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Showing 1-30 of 317 results for "P6887" within Papers
Monique Barreto Santos et al.
Food chemistry, 343, 128529-128529 (2020-11-17)
Vitamin D3 plays a fundamental role in human health; however, it is highly susceptible to environmental conditions and the gastrointestinal tract. In this study, complex coacervates obtained from gelatin A and carboxymethyl tara gum (CMTG) were used as wall materials
Manon Lecomte et al.
The Journal of nutrition, 145(8), 1770-1777 (2015-07-03)
Polar lipid (PL) emulsifiers such as milk PLs (MPLs) may affect digestion and subsequent lipid metabolism, but focused studies on postprandial lipemia are lacking. We evaluated the impact of MPLs on postprandial lipemia in mice and on lipid digestion in
Elizabeth A Kelly et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 150(4), 618-624 (2014-01-01)
(1) Investigate the role of reflux, specifically pepsin, in laryngopharyngeal carcinogenesis. (2) Evaluate effects of chronic pepsin exposure on cell migration, apoptosis, and colony-forming ability in hypopharyngeal cells. Translation research. Academic research laboratory. Human hypopharyngeal squamous carcinoma FaDu cells were
Ana M Rovalino-Córdova et al.
Carbohydrate polymers, 253, 117351-117351 (2020-12-07)
The role of the plant matrix is recognized as the main factor restricting starch digestibility in beans. Several authors have provided insights about the mechanisms behind the reduced starch digestibility in plant matrices. In this study, by means of a
Fabiane Cristina Petry et al.
Food & function, 10(12), 8250-8262 (2019-11-14)
Carotenoid esters are present in considerable amounts in most fruits, such as in citrus. Although the bioavailability of carotenoid esters is similar or even higher compared to that of free carotenoids, these molecules are generally detected only in the free
Alexandra L Klinger et al.
Biochemistry, 53(49), 7724-7734 (2014-11-11)
Structural models of the fibrils formed by the 40-residue amyloid-β (Aβ40) peptide in Alzheimer's disease typically consist of linear polypeptide segments, oriented approximately perpendicular to the long axis of the fibril, and joined together as parallel in-register β-sheets to form
Pulivarthi H Rao
Methods in molecular medicine, 113, 71-83 (2005-06-22)
Multiple myeloma (MM) is a clonal neoplasm of terminally differentiated plasma cells (PCs). Conventional cytogenetic analysis is one of the widely accepted DNA genome-screening tools for identification of chromosomal aberrations in MM. The success rate of detection of abnormal karyotypes
Lara E Davis et al.
Molecular cancer research : MCR, 17(3), 676-685 (2018-12-07)
Soft-tissue sarcomas such as leiomyosarcoma pose a clinical challenge because systemic treatment options show only modest therapeutic benefit. Discovery and validation of targetable vulnerabilities is essential. To discover putative kinase fusions, we analyzed existing transcriptomic data from leiomyosarcoma clinical samples.
L R Riviere et al.
Current protocols in protein science, Chapter 11, Unit 11-Unit 11 (2008-04-23)
Analysis of protein covalent structure is less complex and more accurate when performed on peptides derived from the larger protein. In contrast to acid-promoted total hydrolysis, peptides are typically generated by selective proteolysis, i.e., by specifically cleaving peptide bonds with
M Kinoshita et al.
Alimentary pharmacology & therapeutics, 13(5), 687-694 (1999-05-08)
Ecabet sodium, a novel non-systemic anti-ulcer agent, possesses high affinity to gastric adherent mucus, which plays an important role in the protection of the gastric epithelium against acid and pepsin. To assess the effect of ecabet on pepsin-induced degradation of
Lotti Egger et al.
Food chemistry, 340, 128154-128154 (2020-10-04)
Numerous bacteria are responsible for hydrolysis of proteins during cheese ripening. The raw milk flora is a major source of bacterial variety, starter cultures are needed for successful acidification of the cheese and proteolytic strains like Lactobacillus helveticus, are added
Benoît Stijlemans et al.
PLoS pathogens, 7(6), e1002072-e1002072 (2011-06-24)
The African trypanosome Trypanosoma brucei, which persists within the bloodstream of the mammalian host, has evolved potent mechanisms for immune evasion. Specifically, antigenic variation of the variant-specific surface glycoprotein (VSG) and a highly active endocytosis and recycling of the surface
Philipp Ritter et al.
BMC microbiology, 9, 87-87 (2009-05-12)
Probiotic bacteria are thought to play an important role in the digestive system and therefore have to survive the passage from stomach to intestines. Recently, a novel approach to simulate the passage from stomach to intestines in a single bioreactor
Vito M Butardo et al.
Plant physiology, 173(1), 887-906 (2016-11-25)
A deeper understanding of the regulation of starch biosynthesis in rice (Oryza sativa) endosperm is crucial in tailoring digestibility without sacrificing grain quality. In this study, significant association peaks on chromosomes 6 and 7 were identified through a genomewide association
Shuai Wei et al.
Bioactive materials, 18, 300-320 (2022-04-08)
Compared to conventional artificial nerve guide conduits (NGCs) prepared using natural polymers or synthetic polymers, acellular nerve grafts (ACNGs) derived from natural nerves with eliminated immune components have natural bionic advantages in composition and structure that polymer materials do not
Yaroslav Dubrovskii et al.
Talanta, 197, 374-382 (2019-02-18)
Organophosphates' toxic effect causes covalent binding to serine-198 in the active site of human plasma butyrylcholinesterase (BChE) with loss of enzymatic function (covalent inhibition). Mass spectrometric detection of modified FGESAGAAS peptide at the active site is a powerful exposure biomarker
Alison J Hodgkinson et al.
Food chemistry, 245, 275-281 (2017-12-31)
Many infants and young children are fed nutritional milk formulas. Although products are commonly based on cow milk, goat milk provides an alternative. We directly compared digestion of cow and goat milk proteins, varying pH, enzyme concentrations and incubation times
Bartosz Brzozowski
Journal of the science of food and agriculture, 98(9), 3363-3375 (2017-12-27)
The enzymatic modification of wheat proteins during dough fermentation and its digestion as supported by peptidases of microbiological origin can result in the degradation of important peptides in the pathogenesis of coeliac disease. However, baking bread and the high temperature
Noor Akmal Syed Husain Sharifah et al.
Methods in molecular biology (Clifton, N.J.), 952, 187-196 (2012-10-27)
Fluorescence in situ hybridization (FISH) is increasingly gaining importance in clinical diagnostics settings. Due to the ability of the technique to detect chromosomal abnormalities in samples with low cellularity or containing a mixed population of cells even at a single-cell
R A Rocha et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 59, 104-110 (2013-06-12)
Fluoride is considered important for health because of its beneficial effect on the prevention of dental caries and on bone development in the child population. However, excessive intake has negative effects. The main pathway for exposure is oral, through consumption
Liwei Chen et al.
Frontiers in microbiology, 11, 609734-609734 (2020-12-22)
Lactobacillus fermentum PC1 with proven probiotic properties was used to ferment oats with added honey to develop a probiotic beverage with enhanced bioactive ingredients. The viable Lactobacilli were enumerated during the fermentation and storage at 4°C, as well as after
Yohan Reynaud et al.
Food chemistry, 341(Pt 2), 128276-128276 (2020-10-18)
The present study compared in vivo protein digestion in a miniature pig model with the dynamic in vitro system DiDGI®, using three digestive compartments (stomach, duodenum, and jejunum + ileum). Two soya-based meals-commercial soya milk and tofu-were studied, each with the same
J R Knowles et al.
The Biochemical journal, 113(2), 343-351 (1969-06-01)
1. The pH-dependence of the binding to pepsin of four dipeptide competitive inhibitors is reported. Values of K(i) obtained from equilibrium-dialysis experiments agree closely with those from kinetic measurements. 2. The binding of uncharged N-acyl-dipeptide amides to pepsin is essentially
Jing Zhang et al.
Food & function, 11(2), 1790-1797 (2020-02-14)
The effect of sulfated polysaccharides on the digestion of dietary DNA by pepsin was studied using in vitro simulated gastric juice. The results showed that fucoidan (FUC), dextran sulfate (DS) and chondroitin sulfate (CS) could inhibit the digestion of DNA
Cristina Muñoz-San Martín et al.
Analytical and bioanalytical chemistry, 412(24), 6177-6188 (2020-01-29)
Proteases are involved in cancer' taking part in immune (dis)regulation, malignant progression and tumour growth. Recently, it has been found that expression levels of one of the members of the serine protease family, trypsin, is upregulated in human cancer cells
[Current understanding of the role of Helicobacter pylori infection in gastric carcinogenesis and the pepsin- and pepsinogen-producing function of the stomach].
M N Uspenskaia et al.
Voprosy onkologii, 51(5), 533-539 (2006-06-08)
Shenlin Wang et al.
The Journal of biological chemistry, 289(2), 697-707 (2013-11-23)
Multidomain protein folding is often more complex than a two-state process, which leads to the spontaneous folding of the native state. Pepsin, a zymogen-derived enzyme, without its prosegment (PS), is irreversibly denatured and folds to a thermodynamically stable, non-native conformation
Mostafa Zahir et al.
Food research international (Ottawa, Ont.), 143, 110254-110254 (2021-05-17)
Previous studies showed that in vitro digestibility of proteins in cooked beans is modulated by heat treatment and that the effect may be different whether proteins are heated in intact cotyledon or in a bean flour. In this study, germinated
Sara Darakhshan et al.
Tissue engineering and regenerative medicine, 17(4), 459-475 (2020-07-16)
Currently, there is an urgent need for scalable and reliable in vitro models to assess the effects of therapeutic entities on the human liver. Hepatoma cell lines, including Huh-7, show weakly resemblance to human hepatocytes, limiting their significance in toxicity
Hao Wang et al.
Enzyme and microbial technology, 133, 109465-109465 (2019-12-26)
Beta-glucosidase (BGL1) is widely used in animal feed industries. However, degradation caused by digestive enzymes in the intestine hampers its application. Improving the resistance of feed enzymes against proteases is crucial in livestock farming. To improve the resistance of beta-glucosidase
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