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Showing 1-17 of 17 results for "PHG0003" within Papers
Špela Zupančič et al.
Molecular pharmaceutics, 11(7), 2334-2345 (2014-05-24)
Curcumin has potent antioxidant and anti-inflammatory properties but poor absorption following oral administration owing to its low aqueous solubility. Development of novel formulations to improve its in vivo efficacy is therefore challenging. In this study, formulation of curcumin-loaded DQAsomes (vesicles
Katelyn T Gause et al.
ACS nano, 9(3), 2433-2444 (2015-02-26)
The development of subunit antigen delivery formulations has become an important research endeavor, especially in cases where a whole cell vaccine approach has significant biosafety issues. Particle-based systems have shown particular efficacy due to their inherent immunogenicity. In some cases
Tongtong Ma et al.
International journal of pharmaceutics, 473(1-2), 296-303 (2014-07-02)
Oral delivery of antigens is patient-friendly and efficient way of treating intestinal infections. However, the efficacy of oral vaccines is limited by degradation in the gastrointestinal (GI) tract and poor absorption by enterocytes and antigen-presenting cells (APC). Here we report
Tao Zhang et al.
Fungal genetics and biology : FG & B, 81, 73-81 (2015-06-09)
The mechanisms of cold adaptation by fungi remain unknown. This topic is of high interest due to the emergence of white-nose syndrome (WNS), a skin infection of hibernating bats caused by Pseudogymnoascus destructans (Pd). Recent studies indicated that apart from
Yi-Jun Wang et al.
Biochemical pharmacology, 90(4), 367-378 (2014-06-18)
Cancer cells often become resistant to chemotherapy through a phenomenon known as multidrug resistance (MDR). Several factors are responsible for the development of MDR, preeminent among them being the accelerated drug efflux mediated by overexpression of ATP binding cassette (ABC)
Seyed-Fakhreddin Torabi et al.
Journal of molecular evolution, 81(5-6), 225-234 (2015-11-19)
We report an investigation of the functional relationship between two independently selected RNA-cleaving DNAzymes, NaA43, and Ce13, through in vitro selection. The NaA43 DNAzyme was obtained through a combination of gel-based and column-based in vitro selection in the presence of
S M Kelleher et al.
Nanotechnology, 26(36), 365703-365703 (2015-08-22)
This paper describes the fabrication of oligonucleotide-coated Cy5-doped silica nanoparticles using a combination of multivalent linkers and their use in surface-based DNA sandwich hybridization assays. Dipodal silane is introduced as a means to fabricate amine-coated silica nanoparticles and its advantages
Patricia Lopez-Sanchez et al.
Soft matter, 11(20), 4002-4010 (2015-04-23)
Cellulose hydrogels are extensively applied in many biotechnological fields and are also used as models for plant cell walls. We synthesised model cellulosic hydrogels containing hemicelluloses, as a biomimetic of plant cell walls, in order to study the role of
Tomoya Narawa et al.
Biological & pharmaceutical bulletin, 38(4), 545-551 (2015-04-04)
The stereoselective transport of methotrexate (L-amethopterin, L-MTX) and its enantiomer (D-amethopterin, D-MTX) by the rat proton-coupled folate transporter (rPCFT) were examined using rPCFT-expressing HEK293 cells. The initial rate of uptake of [3H]-L-MTX by the rPCFT followed Michaelis-Menten kinetics, with a
M Mirazul Islam et al.
Acta biomaterialia, 12, 70-80 (2014-12-03)
The implant-host interface is a critical element in guiding tissue or organ regeneration. We previously developed hydrogels comprising interpenetrating networks of recombinant human collagen type III and 2-methacryloyloxyethyl phosphorylcholine (RHCIII-MPC) as substitutes for the corneal extracellular matrix that promote endogenous
Nagaraju Anreddy et al.
Oncotarget, 6(36), 39276-39291 (2015-10-31)
ATP-binding cassette subfamily G member 2 (ABCG2) is a member of the ABC transporter superfamily proteins, which has been implicated in the development of multidrug resistance (MDR) in cancer, apart from its physiological role to remove toxic substances out of
Jessica R Ray et al.
ACS applied materials & interfaces, 7(21), 11117-11126 (2015-05-06)
Polyamide (PA) semipermeable membranes typically used for reverse osmosis water treatment processes are prone to fouling, which reduces the amount and quality of water produced. By synergistically coupling the photothermal and bactericidal properties of graphene oxide (GO) nanosheets, gold nanostars
Susann K J Ludwig et al.
Analytical and bioanalytical chemistry, 406(27), 6857-6866 (2014-06-29)
Current contaminant and residue monitoring throughout the food chain is based on sampling, transport, administration, and analysis in specialized control laboratories. This is a highly inefficient and costly process since typically more than 99% of the samples are found to
Xu Yu et al.
Biosensors & bioelectronics, 66, 520-526 (2014-12-17)
A novel highly sensitive colorimetric assay for DNA detection using cascade amplification strategy based on hybridization chain reaction and enzyme-induced metallization was established. The DNA modified superparamagnetic beads were demonstrated to capture and enrich the target DNA in the hybridization
Mathieu Cayla et al.
PLoS pathogens, 10(9), e1004347-e1004347 (2014-09-19)
Protozoan pathogens of the genus Leishmania have evolved unique signaling mechanisms that can sense changes in the host environment and trigger adaptive stage differentiation essential for host cell infection. The signaling mechanisms underlying parasite development remain largely elusive even though
Peng Zhai et al.
Materials science & engineering. C, Materials for biological applications, 56, 251-259 (2015-08-08)
Poly(lactic-co-glycolic acid) (PLGA) microspheres and PLGA/alginate composite microspheres were prepared by a novel double emulsion and solvent evaporation technique and loaded with bovine serum albumin (BSA) or rabbit anti-laminin antibody protein. The addition of alginate and the use of a
Didem Rodoplu et al.
Current pharmaceutical design, 21(37), 5389-5400 (2015-09-18)
Magnetic nanoparticles are considered as the ideal substrate to selectively isolate target molecules or organisms from sample solutions in a wide variety of applications including bioassays, bioimaging and environmental chemistry. The broad array of these applications in fields requires the
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