PHR1004

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Showing 1-30 of 227 results for "PHR1004" within Papers

Use of in-die powder densification parameters in the implementation of process analytical technologies for tablet production on industrial scale.

Marco Cespi et al.

International journal of pharmaceutics, 477(1-2), 140-147 (2014-10-12)

The use of process analytical technologies (PAT) to ensure final product quality is by now a well established practice in pharmaceutical industry. To date, most of the efforts in this field have focused on development of analytical methods using spectroscopic

Impact of active ingredients on the swelling properties of orally disintegrating tablets prepared by microwave treatment.

Syusuke Sano et al.

International journal of pharmaceutics, 468(1-2), 234-242 (2014-04-09)

The impact of different active pharmaceutical ingredients (APIs) loading on the properties of orally disintegrating tablets (ODTs) prepared according to our previously reported microwave (MW) treatment process was evaluated using famotidine (FAM), acetaminophen (AAP), and ibuprofen (IBU). None of the

Single- and multiple-dose pharmacokinetics of a hydrocodone bitartrate extended-release tablet formulated with abuse-deterrence technology in healthy, naltrexone-blocked volunteers.

Mona Darwish et al.

Clinical therapeutics, 37(2), 390-401 (2014-12-30)

A hydrocodone extended-release (ER) formulation was developed to provide sustained pain relief with twice-daily dosing. Developed using the CIMA abuse-deterrence technology platform (CIMA Labs Inc, Brooklyn Park, Minnesota), this formulation also provides resistance against rapid release of hydrocodone when tablets

Adoption of polymeric micelles to enhance the oral bioavailability of dexibuprofen: formulation, in-vitro evaluation and in-vivo pharmacokinetic study in healthy human volunteers.

Ghada Abdelbary et al.

Pharmaceutical development and technology, 19(6), 717-727 (2013-08-14)

This work aimed to incorporate Dexibuprofen (DXI), the pharmacologically active and more potent form of ibuprofen, into polymeric micelles based tablets with enhanced oral bioavailability. Thin film hydration technique was employed to prepare DXI polymeric micelles using Pluronic® F127 and/or

Electrochemical detection and degradation of ibuprofen from water on multi-walled carbon nanotubes-epoxy composite electrode.

Sorina Motoc et al.

Journal of environmental sciences (China), 25(4), 838-847 (2013-08-09)

This work describes the electrochemical behaviour of ibuprofen on two types of multi-walled carbon nanotubes based composite electrodes, i.e., multi-walled carbon nanotubes-epoxy (MWCNT) and silver-modified zeolite-multi-walled carbon nanotubes-epoxy (AgZMWCNT) composites electrodes. The composite electrodes were obtained using two-roll mill procedure.

The advantages and limitations of the analgesics available for control of postoperative pain after a dental procedure.

Jasmin Davey

SAAD digest, 29, 70-81 (2013-04-02)

Monitoring and removal of residual phthalate esters and pharmaceuticals in the drinking water of Kaohsiung City, Taiwan.

Gordon C C Yang et al.

Journal of hazardous materials, 277, 53-61 (2014-04-08)

This study monitored the occurrence and removal efficiencies of 8 phthalate esters (PAEs) and 13 pharmaceuticals present in the drinking water of Kaohsiung City, Taiwan. The simultaneous electrocoagulation and electrofiltration (EC/EF) process was used to remove the contaminants. To this

Acetaminophen and Ibuprofen overdosage.

Jennifer Argentieri et al.

Pediatrics in review, 33(4), 188-189 (2012-04-05)

In reply to "ibuprofen for prevention of acute mountain sickness-is bigger really better?".

Jeffrey H Gertsch et al.

Wilderness & environmental medicine, 24(2), 178-179 (2013-06-04)

A low cytotoxic cationic metal-organic framework carrier for controllable drug release.

Quan Hu et al.

Journal of medicinal chemistry, 57(13), 5679-5685 (2014-06-13)

A positively charged porous drug carrier MOF-74-Fe(III) (1, MOF = metal-organic framework), which could not be directly synthesized using ferric salts, was prepared through the oxidation of the neutral crystal MOF-74-Fe(II). This cationic host material exhibits very low cytotoxicity upon

Influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis.

Jakub Vysloužil et al.

Acta pharmaceutica (Zagreb, Croatia), 64(4), 403-417 (2014-12-23)

The main objective of this study was to evaluate the influence of the formulation and process parameters on PLGA microparticles containing a practically insoluble model drug (ibuprofen) prepared by the o/w solvent evaporation method. Multivariate data analysis was used. The

Improved neuroprotection using miglustat, curcumin and ibuprofen as a triple combination therapy in Niemann-Pick disease type C1 mice.

Ian M Williams et al.

Neurobiology of disease, 67, 9-17 (2014-03-19)

Niemann-Pick disease type C (NPC) is a neurodegenerative lysosomal storage disorder characterised by the storage of multiple lipids, reduced lysosomal calcium levels, impaired late endosome:lysosome fusion and neuroinflammation. NPC is caused by mutations in either of the two genes, NPC1

Treatment of acute and recurrent idiopathic pericarditis.

Leonard S Lilly

Circulation, 127(16), 1723-1726 (2013-04-24)

Characterization of lung inflammation and its impact on macrophage function in aging.

Cynthia H Canan et al.

Journal of leukocyte biology, 96(3), 473-480 (2014-06-18)

Systemic inflammation that occurs with increasing age (inflammaging) is thought to contribute to the increased susceptibility of the elderly to several disease states. The elderly are at significant risk for developing pulmonary disorders and infectious diseases, but the contribution of

Investigations on the viscoelastic performance of pressure sensitive adhesives in drug-in-adhesive type transdermal films.

Hans-Michael Wolff et al.

Pharmaceutical research, 31(8), 2186-2202 (2014-03-07)

We aimed to investigate the effect of solubility parameter and drug concentration on the rheological behaviour of drug-in-adhesive films intended for transdermal application. Films were prepared over a range of drug concentrations (5%, 10% and 20% w/w) using ibuprofen, benzoic

Molecular insight into affinities of drugs and their metabolites to lipid bilayers.

Markéta Paloncýová et al.

The journal of physical chemistry. B, 117(8), 2403-2410 (2013-02-08)

The penetration properties of drug-like molecules on human cell membranes are crucial for understanding the metabolism of xenobiotics and overall drug distribution in the human body. Here, we analyze partitioning of substrates of cytochrome P450s (caffeine, chlorzoxazone, coumarin, ibuprofen, and

Colchicine for pericarditis.

Samer Alabed et al.

The Cochrane database of systematic reviews, 8(8), CD010652-CD010652 (2014-08-29)

Pericarditis is the inflammation of the pericardium, the membranous sac surrounding the heart. Recurrent pericarditis is the most common complication of acute pericarditis, causing severe and disabling chest pains. Recurrent pericarditis affects one in three patients with acute pericarditis within

Vanishing bile duct syndrome temporally associated with ibuprofen use.

I Alam et al.

The American journal of gastroenterology, 91(8), 1626-1630 (1996-08-01)

Nonsteroidal anti-inflammatory drugs are widely used, but the potential hepatotoxic side effects are not always appreciated. Herein, we report the first case, to our knowledge, of an atopic patient in whom severe cholestatic jaundice from bile ductopenia developed 3 wk

Patient education and self-care for the management of jaw pain upon awakening: a randomized controlled clinical trial comparing the effectiveness of adding pharmacologic treatment with cyclobenzaprine or tizanidine.

Francisco Guedes Pereira Alencar et al.

Journal of oral & facial pain and headache, 28(2), 119-127 (2014-05-14)

To compare the effectiveness of adding cyclobenzaprine, tizanidine, or placebo to patient education and a self-care management program for patients with myofascial pain and specifically presenting with jaw pain upon awakening. Forty-five patients with a diagnosis of myofascial pain based

Influence of ibuprofen on the infection with Listeria monocytogenes.

S Hockertz et al.

Arzneimittel-Forschung, 45(1), 104-107 (1995-01-01)

Listeria monocytogenes is a bacterial infection, which is facultatively localized in monocytes and macrophages. The influence of ibuprofen (CAS 15687-27-1), a nonsteroidal anti-inflammatory drug (NSAID), on this bacterial infection in balb/c mice was investigated. One day prior to sublethal infection

Prostacyclin regulates bone growth via the Epac/Rap1 pathway.

Michele R Hutchison et al.

Endocrinology, 156(2), 499-510 (2014-11-19)

Prostaglandins, particularly PGE2, are important to adult bone and joint health, but how prostaglandins act on growth plate cartilage to affect bone growth is unclear. We show that growth plate cartilage is distinct from articular cartilage with respect to cyclooxygenase

Effects of ibuprofen, diclofenac, naproxen, and piroxicam on the course of pregnancy and pregnancy outcome: a prospective cohort study.

K Nezvalová-Henriksen et al.

BJOG : an international journal of obstetrics and gynaecology, 120(8), 948-959 (2013-03-16)

To investigate the individual effects of ibuprofen, diclofenac, naproxen, and piroxicam on pregnancy outcome. Cohort study. Norwegian population. A total of 90 417 women and singleton child pairs. The Norwegian Mother and Child Cohort Study and Medical Birth Registry of

Multiresidue method for the determination of pharmacologically active substances in egg and honey using a continuous solid-phase extraction system and gas chromatography-mass spectrometry.

Abdelmonaim Azzouz et al.

Food chemistry, 178, 63-69 (2015-02-24)

A sensitive, selective, efficient gas chromatography-mass spectrometry method for the simultaneous determination of 22 pharmacologically active substances (antibacterials, nonsteroidal antiinflammatories, antiseptics, antiepileptics, lipid regulators, β-blockers and hormones) in eggs and honey was developed. The sample pretreatment includes precipitation of proteins

Ibuprofen vs acetaminophen vs their combination in the relief of musculoskeletal pain in the ED: a randomized, controlled trial.

Eric E Bondarsky et al.

The American journal of emergency medicine, 31(9), 1357-1360 (2013-07-31)

Non-opioid analgesics are often administered to emergency department (ED) patients with musculoskeletal pain but if inadequate, opioids are given with associated potential adverse events. We tested the hypothesis that the reduction in pain scores with the combination of ibuprofen and

Acute generalized exanthematic pustulosis due to ibuprofen.

Lourdes Arochena et al.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110(5), 386-387 (2013-04-30)

Characterization of cefalexin degradation capabilities of two Pseudomonas strains isolated from activated sludge.

Bokun Lin et al.

Journal of hazardous materials, 282, 158-164 (2014-07-30)

Pharmaceuticals have recently been regarded as contaminants of emerging concern. To date, there is limited knowledge about antibiotic-degrading microorganisms in conventional activated sludge treatment systems and their characteristics toward antibiotic degradation especially in the presence of a pharmaceutical mixture. As

Practical approach to prepare solid dispersion drug product using spherical silicate.

Kentaro Nagane et al.

International journal of pharmaceutics, 475(1-2), 364-371 (2014-08-19)

The purpose of this study is to establish a novel approach for preparing a solid dispersion drug product using spherical silicate by a Wurster-type fluidized bed granulator. The spherical silicate used in this study has porous structure and ideal particle

Innovative sampling and extraction methods for the determination of nonsteroidal anti-inflammatory drugs in water.

Shivani Tanwar et al.

Journal of pharmaceutical and biomedical analysis, 106, 100-106 (2014-12-01)

Two different innovative approaches were used for the determination of nonsteroidal anti-inflammatory drugs (NSAIDs) in water: stir bar sorptive extraction (SBSE) and passive sampling, followed by electrospray ionization liquid chromatography-tandem mass spectrometry. SBSE was developed by comparing EG-Silicone and PDMS

Handling Ibuprofen increases pain tolerance and decreases perceived pain intensity in a cold pressor test.

Abraham M Rutchick et al.

PloS one, 8(3), e56175-e56175 (2013-03-08)

Pain contributes to health care costs, missed work and school, and lower quality of life. Extant research on psychological interventions for pain has focused primarily on developing skills that individuals can apply to manage their pain. Rather than examining internal

Comparative pharmacokinetics of rhein in normal and loperamide-induced constipated rats and microarray analysis of drug-metabolizing genes.

Mei-Ling Hou et al.

Journal of ethnopharmacology, 155(2), 1291-1299 (2014-07-22)

Rhein is a pharmacological active component found in Rheum palmatum L. that is the major herb of the San-Huang-Xie-Xin-Tang (SHXXT), a medicinal herbal product used as a remedy for constipation. Here we have investigated the comparative pharmacokinetics of rhein in

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