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Showing 1-30 of 392 results for "P9620" within Papers
Saima I Machlovi et al.
Neurobiology of disease, 164, 105615-105615 (2022-01-16)
Common genetic variants in more than forty loci modulate risk for Alzheimer's disease (AD). AD risk alleles are enriched within enhancers active in myeloid cells, suggesting that microglia, the brain-resident macrophages, may play a key role in the etiology of
Simon X M Dong et al.
BMC infectious diseases, 21(1), 655-655 (2021-07-09)
Macrophages, besides resting latently infected CD4+ T cells, constitute the predominant stable, major non-T cell HIV reservoirs. Therefore, it is essential to eliminate both latently infected CD4+ T cells and tissue macrophages to completely eradicate HIV in patients. Until now
Xiajie Zhang et al.
Molecular oncology, 16(2), 447-465 (2021-10-18)
Breast cancer is the most diagnosed malignancy in women, with over half a million women dying from this disease each year. In our previous studies, ā40p53, an N-terminally truncated p53 isoform, was found to be upregulated in breast cancers, and
Bo-Xue Ren et al.
British journal of pharmacology, 179(11), 2659-2677 (2021-12-03)
The zinc finger transcription factor Snail is aberrantly activated in many human cancers and strongly associated with poor prognosis. As a transcription factor, Snail has been traditionally considered an 'undruggable' target. Here, we identified a potent small-molecule inhibitor of Snail
Pihai Gong et al.
International journal of molecular sciences, 25(8) (2024-04-27)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to raise concerns worldwide. Numerous host factors involved in SARS-CoV-2 infection have been identified, but the regulatory mechanisms of these host factor remain unclear. Here, we report the role of G-quadruplexes
Roza K Przanowska et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(6), 7687-7702 (2020-04-12)
miR-206, miR-1a-1, and miR-1a-2 are induced during differentiation of skeletal myoblasts and promote myogenesis in vitro. miR-206 is required for skeletal muscle regeneration in vivo. Although this miRNA family is hypothesized to play an essential role in differentiation, a triple
Nan Wang et al.
eLife, 12 (2023-01-06)
Non-coding RNAs exert diverse functions in many cell types. In addition to transcription factors from coding genes, non-coding RNAs may also play essential roles in shaping and directing the fate of germ cells. The presence of many long non-coding RNAs
Lingfei Jia et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(13), 2003376-2003376 (2021-07-15)
Cancer stemness and immune evasion are closely associated, and play critical roles in tumor development and resistance to immunotherapy. However, little is known about the underlying molecular mechanisms that coordinate this association. Here, it is reported that elevated circular RNA
Bert Maier et al.
Methods in molecular biology (Clifton, N.J.), 2130, 103-114 (2020-12-08)
RNA interference (RNAi) allows for the selective downregulation of gene expression by neutralizing targeted mRNA molecules and has frequently been used in high-throughput screening endeavors. Here, we describe a protocol for the highly parallel RNAi-mediated downregulation of gene expression in
Yonghua Zheng et al.
Technology in cancer research & treatment, 22, 15330338231161139-15330338231161139 (2023-03-18)
Objectives: This study aims to investigate the function of the protein arginine methyltransferase 5 (PRMT5) and fibroblast growth factor receptor 3 (FGFR3)/Akt signaling axis in the epithelial-mesenchymal transition (EMT) of human lung cancer. Methods: The mRNA and protein expression levels
Mi-Jeong Kim et al.
Cells, 9(5) (2020-05-10)
Toll-like receptors (TLRs) induce the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-ĪŗB) and autophagy through the TNF (Tumor necrosis factor) receptor-associated factor 6 (TRAF6)-evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) and TRAF6-BECN1 signaling axes, respectively. Having
Niels Boegholm et al.
The EMBO journal, 42(18), e111807-e111807 (2023-08-22)
Cilia are important cellular organelles for signaling and motility and are constructed via intraflagellar transport (IFT). RabL2 is a small GTPase that localizes to the basal body of cilia via an interaction with the centriolar protein CEP19 before downstream association
Katharina Clemm von Hohenberg et al.
Nature communications, 13(1), 668-668 (2022-02-05)
DENR and MCTS1 have been identified as oncogenes in several different tumor entities. The heterodimeric DENRĀ·MCTS1 protein complex promotes translation of mRNAs containing upstream Open Reading Frames (uORFs). We show here that DENR is phosphorylated on Serine 73 by Cyclin
Jason Godfrey et al.
Cancer & metabolism, 10(1), 4-4 (2022-02-07)
Deregulated glucose metabolism is a critical component of cancer growth and survival, clinically evident via FDG-PET imaging of enhanced glucose uptake in tumor nodules. Tumor cells utilize glucose in a variety of interconnected biochemical pathways to generate energy, anabolic precursors
Jianfeng Shen et al.
Investigative ophthalmology & visual science, 51(1), 35-46 (2009-07-25)
To characterize the neuroprotective mechanisms of erythropoietin (EPO) against the stress of glyoxal-advanced glycation end products (AGEs) in retinal neuronal cells. Rat retinal organ culture, primary retinal neuron culture, and retinal cell line (R28 cell) culture under glyoxal-AGEs insult were
Qizhi Geng et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10(30), e2303224-e2303224 (2023-09-04)
Phosphorylation of Ser10 of histone H3 (H3S10p), together with the adjacent methylation of Lys9 (H3K9me), has been proposed to function as a 'phospho-methyl switch' to regulate mitotic chromatin architecture. Despite of immense understanding of the roles of H3S10 phosphorylation, how
The persistent plausibility of protein synthesis in the nucleus: process, palimpsest or pitfall?
Thoru Pederson
Current opinion in cell biology, 25(4), 520-521 (2013-07-23)
Selective desulfurization significantly expands sequence variety of 3'-peptidyl-tRNA mimics obtained by native chemical ligation.
Anna-Skrollan Geiermann et al.
Chembiochem : a European journal of chemical biology, 13(12), 1742-1745 (2012-07-13)
Zhimin Gu et al.
Nature genetics, 53(5), 672-682 (2021-04-10)
Transposable elements or transposons are major players in genetic variability and genome evolution. Aberrant activation of long interspersed element-1 (LINE-1 or L1) retrotransposons is common in human cancers, yet their tumor-type-specific functions are poorly characterized. We identified MPHOSPH8/MPP8, a component
Li Zhang et al.
Arteriosclerosis, thrombosis, and vascular biology, 37(11), 2182-2194 (2017-09-16)
hnRNPA1 (heterogeneous nuclear ribonucleoprotein A1) plays a variety of roles in gene expression. However, little is known about the functional involvement of hnRNPA1 in vascular smooth muscle cell (VSMC) function and neointima hyperplasia. In this study, we have attempted to
Timothy O Adekoya et al.
Carcinogenesis, 42(5), 772-783 (2021-03-13)
Prostate cancer (PCa) constitutes a serious health challenge and remains one of the main causes of cancer-related death among men. The more aggressive form of the disease has been attributed to androgen independence, resulting in a lack of response to
Antonio Marzio et al.
Cell, 185(1), 169-183 (2021-12-29)
Non-small cell lung cancers (NSCLCs) harboring KEAP1 mutations are often resistant to immunotherapy. Here, we show that KEAP1 targets EMSY for ubiquitin-mediated degradation to regulate homologous recombination repair (HRR) and anti-tumor immunity. Loss of KEAP1 in NSCLC induces stabilization of
Adel Hammoutene et al.
Journal of hepatology, 72(3), 528-538 (2019-11-15)
Previous studies demonstrated that autophagy is protective in hepatocytes and macrophages, but detrimental in hepatic stellate cells in chronic liver diseases. The role of autophagy in liver sinusoidal endothelial cells (LSECs) in non-alcoholic steatohepatitis (NASH) is unknown. Our aim was
Anya Bauer et al.
PLoS pathogens, 19(7), e1011059-e1011059 (2023-07-03)
Transmitted/founder (TF) simian-human immunodeficiency viruses (SHIVs) express HIV-1 envelopes modified at position 375 to efficiently infect rhesus macaques while preserving authentic HIV-1 Env biology. SHIV.C.CH505 is an extensively characterized virus encoding the TF HIV-1 Env CH505 mutated at position 375
Ruilin Tian et al.
Neuron, 104(2), 239-255 (2019-08-20)
CRISPR/Cas9-based functional genomics have transformed our ability to elucidate mammalian cell biology. However, most previous CRISPR-based screens were conducted in cancer cell lines rather than healthy, differentiated cells. Here, we describe a CRISPR interference (CRISPRi)-based platform for genetic screens in
Trang T T Nguyen et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 28(9), 1881-1895 (2022-04-14)
Novel therapeutic targets are critical to unravel for the most common primary brain tumor in adults, glioblastoma (GBM). We have identified a novel synthetic lethal interaction between ClpP activation and HDAC1/2 inhibition that converges on GBM energy metabolism. Transcriptome, metabolite
Russell E Brown et al.
Neuroreport, 23(15), 900-903 (2012-09-12)
In marked contrast to several other species, including rats and humans, leptin gene expression is undetectable in mouse brain. This unexpected finding may reflect unique energy regulation pathways in the mouse. We investigated possible mechanisms by which leptin (ob) gene
Amber M Cheatham et al.
The Journal of cell biology, 222(10) (2023-09-13)
In mammalian cells, misfolded glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are cleared out of the ER to the Golgi via a constitutive and a stress-inducible pathway called RESET. From the Golgi, misfolded GPI-APs transiently access the cell surface prior to rapid internalization
Yaoxing Wu et al.
Frontiers in microbiology, 13, 889693-889693 (2022-07-23)
In the past decade, dengue virus infection is one of the most prevalent and rapidly spreading arthropod-borne diseases worldwide with about 400 million infections every year. Although it has been reported that the dengue virus could take advantage of autophagy
Marie Piecyk et al.
Molecular oncology (2023-07-15)
Nutrient availability is a key determinant of tumor cell behavior. While nutrient-rich conditions favor proliferation and tumor growth, scarcity, and particularly glutamine starvation, promotes cell dedifferentiation and chemoresistance. Here, linking ribosome biogenesis plasticity with tumor cell fate, we uncover that
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