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Showing 1-30 of 307 results for "P9767" within Papers
Nina Dinjaski et al.
Biomaterials, 35(1), 14-24 (2013-10-08)
Biomaterial-associated infections represent a significant clinical problem, and treatment of these microbial infections is becoming troublesome due to the increasing number of antibiotic-resistant strains. Here, we report a naturally functionalized bacterial polyhydroxyalkanoate (PHACOS) with antibacterial properties. We demonstrate that PHACOS
Martin Benzler et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 189(3-4), 413-424 (2019-05-28)
Saturated fatty acids are implicated in the development of metabolic diseases, including obesity and type 2 diabetes. There is evidence, however, that polyunsaturated fatty acids can counteract the pathogenic effects of saturated fatty acids. To gain insight into the early
Piyali Majumder et al.
Molecular and cellular biochemistry, 459(1-2), 171-182 (2019-06-04)
Alzheimer's disease (AD) and type 2 diabetes (T2D) share the common hallmark of insulin resistance. It is conjectured that receptor tyrosine kinases (RTKs) play definitive roles in the process. To decipher the signaling overlap behind this phenotypic resemblance, the activity
Yen-Hsiang Chang et al.
Frontiers in endocrinology, 11, 445-445 (2020-08-28)
Background: Plenty of evidence suggested that chronic low-grade inflammation triggered by innate immunity activation contributes to the pathogenesis of type 2 diabetes (T2D). Using the trans-mitochondrial cybrid cell model, we have demonstrated that mitochondria independently take part in the pathological
Wen-Chih Lee et al.
Cell reports, 32(10), 108108-108108 (2020-09-10)
The metabolic program of osteoblasts, the chief bone-making cells, remains incompletely understood. Here in murine calvarial cells, we establish that osteoblast differentiation under aerobic conditions is coupled with a marked increase in glucose consumption and lactate production but reduced oxygen
Dongmei Shi et al.
Lipids in health and disease, 13, 173-173 (2014-11-20)
The endocannabinoids system (ECs) mediated mainly by CB1 and CB2 receptors plays an important role in non-alcoholic fatty liver disease by regulating lipid metabolism. This study is to further investigate the expression of CB1 and CB2 in the fat accumulation
Ji Hye Yang et al.
Life science alliance, 3(7) (2020-06-04)
Despite the importance of mitochondrial fatty acid oxidation (FAO) in cancer metabolism, the biological mechanisms responsible for the FAO in cancer and therapeutic intervention based on catabolic metabolism are not well defined. In this study, we observe that Snail (SNAI1)
Seung-Min Lee et al.
Nature communications, 11(1), 5661-5661 (2020-11-11)
Sarcopenia is characterized by decreased skeletal muscle mass and function with age. Aged muscles have altered lipid compositions; however, the role and regulation of lipids are unknown. Here we report that FABP3 is upregulated in aged skeletal muscles, disrupting homeostasis
Michaela Schäfer et al.
Molecular metabolism, 5(2), 67-78 (2016-02-26)
Cancer cachexia affects the majority of tumor patients and significantly contributes to high mortality rates in these subjects. Despite its clinical importance, the identity of tumor-borne signals and their impact on specific peripheral organ systems, particularly the heart, remain mostly
Vanja Panic et al.
eLife, 9 (2020-08-17)
Brown adipose tissue (BAT) is composed of thermogenic cells that convert chemical energy into heat to maintain a constant body temperature and counteract metabolic disease. The metabolic adaptations required for thermogenesis are not fully understood. Here, we explore how steady
Sarah Krantz et al.
The Journal of biological chemistry, 297(6), 101410-101410 (2021-11-18)
Pluripotent stem cells are known to shift their mitochondrial metabolism upon differentiation, but the mechanisms underlying such metabolic rewiring are not fully understood. We hypothesized that during differentiation of human induced pluripotent stem cells (hiPSCs), mitochondria undergo mitophagy and are
Reinforcement Learning Recruits Somata and Apical Dendrites across Layers of Primary Sensory Cortex.
Clay O Lacefield et al.
Cell reports, 26(8), 2000-2008 (2019-02-21)
The mammalian brain can form associations between behaviorally relevant stimuli in an animal's environment. While such learning is thought to primarily involve high-order association cortex, even primary sensory areas receive long-range connections carrying information that could contribute to high-level representations.
Lin Yao et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 313(5), R560-R571 (2017-08-25)
Obesity-induced vascular dysfunction involves pathological remodeling of the visceral adipose tissue (VAT) and increased inflammation. Our previous studies showed that arginase 1 (A1) in endothelial cells (ECs) is critically involved in obesity-induced vascular dysfunction. We tested the hypothesis that EC-A1
Eugenio Cersosimo et al.
Molecular biology reports, 47(9), 6561-6572 (2020-08-14)
After confirmation of the presence of adiponectin (ADPN) receptors and intra-cellular binding proteins in coronary artery smooth muscle cells (VSMC), we tested the hypotheses that, in acute insulin resistance: (i) the activation/inactivation of metabolic and mitogenic insulin signaling pathways are
William T Hay et al.
Carbohydrate polymers, 161, 140-148 (2017-02-13)
The rheological properties of aqueous solutions and films made from blends of polyvinyl alcohol (PVOH) and amylose-hexadecylammonium chloride inclusion complexes (Hex-Am) were investigated to better understand the polymer interactions and processing parameters. Aqueous solutions of Hex-Am displayed non-Newtonian shear thinning
Youxi Yu et al.
International journal of biological sciences, 17(10), 2576-2589 (2021-07-31)
Background: Nonalcoholic steatohepatitis (NASH) is the most severe form of non-alcoholic fatty liver disease (NAFLD) and a potential precursor of hepatocellular carcinoma (HCC). In our previous studies, we found that endocrine fibroblast growth factor 21 (FGF21) played a key role
S N Patel et al.
Science advances, 7(7) (2021-02-14)
Three-dimensional (3D) multicellular organoids recapitulate the native complexities of human tissue better than traditional cellular monolayers. As organoids are insufficiently supported using standard static culture, microphysiological systems (MPSs) provide a key enabling technology to maintain organoid physiology in vitro. Here
Jun-Su Lee et al.
Biochemical and biophysical research communications, 489(3), 299-304 (2017-05-30)
Liver receptor homolog-1 (LRH-1) is a nuclear receptor that plays an important role in the regulation of bile acid biosynthesis, cholesterol reverse transport, steroidogenesis, and exocrine pancreatic enzyme production. In the current study, previously published data from a genome wide
ChangHyuk Kwon et al.
Biochemical and biophysical research communications, 526(2), 539-545 (2020-04-05)
The pathogenesis of non-alcoholic fatty liver disease (NAFLD) remains unclear. Humanin (HN), a cytoprotective polypeptide, reportedly exhibits neuroprotective effects via suppression of inflammation and improvement of insulin resistance in neurons. This study aim was to investigate effects of HN on
Timothy J Sargeant et al.
Nature cell biology, 16(11), 1057-1068 (2014-10-07)
We have previously demonstrated that Stat3 regulates lysosomal-mediated programmed cell death (LM-PCD) during mouse mammary gland involution in vivo. However, the mechanism that controls the release of lysosomal cathepsins to initiate cell death in this context has not been elucidated.
P S Dalvi et al.
International journal of obesity (2005), 41(1), 149-158 (2016-10-25)
Consumption of dietary fat is one of the key factors leading to obesity. High-fat diet (HFD)-induced obesity is characterized by induction of inflammation in the hypothalamus; however, the temporal regulation of proinflammatory markers and their impact on hypothalamic appetite-regulating neuropeptide
Themis Thoudam et al.
Diabetes, 68(3), 571-586 (2018-12-14)
Mitochondria-associated endoplasmic reticulum membrane (MAM) is a structural link between mitochondria and endoplasmic reticulum (ER). MAM regulates Ca2+ transport from the ER to mitochondria via an IP3R1-GRP75-VDAC1 complex-dependent mechanism. Excessive MAM formation may cause mitochondrial Ca2+ overload and mitochondrial dysfunction.
Lisa S Pike Winer et al.
PloS one, 9(10), e109916-e109916 (2014-11-02)
Cancer cells exhibit remarkable alterations in cellular metabolism, particularly in their nutrient substrate preference. We have devised several experimental methods that rapidly analyze the metabolic substrate flux in cancer cells: glycolysis and the oxidation of major fuel substrates glucose, glutamine
Ketan Thombare et al.
PloS one, 12(5), e0177605-e0177605 (2017-05-19)
Fatty acids acutely stimulate GLP-1 secretion from L-cells in vivo. However, a high fat diet has been shown to reduce the density of L-cells in the mouse intestine and a positive correlation has been indicated between L-cell number and GLP-1
Tatsuya Tominaga et al.
The Journal of biological chemistry, 291(3), 1348-1367 (2015-11-19)
The kidney is one of the target organs for various metabolic diseases, including diabetes, metabolic syndrome, and obesity. Most of the metabolic studies underscore glomerular pathobiology, although the tubulo-interstitial compartment has been underemphasized. This study highlights mechanisms concerning the pathobiology
Yun-Hee Youm et al.
Nature medicine, 21(3), 263-269 (2015-02-17)
The ketone bodies β-hydroxybutyrate (BHB) and acetoacetate (AcAc) support mammalian survival during states of energy deficit by serving as alternative sources of ATP. BHB levels are elevated by starvation, caloric restriction, high-intensity exercise, or the low-carbohydrate ketogenic diet. Prolonged fasting
Min Sun et al.
Pharmaceutical biology, 58(1), 674-685 (2020-07-14)
Rubus species (Rosaceae) have been used in folk medicine to treat diabetes due to their hypoglycaemic activity. To screen the active components that act as hypoglycaemic agents in Rubus amabilis Focke and the underlying mechanisms. Aqueous stem extract of R.
Belén Picatoste et al.
PloS one, 8(10), e78330-e78330 (2013-12-05)
Myocardial fibrosis is a key process in diabetic cardiomyopathy. However, their underlying mechanisms have not been elucidated, leading to a lack of therapy. The glucagon-like peptide-1 (GLP-1) enhancer, sitagliptin, reduces hyperglycemia but may also trigger direct effects on the heart.
Hyunjung Lee et al.
Aging, 13(4), 4881-4894 (2021-02-04)
Post-menopausal conditions exacerbate the biological aging process and this is often accompanied by visceral adiposity with sarcopenia. Mitochondrial impairment is a hallmark of frailty and sarcopenia in the elderly. However, the exact mechanism underlying the development of obesogenic sarcopenia and
Eleonora Cremonini et al.
Archives of biochemistry and biophysics, 646, 55-63 (2018-04-03)
While diets rich in fruit and vegetables can decrease the risk for type 2 diabetes (T2D), diets rich in fat and carbohydrates can increase it. The flavanol-3-ol (-)-epicatechin (EC) can improve insulin sensitivity both in humans and animal models of
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