptomatic control and potential to exacerbate the seizure condition
Gregory M Jacobson et al.
Brain research, 1360, 198-204 (2010-09-14)
Large-scale synchronous firing of neurons during seizures is modulated by electrotonic coupling between neurons via gap junctions. To explore roles for connexin36 (Cx36) gap junctions in seizures, we examined the seizure threshold of connexin36 knockout (Cx36KO) mice using a pentylenetetrazol
R Joshi et al.
Indian journal of experimental biology, 53(7), 446-451 (2015-08-08)
Panchagavya Ghrita (PG), according to Ayurvedic formulary of India (AFI), is used to treat epilepsy (apasmara), fever (jvara), mania (unmade) and jaundice (kamala). In the present study, we examined its effect on convulsions, oxidative stress and cognitive impairment in pentylenetetrazole
Alessia Leonetti et al.
Amino acids, 52(2), 129-139 (2019-06-15)
Several studies have demonstrated high polyamine levels in brain diseases such as epilepsy. Epilepsy is the fourth most common neurological disorder and affects people of all ages. Excitotoxic stress has been associated with epilepsy and it is considered one of
Pavel Mareš et al.
Pharmaceutics, 13(9) (2021-09-29)
The GluN2B subunit of NMDA receptors represents a perspective therapeutic target in various CNS pathologies, including epilepsy. Because of its predominant expression in the immature brain, selective GluN2B antagonists are expected to be more effective early in postnatal development. The
Ahmet Sevki Taskiran et al.
Experimental brain research, 239(2), 591-599 (2021-01-02)
Recent studies have shown that natural antioxidant compounds have positive effects on the nervous system. Lycopene, the red pigment in tomatoes, is one of the potent natural antioxidants, and is used as supplementation because of its well-known health benefits. However
Alison L Althaus et al.
Neuropharmacology, 181, 108333-108333 (2020-09-26)
Zuranolone (SAGE-217) is a novel, synthetic, clinical stage neuroactive steroid GABAA receptor positive allosteric modulator designed with the pharmacokinetic properties to support oral daily dosing. In vitro, zuranolone enhanced GABAA receptor current at nine unique human recombinant receptor subtypes, including
Agha Habibur Rehman et al.
Pakistan journal of pharmaceutical sciences, 32(2), 675-681 (2019-05-14)
Epilepsy remains a major chronic neurological disorder with significantly higher refractory seizure rate. Based on the folk medicine literature, we explored the anticonvulsant and antiepileptogenic activity of aqueous ethanolic extracts of Fumaria indica, Euphorbia lactea, Euphorbia helioscopia, Neurada procumbens, and
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